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    Academic Journals

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• QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis

  Authors:J.-U. Appelt, F.A. Giordano, M. Ecker, I. Roeder, N. Grund, A. Hotz-Wagenblatt, et al.From:Gene Therapy (Vol. 16, Issue 7) Peer-Reviewed

  July 20095,710 words Report Several events of insertional mutagenesis in pre-clinical and clinical gene therapy studies have created intense interest in assessing the genomic insertion profiles of gene therapy vectors. For the construction of such...

• Use of insertional mutagenesis to tag putative parasitic fitness genes in the Dutch elm disease fungus Ophiostoma novo-ulmi subsp. novo-ulmi

  Authors:Karine V. Plourde, Volker Jacobi, and Louis BernierFrom:Canadian Journal of Microbiology (Vol. 54, Issue 9) Peer-Reviewed

  Sept. 20083,002 words Report 1490LAbstract: We used insertional mutagenesis to produce genetically tagged mutants of the Dutch elm disease fungus Ophiostoma novo-ulmi subsp. novo-ulmi. We first optimized transformation of O. novo-ulmi protoplasts by the...

• Maternally inherited transposition excision in Drosophila simulans

  Authors:Glenn J. Bryan and Daniel L. HartlFrom:Science (Vol. 240, Issue 4849) Peer-Reviewed

  Apr. 8, 19881,090 words Article Maternally Inherited Transposon Excision in Drosophila simulans CYTOPLASMIC TRANSMISSION OF SUBSTANCES regulating the mobilization of transposable elements is an important feature of hybrid dysgenesis in Drosophila...

• Stat acetylation--a key facet of cytokine signaling?

  Authors:John J. O'Shea, Yuka Kanno, Xiaomin Chen, and David E. LevyFrom:Science (Vol. 307, Issue 5707) Peer-Reviewed

  Jan. 14, 20051,428 words Article 1420LDNA binding proteins called Stats (signal transducers and activators of transcription) carry signals from cytokines and other extracellular stimuli into the cell nucleus (1, 2). Stats each carry a Src homology 2 (SH2)...

• INTEGRATING DNA: Transposases and Retroviral Integrases

  Authors:L. Haren, B. Ton-Hoang, and M. ChandlerFrom:Annual Review of Microbiology (Vol. 53) Peer-Reviewed

  Annual 199915,075 words Article Laboratorie de Microbiologie et Genetique Molecularie, CNRS (UPR 9007) and Universite Paul Sabatier, 31062 Toulouse, France; e-mail: mike@ibcg.biotoul.fr Key Words transposons, insertion sequences, structure,...

• Phenotypic diversity mediated by the maize transposable elements Ac and Spm

  Author:Susan R. WesslerFrom:Science (Vol. 242, Issue 4877) Peer-Reviewed

  Oct. 21, 19884,841 words Article Phenotypic Diversity Mediated by the Maize Transposable Elements Ac and Spm MAIZE TRANSPOSABLE ELEMENTS ARE RESPONSIBLE FOR a remarkable variety of unstable mutant phenotypes. The phenotypes of several alleles, each...

• A robust benchmark for detection of germline large deletions and insertions

  Authors:Justin M. Zook, Nancy F. Hansen, Nathan D. Olson, Lesley Chapman, James C. Mullikin, Chunlin Xiao, et al.From:Nature Biotechnology (Vol. 38, Issue 11) Peer-Reviewed

  Nov. 20209,255 words Technical report 1580LNew technologies and analysis methods are enabling genomic structural variants (SVs) to be detected with ever-increasing accuracy, resolution and comprehensiveness. To help translate these methods to routine research...

• Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains

  Authors:Jacob A. Aten, Jan Stap, Przemek M. Krawczyk, Carel H. van Oven, Ron A. Hoebe, Jeroen Essers, et al.From:Science (Vol. 303, Issue 5654) Peer-Reviewed

  Jan. 2, 20042,295 words Article 1440LInteractions between ends from different DNA double-strand breaks (DSBs) can produce tumorigenic chromosome translocations. Two theories for the juxtaposition of DSBs in translocations, the static "contact-first" and...