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    Academic Journals

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• Control of regulatory T cell development by the transcription factor Foxp3. (Reports)

  Authors:Shohei Hori, Takashi Nomura, and Shimon SakaguchiFrom:Science (Vol. 299, Issue 5609) Peer-Reviewed

  Feb. 14, 20032,372 words Article Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show...

• First portrait of an oncogene product

  Author:Jean L. MarxFrom:Science (Vol. 239, Issue 4842) Peer-Reviewed

  Feb. 19, 1988976 words Article First Portrait of an Oncogene Product A research article in this issue of Science marks a new milestone in the quest to understand the action of the cancer-causing oncogenes. On page 888, Sung-Hou Kim of the...

• Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP

  Authors:Koozi Matuoka, Kiyoko Fukami, Osamu Nakanishi, Sadaaki Kawai, and Tadaomi TakenawaFrom:Science (Vol. 239, Issue 4840) Peer-Reviewed

  Feb. 5, 19881,726 words Article Mitogenesis in Response to PDGF and Bombesin Abolished by Microinjection of Antibody to PIP.sub.2 MUCH ATTENTION HAS BEEN PAID to inositol phospholipids recently because of their crucial, although so far indecisive,...

• cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis

  Authors:S. Schacher, V.F. Castellucci, and E.R. KandelFrom:Science (Vol. 240, Issue 4859) Peer-Reviewed

  June 17, 19881,197 words Article cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis THE GILL- AND SIPHON-WITHDRAWal reflex in Aplysias can undergo short-term sensitization, lasting minutes to hours, and...

• A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro

  Authors:Alan M. Gewirtz and Bruno CalabrettaFrom:Science (Vol. 242, Issue 4883) Peer-Reviewed

  Dec. 2, 19881,835 words Article A c-myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro THE PROTO-ONCOGENE C-myb, THE normal cellular homolog of the avian myeloblastosis virus transforming gene v-myb, may play an...

• Protein translocation across membranes

  Authors:Keith Verner and Gottfried SchatzFrom:Science (Vol. 241, Issue 4871) Peer-Reviewed

  Sept. 9, 19884,064 words Article Protein Translocation Across Membranes AN AVERAGE CELL SYNTHESIZES 10.sup.3 TO 10.sup.4 DIFFERENT polypeptides, each of which must reach a specific intracellular location to perform its function. Some proteins are...

• Phosphorylation of the transcription factor PHO4 by a cyclin-cdk complex, PHO8O-PHO85

  Authors:Arie Kaffman, Ira Herskowitz, Robert Tjian, and Erin K. O'SheaFrom:Science (Vol. 263, Issue 5150) Peer-Reviewed

  Feb. 25, 19944,013 words Article Induction of the yeast gene PHO5 is mediated by the transcription factors PHO2 and PHO4. PHO5 transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and PHO85 inactivate PHO2...

• The N-end rule in bacteria

  Authors:John W. Tobias, Thomas E. Shrader, Gabrielle Rocap, and Alexander VarshavskyFrom:Science (Vol. 254, Issue 5036) Peer-Reviewed

  Nov. 29, 19912,548 words Article AMONG THE FUNCTIONS OF Protein degradation in living cells are the elimination of abnormal proteins and the temporal control of many cellular processes that involve short-lived regulators [1]. The metabolic instability...

• Dominance in physiological phenotypes and fitness at an enzyme locus

  Authors:Thomas J. Hilbish and Richard K. KoehnFrom:Science (Vol. 229) Peer-Reviewed

  July 5, 19851,485 words Article Biochemical differences in aminopeptidase-I (AM-I) allozymes (products of the Lap locus) in the marine mussel Mytilus edulis (1) result in genotypespecific rates of change in the free amino acid (FAA) pool when mussels...

• Two molecular transitions influence cardiac sodium channel gating

  Authors:David T. Yue, John H. Lawrence, and Eduardo MarbanFrom:Science (Vol. 244, Issue 4902) Peer-Reviewed

  Apr. 21, 19892,001 words Article Two Molecular Transitions Influence Cardiac Sodium Channel Gating VOLTAGE-DRIVEN CONFORMATIONAL changes that control the opening and closing of Na.sup.+ channels form the molecular basis for membrane excitability....

• Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction

  Authors:Matthias W. Hentze, Tracey A. Rouault, Joe B. Harford, and Richard D. KlausnerFrom:Science (Vol. 244, Issue 4902) Peer-Reviewed

  Apr. 21, 19891,836 words Article Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction THE FORMATION OF SPECIFIC NUcleic acid-protein complexes has been shown to play a key role in DNA transcription, pre-mRNA...

• Dephosphorylation of Cdk2 Thr(super160) by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin

  Authors:Randy Y.C. Poon and Tony HunterFrom:Science (Vol. 270, Issue 5233) Peer-Reviewed

  Oct. 6, 19952,637 words Article The activation of cyclin-dependent kinases (CDKs) requires the phosphorylation of a conserved threonine ([Thr.sup.160] in Cdk2) by CDK-activating kinase (CAK). Human KAP (also called Cdi1), a CDK-associated phosphatase,...

• Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

  Authors:Yolanda Sanchez and Stephen J. ElledgeFrom:Science (Vol. 277, Issue 5331) Peer-Reviewed

  Sept. 5, 19972,759 words Article In response to DNA damage, mammalian cells prevent cell cycle progression through the control of critical cell cycle regulators. A human gene was identified that encodes the protein Chk1, a homolog of the...

• Control of mitochondrial function and cell growth by the atypical cadherin Fat1

  Authors:Longyue L. Cao, Dario F. Riascos-Bernal, Prameladevi Chinnasamy, Charlene M. Dunaway, Rong Hou, Mario A. Pujato, et al.From:Nature (Vol. 539, Issue 7630) Peer-Reviewed

  Nov. 24, 20169,694 words Report 1580LAuthor(s): Longyue L. Cao [1, 2]; Dario F. Riascos-Bernal [1, 2]; Prameladevi Chinnasamy [1, 2]; Charlene M. Dunaway [1, 2]; Rong Hou [1, 2]; Mario A. Pujato [3]; Brian P. ORourke [4]; Veronika Miskolci [5]; Liang Guo...

• MicroRNA-223 is a crucial mediator of PPAR[gamma]-regulated alternative macrophage activation

  Authors:Wei Ying, Alexander Tseng, Richard Cheng-An Chang, Andrew Morin, Tyler Brehm, Karen Triff, et al.From:Journal of Clinical Investigation (Vol. 125, Issue 11) Peer-Reviewed

  Nov. 20156,165 words Report 1470LPolarized activation of adipose tissue macrophages (ATMs) is crucial for maintaining adipose tissue function and mediating obesity-associated cardiovascular risk and metabolic abnormalities; however, the regulatory...

• Interleukin-3-induced phosphorylation of BAD through the protein kinase akt

  Authors:Luis del Peso, Maribel Gonzalez-Garcia, Carmen Page, Roman Herrera, and Gabriel NunezFrom:Science (Vol. 278, Issue 5338) Peer-Reviewed

  Oct. 24, 19972,092 words Article BAD is a distant member of the Bc1-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation induced by interleukin-3 (IL-3) was inhibited by specific inhibitors of phosphoinositide...

• Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

  Authors:Holger Rehmann, Ernesto Arias-Palomo, Michael A. Hadders, Frank Schwede, Oscar Llorca, and Johannes L. BosFrom:Nature (Vol. 455, Issue 7209) Peer-Reviewed

  Sept. 4, 20084,457 words Report 1410LEpac proteins are activated by binding of the second messenger cAMP and then act as guanine nucleotide exchange factors for Rap proteins (1,2). The Epac proteins are involved in the regulation of cell adhesion 3 and...

• Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease

  Authors:Peter R. Baker, II and Jacob E. FriedmanFrom:Journal of Clinical Investigation (Vol. 128, Issue 9) Peer-Reviewed

  Sept. 201810,767 words Report 1410LNonalcoholic fatty liver disease (NAFLD) is a global epidemic in obese children and adults, and the onset might have fetal origins. A growing body of evidence supports the role of developmental programming, whereby the...

• Combinatorial synthesis of genetic networks. (Reports)

  Authors:Calin C. Guet, Michael B. Elowitz, Weihong Hsing, and Stanislas LeiblerFrom:Science (Vol. 296, Issue 5572) Peer-Reviewed

  May 24, 20023,260 words Article A central problem in biology is determining how genes interact as parts of functional networks. Creation and analysis of synthetic networks, composed of well-characterized genetic elements, provide a framework for...

• Quality Control Mechanisms During Translation

  Authors:Michael Ibba and Dieter SollFrom:Science (Vol. 286, Issue 5446) Peer-Reviewed

  Dec. 3, 19994,313 words Article Translation uses the genetic information in messenger RNA (mRNA) to synthesize proteins. Transfer RNAs (tRNAs) are charged with an amino acid and brought to the ribosome, where they are paired with the corresponding...