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Academic Journals
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From:Indian Journal of Human Genetics (Vol. 15, Issue 3) Peer-ReviewedByline: Subhasis. Chattopadhyay, Nitya. Chakraborty Glucocorticoid-induced tumor necrosis factor receptor (TNFR) (GITR) family-related gene is a member of the TNFR super family. GITR works as one of the...
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From:The Scientist (Vol. 15, Issue 19) Peer-ReviewedResearchers at Massachusetts General Hospital (MGH) have solved the structure of integrin [Alpha]V[Beta]3 after they fully determined its extracellular portion (J.-P. Xiong et al., "Crystal structure of the...
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From:Science (Vol. 243, Issue 4889) Peer-ReviewedIsolation and Expression of Functional High-Affinity Fc Receptor Complementary DNAs THE MACROPHAGE-SPECIFIC RECEPTOR (FcRI) for the constant region (Fc) of immunoglobulin G (IgG) plays a central role in...
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From:BioMed Research International (Vol. 2021) Peer-ReviewedObjectives. Systemic vasculitis includes a group of disorders characterized by inflammation of the vessel wall, involving multiple systems, and can cause malignant hypertension. CD163 is a specific marker of...
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From:Nature (Vol. 597, Issue 7877) Peer-ReviewedScientists borrow features of the body's receptor for tetrodotoxin to create a useful synthetic structure. Scientists borrow features of the body's receptor for tetrodotoxin to create a useful synthetic structure....
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From:Nature (Vol. 599, Issue 7885) Peer-ReviewedThe majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual human leukocyte antigen (HLA) allotypes.sup.1....
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From:Journal of Clinical Investigation (Vol. 131, Issue 9) Peer-ReviewedThe melanocortin 4 receptor (MC4R) plays a critical role in the long-term regulation of energy homeostasis, and mutations in the MC4R are the most common cause of monogenic obesity. However, the precise molecular and...
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From:Gene Therapy (Vol. 10, Issue 17) Peer-ReviewedRecombinant immunoreceptors are modularily composed of extracellular antigen binding and intracellular signalling domains that are preferentially derived from CD3[zeta] or Fc[var epsilon]RI[gamma]. The impact of the...
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From:PLoS ONE (Vol. 11, Issue 5) Peer-ReviewedThe loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of [rho]1 GABA.sub.C receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative...
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From:Nature (Vol. 598, Issue 7881) Peer-ReviewedPlant immune responses are mainly activated by two types of receptor. Pattern recognition receptors localized on the plasma membrane perceive extracellular microbial features, and nucleotide-binding leucine-rich repeat...
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From:Journal of Pakistan Medical Association (Vol. 71, Issue 1)Byline: Tayyaba Afzal, Ghazala Kaukab Raja, Maimoona Afzal, Shakeel Ahmad, Nighat Sultana and Umm e Kalsoom Keywords: Polycystic ovary syndrome, ERBB4, Multifactorial disorder, Pakistani population. Introduction...
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From:Nature (Vol. 579, Issue 7800) Peer-ReviewedSpecies that propagate by sexual reproduction actively guard against the fertilization of an egg by multiple sperm (polyspermy). Flowering plants rely on pollen tubes to transport their immotile sperm to fertilize the...
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From:Nature (Vol. 577, Issue 7790) Peer-ReviewedHumoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males.sup.1-3. However, the mechanisms underlying such sexual dimorphism are not well...
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From:BMC Research Notes (Vol. 5, Issue 1) Peer-ReviewedBackground Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of...
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From:PLoS ONE (Vol. 11, Issue 1) Peer-ReviewedProstaglandin E2 (PGE2) plays an important role in a broad spectrum of physiological and pathological processes by interacting with E-type prostanoid receptors (EPs). EP4 is one of four EP subtypes known to mediate the...
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From:PLoS ONE (Vol. 12, Issue 8) Peer-ReviewedDue to the close genetic background, high similarity of physiology, and susceptibility to infectious and metabolic diseases with humans, rhesus macaques have been widely used as an important animal model in biomedical...
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From:Nature (Vol. 571, Issue 7764) Peer-ReviewedThe oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncogene (GLI)...
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From:Nature (Vol. 533, Issue 7604) Peer-ReviewedThe way in which ketamine exerts its antidepressant effects has been perplexing. Evidence that a metabolite of the drug is responsible, and acts on a different target from ketamine, might be the key to an answer. See...
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From:Nature (Vol. 559, Issue 7712) Peer-ReviewedG-protein-coupled receptors (GPCRs) are key cell-surface proteins that transduce external environmental cues into biochemical signals across the membrane. GPCRs are intrinsically allosteric proteins; they interact via...
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From:Journal of Clinical Investigation (Vol. 131, Issue 1) Peer-ReviewedThe success of tumor immunotherapy, while partial, confirms the existence and importance of tumor immunosurveillance. [CD8.sup.+] T cell recognition of tumor-specific peptides bound to MHC class I (MHC-I) molecules is...