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From:PLoS ONE (Vol. 7, Issue 10) Peer-ReviewedAuthor(s): Mária Dzunková 1 , 2 , Giuseppe D'Auria 1 , 2 , * , David Pérez-Villarroya 1 , Andrés Moya 1 , 2 Introduction Since the late nineties, metagenomic-based methodologies have been applied to decipher the...
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From:Nature (Vol. 517, Issue 7533) Peer-ReviewedFunctional regeneration after nervous system injury requires transected axons to reconnect with their original target tissue. Axonal fusion, a spontaneous regenerative mechanism identified in several species, provides...
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From:PLoS ONE (Vol. 13, Issue 5) Peer-ReviewedTraditionally, microsecond pulsed electric field was widely used in cell electrofusion technology. However, it was difficult to fuse the cells with different sizes. Because the effect of electroporation based on...
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From:Science (Vol. 237) Peer-ReviewedIdentification by Cell Fusion of Gene Sequences That Interact with Positive Trans-Acting Factors EARLY INVESTIGATIONS WITH STABLEhybrid cell lines implicated both repression and activation mechanisms in the cell...
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From:Neural Regeneration Research (Vol. 11, Issue 2) Peer-ReviewedByline: George. Bittner, Michelle. Mikesh, Cameron. Ghergherehchi Some biological uses of polyethylene glycol (PEG): The use of PEG as a membrane fusogen was first reported in 1976 with the creation of cell hybrids,...
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From:Nature (Vol. 534, Issue 7608) Peer-ReviewedSperm-egg binding is mediated by two cell-surface proteins. Structural analysis of these proteins, separately and in complex, provides insight into the recognition process and the subsequent sperm-egg fusion. See...
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From:Nature (Vol. 485, Issue 7399) Peer-ReviewedAn outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we...
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From:Science (Vol. 255, Issue 5052) Peer-ReviewedGuanosine triphosphate (GTP)-binding proteins are required for intracellular vesicular transport. Mastoparan is a peptide component of wasp venom that increases nucleotide exchange in some classes of G [Alpha] subunits...
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From:PLoS ONE (Vol. 11, Issue 5) Peer-ReviewedDifferentiated somatic cells can be reprogrammed into the pluripotent state by cell-cell fusion. In the pluripotent state, reprogrammed cells may then self-renew and differentiate into all three germ layers....
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From:Science (Vol. 272, Issue 5270) Peer-ReviewedHuman immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the [CD4.sup.+] target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell...
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From:PLoS ONE (Vol. 11, Issue 8) Peer-ReviewedRecent development in 3D printing technology has opened an exciting possibility for manufacturing 3D devices on one's desktop. We used 3D modeling programs to design 3D models of a tissue-handling system and these...
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From:Nature (Vol. 592, Issue 7854) Peer-ReviewedAmong primates, humans display a unique trajectory of development that is responsible for the many traits specific to our species. However, the inaccessibility of primary human and chimpanzee tissues has limited our...
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From:Science (Vol. 242, Issue 4881) Peer-ReviewedActivation of Developmentally Mutated Human Globin Genes by Cell Fusion DURING HUMAN ONTOGENY THERE is a switch from embryonic to fetal globin production early in development and a switch from fetal to adult globin...
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From:Regenerative Medicine (Vol. 3, Issue 2)Author(s): Martin Körbling [[dagger]] 1 , Marcos J de Lima 1 , Elizabeth Thomas 2 , Abha Khanna 2 , Amer M Najjar 3 , Jun Gu 4 , Juri G Gelovani 3 , Russell Broaddus 2 Keywords: BCR/ABL fusion gene; cell-to-cell...
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From:Stroke Research and TreatmentPeer-ReviewedIn this study, we used a model of a hemorrhagic stroke in a motor zone of the cortex in rats at the age of 3 months The report shows that cortical neurons can fuse with oligodendrocytes. In formed binuclear cells, the...
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From:Science (Vol. 305, Issue 5685) Peer-ReviewedCell-cell fusion is a key process that occurs during fertilization as well as during the development of a variety of tissues such as muscle and bone. Intracellular and viral fusion events are relatively well...
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From:Nature (Vol. 495, Issue 7440) Peer-ReviewedWhether it is an egg and sperm joining during fertilization or bone cells merging during development, cell fusion may start with a neighbourly poke. Elizabeth Chen and her team at Johns Hopkins University in...
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From:Canadian Journal of Microbiology (Vol. 67, Issue 5) Peer-ReviewedFungal protoplast fusion is an approach to introduce novel characteristics into industrially important strains. Cellulases, essential enzymes with a wide range of biotechnological applications, are produced by many...
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From:Nature (Vol. 416, Issue 6880) Peer-ReviewedAuthor(s): Andrew E. Wurmser; Fred H. Gage (corresponding author) Most readers have probably heard of stem cells -- unspecialized cells that can generate a variety of more specialized cell types. Not so long ago, it...
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From:Science (Vol. 230) Peer-ReviewedDetection of DNA Sequences in Nuclei in Suspension by in Situ Hybridization and Dual Beam Flow Cytometry Flow cytometry is widely used for the analysis of cell nuclei and chromosomes. With this technique, the binding...