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    Academic Journals

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• Ultraviolet irradiation transforms C3H10T1-2 cells to a unique, suppressible phenotype

  Authors:Harvey R. Herschmann and David W. BrankowFrom:Science (Vol. 234) Peer-Reviewed

  Dec. 12, 19862,301 words Article Ultraviolet Irradiation Transforms C3H10T1/2 Cells to a Unique, Suppressible Phenotype C3H10T1/2 CELLS (1) ARE A MAJOR cell culture model for the study of transformation by chemical carcinogens (2, 3) and ionizing...

• The role of CT10 regulation of kinase-like in cancer

  Authors:Chunmei Guo, Shuqing Liu, and Ming-Zhong SunFrom:Future Oncology (Vol. 10, Issue 16) Peer-Reviewed

  Dec. 20147,544 words Report 1750LAuthor(s): Chunmei Guo aff1 , Shuqing Liu aff2 , Ming-Zhong Sun [*] aff1 KEYWORDS biomarker; cancer; CRKL; invasion; metastasis The CT10 regulation of kinase (CRK) protein family functions as adapter proteins...

• Mechanical induction of the tumorigenic [beta]-catenin pathway by tumour growth pressure

  Authors:Maria Elena Fernandez-Sanchez, Sandrine Barbier, Joanne Whitehead, Gaelle Bealle, Aude Michel, Heldmuth Latorre-Ossa, et al.From:Nature (Vol. 523, Issue 7558) Peer-Reviewed

  July 2, 20158,224 words Clinical report 1520LThe tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper-proliferative cells (1,2). Here we explore the...

• Oral carcinogenesis and oral cancer chemoprevention: a review

  Authors:Takuji Tanaka, Mayu Tanaka, and Takahiro TanakaFrom:Pathology Research InternationalPeer-Reviewed

  Annual 20118,429 words Report 1460LOral cancer is one of the major global threats to public health. The development of oral cancer is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for...

• Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

  From:Nature Medicine (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 200926 words Brief article 850LGain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Sanada, M. et al. Nature 460, 904-908. Loss of heterozygosity uncovers a gain-of-function mutation that promotes tumorigenesis....

• TGF-βI[superscript two] and its coreceptors in cancerogenesis: an overview

  Authors:Jelena MilovanovicA and Dragica NikolicA-VukosavljevicAFrom:Biomarkers in Medicine (Vol. 5, Issue 6) Peer-Reviewed

  Dec. 20117,053 words Report 1200LAuthor(s): Nataša TodorovicÄ-RakovicÄ [**] 2 , Jelena MilovanovicÄ 1 , Dragica NikolicÄ-VukosavljevicÄ 1 KEYWORDS : [beta]β-glycan; cancer; endoglin; TGF-[beta]β The TGF-[beta]β family are...

• The source of Wnt expression in the colon; subepithelial myofibroblasts and the maintenance of the stem cell niche

  Authors:S. Bamba, W.R. Otto, C.Y. Lee, M. Brittan, and N.A. WrightFrom:Gut (Vol. 53, Issue 4) Peer-Reviewed

  Apr. 2004326 words Brief article Background: Wnt signalling is known to play an important role in the various stages of embryogenesis and carcinogenesis; recent reports have implicated that Wnt proteins could act as growth factors, maintaining the stem...

• Poisoning in the Name of Progress

  Author:Chris BusbyFrom:The Ecologist (Vol. 29, Issue 7) Peer-Reviewed

  Nov. 19994,336 words Article The exposure to increased levels of radiation as a result of the development of nuclear weapons and nuclear power has been associated with an increase in cancers. Topics discussed include the cancer epidemic, the nuclear...

• Activation of ras oncogenes preceding the onset of neoplasia

  Authors:Ramesh Kumar, Saraswati Sukumar, and Mariano BarbacidFrom:Science (Vol. 248, Issue 4959) Peer-Reviewed

  June 1, 19902,123 words Article Activation of ras Oncogenes Preceding the Onset of Neoplasia ACTIVATED ras ONCOGENES HAVE been identified in some common forms of human cancer including carcinomas of the lung, colon, and pancreas [1]. In many...

• The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

  Authors:Nicholas Dyson, Peter M. Howley, Karl Munger, and Ed HarlowFrom:Science (Vol. 243, Issue 4893) Peer-Reviewed

  Feb. 17, 19891,652 words Article The Human Papilloma Virus--16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product THE RETINOBLASTOMA GENE, RB1, is deleted or mutated in many human tumors or tumor cell lines, including retinoblastomas,...

• Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription

  Authors:Morris J. Birnbaum, Howard C. Haspel, and Ora M. RosenFrom:Science (Vol. 235) Peer-Reviewed

  Mar. 20, 19872,671 words Article Transformation of Rat Fibroblasts by FSV Rapidly Increases Glucose Transporter Gene Transcription ONCOGENIC TRANSFORMATION BYviruses involves complex changes in the expression of numerous cellular genes (1). Critical...

• Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?

  Authors:Mariano Bizzarri and Alessandra CucinaFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20148,144 words Report 1610LThe somatic mutation theory of carcinogenesis has eventually accumulated an impressive body of shortfalls and paradoxes, as admittedly claimed by its own supporters given that the cell-based approach can hardly explain...

• The Expression of Ribonucleotide Reductase M2 in the Carcinogenesis of Uterine Cervix and Its Relationship with Clinicopathological Characteristics and Prognosis of Cancer Patients

  Authors:Ying-Fang Su, Tzu-Fan Wu, Jiunn-Liang Ko, Hsiu-Ting Tsai, Yi-Torng Tee, Ming-Hsien Chien, et al.From:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 17, 20145,405 words Article 1420LAuthor(s): Ying-Fang Su 1,2,3, Tzu-Fan Wu 1, Jiunn-Liang Ko 1, Hsiu-Ting Tsai 4,5, Yi-Torng Tee 1,6,7, Ming-Hsien Chien 8,9, Chi-Hung Chou 1,10, Wea-Lung Lin 6,11, Hui-Ying Low 7, Ming-Yung Chou 2, Shun-Fa Yang 1,...

• Promoter Hypermethylation of KLF4 Inactivates Its Tumor Suppressor Function in Cervical Carcinogenesis

  Authors:Wen-Ting Yang and Peng-Sheng ZhengFrom:PLoS ONE (Vol. 9, Issue 2) Peer-Reviewed

  Feb. 14, 20145,679 words Article 1490LAuthor(s): Wen-Ting Yang 1,2, Peng-Sheng Zheng 1,2,3,* Introduction Cervical cancer is a major contributor to cancer-related death in females worldwide and accounts for 250,000 deaths each year [1]. Although...

• Exosomes and tumor-mediated immune suppression

  Author:Theresa L. WhitesideFrom:Journal of Clinical Investigation (Vol. 126, Issue 4) Peer-Reviewed

  Apr. 20166,863 words Report 1420LTumor-derived exosomes (TEX) are harbingers of tumor-induced immune suppression: they carry immunosuppressive molecules and factors known to interfere with immune cell functions. By delivering suppressive cargos...

• Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity

  Authors:Ruth Eichner, Michael Heider, Vanesa Fernandez-Saiz, Frauke van Bebber, Anne-Kathrin Garz, Simone Lemeer, et al.From:Nature Medicine (Vol. 22, Issue 7) Peer-Reviewed

  July 20169,182 words Report 1450LImmunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q)...

• Cotargeting MNK and MEK kinases induces the regression of WF7-mutant cancers

  Authors:Rebecca Lock, Rachel Ingraham, Ophelia Maertens, Abigail L. Miller, Nelly Weledji, Eric Legius, et al.From:Journal of Clinical Investigation (Vol. 126, Issue 6) Peer-Reviewed

  June 20164,861 words Report 1460LNeurofibromin 1-mutant (WF7-mutant) cancers are driven by excessive Ras signaling; however, there are currently no effective therapies for these or other Ras-dependent tumors. While combined MEK and mTORC1 suppression...

• Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

  Authors:Petrus R. de Jong, Naoki Takahashi, Alexandra R. Harris, Jihyung Lee, Samuel Bertin, James Jeffries, et al.From:Journal of Clinical Investigation (Vol. 124, Issue 9) Peer-Reviewed

  Sept. 20148,909 words Report 1370LThe intestinal epithelium has a high rate of turnover, and dysregulation of pathways that regulate regeneration can lead to tumor development; however, the negative regulators of oncogenic events in the intestinal...

• The Updated World Health Organization Glioma Classification: Cellular and Molecular Origins of Adult Infiltrating Gliomas

  Author:David J. PisapiaFrom:Archives of Pathology & Laboratory Medicine (Vol. 141, Issue 12) Peer-Reviewed

  Dec. 1, 201711,540 words Report 2060LContext.--In the recently updated World Health Organization (WHO) classification of central nervous system tumors, our concept of infiltrating gliomas as a molecular dichotomy between oligodendroglial and astrocytic...

• Requirement of NF-kappa-B activation to suppress p53-independent apoptosis induced by oncogenic ras

  Authors:Marty W. Mayo, Cun-Yu Wang, Patricia C. Cogswell, Kelley S. Rogers-Graham, Scott W. Lowe, Channing J. Der, et al.From:Science (Vol. 278, Issue 5344) Peer-Reviewed

  Dec. 5, 19972,630 words Article The ras proto-oncogene is frequently mutated in human tumors and functions to chronically stimulate signal transduction cascades resulting in the synthesis or activation of specific transcription factors, including Ets,...