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    Academic Journals

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• Select Stem cells: Cause and consequence in aged-muscle decline

  1

  Stem cells: Cause and consequence in aged-muscle decline

  Authors:Susan Eliazer and Andrew S. BrackFrom:Nature (Vol. 540, Issue 7633) Peer-Reviewed

  Dec. 15, 20161,261 words Article 1610LAuthor(s): Susan Eliazer [1]; Andrew S. Brack (corresponding author) [1] As muscle stem cells age, their ability to regenerate skeletal muscle following injury declines. One factor that might be responsible is...
• Select FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

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  FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

  Authors:Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D. Dekker, Baojie Li, et al.From:Journal of Clinical Investigation (Vol. 127, Issue 4) Peer-Reviewed

  Apr. 20178,305 words Report 1390LA hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adipocyte coupled with a decrease in self-renewal capacity. However, how these...
• Select Impact of genomic damage and ageing on stem cell function

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  Impact of genomic damage and ageing on stem cell function

  Authors:Axel Behrens, Jan M. van Deursen, K. Lenhard Rudolph, and Bjorn SchumacherFrom:Nature Cell Biology (Vol. 16, Issue 3) Peer-Reviewed

  Mar. 20146,805 words Report 1480LImpairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells...
• Select Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

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  Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

  Authors:Laura Lukjanenko, M. Juliane Jung, Nagabhooshan Hegde, Claire Perruisseau-Carrier, Eugenia Migliavacca, Michelle Rozo, et al.From:Nature Medicine (Vol. 22, Issue 8) Peer-Reviewed

  Aug. 20168,075 words Report 1470LAge-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of...
• Select Development of a conditionally immortalized human pancreatic [beta] cell line

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  Development of a conditionally immortalized human pancreatic [beta] cell line

  Authors:Raphael Scharfmann, Severine Pechberty, Yasmine Hazhouz, Manon von Bulow, Emilie Bricout-Neveu, Maud Grenier-Godard, et al.From:Journal of Clinical Investigation (Vol. 124, Issue 5) Peer-Reviewed

  May 20146,994 words Report 1410LDiabetic patients exhibit a reduction in [beta] cells, which secrete insulin to help regulate glucose homeostasis; however, little is known about the factors that regulate proliferation of these cells in human pancreas....
• Select DNA damage induced by human CD40 ligand mutant promotes senescence and induces demethylation of GATA4 in lung cancer

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  DNA damage induced by human CD40 ligand mutant promotes senescence and induces demethylation of GATA4 in lung cancer

  Authors:Yue Li, Yunyan Wei, Weiwei Yuan, Qiqing Huang, Yaya Zhao, Weihong Zhao, et al.From:Oncology Reports (Vol. 39, Issue 5) Peer-Reviewed

  May 20184,546 words Report 1310LThe ligand of CD40, known as CD154 or CD40L, is the key to immunostimulatory and anticancer activity, but how CD40L affects cellular senescence is unclear. Thus, we studied a membrane-stable mutant form CD40L (CD40L-M)...
• Select Mechanisms and functions of cellular senescence

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  Mechanisms and functions of cellular senescence

  Authors:Nicolas Herranz and Jesus GilFrom:Journal of Clinical Investigation (Vol. 128, Issue 4) Peer-Reviewed

  Apr. 20187,892 words Report 1330LCellular senescence is a highly stable cell cycle arrest that is elicited in response to different stresses. By imposing a growth arrest, senescence limits the replication of old or damaged cells. Besides exiting the...
• Select Aging in Saccharomyces cerevisiae

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  Aging in Saccharomyces cerevisiae

  Authors:David Sinclair, Kevin Mills, and Leonard GuaranteFrom:Annual Review of Microbiology (Vol. 52) Peer-Reviewed

  Annual 199810,804 words Article The aging in Saccharomyces cerevisiae cells has been found to have a strong genetic component. The activities of genes the influence yeast longevity such as the ras, LAG1, LAC1, LAG2, the UTH genes, SIR4-42 and SGS1...
• Select NURD keeps chromatin young: progerin, a mutated form of lamin a, causes the premature ageing disease Hutchinson-Gilford progeria syndrome and is also involved in normal ageing. Progerin accumulation leads to distinct chromatin-related defects and the NURD complex appears to affect ageing-related chromatin defects

  9

  NURD keeps chromatin young: progerin, a mutated form of lamin a, causes the premature ageing disease Hutchinson-Gilford progeria syndrome and is also involved in normal ageing. Progerin accumulation leads to distinct chromatin-related defects and the NURD complex appears to affect ageing-related chromatin defects

  Authors:Eran Meshorer and Yosef GruenbaumFrom:Nature Cell Biology (Vol. 11, Issue 10) Peer-Reviewed

  Oct. 20091,113 words Report 1460LAgeing involves various cellular and molecular alterations and studying their molecular basis is often difficult. The childhood ageing disease Hutchinson-Gilford progeria syndrome (HGPS) (1,2) is caused by a shortened...
• Select Repeated intra-nigrostriatal injection of phorbol myristate acetate induces microglial senescence in adult rats

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  Repeated intra-nigrostriatal injection of phorbol myristate acetate induces microglial senescence in adult rats

  Authors:Lin Liu, Xiao-Guang Luo, Hong-Mei Yu, Yu Feng, Yan Ren, Ya-Fu Yin, et al.From:Molecular Medicine Reports (Vol. 12, Issue 5) Peer-Reviewed

  Nov. 20155,236 words Report 1340LPhorbol myristate acetate (PMA), as a potent tumor promoter, may induce microglial senescence. The present study investigated the effect of PMA infection on microglial senescence. From 58 male Sprague-Dawley rats, 10...
• Select Potential of bone marrow mesenchymal stem cells in rejuvenation of the aged skin of rats

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  Potential of bone marrow mesenchymal stem cells in rejuvenation of the aged skin of rats

  Authors:Zhen Liu, Guo-Dong Hu, Xiao-Bo Luo, Bin Yin, Bin Shu, Jing-Zhi Guan, et al.From:Biomedical Reports (Vol. 6, Issue 3) Peer-Reviewed

  Mar. 20174,033 words Report 1440LAbstract. The aim of the present study was to evaluate the anti-aging effects of bone marrow-mesenchymal stem cells (BM-MSCs) in a D-galactose-induced skin aging rat model. Male Sprague Dawley rats were randomly divided...
• Select Senotherapeutics for healthy ageing

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  Senotherapeutics for healthy ageing

  Authors:Laura J. Niedernhofer and Paul D. RobbinsFrom:Nature Reviews Drug Discovery (Vol. 17, Issue 5) Peer-Reviewed

  May 20181,793 words Report 1500LAuthor(s): Laura J. Niedernhofer (corresponding author) [1]; Paul D. Robbins (corresponding author) [1] The recent manuscript by Childs et al . in Nature Reviews Drug Discovery [1] thoroughly reviewed the important...
• Select Senescent cells harbour features of the cancer epigenome

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  Senescent cells harbour features of the cancer epigenome

  Authors:Hazel A. Cruickshanks, Tony McBryan, David M. Nelson, Nathan D. VanderKraats, Parisha P. Shah, John van Tuyn, et al.From:Nature Cell Biology (Vol. 15, Issue 12) Peer-Reviewed

  Dec. 20139,608 words Report 1360LAltered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential...
• Select The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence

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  The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence

  Authors:Juliane Wolf, Birgit Weinberger, and Beatrix Grubeck-LoebensteinFrom:Immunity & Ageing (Vol. 9) Peer-Reviewed

  Mar. 29, 20122,765 words Report 1470LBackground As a chronic antigenic stressor human Cytomegalovirus (CMV) contributes substantially to age-related alterations of the immune system. Even though monocytes have the greatest propensity for CMV-infection...
• Select Senescent cells: an emerging target for diseases of ageing

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  Senescent cells: an emerging target for diseases of ageing

  Authors:Bennett G. Childs, Martina Gluscevic, Darren J. Baker, Remi-Martin Laberge, Dan Marquess, Jamie Dananberg, et al.From:Nature Reviews Drug Discovery (Vol. 16, Issue 10) Peer-Reviewed

  Oct. 201716,748 words Report 1580LChronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular...
• Select Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1

  16

  Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1

  Authors:Dae-Gwan Yi, Sujin Hong, and Won-Ki HuhFrom:PLoS ONE (Vol. 13, Issue 6) Peer-Reviewed

  June 18, 20188,478 words Report 1490LMitochondrial dysfunction leads to the accumulation of reactive oxygen species (ROS) which is associated with cellular dysfunction, disease etiology, and senescence. Here, we used the eukaryotic model Saccharomyces...
• Select Senescent glia spell trouble in Alzheimer's disease

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  Senescent glia spell trouble in Alzheimer's disease

  Authors:David Holtzman and Jason UlrichFrom:Nature Neuroscience (Vol. 22, Issue 5) Peer-Reviewed

  May 20191,417 words Report 1560LDNA damage or cellular stresses can induce senescence, and increased senescence with aging contributes to age-associated tissue damage, inflammation and disease. Zheng and colleagues report increased senescent...
• Select Reproductive cloning conserves cellular senescence

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  Reproductive cloning conserves cellular senescence

  Author:John M. SedivyFrom:Nature Cell Biology (Vol. 5, Issue 6) Peer-Reviewed

  June 20031,664 words Article 1420LAuthor(s): John M. Sedivy [1] Reproductive cloning by transfer of diploid nuclei from somatic cells to enucleated oocytes has been achieved in several mammalian species [1]. In the case of large farm animals, this...
• Select Increased tumour cell dissemination and cellular senescence in the absence of [beta]1-integrin function

  19

  Increased tumour cell dissemination and cellular senescence in the absence of [beta]1-integrin function

  From:Nature Reviews Cancer (Vol. 7, Issue 7) Peer-Reviewed

  July 2007123 words Brief article, Clini... 1240LKren, A. et al. EMBO J. 31 May 2007 (doi: 10.1038/sj.emboj.7601738) Gerhard Christofori and colleagues have used the Rip1Tag2 mouse model of pancreatic [beta]-cell tumours to examine the consequence of loss of...
• Select Aging T cells

  20

  Aging T cells

  Author:Laurie A. DempseyFrom:Nature Immunology (Vol. 13, Issue 12) Peer-Reviewed

  Dec. 2012158 words Brief article, Repor... 1350LElderly humans mount weaker immune responses after infection or vaccination than do younger humans. In Nature Medicine, Goronzy and colleagues identify age-related defects in TCR signaling capacity that lessens the...