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    Academic Journals

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• CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer

  Authors:Kristina Stenstedt, Sandra Travica, Jia Guo, Isabel Barragan, Klaus Pors, Laurence Patterson, et al.From:Pharmacogenomics (Vol. 14, Issue 13) Peer-Reviewed

  Oct. 20134,548 words Report 1480LAuthor(s): Kristina Stenstedt 1 2 , Sandra Travica 2 , Jia Guo 2 , Isabel Barragan 2 , Klaus Pors 3 , Laurence Patterson 3 , David Edler 1 , Souren Mkrtchian 2 , Inger Johansson 2 , Magnus Ingelman-Sundberg [*] 4...

• Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy

  Authors:Pradeep Venkatesh, Varun Gogia, Shikha Gupta, Akshay Tayade, Neha Shilpy, Bhavin Shah, et al.From:Indian Journal of Ophthalmology (Vol. 63, Issue 4) Peer-Reviewed

  Apr. 20152,992 words Report 1720LByline: Pradeep. Venkatesh, Varun. Gogia, Shikha. Gupta, Akshay. Tayade, Neha. Shilpy, Bhavin. Shah, Randeep. Guleria Purpose: To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute...

• Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: Possible role of CYP3A4 inhibition by pravastatin

  Authors:Chong-Ki Lee, Jun-Shik Choi, and Dong-Hyun ChoiFrom:Indian Journal of Pharmacology (Vol. 44, Issue 5) Peer-Reviewed

  September-October 20123,162 words Report 1610LByline: Chong-Ki. Lee, Jun-Shik. Choi, Dong-Hyun. Choi Objective: The aim of this study was to investigate the effects of pravastatin on the pharmacokinetics of nimodipine in rats. Materials and Methods: The effect...

• 12G Kinase inhibitors

  From:MPR Hematology and Oncology Edition (Vol. 3, Issue 3)

  Fall 20103,694 words Article PRESCRIBING NOTES Protein kinases are components of signal transduction pathways that effect gene transcription and/or DNA synthesis. Protein kinases can be classified as tyrosine kinases, serine/ threonine kinases,...

• Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: resolution of AmpliChip CYP450 test no-calls

  Authors:Andrea Gaedigk, Juanjo Hernandez, Virginia Garcia-Solaesa, Santiago Sanchez, and Maria Isidoro-GarciaFrom:Pharmacogenomics (Vol. 12, Issue 11) Peer-Reviewed

  Nov. 20113,674 words Article 1410LAuthor(s): Andrea Gaedigk [[dagger]] 5 , Juanjo Hernandez 1 , Virginia García-Solaesa 2 , Santiago Sánchez 3 , Maria Isidoro-García 2 4 KEYWORDS : AmpliChip; CNV; CYP2D6 ; CYP2D6*9 ; CYP2D6*9x2 ; gene...

• Pharmacogenetics of coumarinic oral anticoagulants

  Authors:Vangelis G Manolopoulos, Georgia Ragia, and Anna TavridouFrom:Pharmacogenomics (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 20102,172 words Clinical report 1420LAuthor(s): Vangelis G Manolopoulos [[dagger]] 1 , Georgia Ragia 2 , Anna Tavridou 3 KEYWORDS : acenocoumarol; CYP2C9 polymorphism; oral anticoagulant; pharmacogenetics; phenprocoumon; VKORC1 polymorphism;...

• Pharmacogenomics of anti-TB drugs-related hepatotoxicity

  Authors:Puspita Das Roy, Mousumi Majumder, and Bidyut RoyFrom:Pharmacogenomics (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 20086,961 words Article Author(s): Puspita Das Roy 1 , Mousumi Majumder 1 , Bidyut Roy [[dagger]] 1 Keywords: antituberculosis drugs; hepatotoxicity; isoniazid; pharmacogenomics Approximately a third of the world's population is...

• Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians

  Authors:Paola Borgiani, Cinzia Ciccacci, Vittorio Forte, Silvia Romano, Giorgio Federici, and Giuseppe NovelliFrom:Pharmacogenomics (Vol. 8, Issue 11) Peer-Reviewed

  Nov. 20073,213 words Article 1410LAuthor(s): Paola Borgiani 1 2 , Cinzia Ciccacci 1 , Vittorio Forte 3 , Silvia Romano 1 , Giorgio Federici 4 , Giuseppe Novelli [[dagger]] 1 2 5 Keywords : CYP2C9; mean weekly warfarin dose; pharmacogenetics;...

• Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix.sup.[R] database

  Authors:Brigitte Ganter, Ronald D Snyder, Donald N Halbert, and May D LeeFrom:Pharmacogenomics (Vol. 7, Issue 7) Peer-Reviewed

  Oct. 200611,464 words Report Author(s): Brigitte Ganter 1 , Ronald D Snyder 2 , Donald N Halbert [[dagger]] 1 , May D Lee 1 Keywords: drug discovery and development; inducible nitric oxide synthase; mechanism of action; mechanism of toxicity;...

• The pharmacogenetics of analgesia: toward a genetically-based approach to pain management

  Authors:Christopher M. Flores and Jeffrey S. MogilFrom:Pharmacogenomics (Vol. 2, Issue 3) Peer-Reviewed

  Aug. 1, 20018,135 words Report 1550LInterindividual differences in the experience of pain have been appreciated clinically for over a century. More recently, there has been a growing body of evidence demonstrating differences in analgesic response to...

• Drug metabolism genotype and clozapine-induced pancreatitis

  Author:Y.W. Francis LamFrom:The Brown University Psychopharmacology Update (Vol. 22, Issue 4)

  Apr. 2011900 words Article 1500LThe atypical antipsychotic clozapine (Clozaril) is very effective in managing patients with treatment-resistant schizophrenia. However, its pharmacokinetic profile is highly variable and can be altered by changes in...

• Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women

  Authors:Jennifer Prescott, Deborah J. Thompson, Peter Kraft, Stephen J. Chanock, Tina Audley, Judith Brown, et al.From:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 4, 20127,285 words Article 1580LAuthor(s): Jennifer Prescott 1 , 2 , Deborah J. Thompson 3 , Peter Kraft 2 , Stephen J. Chanock 4 , Tina Audley 3 , Judith Brown 3 , Jean Leyland 3 , Elizabeth Folkerd 5 , Deborah Doody 5 , Susan E. Hankinson 1 , 2 , 6...

• Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS

  Authors:Frank P. Diekstra, Christiaan G. J. Saris, Wouter van Rheenen, Lude Franke, Ritsert C. Jansen, Michael A. van Es, et al.From:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 11, 20126,520 words Article 1460LAuthor(s): Frank P. Diekstra 1 , Christiaan G. J. Saris 1 , Wouter van Rheenen 1 , Lude Franke 2 , Ritsert C. Jansen 2 , 3 , Michael A. van Es 1 , Paul W. J. van Vught 1 , Hylke M. Blauw 1 , Ewout J. N. Groen 1 , Steve...

• Genetic Polymorphisms in CYP2E1: Association with Schizophrenia Susceptibility and Risperidone Response in the Chinese Han Population

  Authors:Ran Huo, Kefu Tang, Zhiyun Wei, Lu Shen, Yuyu Xiong, Xi Wu, et al.From:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 11, 20125,829 words Article 1490LAuthor(s): Ran Huo 1 , 2 , Kefu Tang 1 , 2 , Zhiyun Wei 1 , 2 , Lu Shen 1 , 2 , Yuyu Xiong 1 , 2 , Xi Wu 1 , 2 , Jiamin Niu 3 , Xia Han 3 , Zhengan Tian 4 , Lun Yang 1 , 2 , Guoyin Feng 1 , 2 , 5 , Lin He 1 , 2 , 6 , *...

• Prox1 Directly Interacts with LSD1 and Recruits the LSD1/NuRD Complex to Epigenetically Co-Repress CYP7A1 Transcription

  Authors:Huafang Ouyang, Yi Qin, Yanfeng Liu, Youhua Xie, and Jing LiuFrom:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 23, 20137,162 words Article 1560LAuthor(s): Huafang Ouyang 1, Yi Qin 1, Yanfeng Liu 2, Youhua Xie 1,2,*, Jing Liu 2,* Introduction Bile acids (BA) are synthesized in the liver and function as physiological detergents that facilitate intestinal...

• Overexpression of AaWRKY1 Leads to an Enhanced Content of Artemisinin in Artemisia annua

  Authors:Weimin Jiang, Xueqing Fu, Qifang Pan, Yueli Tang, Qian Shen, Zongyou Lv, et al.From:BioMed Research InternationalPeer-Reviewed

  Annual 20165,908 words Article 1160LArtemisinin is an effective component of drugs against malaria. The regulation of artemisinin biosynthesis is at the forefront of artemisinin research. Previous studies showed that AaWRKY1 can regulate the expression of...

• POD-1/Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells

  Authors:M.M. Franca, N.P. Abreu, T.A.M. Vrechi, and C.F. LotfiFrom:Brazilian Journal of Medical and Biological Research (Vol. 48, Issue 12) Peer-Reviewed

  Dec. 20154,452 words Report 1480LDuring gonad and adrenal development, the POD-1/capsulin/TCF21 transcription factor negatively regulates SF-1/NR5A1 expression, with higher SF-1 levels being associated with increased adrenal cell proliferation and...

• Adrenal glands of Spix's yellow-toothed cavy (Galea spixii, Wagler, 1831): morphological and morphometric aspects/ Glandulas adrenais de preas (Galea spixii, Wagler, 1831): aspectos morfologicos e morfometricos

  Authors:A.C. Santos, D.C. Viana, B.M. Bertassoli, B.G. Vasconcelos, D.M. Oliveira, R.E.G. Rici, et al.From:Brazilian Journal of Biology (Vol. 76, Issue 3) Peer-Reviewed

  July-September 20165,426 words Article 1400LConsidering the physiological importance and need of greater morphophysiological knowledge of adrenal glands, the aims of present study were compare the morphometric data between left and right adrenal of male and...

• Predictions of metabolic drug-drug interactions using physiologically based modelling: two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil

  Authors:Nathalie Perdaems, Helene Blasco, Cedric Vinson, Marylore Chenel, Sarah Whalley, Fanny Cazade, et al.From:Clinical Pharmacokinetics (Vol. 49, Issue 4) Peer-Reviewed

  Apr. 201010,112 words Report 1530LBackground and Objective: Nowadays, evaluation of potential risk of metabolic drug-drug interactions (mDDIs) is of high importance within the pharmaceutical industry, in order to improve safety and reduce the attrition...

• 57 Varieties: the human cytochromes P450

  Author:David F.V. LewisFrom:Pharmacogenomics (Vol. 5, Issue 3) Peer-Reviewed

  Apr. 1, 20042,686 words Report 1590LThe human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that approximately one-half are associated with the...