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    Academic Journals

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• GITR expression on T-cell receptor-stimulated human CD8[sup]+ T cell in a JNK-dependent pathway

  Authors:Subhasis Chattopadhyay and Nitya ChakrabortyFrom:Indian Journal of Human Genetics (Vol. 15, Issue 3) Peer-Reviewed

  September-December 20091,918 words Report Byline: Subhasis. Chattopadhyay, Nitya. Chakraborty Glucocorticoid-induced tumor necrosis factor receptor (TNFR) (GITR) family-related gene is a member of the TNFR super family. GITR works as one of the...

• Crystal Structure of [Alpha]V[Beta]3

  Author:Hal CohenFrom:The Scientist (Vol. 15, Issue 19) Peer-Reviewed

  Oct. 1, 2001240 words Brief article Researchers at Massachusetts General Hospital (MGH) have solved the structure of integrin [Alpha]V[Beta]3 after they fully determined its extracellular portion (J.-P. Xiong et al., "Crystal structure of the...

• Isolation and expression of functional high-affinity Fc receptor complementary DNAs

  Authors:Janet M. Allen and Brian SeedFrom:Science (Vol. 243, Issue 4889) Peer-Reviewed

  Jan. 20, 19891,215 words Article Isolation and Expression of Functional High-Affinity Fc Receptor Complementary DNAs THE MACROPHAGE-SPECIFIC RECEPTOR (FcRI) for the constant region (Fc) of immunoglobulin G (IgG) plays a central role in...

• Increased Urinary CD163 Levels in Systemic Vasculitis with Renal Involvement.

  Authors:Xiayire Aierken, Qing Zhu, Ting Wu, Sha sha Liu, Yuan yuan Cao, Xin tian Cai, et al.From:BioMed Research International (Vol. 2021) Peer-Reviewed

  May 3, 20215,398 words Report 1370LObjectives. Systemic vasculitis includes a group of disorders characterized by inflammation of the vessel wall, involving multiple systems, and can cause malignant hypertension. CD163 is a specific marker of...

• An unruly painkiller is tamed with inspiration from nature.

  From:Nature (Vol. 597, Issue 7877) Peer-Reviewed

  Sept. 23, 2021279 words Brief article 1260LScientists borrow features of the body's receptor for tetrodotoxin to create a useful synthetic structure. Scientists borrow features of the body's receptor for tetrodotoxin to create a useful synthetic structure....

• Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.

  Authors:Mark Yarmarkovich, Quinlen F. Marshall, John M. Warrington, Rasika Premaratne, Alvin Farrel, David Groff, et al.From:Nature (Vol. 599, Issue 7885) Peer-Reviewed

  Nov. 18, 202114,526 words Report 1640LThe majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual human leukocyte antigen (HLA) allotypes.sup.1....

• Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.

  Authors:Yi Wang, Adelaide Bernard, Fanny Comblain, Xinyu Yue, Christophe Paillart, Sumei Zhang, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 9) Peer-Reviewed

  May 1, 20217,925 words Report 1400LThe melanocortin 4 receptor (MC4R) plays a critical role in the long-term regulation of energy homeostasis, and mutations in the MC4R are the most common cause of monogenic obesity. However, the precise molecular and...

• T-cell activation by recombinant immunoreceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells

  Authors:C Heuser, A Hombach, C Losch, K Manista, and H AbkenFrom:Gene Therapy (Vol. 10, Issue 17) Peer-Reviewed

  Aug. 3, 20036,782 words Article 1850LRecombinant immunoreceptors are modularily composed of extracellular antigen binding and intracellular signalling domains that are preferentially derived from CD3[zeta] or Fc[var epsilon]RI[gamma]. The impact of the...

• Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of [rho]1 GABA.sub.C Receptors via Site Mutation and Partial Agonism

  Authors:Moawiah M. Naffaa, Nathan Absalom, V. Raja Solomon, Mary Chebib, David E. Hibbs, and Jane R. HanrahanFrom:PLoS ONE (Vol. 11, Issue 5) Peer-Reviewed

  May 31, 20167,859 words Report 1600LThe loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of [rho]1 GABA.sub.C receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative...

• Activation of TIR signalling boosts pattern-triggered immunity.

  Authors:Hainan Tian, Zhongshou Wu, Siyu Chen, Kevin Ao, Weijie Huang, Hoda Yaghmaiean, et al.From:Nature (Vol. 598, Issue 7881) Peer-Reviewed

  Oct. 21, 202110,621 words Report 1500LPlant immune responses are mainly activated by two types of receptor. Pattern recognition receptors localized on the plasma membrane perceive extracellular microbial features, and nucleotide-binding leucine-rich repeat...

• SHORT COMMUNICATION - Genetic association study of ERBB4 SNP rs1351592 with polycystic ovary syndrome in Pakistani population

  Authors:Tayyaba Afzal, Ghazala Kaukab Raja, Afzal Maimoona, Shakeel Ahmad, Nighat Sultana, and Umm e KalsoomFrom:Journal of Pakistan Medical Association (Vol. 71, Issue 1)

  Jan. 31, 20211,453 words Report 1470LByline: Tayyaba Afzal, Ghazala Kaukab Raja, Maimoona Afzal, Shakeel Ahmad, Nighat Sultana and Umm e Kalsoom Keywords: Polycystic ovary syndrome, ERBB4, Multifactorial disorder, Pakistani population. Introduction...

• FERONIA controls pectin- and nitric oxide-mediated male-female interaction

  Authors:Qiaohong Duan, Ming-Che James Liu, Daniel Kita, Samuel S. Jordan, Fang-Ling Jessica Yeh, Robert Yvon, et al.From:Nature (Vol. 579, Issue 7800) Peer-Reviewed

  Mar. 202013,033 words Report 1520LSpecies that propagate by sexual reproduction actively guard against the fertilization of an egg by multiple sperm (polyspermy). Flowering plants rely on pollen tubes to transport their immotile sperm to fertilize the...

• A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity.

  Authors:Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, et al.From:Nature (Vol. 577, Issue 7790) Peer-Reviewed

  Jan. 16, 202010,542 words Report 1530LHumoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males.sup.1-3. However, the mechanisms underlying such sexual dimorphism are not well...

• Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

  Authors:Lilija Kovalchuka, Jelena Eglite, Irina Lucenko, Mara Zalite, Ludmila Viksna, and Angelika KrumiAaFrom:BMC Research Notes (Vol. 5, Issue 1) Peer-Reviewed

  Aug. 14, 20122,745 words Report 1310LBackground Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of...

• Molecular Characterization of E-Type Prostanoid Receptor 4 (EP4) from Ayu (Plecoglossus altivelis) and Its Functional Analysis in the Monocytes/Macrophages

  Authors:Ye-Jing Rong, Xin-Jiang Lu, and Jiong ChenFrom:PLoS ONE (Vol. 11, Issue 1) Peer-Reviewed

  Jan. 25, 20167,756 words Report 1360LProstaglandin E2 (PGE2) plays an important role in a broad spectrum of physiological and pathological processes by interacting with E-type prostanoid receptors (EPs). EP4 is one of four EP subtypes known to mediate the...

• A comprehensive profiling of T- and B-lymphocyte receptor repertoires from a Chinese-origin rhesus macaque by high-throughput sequencing

  Authors:Longfei Fu, Xinyang Li, Wei Zhang, Changxi Wang, Jinghua Wu, Huanming Yang, et al.From:PLoS ONE (Vol. 12, Issue 8) Peer-Reviewed

  Aug. 16, 20178,012 words Report 1790LDue to the close genetic background, high similarity of physiology, and susceptibility to infectious and metabolic diseases with humans, rhesus macaques have been widely used as an important animal model in biomedical...

• Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G.sub.i.

  Authors:Xiaofeng Qi, Heng Liu, Bonne Thompson, Jeffrey McDonald, Cheng Zhang, and Xiaochun LiFrom:Nature (Vol. 571, Issue 7764) Peer-Reviewed

  July 20197,439 words Report 1390LThe oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncogene (GLI)...

• Ketamine steps out of the darkness.

  Author:Roberto MalinowFrom:Nature (Vol. 533, Issue 7604) Peer-Reviewed

  May 26, 20161,405 words Report 1340LThe way in which ketamine exerts its antidepressant effects has been perplexing. Evidence that a metabolite of the drug is responsible, and acts on a different target from ketamine, might be the key to an answer. See...

• Structural insights into G-protein-coupled receptor allostery

  Authors:David M. Thal, Alisa Glukhova, Patrick M. Sexton, and Arthur ChristopoulosFrom:Nature (Vol. 559, Issue 7712) Peer-Reviewed

  July 20189,483 words Report 1560LG-protein-coupled receptors (GPCRs) are key cell-surface proteins that transduce external environmental cues into biochemical signals across the membrane. GPCRs are intrinsically allosteric proteins; they interact via...

• Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation.

  Authors:Devin Dersh and Jonathan W. YewdellFrom:Journal of Clinical Investigation (Vol. 131, Issue 1) Peer-Reviewed

  Jan. 1, 20211,980 words Report 1470LThe success of tumor immunotherapy, while partial, confirms the existence and importance of tumor immunosurveillance. [CD8.sup.+] T cell recognition of tumor-specific peptides bound to MHC class I (MHC-I) molecules is...