Search Results

• • 833 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Multiple biomarkers in molecular oncology. I. Molecular diagnostics applications in cervical cancer detection

  Author:Douglas P MalinowskiFrom:Expert Review of Molecular Diagnostics (Vol. 7, Issue 2) Peer-Reviewed

  Mar. 200710,136 words Article Author(s): Douglas P Malinowski 1 Keywords: biomarker; cervical neoplasia; clinical molecular diagnostics The detection and diagnosis of cancer, together with the prognosis for disease progression, play a...

• Proteomic dissection of DNA polymerization

  Authors:Jennifer L Beck, Thitima Urathamakul, Stephen J Watt, Margaret M Sheil, Patrick M Schaeffer, and Nicholas E DixonFrom:Expert Review of Proteomics (Vol. 3, Issue 2) Peer-Reviewed

  Apr. 200613,031 words Report 1440LAuthor(s): Jennifer L Beck 1 , Thitima Urathamakul 2 , Stephen J Watt 3 , Margaret M Sheil 4 , Patrick M Schaeffer 5 , Nicholas E Dixon 6 Keywords : DNA polymerase; DNA repair; DNA replication; electrospray...

• Systematic Analysis of Cell Cycle Effects of Common Drugs Leads to the Discovery of a Suppressive Interaction between Gemfibrozil and Fluoxetine

  Authors:Scott A. Hoose, Camille Duran, Indranil Malik, Shabnam Eslamfam, Samantha C. Shasserre, S. Sabina Downing, et al.From:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 2, 20125,027 words Article 1410LAuthor(s): Scott A. Hoose 1 , Camille Duran 1 , Indranil Malik 1 , Shabnam Eslamfam 1 , Samantha C. Shasserre 1 , S. Sabina Downing 1 , Evelyn M. Hoover 1 , Katherine E. Dowd 1 , Roger Smith 2 , Michael Polymenis 1 , *...

• Cyclic Peptide Inhibitors of the [beta]-Sliding Clamp in Staphylococcus aureus

  Authors:Susanne Kjelstrup, Paula Melo Paulon Hansen, Line E. Thomsen, Paul Robert Hansen, and Anders Lobner-OlesenFrom:PLoS ONE (Vol. 8, Issue 9) Peer-Reviewed

  Sept. 4, 20139,360 words Article 1420LAuthor(s): Susanne Kjelstrup 1, Paula Melo Paulon Hansen 1, Line E. Thomsen 2, Paul Robert Hansen 3, Anders Løbner-Olesen 1,* Introduction In recent years, many bacterial pathogens have become resistant or...

• The Mini-Chromosome Maintenance (Mcm) Complexes Interact with DNA Polymerase [alpha]-Primase and Stimulate Its Ability to Synthesize RNA Primers

  Authors:Zhiying You, Mariarosaria De Falco, Katsuhiko Kamada, Francesca M. Pisani, and Hisao MasaiFrom:PLoS ONE (Vol. 8, Issue 8) Peer-Reviewed

  Aug. 20, 201310,259 words Article 1470LAuthor(s): Zhiying You 1,*, Mariarosaria De Falco 2, Katsuhiko Kamada 3, Francesca M. Pisani 2, Hisao Masai 1 Introduction In eukaryotic cells, the initiation of DNA replication proceeds in two steps:...

• A conversation with Bruce Alberts

  Author:Ushma S. NeillFrom:Journal of Clinical Investigation (Vol. 126, Issue 12) Peer-Reviewed

  Dec. 20162,264 words Report 1100LThe name Bruce Alberts is synonymous with the textbook Molecular Biology of the Cell, a text that has inspired legions of science students. Over the course of a storied career, Alberts (Figure 1), a professor at UCSF,...

• Misactivation of Hedgehog signaling causes inherited and sporadic cancers

  Authors:David R. Raleigh and Jeremy F. ReiterFrom:Journal of Clinical Investigation (Vol. 129, Issue 2) Peer-Reviewed

  Feb. 20199,931 words Report 1410LThe Hedgehog pathway is critical for the development of diverse organs. Misactivation of the Hedgehog pathway can cause developmental abnormalities and cancers, including medulloblastoma, the most common pediatric brain...

• Effects of Estrogen and Estrogen Receptors on Transcriptomes of HepG2 Cells: A Preliminary Study Using RNA Sequencing

  Authors:Minqian Shen, Jingyi Cao, and Haifei ShiFrom:International Journal of Endocrinology (Vol. 2018) Peer-Reviewed

  Annual 201810,112 words Article 1510LMen have a much higher incidence of hepatocellular carcinoma (HCC), the predominant form of liver cancer, than women, suggesting that estrogens play a protective role in liver cancer development and progression. To...

• Oxidative stress in Shiga toxin production by enterohemorrhagic Escherichia coli

  Authors:Katarzyna Licznerska, Bozena Nejman-Falenczyk, Sylwia Bloch, Aleksandra Dydecka, Gracja Topka, Tomasz Gasior, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2015) Peer-Reviewed

  Annual 20154,348 words Article 1560LVirulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells...

• MCM paradox: abundance of eukaryotic replicative helicases and genomic integrity

  Authors:Mitali Das, Sunita Singh, Satyajit Pradhan, and Gopeshwar NarayanFrom:Molecular Biology InternationalPeer-Reviewed

  Annual 20149,252 words Report 1420LAs a crucial component of DNA replication licensing system, minichromosome maintenance (MCM) 2-7 complex acts as the eukaryotic DNA replicative helicase. The six related MCM proteins form a heterohexamer and bind with...

• Loss of ATRX Does Not Confer Susceptibility to Osteoarthritis

  From:PLoS ONE (Vol. 8, Issue 12) Peer-Reviewed

  Dec. 30, 20136,497 words Article 1370LThe chromatin remodelling protein ATRX is associated with the rare genetic disorder ATR-X syndrome. This syndrome includes developmental delay, cognitive impairment, and a variety of skeletal deformities. ATRX plays a...

• CenH3/CID Incorporation Is Not Dependent on the Chromatin Assembly Factor CHD1 in Drosophila

  Authors:Valerie Podhraski, Beatriz Campo-Fernandez, Hildegard Worle, Paolo Piatti, Harald Niederegger, Gunther Bock, et al.From:PLoS ONE (Vol. 5, Issue 4) Peer-Reviewed

  Apr. 9, 20106,962 words Article 1420LCHD1 is a SNF2-related ATPase that is required for the genome-wide incorporation of variant histone H3.3 in the paternal pronucleus as well as in transcriptionally active nuclei in Drosophila embryos. The S. pombe and...

• Chad Nusbaum

  From:Nature (Vol. 440, Issue 7087) Peer-Reviewed

  Apr. 2006478 words Article 1250LHow to unpick the mysteries of a human chromosome. Author Affiliations: Sometimes it pays to save the most difficult part of a project until last. For the researchers charged with sequencing four human chromosomes...

• Microgravity Promotes Differentiation and Meiotic Entry of Postnatal Mouse Male Germ Cells

  Authors:Manuela Pellegrini, Sara Di Siena, Giuseppina Claps, Silvia Di Cesare, Susanna Dolci, Pellegrino Rossi, et al.From:PLoS ONE (Vol. 5, Issue 2) Peer-Reviewed

  Feb. 4, 20106,048 words Article 1530LA critical step of spermatogenesis is the entry of mitotic spermatogonia into meiosis. Progresses on these topics are hampered by the lack of an in vitro culture system allowing mouse spermatogonia differentiation and...

• Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence

  Authors:Hanane Agherbi, Anne Gaussmann-Wenger, Christophe Verthuy, Lionel Chasson, Manuel Serrano, and Malek DjabaliFrom:PLoS ONE (Vol. 4, Issue 5) Peer-Reviewed

  May 20, 20095,832 words Article 1430LBackground The INK4/ARF locus encodes three tumor suppressor genes (p15.sup.Ink4b, Arf and p16.sup.Ink4a) and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression...

• Replication and protection of telomeres

  Authors:Ramiro E. Verdun and Jan KarlsederFrom:Nature (Vol. 447, Issue 7147) Peer-Reviewed

  June 21, 20078,549 words Report 1600LDuring the evolution of linear genomes, it became essential to protect the natural chromosome ends to prevent triggering of the DNA-damage repair machinery and enzymatic attack. Telomeres -- tightly regulated complexes...

• Group II Intron-Based Gene Targeting Reactions in Eukaryotes

  Authors:Marta Mastroianni, Kazuo Watanabe, Travis B. White, Fanglei Zhuang, Jamie Vernon, Manabu Matsuura, et al.From:PLoS ONE (Vol. 3, Issue 9) Peer-Reviewed

  Sept. 1, 200813,702 words Article 1710LBackground Mobile group II introns insert site-specifically into DNA target sites by a mechanism termed retrohoming in which the excised intron RNA reverse splices into a DNA strand and is reverse transcribed by the...

• Single Cell Analysis of Human RAD18-Dependent DNA Post-Replication Repair by Alkaline Bromodeoxyuridine Comet Assay

  Authors:Monika Morocz, Himabindu Gali, Istvan Rasko, C. Stephen Downes, and Lajos HaracskaFrom:PLoS ONE (Vol. 8, Issue 8) Peer-Reviewed

  Aug. 6, 20136,875 words Article 1640LDamage to DNA can block replication progression resulting in gaps in the newly synthesized DNA. Cells utilize a number of post-replication repair (PRR) mechanisms such as the RAD18 controlled translesion synthesis or...

• Functions of Fun30 Chromatin Remodeler in Regulating Cellular Resistance to Genotoxic Stress

  Authors:Xin Bi, Qun Yu, Jasmine Siler, Chong Li, and Ali KhanFrom:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 25, 20158,349 words Article 1460LThe Saccharomyces cerevisiae Fun30 chromatin remodeler has recently been shown to facilitate long-range resection of DNA double strand break (DSB) ends, which proceeds homologous recombination (HR). This is believed to...

• Transformation with Oligonucleotides Creating Clustered Changes in the Yeast Genome

  Authors:Gina P. Rodriguez, Joseph B. Song, and Gray F. CrouseFrom:PLoS ONE (Vol. 7, Issue 8) Peer-Reviewed

  Aug. 14, 20126,343 words Article 1590LWe have studied single-strand oligonucleotide (oligo) transformation of yeast by using 40-nt long oligos that create multiple base changes to the yeast genome spread throughout the length of the oligos, making it...