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Academic Journals
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From:Nature Biotechnology (Vol. 39, Issue 5) Peer-ReviewedDNA point accumulation in nanoscale topography (DNA-PAINT) increases the resolution and multiplexing capabilities of super-resolution imaging, but cellular DNA interferes with DNA-DNA hybridization between target and...
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From:Canadian Journal of Chemistry (Vol. 93, Issue 3) Peer-ReviewedLanthanides represent a group of very important but challenging analytes for biosensor development. These 15 elements are very similar in their chemical properties. So far, limited success has been realized using the...
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From:Evolution (Vol. 51, Issue 6) Peer-ReviewedResearch was conducted to examine the patterns of pleiotropic effects of individual gene loci on mandibular morphology. The objective of the study was to find out whether the pleiotropic effects of individual genes are...
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From:Biochemistry (Moscow) (Vol. 85, Issue 4) Peer-ReviewedDamaged DNA bases are removed by the base excision repair (BER) mechanism. This enzymatic process begins with the action of one of DNA glycosylases, which recognize damaged DNA bases and remove them by hydrolyzing...
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From:Science (Vol. 289, Issue 5476) Peer-ReviewedGenomic evolution has been profoundly influenced by DNA transposition, a process whereby defined DNA segments move freely about the genome. Transposition is mediated by transposases, and similar events are catalyzed by...
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From:The Scientist (Vol. 19, Issue 19) Peer-ReviewedMicroarrays present researchers with something of a catch-22: In order to find something, you have to know what you're looking for. If you're looking for new functional elements, your microarray needs to contain probes...
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From:Science (Vol. 288, Issue 5474) Peer-ReviewedMammals undergo the unique process of genomic imprinting. In this process, a gene on one chromosome is silenced, whereas its allele on the other chromosome is expressed. There are several ways to silence genes, the best...
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From:Nature (Vol. 464, Issue 7293) Peer-ReviewedRhodopsin activation tracked The G-protein-coupled receptor (GPCR) rhodopsin is responsible for dim-light vision. Incoming light isomerizes the protein's retinal chromophore and triggers concerted movements of...
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From:Diabetes (Vol. 38, Issue 12) Peer-ReviewedInsulin binds to cells at specific protein sites called receptors. The insulin receptor consists of two alpha subunits and two beta subunits. The alpha subunits occupy the outer surface of the cell, whereas the beta...
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From:Canadian Journal of Microbiology (Vol. 58, Issue 3) Peer-ReviewedDNA stable-isotope probing (DNA-SIP) is a cultivation-independent technique that makes it possible to associate metabolic function and taxonomic identity in a wide range of terrestrial and aquatic environments. In...
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From:Science (Vol. 286, Issue 5442) Peer-ReviewedAlthough data on nucleotide sequence variation in the human nuclear genome have begun to accumulate, little is known about genomic diversity in chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). A 10,154-base...
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From:PLoS ONE (Vol. 15, Issue 9) Peer-ReviewedTurn-on fluorescent probes show enhanced emission upon DNA binding, advocating their importance in imaging cellular DNA. We have probed the DNA binding mode of thiazole-coumarin (TC) conjugate, a recently reported...
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From:PLoS ONE (Vol. 11, Issue 3) Peer-ReviewedIn the recent years, many protocols aimed at reproducibly sequencing reduced-genome subsets in non-model organisms have been published. Among them, RAD-sequencing is one of the most widely used. It relies on digesting...
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From:BMC Research Notes (Vol. 1) Peer-ReviewedBackground Affymetrix GeneChips can be re-annotated at the probe-level by breaking up the original probe-sets and recomposing new probe-sets based on up-to-date genomic knowledge, such as available in Entrez Gene....
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From:Human Biology (Vol. 77, Issue 4) Peer-ReviewedWe report on the use of rare mutations to tackle biosocial questions such as kinship and differential burial practices from past human populations. To do this, we have inferred nucleotide position 73 of HVS-II in...
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From:Science (Vol. 257, Issue 5072) Peer-ReviewedSeveral weeks ago, Science and AAAS hosted an entirely new meeting in San Francisco: Science Innovation "92, designed to showcase the latest and hottest advances in technique, particularly in the field of biomedicine....
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From:British Medical Journal (Vol. 308, Issue 6929) Peer-ReviewedAbnormal CD44 gene activity detected in urine samples appears to be useful in diagnosing early bladder cancer. Bladder cancer can be cured by surgery if detected early enough. Abnormal CD44 gene patterns have been...
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From:The Scientist (Vol. 17, Issue 1) Peer-ReviewedAffymetrix, the Santa Clara, Calif.-based manufacturer of GeneChip[R] microarrays, has developed a new Lamp device to create microarrays, according to a recently awarded patent. (1) The new technique replaces physical...
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From:American Zoologist (Vol. 39, Issue 5) Peer-ReviewedThe study of Hox gene evolution among vertebrates continues to serve as a paradigm for those interested in vertebrate genome evolution and development. Recent exciting discoveries about Hox gene composition in fishes,...
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From:Science (Vol. 252, Issue 5009) Peer-ReviewedFRAGILE X SYNDROME IS THE MOST common form of familial mental retardation [1]. It is associated with a rare, fragile site at Xq27.3 (FRAXA); this association allows for cytogenetic prenatal diagnosis and carrier...