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• Cisplatin induced paroxysmal supraventricular tachycardia

  Authors:Waseem Raja, M. Mir, Imtiyaz Dar, Muzamil Banday, and Irfan AhmadFrom:Indian Journal of Medical and Paediatric Oncology (Vol. 34, Issue 4) Peer-Reviewed

  October-December 20131,053 words Article 1370LByline: Waseem. Raja, M. Mir, Imtiyaz. Dar, Muzamil. Banday, Irfan. Ahmad Cisplatin or cis-diamminedichloroplatinum (CDDP) is the first member of a class of platinum-containing anti-cancer drugs that act by binding...

• Genetic variation in Otos is associated with cisplatin-induced ototoxicity

  Authors:Timothy F Spracklen, Heather Whitehorn, Anna Alvera Vorster, Lebogang Ramma, Sameera Dalvie, and Rajkumar S RamesarFrom:Pharmacogenomics (Vol. 15, Issue 13) Peer-Reviewed

  Oct. 20146,242 words Report 1600LAuthor(s): Timothy F Spracklen aff1 , Heather Whitehorn aff1 , Anna Alvera Vorster aff1 , Lebogang Ramma aff2 , Sameera Dalvie aff3 , Rajkumar S Ramesar [*] aff1 Keywords: cisplatin; hearing loss; Otos ;...

• Protective effect of Artemisia asiatica (Pamp.) Nakai ex Kitam ethanol extract against cisplatin-induced apoptosis of human HaCaT keratinocytes: involvement of NF-kappa B- and Bcl-2-controlled mitochondrial signaling

  Authors:Jae Won Chang, Hye Sook Hwang, Yeon Soo Kim, Haeng Jun Kim, Yoo Seob Shin, Tatsanachat Jittreetat, et al.From:Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Vol. 22, Issue 6) Peer-Reviewed

  June 15, 20154,673 words Report 1440LABSTRACT Background: Oral mucositis is a common adverse effect of antineoplastic chemotherapy limiting sufficient dose of chemoregimen. Numerous attempts to mitigate chemotherapy-induced oral mucositis have failed to...

• Cisplatin: arterial occlusion leading to gangrene: case report

  From:Reactions Weekly (Issue 1336)

  Jan. 29, 2011263 words Brief article, Case ... 1060L[S] A 50-year-old man developed arterial occlusion leading to gangrene of the toe during cisplatin-based chemotherapy for testicular cancer. The man, who was a chronic smoker, began an etoposide-cisplatin...

• Research Highlights: Highlights from the latest articles in pharmacogenomics of irinotecan/cisplatin toxicity

  Authors:Godefridus J Peters and Elisa GiovannettiFrom:Pharmacogenomics (Vol. 13, Issue 13) Peer-Reviewed

  Oct. 20121,319 words Report 1340LAuthor(s): Godefridus J Peters [*] 2 , Elisa Giovannetti 1 Evaluation of: Han JY, Shin ES, Lee YS et al. A genome-wide association study for irinotecan-related severe toxicities in patients with advanced...

• Cisplatin/various drugs interaction: renal impairment: case report

  From:Reactions Weekly (Issue 1283)

  Jan. 9, 2010189 words Brief article, Case ... [X] [S] A 63-year-old man with hypertension and type 2 diabetes mellitus started treatment with cisplatin [dosage not stated] and gemcitabine for high-grade urethral cancer. He was also started on...

• Phase I/II Trial of Erlotinib and Cisplatin in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: A Princess Margaret Hospital Phase II Consortium and National Cancer Institute of Canada Clinical Trials Group Study

  From:Abstracts in Hematology & Oncology (Vol. 10, Issue 4)

  Nov. 1, 20071,523 words Clinical report, Edi... 1890LSiu LL, Soulieres D, Chen EX, et al. J Clin Oncol. 2007;25:2178-2183. ABSTRACT This phase 2 study of patients with recurrent or metastatic squamous cell carcinoma of the head and neck enrolled patients who had no...

• Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials

  From:British Medical Journal (Vol. 311, Issue 7010) Peer-Reviewed

  Oct. 7, 19957,804 words Article Chemotherapy may somewhat prolong survival among patients with non-small cell lung cancer, a cancer with low survival chances. Most lung cancers are of the non-small cell type. Researchers analyzed the effect of...

• Comparison of cisplatin sensitivity and the 18F fluoro-2-deoxy 2 glucose uptake with proliferation parameters and gene expression in squamous cell carcinoma cell lines of the head and neck

  Authors:Eva Henriksson, Elisabeth Kjellen, Bo Baldetorp, Par-Ola Bendahl, Ake Borg, Eva Brun, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 28) Peer-Reviewed

  Feb. 13, 20095,466 words Report Authors: Eva Henriksson (corresponding author) [1]; Elisabeth Kjellén [2]; Bo Baldetorp [2]; Pär-Ola Bendahl [2]; Åke Borg [2]; Eva Brun [2]; Fredrik Mertens [3]; Tomas Ohlsson [4]; Karin Rennstam [2]; Johan Wennerberg...

• Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

  Authors:Cristina Federici, Francesco Petrucci, Stefano Caimi, Albino Cesolini, Mariantonia Logozzi, Martina Borghi, et al.From:PLoS ONE (Vol. 9, Issue 2) Peer-Reviewed

  Feb. 6, 20148,017 words Article 1540LAuthor(s): Cristina Federici 1, Francesco Petrucci 2, Stefano Caimi 2, Albino Cesolini 3, Mariantonia Logozzi 1, Martina Borghi 1, Sonia D'Ilio 4, Luana Lugini 1, Nicola Violante 2, Tommaso Azzarito 1, Costanza Majorani...

• Cachexia induces head and neck changes in locally advanced oropharyngeal carcinoma during definitive cisplatin and image-guided volumetric-modulated arc radiation therapy

  Authors:R. Mazzola, F. Ricchetti, A. Florentino, G. Di Paola, S. Fersino, N. Giaj Levra, et al.From:European Journal of Clinical Nutrition (Vol. 70, Issue 6) Peer-Reviewed

  June 20164,082 words Report 1630LBACKGROUND/OBJECTIVES: Cancer cachexia is a syndrome characterized by weight loss (WL) and sarcopenia. Aim of the study was to assess the impact of cachexia on head and neck changes during definitive cisplatin and...

• Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

  Authors:Bahram Rasoulian, Ayat Kaeidi, Maryam Rezaei, and Zahra HajializadehFrom:Oxidative Medicine and Cellular Longevity (Vol. 2017) Peer-Reviewed

  Annual 20175,649 words Article 1420LOur previous in vitro studies demonstrated that oxygen pretreatment significantly protects human embryonic renal tubular cell against acute cisplatin- (CP-) induced cytotoxicity. The present study was designed to...

• Hemin attenuates cisplatin-induced acute renal injury in male rats

  Authors:Mohamed A. Al- Kahtani, Ashraf M. Abdel-Moneim, Omar M. Elmenshawy, and Mohamed A. El- KershFrom:Oxidative Medicine and Cellular Longevity (Vol. 2014) Peer-Reviewed

  Annual 20144,811 words Report 1350LBackground. The aim of this study is to investigate the protective effects of hemin (the heme oxygenase-1 [OH-1] inducer) against nephrotoxic effects induced by cisplatin [cis- diamminedichloroplatinum II (CP)] in male...

• A Head and Neck Cancer Tumor Response-Specific Gene Signature for Cisplatin, 5-Fluorouracil Induction Chemotherapy Fails with Added Taxanes

  Authors:Celine Tomkiewicz, Stephane Hans, Marie Helene Mucchielli, Nicolas Agier, Herve Delacroix, Laetitia Marisa, et al.From:PLoS ONE (Vol. 7, Issue 10) Peer-Reviewed

  Oct. 9, 20127,195 words Article 1560LBackground It is a major clinical challenge to predict which patients, with advanced stage head and neck squamous cell carcinoma, will not exhibit a reduction in tumor size following induction chemotherapy in order...

• EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer

  Authors:Xuemin Wang, Pan Jiang, Pengqi Wang, Chung S. Yang, Xuerong Wang, and Qing FengFrom:PLoS ONE (Vol. 10, Issue 4) Peer-Reviewed

  Apr. 30, 20156,454 words Article 1310LCisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has...

• A Gene Expression Signature of Acquired Chemoresistance to Cisplatin and Fluorouracil Combination Chemotherapy in Gastric Cancer Patients

  Authors:Hark Kyun Kim, Il Ju Choi, Chan Gyoo Kim, Hee Sung Kim, Akira Oshima, Aleksandra Michalowski, et al.From:PLoS ONE (Vol. 6, Issue 2) Peer-Reviewed

  Feb. 18, 20117,738 words Clinical report 1680LBackground We initiated a prospective trial to identify transcriptional alterations associated with acquired chemotherapy resistance from pre- and post-biopsy samples from the same patient and uncover potential...

• Rosmarinic Acid, Active Component of Dansam-Eum Attenuates Ototoxicity of Cochlear Hair Cells through Blockage of Caspase-1 Activity

  Authors:Hyun-Ja Jeong, Youngjin Choi, Min-Ho Kim, In-Cheol Kang, Jeong-Han Lee, Channy Park, et al.From:PLoS ONE (Vol. 6, Issue 4) Peer-Reviewed

  Apr. 15, 20116,390 words Article 1290LCisplatin causes auditory impairment due to the apoptosis of auditory hair cells. There is no strategy to regulate ototoxicity by cisplatin thus far. Dansam-Eum (DSE) has been used for treating the central nerve system...

• Dexamethasone Reduces Sensitivity to Cisplatin by Blunting p53-Dependent Cellular Senescence in Non-Small Cell Lung Cancer

  Authors:Haiyan Ge, Songshi Ni, Xingan Wang, Nuo Xu, Ying Liu, Xun Wang, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 18, 20128,486 words Article 1410LIntroduction Dexamethasone (DEX) co-treatment has proved beneficial in NSCLC patients, improving clinical symptoms by the reduction of side effects after chemotherapy. However, recent studies have shown that DEX...

• Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats

  Authors:Andres Quesada, Ana Belen Segarra, Sebastian Montoro-Molina, Maria del Carmen de Gracia, Antonio Osuna, Francisco O'Valle, et al.From:PLoS ONE (Vol. 12, Issue 4) Peer-Reviewed

  Apr. 11, 20175,030 words Report 1570LPurpose The aim of this work was to investigate if the content of glutamyl aminopeptidase (GluAp) in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats....

• Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment

  Authors:Jeewon Kim, Che-Hong Chen, Jieying Yang, and Daria Mochly-RosenFrom:Journal of Biomedical Science (Vol. 24, Issue 1) Peer-Reviewed

  May 22, 20174,510 words Report 1500LBackground The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and...