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From:Science (Vol. 288, Issue 5465) Peer-ReviewedA cell's nucleus represents a miracle of ordered packing, and the giant nuclei of larval Drosophila salivary glands provide a useful model to study chromosomal packing because they must accommodate giant polytene...
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From:Diabetes (Vol. 62, Issue 2) Peer-ReviewedReceptor for advanced glycation end products (RAGE) has been shown to be involved in adiposity as well as atherosclerosis even in nondiabetic conditions. In this study, we examined mechanisms underlying how RAGE...
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From:Egyptian Journal of Dermatology and Venerology (Vol. 37, Issue 2) Peer-ReviewedByline: Mahmoud. Kamel, Eman. Hassan, Mona. Sobhy, Maryam. El Sayes Background Psoriasis is a chronic inflammatory disease with systemic immunological disturbance. Suggested pathophysiology linking psoriasis and...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2017) Peer-Reviewed
Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation
HMGB1, a highly conserved nonhistone DNA-binding protein, plays an important role in inflammatory diseases. Once released to the extracellular space, HMGB1 acts as a proinflammatory cytokine that triggers inflammatory... -
From:PLoS ONE (Vol. 6, Issue 1) Peer-ReviewedBackground High mobility group box 1 protein (HMGB1) is a major endogenous danger signal that triggers inflammation and immunity during septic and aseptic stresses. HMGB1 recently emerged as a key soluble factor in...
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From:PLoS ONE (Vol. 6, Issue 6) Peer-ReviewedBackground Determine global gene dysregulation affecting 4q-linked (FSHD-1) and non 4q-linked (FSHD-2) cells during early stages of myogenic differentiation. This approach has been never applied to FSHD pathogenesis....
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From:PLoS ONE (Vol. 11, Issue 11) Peer-ReviewedInduction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs (miRNAs) are highly regulated in erythroid cells during the...
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From:PLoS ONE (Vol. 9, Issue 7) Peer-ReviewedRationale Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance leading to right ventricular failure and death. Recent studies have suggested that chronic inflammatory...
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From:PLoS ONE (Vol. 9, Issue 6) Peer-ReviewedThe architectural transcription factor HMGA2 is abundantly expressed during embryonic development. In several malignant neoplasias including prostate cancer, high re-expression of HMGA2 is correlated with malignancy and...
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From:PLoS ONE (Vol. 16, Issue 4) Peer-ReviewedGastric cancer is one of the leading causes of cancer death worldwide. Previous studies demonstrated that activation of STAT3 is crucial for the development and progression of gastric cancer. However, the role of STAT3...
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From:PLoS ONE (Vol. 3, Issue 8) Peer-ReviewedBackground Protein HMGB1, an abundant nuclear non-histone protein that interacts with DNA and has an architectural function in chromatin, was strikingly shown some years ago to also possess an extracellular function...
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From:Future Oncology (Vol. 3, Issue 4) Peer-ReviewedSingle nucleotide polymorphisms in inflammation-related genes may be related to increased risk of lung cancer, especially in heavy smokers A new discovery, made by researchers in the USA, has revealed how the risk of...
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From:Science (Vol. 294, Issue 5550) Peer-ReviewedDNA replication origins are fundamental to chromosome organization and duplication, but understanding of these elements is limited because only a small fraction of these sites have been identified in eukaryotic genomes....
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From:Journal of Immunology Research (Vol. 2016) Peer-Reviewed
Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy
High mobility group box 1 (HMGB1) is a member of the "danger associated molecular patterns" (DAMPs) than can localize in various compartments of the cell (from the nucleus to the cell surface) and subserve different... -
From:PLoS ONE (Vol. 12, Issue 11) Peer-ReviewedHistone H1 molecules play a key role in establishing and maintaining higher order chromatin structures. They can bind to linker DNA entering and exiting the nucleosome and regulate transcriptional activity. Tetrahymena...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-ReviewedBackground Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of...
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From:PLoS ONE (Vol. 6, Issue 3) Peer-ReviewedBackground Necrosis, a type of cell death accompanied by the rupture of the plasma membrane, promotes tumor progression and aggressiveness by releasing the pro-inflammatory and angiogenic cytokine high mobility group...
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From:PLoS ONE (Vol. 10, Issue 2) Peer-ReviewedHigh mobility group box 1 (HMGB1) is a nuclear protein that involves the binding with DNA and influences chromatin regulation and transcription. HMGB1 is also a cytokine that can activate monocytes and neutrophils...
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From:BioMed Research International (Vol. 2018) Peer-ReviewedNuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) is a 27 kD chromosomal, highly conserved, and vertebrate-specific protein. NUCKS1 gene encodes a nuclear protein and the conserved regions of NUCKS1...
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From:PLoS ONE (Vol. 7, Issue 12) Peer-ReviewedAuthor(s): Martin Andrassy 1 , * , H. Christian Volz 1 , Alena Schuessler 1 , Gitsios Gitsioudis 1 , Nina Hofmann 1 , Danai Laohachewin 1 , Alexandra R. Wienbrandt 1 , Ziya Kaya 1 , Angelika Bierhaus 2 , Evangelos...