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    Academic Journals

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• Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation

  Authors:William A. Taylor, Edgard M. Mejia, Ryan W. Mitchell, Patrick C. Choy, Genevieve C. Sparagna, and Grant M. HatchFrom:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 9, 20127,667 words Article 1540LAuthor(s): William A. Taylor 1 , Edgard M. Mejia 1 , Ryan W. Mitchell 1 , Patrick C. Choy 2 , Genevieve C. Sparagna 3 , Grant M. Hatch 1 , 2 , * Introduction Trifunctional protein is a multifunctional,...

• Chemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin Fluctuation

  Authors:Yu-Jen Chao, Jui-Fen Chan, and Yuan-Hao Howard HsuFrom:PLoS ONE (Vol. 11, Issue 9) Peer-Reviewed

  Sept. 14, 20166,359 words Article 1380LChemotherapy drugs have been prescribed for the systemic treatment of cancer. We selected three chemotherapy drugs, including methotrexate, mitomycine C and vincristine to inhibit the proliferation of HT1080 human...

• Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies

  Authors:Barton F. Haynes, Judith Fleming, E. William St. Clair, Herman Katinger, Gabriela Stiegler, Renate Kunert, et al.From:Science (Vol. 308, Issue 5730) Peer-Reviewed

  June 24, 20051,861 words Article 1620LThe design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs)...

• AMP-activated protein kinase [alpha]2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function

  Authors:Yoni Athea, Benoit Viollet, Philippe Mateo, Delphine Rousseau, Marta Novotova, Anne Garnier, et al.From:Diabetes (Vol. 56, Issue 3) Peer-Reviewed

  Mar. 20075,948 words Disease/Disorder ove... 1420LAMP-activated protein kinase (AMPK) plays an important role in controlling energy homeostasis and is envisioned as a promising target to treat metabolic disorders. In the heart, AMPK is involved in short-term regulation...

• Structure of a mitochondrial ATP synthase with bound native cardiolipin.

  Authors:Alexander Mühleip, Sarah E McComas, and Alexey AmuntsFrom:eLife (Vol. 8) Peer-Reviewed

  Nov. 18, 201915,643 words Article 1460LThe mitochondrial ATP synthase fuels eukaryotic cells with chemical energy. Here we report the cryo-EM structure of a divergent ATP synthase dimer from mitochondria of Euglena gracilis, a member of the phylum Euglenozoa...

• SPG20 Protein Spartin Associates with Cardiolipin via Its Plant-Related Senescence Domain and Regulates Mitochondrial Ca.sup.2+ Homeostasis

  Authors:Dinesh C. Joshi and Joanna C. BakowskaFrom:PLoS ONE (Vol. 6, Issue 4) Peer-Reviewed

  Apr. 29, 20118,391 words Article 1420LHereditary spastic paraplegias (HSPs) are a group of neurological disorders characterized clinically by spasticity of lower limbs and pathologically by degeneration of the corticospinal tract. Troyer syndrome is an...

• Downregulation of the Mitochondrial Phosphatase PTPMT1 Is Sufficient to Promote Cancer Cell Death

  Authors:Natalie M. Niemi, Nathan J. Lanning, Laura M. Westrate, and Jeffrey P. MacKeiganFrom:PLoS ONE (Vol. 8, Issue 1) Peer-Reviewed

  Jan. 10, 20138,141 words Article 1520LProtein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a dual specificity phosphatase exclusively localized to the mitochondria, and has recently been shown to be a critical component in the...

• Simultaneous Quantification of Anticardiolipin IgG and IgM by Time Resolved Fluoroimmunoassay

  Authors:Zhigang Hu, Xiaoying Jing, Jie Liu, Mei Li, Yan Ye, and Yu ChenFrom:PLoS ONE (Vol. 11, Issue 9) Peer-Reviewed

  Sept. 23, 20164,352 words Article 1590LThe autoimmune disease antiphospholipid syndrome (APS) is characterized by the presence of anticardiolipin antibodies (aCL), along with anti-[beta].sub.2 -glycoprotein I ([beta].sub.2 GPI) antibodies and lupus...

• Naja naja oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic Three-Fingered Cytotoxins

  Authors:Sardar E. Gasanov, Indira H. Shrivastava, Firuz S. Israilov, Aleksandr A. Kim, Kamila A. Rylova, Boris Zhang, et al.From:PLoS ONE (Vol. 10, Issue 6) Peer-Reviewed

  June 19, 201514,614 words Article 1660LCobra venom cytotoxins are basic three-fingered, amphipathic, non-enzymatic proteins that constitute a major fraction of cobra venom. While cytotoxins cause mitochondrial dysfunction in different cell types, the...

• Antibodies against Native and Oxidized Cardiolipin and Phosphatidylserine and Phosphorylcholine in Atherosclerosis Development

  Authors:Anna G. Frostegard, Jun Su, Xiang Hua, Max Vikstrom, Ulf de Faire, and Johan FrostegardFrom:PLoS ONE (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 4, 20144,522 words Article 1470LBackground Antibodies against cardiolipin and phosphatidylserine (anti-CL and anti-PS) are associated with thrombosis. In contrast, we determined that IgM antibodies against oxidized CL and PS (OxCL and OxPS) and...

• Cytochrome c Negatively Regulates NLRP3 Inflammasomes

  Authors:Chong-Shan Shi and John H. KehrlFrom:PLoS ONE (Vol. 11, Issue 12) Peer-Reviewed

  Dec. 28, 20165,637 words Report 1420LThe release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to...

• Assessing Phospholipase A.sub.2 Activity toward Cardiolipin by Mass Spectrometry

  Authors:Yuan-Hao Hsu, Darren S. Dumlao, Jian Cao, and Edward A. DennisFrom:PLoS ONE (Vol. 8, Issue 3) Peer-Reviewed

  Mar. 22, 20135,398 words Article 1390LAuthor(s): Yuan-Hao Hsu 1 , 2 , 3 , * , Darren S. Dumlao 2 , 3 , Jian Cao 2 , 3 , Edward A. Dennis 2 , 3 , * Introduction Over the past 40 years, scientists have devoted themselves to understanding the enzymes...

• Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes

  Authors:Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, and Ko TakakuraFrom:Journal of Anesthesia (Vol. 24, Issue 4) Peer-Reviewed

  Aug. 20102,049 words Article 1420LMembranous lipid bilayers have been reconsidered as the site of action of local anesthetics (LAs). Recent understanding of biomembranes indicates the existence of lipid raft microdomains enriched in cholesterol and...

• Effect of cardiolipin on the antimicrobial activity of a new amphiphilic aminoglycoside derivative on Pseudomonas aeruginosa

  Authors:Jitendriya Swain, Micheline El Khoury, Julie Kempf, Florian Briee, Patrick Van Der Smissen, Jean-Luc Decout, et al.From:PLoS ONE (Vol. 13, Issue 8) Peer-Reviewed

  Aug. 20, 20185,884 words Article 1480LAmphiphilic aminoglycoside derivatives are promising new antibacterials active against Gram-negative bacteria such as Pseudomonas aeruginosa, including colistin resistant strains. In this study, we demonstrated that...

• CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System

  Authors:Adwitiya Kar, Haley Beam, Megan B. Borror, Michael Luckow, Xiaoli Gao, and Shane L. ReaFrom:PLoS ONE (Vol. 11, Issue 9) Peer-Reviewed

  Sept. 7, 201612,215 words Article 1520LUbiquinone (Q.sub.n) functions as a mobile electron carrier in mitochondria. In humans, Q biosynthetic pathway mutations lead to Q.sub.10 deficiency, a life threatening disorder. We have used a Saccharomyces cerevisiae...

• Ionization Constants pK.sub.a of Cardiolipin

  Authors:Gerd Olofsson and Emma SparrFrom:PLoS ONE (Vol. 8, Issue 9) Peer-Reviewed

  Sept. 13, 20135,269 words Article 1550LCardiolipin is a phospholipid found in the inner mitochondrial membrane and in bacteria, and it is associated with many physiological functions. Cardiolipin has a dimeric structure consisting of two phosphatidyl...

• Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes

  Authors:Baikuntha Aryal and V. Ashutosh RaoFrom:PLoS ONE (Vol. 11, Issue 7) Peer-Reviewed

  July 19, 20168,145 words Report 1530LCardiolipin (CL) is an inner mitochondrial membrane phospholipid which plays an important role in mitochondrial function. Perturbation in CL biosynthesis alters mitochondrial bioenergetics causing a severe genetic...

• Cardiolipin targets a dynamin-related protein to the nuclear membrane.

  Authors:Usha Pallabi Kar, Himani Dey, and Abdur RahamanFrom:eLife (Vol. 10) Peer-Reviewed

  Mar. 4, 202114,228 words Article 1450LDynamins are targeted to specific cellular membranes that they remodel via membrane fusion or fission. The molecular basis of conferring specificity to dynamins for their target membrane selection is not known. Here, we...

• SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

  Authors:Yuxun Zhang, Sivakama S. Bharathi, Matthew J. Rardin, Radha Uppala, Eric Verdin, Bradford W. Gibson, et al.From:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 26, 20155,597 words Article 1380LSIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we demonstrate that SIRT3 and SIRT5 both target human very long-chain...

• Mechanistic Issues of the Interaction of the Hairpin-Forming Domain of tBid with Mitochondrial Cardiolipin

  Authors:Francois Gonzalvez, Fabrizio Pariselli, Olivier Jalmar, Pauline Dupaigne, Franck Sureau, Marc Dellinger, et al.From:PLoS ONE (Vol. 5, Issue 2) Peer-Reviewed

  Feb. 22, 20108,895 words Article 1520LBackground The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, Bid is cleaved by caspase-8 into its active form, tBid (truncated...