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    Academic Journals

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• Computational modeling and in silico analysis of differential regulation of myo -inositol catabolic enzymes in Cryptococcus neoformans

  Authors:Emalee A. Mackenzie and Lisa S. KligFrom:BMC Molecular Biology (Vol. 9) Peer-Reviewed

  Oct. 14, 20084,711 words Report Background Inositol is a key cellular metabolite for many organisms. Cryptococcus neoformans is an opportunistic pathogen which primarily infects the central nervous system, a region of high inositol concentration,...

• Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts

  Authors:Martha P. Montgomery, Noeline Nakasujja, Bozena M. Morawski, Radha Rajasingham, Joshua Rhein, Elizabeth Nalintya, et al.From:BMC Neurology (Vol. 17, Issue 1) Peer-Reviewed

  June 12, 20174,820 words Report 1430LBackground HIV-infected persons with detectable cryptococcal antigen (CrAg) in blood have increased morbidity and mortality compared with HIV-infected persons who are CrAg-negative. This study examined neurocognitive...

• Comparative proteomic analysis of Gib2 validating its adaptor function in Cryptococcus neoformans

  Authors:Gillian O. Bruni, Blake Battle, Ben Kelly, Zhengguang Zhang, and Ping WangFrom:PLoS ONE (Vol. 12, Issue 7) Peer-Reviewed

  July 7, 20175,233 words Report 1560LCryptococcus neoformans causes often-fatal fungal meningoencephalitis in immunocompromised individuals. While the exact disease mechanisms remain elusive, signal transduction pathways mediated by key elements such as...

• MLST reveals a clonal population structure for Cryptococcus neoformans molecular type VNI isolates from clinical sources in Amazonas, Northern-Brazil

  Authors:Diego Fernando Silva Rocha, Katia Santana Cruz, Carla Silvana da Silva Santos, Lizandra Stephanny Fernandes Menescal, Joao Ricardo da Silva Neto, Silviane Bezerra Pinheiro, et al.From:PLoS ONE (Vol. 13, Issue 6) Peer-Reviewed

  June 8, 20187,124 words Report 1580LCryptococcosis is considered endemic in Amazonas state, occurring more frequently in individuals with AIDS, who are predominantly infected by Cryptococcus neoformans molecular type VNI. Infections by Cryptococcus gattii...

• Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

  Authors:Benjamin Hommel, Aude Sturny-Leclere, Stevenn Volant, Nathanael Veluppillai, Magalie Duchateau, Chen-Hsin Yu, et al.From:PLoS Pathogens (Vol. 15, Issue 7) Peer-Reviewed

  July 29, 201918,222 words Report 1520LMetabolically quiescent pathogens can persist in a viable non-replicating state for months or even years. For certain infectious diseases, such as tuberculosis, cryptococcosis, histoplasmosis, latent infection is a...

• Spatio-temporal regulation of nuclear division by Aurora B kinase Ipl1 in Cryptococcus neoformans

  Authors:Neha Varshney, Subhendu Som, Saptarshi Chatterjee, Shreyas Sridhar, Dibyendu Bhattacharyya, Raja Paul, et al.From:PLoS Genetics (Vol. 15, Issue 2) Peer-Reviewed

  Feb. 14, 201915,200 words Technical report 1670LThe nuclear division takes place in the daughter cell in the basidiomycetous budding yeast Cryptococcus neoformans. Unclustered kinetochores gradually cluster and the nucleus moves to the daughter bud as cells enter...

• Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

  Authors:Ko Sato, Hideki Yamamoto, Toshiki Nomura, Ikumi Matsumoto, Tomomitsu Miyasaka, Tong Zong, et al.From:PLoS ONE (Vol. 10, Issue 9) Peer-Reviewed

  Sept. 18, 20158,815 words Report 1430LType I interferons (IFNs) are secreted by many cell types upon stimulation via pattern recognition receptors and bind to IFN-[alpha]/[beta] receptor (IFNAR), which is composed of IFNAR1 and IFNAR2. Although type I IFNs...

• Details on emerging fungal threat

  Author:David OjciusFrom:Nature Reviews Microbiology (Vol. 8, Issue 6) Peer-Reviewed

  June 2010226 words Brief article 1410LThe pathogenic fungus Cryptococcus gattii has emerged over the past decade in the Pacific Northwest of the United States and Canada. Historically, C. gattii has been associated with eucalyptus trees in tropical and...

• The Uve1 endonuclease is regulated by the white collar complex to protect Cryptococcus neoformans from UV damage

  Authors:Surbhi Verma and Alexander IdnurmFrom:PLoS Genetics (Vol. 9, Issue 9) Peer-Reviewed

  Sept. 201311,310 words Report 1420LThe pathogenic fungus Cryptococcus neoformans uses the Bwc1-Bwc2 photoreceptor complex to regulate mating in response to light, virulence and ultraviolet radiation tolerance. How the complex controls these functions is...

• Immune Modulation Mediated by Cryptococcal Laccase Promotes Pulmonary Growth and Brain Dissemination of Virulent Cryptococcus neoformans in Mice

  Authors:Yafeng Qiu, Michael J. Davis, Jeremy K. Dayrit, Zachary Hadd, Daniel L. Meister, John J. Osterholzer, et al.From:PLoS ONE (Vol. 7, Issue 10) Peer-Reviewed

  Oct. 22, 20128,333 words Report 1540LAuthor(s): Yafeng Qiu 1 , 2 , Michael J. Davis 1 , 2 , Jeremy K. Dayrit 1 , 2 , Zachary Hadd 2 , Daniel L. Meister 2 , John J. Osterholzer 1 , 2 , Peter R. Williamson 3 , 4 , Michal A. Olszewski 1 , 2 , *...

• Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH

  Authors:Man Shun Fu, Carolina Coelho, Carlos M. De Leon-Rodriguez, Diego C. P. Rossi, Emma Camacho, Eric H. Jung, et al.From:PLoS Pathogens (Vol. 14, Issue 6) Peer-Reviewed

  June 15, 201815,212 words Report 1480LCryptococcus neoformans is a facultative intracellular pathogen and its interaction with macrophages is a key event determining the outcome of infection. Urease is a major virulence factor in C. neoformans but its role...

• Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformansby microglial cells

  Authors:Sandra Redlich, Sandra Ribes, Sandra Schutze, Helmut Eiffert, and Roland NauFrom:Journal of Neuroinflammation (Vol. 10, Issue 1) Peer-Reviewed

  June 5, 20133,972 words Report 1410LBackground Toll-Like receptors (TLRs) belong to the family of pattern-recognition receptors with a crucial function of recognising pathogen-associated molecular patterns (PAMPs). Cryptococcal meningitis is a...

• A proteomic interrogation of Cryptococcus neoformans: interaction networks for calcineurin in a heated environment

  Authors:Oleh A Mulyar, Allen CT Teng, and Anthony O GramoliniFrom:Expert Review of Proteomics (Vol. 9, Issue 1) Peer-Reviewed

  Feb. 20122,023 words Report 1400LAuthor(s): Oleh A Mulyar 1 , Allen CT Teng 1 , Anthony O Gramolini [**] 2 Keywords : calcineurin; calmodulin; coatomer proteins; mass spectrometry; protein-protein interaction Cryptococcal yeasts are...

• Clinical manifestations and management of cryptococcal infection

  Authors:S. Subramanian and D. MathaiFrom:Journal of Postgraduate Medicine (Vol. 51, Issue 5) Peer-Reviewed

  October-December 20055,749 words Article 1910LByline: S. Subramanian, D. Mathai Cryptococcus neoformans is an important fungal pathogen causing invasive infection, especially of the central nervous system in this era of the HIV/AIDS epidemic. The choice of...

• Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal

  Authors:Deborah J. Springer, R. Blake Billmyre, Elan E. Filler, Kerstin Voelz, Rhiannon Pursall, Piotr A. Mieczkowski, et al.From:PLoS Pathogens (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 201412,982 words Report 1610LOngoing Cryptococcus gattii outbreaks in the Western United States and Canada illustrate the impact of environmental reservoirs and both clonal and recombining propagation in driving emergence and expansion of microbial...

• Evidence for genetic incompatibilities associated with post-zygotic reproductive isolation in the human fungal pathogen Cryptococcus neoformans

  Authors:Aaron A. Vogan and Jianping XuFrom:Genome (Vol. 57, Issue 6) Peer-Reviewed

  June 20148,813 words Report 1440LHybridization is a potent mechanism for generating unique strains with broad host ranges and increased virulence in fungal pathogens. In the opportunistic basidiomycete pathogen Cryptococcus neoformans, intervarietal...

• Airborne fungus

  From:Nature Medicine (Vol. 16, Issue 6) Peer-Reviewed

  June 201052 words Brief article Apr 22 Scientists warned of a deadly airborne fungus, Cryptococcus gattii, spreading from Vancouver Island, Canada to mainland British Columbia and the Pacific Northwest in the US. Although responsible for only a...

• HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans

  Authors:Won Hee Jung, Sanjay Saikia, Guanggan Hu, Joyce Wang, Carlen Ka-Yin Fung, Cletus D'Souza, et al.From:PLoS Pathogens (Vol. 6, Issue 11) Peer-Reviewed

  Nov. 201011,879 words Report 1480LThe fungal pathogen Cryptococcus neoformans is a major cause of illness in immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire nutrients during proliferation in host tissue and the...

• PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex

  Authors:Ci Fu and Joseph HeitmanFrom:PLoS Genetics (Vol. 13, Issue 11) Peer-Reviewed

  Nov. 27, 201716,071 words Report 1610LSexual reproduction is critical for successful evolution of eukaryotic organisms in adaptation to changing environments. In the opportunistic human fungal pathogens, the Cryptococcus pathogenic species complex, C....

• Co-production of single cell oil and gluconic acid using oleaginous Cryptococcus podzolicus DSM 27192

  Authors:Xiujuan Qian, Olga Gorte, Lin Chen, Wenming Zhang, Weiliang Dong, Jiangfeng Ma, et al.From:Biotechnology for Biofuels (Vol. 12, Issue 1) Peer-Reviewed

  May 21, 20195,445 words Report 1570LBackground The co-production of single cell oil (SCO) with value-added products could improve the economic viability of industrial SCO production. The newly isolated oleaginous yeast Cryptococcus podzolicus DSM 27192...