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    Academic Journals

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• Synthesis of 6-(alkoxymethyl)- and 6-(alkylsulfanylmethyl)furo[2,3-d]pyrimidin-2(3H)-one analogues (1,2)

  Authors:Zlatko Janeba, Noha Maklad, and Morris J. RobinsFrom:Canadian Journal of Chemistry (Vol. 84, Issue 4) Peer-Reviewed

  Apr. 20065,919 words Article 1230LTreatment of 6-(hydroxymethyl)furo[2,3-d]pyrimidin-2(3H)-one (2) with 1-iodoalkanes and potassium carbonate resulted in predominant formation of N3 (and minor amounts of O2) alkylated regioisomers. Treatment of the...

• Synthesis and enhanced neuroprotective activity of C60-based ebselen derivatives

  Authors:Xu-Feng Liu, Wen-Chao Guan, and Weng-Shan KeFrom:Canadian Journal of Chemistry (Vol. 85, Issue 3) Peer-Reviewed

  Mar. 20075,658 words Article 1630LAbstract: A [C.sub.60]-based ebselen derivative 4 was synthesized through the cycloaddition of [C.sub.60 with the azide (3) containing the ebselen component. It was obtained in a four-step synthesis starting from...

• Regioselective synthesis of some pyrazole scaffolds attached to benzothiazole and benzimidazole moieties

  Authors:Nabila A. Kheder, Yahia N. Mabkhot, Fawzia R. Zahian, and Sara S. MohamedFrom:Journal of Chemistry (Vol. 2014) Peer-Reviewed

  Annual 20142,644 words Report 1220LCondensation of 2-(benzothiazol-2-yl)acetonitrile (1) or 2-(1-methyl-1H-benzimidazol-2-yl)acetonitrile (2) with thiophene-2carbaldehyde afforded the corresponding acrylonitrile derivatives 3 or 4, respectively. The...

• Crystal structure of pentalenene synthase: mechanistic insights of terpenoid cyclization reactions in biology

  Authors:Charles A. Lesburg and David W. ChristiansonFrom:Science (Vol. 277, Issue 5333) Peer-Reviewed

  Sept. 19, 19972,478 words Article The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pentalenene....

• Advances in heterocyclic chemistry for API synthesis: efficient syntheses are possible using multi-component and cross-dehydrogenative, heteroaromatic C-H silylation reactions

  Author:Cythia A. ChallenerFrom:Pharmaceutical Technology Europe (Vol. 27, Issue 11) Peer-Reviewed

  Nov. 20151,316 words Article 1520LThe structural complexity of newer small-molecule drug candidates is increasing, with many containing several different heterocyclic substructures and numerous stereogenic centers. Preparing single isomers of these...

• Synthesis, Characterization, and Antibacterial Activity of Diethyl 1-((4-Methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H -1,2,3-triazole-4,5-dicarboxylate

  Authors:S. Boukhssas, Y. Aouine, H. Faraj, A. Alami, A. El Hallaoui, and H. BekkariFrom:Journal of Chemistry (Vol. 2017) Peer-Reviewed

  Annual 20172,131 words Technical report 1310LThe compound, diethyl 1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H- 1,2,3-triazole-4,5-dicarboxylate 2, was synthesized in high yield, through 1,3-dipolar cycloaddition reaction of 4-(azidomethyl)-4-...

• Development of the covalent antibody-DNA conjugates technology for detection of IgE and IgM antibodies by immuno-PCR

  Authors:Artem V. Maerle, Maria A. Simonova, Victor D. Pivovarov, Daria V. Voronina, Polina E. Drobyazina, Dmitriy Yu. Trofimov, et al.From:PLoS ONE (Vol. 14, Issue 1) Peer-Reviewed

  Jan. 4, 20197,536 words Report 1390LImmuno-PCR (iPCR) is one of the methods used for the detection of a wide range of analytes and features the high sensitivity of the polymerase chain reaction (PCR) method. iPCR uses antibodies coupled to DNA, followed...

• Reaction of nitrilimines with pyruvaldehyde hydrazones: synthesis and antimicrobial evaluation of some new 1,2,4-triazole derivatives

  Author:Hany M. DalloulFrom:Journal of Chemistry (Vol. 2015) Peer-Reviewed

  Annual 20154,030 words Report 1130LA new series of 1,3,4,5,5-pentasubstituted-1,2,4-triazoles (4a-j, 6a-j) have been synthesized by the 1,3-dipolar cycloaddition of suitable nitrilimines 2 to pyruvaldehyde (2-oxopropanal) hydrazones having (COPh, COOMe,...

• A computational study of the 1,3-dipolar cycloaddition reaction mechanism for nitrilimines (1)

  Authors:Robert C. Mawhinney, Heidi M. Muchall, and Gilles H. PeslherbeFrom:Canadian Journal of Chemistry (Vol. 83, Issue 9) Peer-Reviewed

  Sept. 20056,295 words Article The [3+2] and [1+2] cycloaddition pathways between ethene and a series of 13 nitrilimines ([R.sub.1]CNN[R.sub.2]) have been examined by density functional theory [PBE0/6-311++G(2df, pd)] calculations. All reactions have...

• Toward the total synthesis of lophotoxin--new methodologies and synthetic strategies (1)

  Authors:Peter Wipf and Michel GrenonFrom:Canadian Journal of Chemistry (Vol. 84, Issue 10) Peer-Reviewed

  Oct. 200611,285 words Article 1480LAbstract: Our recent progress toward the synthesis of the furanocembranolide lophotoxin (1) is disclosed. Strategies for the stereoselective incorporation of the [C.sub.13] stereocenter by a catalytic desymmetrization...

• Zippier synthesis in water: complex toxin molecules are the ultimate challenge for organic chemists--even successful syntheses often involve an impractical number of steps. A biologically inspired reaction might simplify things

  Author:Masayuki InoueFrom:Nature (Vol. 449, Issue 7163) Peer-Reviewed

  Oct. 11, 20071,144 words Report 1360LNature creates many complex organic molecules, but some of the most spectacular are the brevetoxins and ciguatoxins produced by marine microorganisms (1). Brevetoxins are the toxic component of dramatic natural...

• Effect of concurrent ZnO addition and [AlF.sub.3] reduction on the elastic properties of tellurite based glass system

  Authors:Haji Abdul Aziz Sidek, Raouf El-Mallawany, Krishnaswamy Hariharan, and Shaharuddin RosmawatiFrom:Advances in Condensed Matter PhysicsPeer-Reviewed

  Annual 20144,301 words Report 1450LNew ternary zinc oxyfluorotellurite (ZOFT) with the composition (ZnO)x-([AlF.sub.3])y-(Te[O.sub.2])z, where 5 < x < 35; 5 [less than or equal to] y [less than or equal to] 25; 60 [less than or equal to] z [less than or...

• Catalyst targets spot on carbon ring

  From:Nature (Vol. 498, Issue 7454) Peer-Reviewed

  June 20, 2013137 words Brief article 1330LA metal catalyst makes sure that molecules join at the correct region of a carbon ring, disrupting the same bond every time. Chemists have made strides in identifying reactions that disrupt notoriously unreactive...

• Efforts toward electrocyclization of vinyl azomethine ylides generated via electrocyclic ring-opening of 4-oxazolines

  Authors:Jessica Burleson, Amber Hibberd, and Don WarnerFrom:Journal of the Idaho Academy of Science (Vol. 41, Issue 1) Peer-Reviewed

  June 2005143 words Brief article Five-membered nitrogen-containing rings, pyrrolidines, are found in a plethora of medicinally useful compounds. The traditional cycloaddition reactions utilized in the formation of pyrrolidines have the disadvantage of...

• Synthesis of isoxazole conjugates of sugars via 1,3-dipolar cycloaddition

  Authors:Vipraja V. Vaidya, Karuna S. Wankhede, Manikrao M. Salunkhe, and Girish K. TrivediFrom:Canadian Journal of Chemistry (Vol. 86, Issue 2) Peer-Reviewed

  Feb. 20082,277 words Report 1440LAbstract: Isoxazole conjugates of sugar have been synthesized by the aid of 1,3-dipolar cycloaddition in a click chemistry approach. The sugar-derived propargyl ethers underwent 1,3-dipolar cycloadditions smoothly with...

• Intramolecular [4 + 3] cycloadditions--stereochemical issues in the cycloaddition reactions of cyclopentenyl cations--a synthesis of (+)-dactylol (1)

  Authors:Michael Harmata, Paitoon Rashatasakhon, and Charles L. BarnesFrom:Canadian Journal of Chemistry (Vol. 84, Issue 10) Peer-Reviewed

  Oct. 200611,705 words Article 1330LAbstract: Five cyclopentanones were prepared for the purpose of examining the effects of stereogenic centers on the course of the intramolecular [4 + 3] cycloaddition reactions of cyclopentenyl cations. One substrate...

• Synthesis of a hindered [C.sub.2]-symmetric hydrazine and diamine by a crisscross cycloaddition of citronellal azine (1)

  Authors:Barry B. Snider, James F. Grabowski, Roger W. Alder, Bruce M. Foxman, and Lin YangFrom:Canadian Journal of Chemistry (Vol. 84, Issue 10) Peer-Reviewed

  Oct. 20065,928 words Article 1550LAbstract: Crisscross cycloaddition of citronellal azine (6) with 2 equiv. of TFA and powdered 3 [Angstrom] molecular sieves in C[H.sub.2][Cl.sub.2] at reflux for 22 h afforded 37% of the desired [C.sub.2]-symmetric...

• 1,3-Dipolar cycloaddition of nitrile oxides with C1-substituted 7-oxabenzonorbornadienes

  Authors:Jaipal R. Nagireddy, Emily Carlson, and William TamFrom:Canadian Journal of Chemistry (Vol. 92, Issue 11) Peer-Reviewed

  Nov. 20145,299 words Report 1470L1,3-Dipolar cycloadditions of unsymmetrical C1-substituted 7-oxabenzonorbornadienes with acetonitrile oxide and benzonitrile oxide were investigated to probe the regio- and stereoselectivities of these reactions. All...

• Kinetics and mechanism of phenoxide anions addition to 4-nitrobenzofurazan in aqueous solution

  Authors:S. Ben Salah, T. Boubaker, and R. GoumontFrom:Canadian Journal of Chemistry (Vol. 95, Issue 7) Peer-Reviewed

  July 20173,240 words Report 2020LAbstract: Second-order rate constants ([k.sub.1]) for the [sigma]-complexation of 4-nitrobenzofurazan 1 with four 4-X-substituted phenoxide anions 2a-2d (X = OC[H.sub.3], C[H.sub.3], H and Cl) were measured in aqueous...

• Heterocyclisation of substituted ylidenethiocarbonohydrazides using dimethyl acetylenedicarboxylate

  Authors:Alaa A. Hassan, Fathy F. Abdel-Latif, Mohamed Abdel Aziz, Sara M. Mostafa, Stefan Brase, and Martin NiegerFrom:Chemical Papers (Vol. 69, Issue 7) Peer-Reviewed

  July 20154,280 words Report 1390LA facile and rapid procedure for the synthesis of dimethyl-2-[3-amino-5-(2-methoxy-2-oxoethylidene)-4-oxothiazolidin-2-ylidenehydrazono]succinate, dimethyl...