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Academic Journals
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From:Epigenomics (Vol. 6, Issue 1) Peer-ReviewedResearchers from Boston University School of Medicine (MA, USA) have identified a way to affect cell signaling that may prevent angiogenesis, the formation of new blood vessels, and therefore cancer growth. The...
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From:Neural Regeneration Research (Vol. 8, Issue 9) Peer-ReviewedByline: Hongyan. Wang, Yingquan. Zhang, Mingqi. Qiao Abstract The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an...
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From:Neural Regeneration Research (Vol. 9, Issue 14) Peer-ReviewedByline: Ning. Li, Yuehua. Li, Xuanchu. Duan Optic nerve transection increased the expression of heat shock protein 72 (HSP72) in the lateral geniculate body, indicating that this protein is involved in the prevention...
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From:Journal of Clinical Investigation (Vol. 125, Issue 4) Peer-ReviewedExtracellular ATP is a signal of tissue damage and induces macrophage responses that amplify inflammation and coagulation. Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the...
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From:Immunotherapy (Vol. 7, Issue 4) Peer-ReviewedAuthor(s): Tracy L Putoczki aff1 , Matthias Ernst [*] aff1 aff2 Keywords: cancer; GP130; IL-11; IL-6; inflammation; STAT3; therapy Background IL-11 is a member of the IL-6 family of cytokines, which includes...
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From:International Journal of HypertensionPeer-ReviewedSodium transport through various nephron segments is quite important in regulating sodium reabsorption and blood pressure. Among several regulators of this process, insulin acts on almost all the nephron segments and is...
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From:PVRI Review (Vol. 2, Issue 1) Peer-ReviewedByline: Swapna. Menon A list of citations for the months of August to December 28, 2009 is available at [SUPPORTING:1] The list was obtained using the following search strategy in PubMed: Keywords: "pulmonary...
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From:PVRI Review (Vol. 1, Issue 1) Peer-ReviewedByline: Nicholas. Morrell The identification of heterozygous germline mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor for the transforming growth factor-[sz] (TGF-[sz]) superfamily,...
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From:Expert Review of Gastroenterology & Hepatology (Vol. 3, Issue 1) Peer-ReviewedAuthor(s): Raquel Seruca [[dagger]] 1 , Sérgia Velho 2 , Carla Oliveira 3 , Marina Leite 4 , Paulo Matos 5 , Peter Jordan 6 Colorectal cancer (CRC) represents one of the leading causes of cancer mortality in the...
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From:Expert Review of Hematology (Vol. 2, Issue 2) Peer-ReviewedAuthor(s): Marc R Mansour 1 Keywords: γ-secretase inhibitor; Kras; Notch mutations; Ras signaling; T-cell acute lymphoblastic leukemia In the article being evaluated, Kindler and colleagues describe the...
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From:Biomarkers in Medicine (Vol. 5, Issue 6) Peer-ReviewedAuthor(s): Nataša TodorovicÄ-RakovicÄ [**] 2 , Jelena MilovanovicÄ 1 , Dragica NikolicÄ-VukosavljevicÄ 1 KEYWORDS : [beta]β-glycan; cancer; endoglin; TGF-[beta]β The TGF-[beta]β family are...
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From:Future Microbiology (Vol. 5, Issue 8)Author(s): David J Clarke 1 Keywords * biofilm; colanic acid; motility; Rcs phosphorelay; virulence The Rcs phosphorelay was originally identified over 30 years ago as a positive regulator of colanic acid...
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From:Diabetes (Vol. 49, Issue 5) Peer-ReviewedGlucose and growth factors regulate islet [Beta]-cell proliferation. Although glucose metabolism is required for this process, little is known about signaling pathways and transcription factors involved. Previously, we...
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From:Physiological Reviews (Vol. 79, Issue 3) Peer-ReviewedRecent developments in understanding signal transduction from the endoplasmic reticulum (ER) to the cell nucleus has been studied. Emphasis is given on the three types of stress experienced by the ER. These are the...
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From:Science (Vol. 262, Issue 5141) Peer-ReviewedMost members of the guanosine triphosphatase (GTPase) superfamily hydrolyze guanosine triphosphate (GTP) quite slowly unless stimulated by a GTPase activating protein or GAP. The [alpha] subunits (G[alpha]) of the...
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From:Science (Vol. 257, Issue 5066) Peer-ReviewedActivation of protein-tyrosine kinases (PTKs) is required for singal transaction during T activation, although the pathway used during thymic selection is unknown. An in vitro system was established in which T cell...
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From:Science (Vol. 254, Issue 5034) Peer-ReviewedBinding of ligand or antibody to certain cell-surface proteins that are anchored to the membrane by glycophosphatidylinositol (GPI) can cause activation of leukocytes. However, it is not known how these molecules, which...
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From:Science (Vol. 265, Issue 5169) Peer-ReviewedA gene encoding a 35-kilodalton guanosine triphosphate (GTP)--binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells. Gem and Rad, the product of a gene overexpressed in skeletal muscle in...
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From:Science (Vol. 265, Issue 5179) Peer-ReviewedTo identify proteins that may participate in the activation of the protein kinase Raf, proteins that interact with Raf were selected in a two-hybrid screen. Two members of the protein family were isolated that interacted...
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From:Science (Vol. 270, Issue 5234) Peer-ReviewedStimulation of rat vascular smooth muscle cells (VSMCs) by platelet-derived growth factor (PDGF) transiently increased the intracellular concentration of hydrogen peroxide ([H.sub.2][O.sub.2]). This increase could be...