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    Academic Journals

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• Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics

  Author:Ingolf CascorbiFrom:Pharmacogenomics (Vol. 14, Issue 15) Peer-Reviewed

  Nov. 20131,921 words Article 1600LAuthor(s): Ingolf Cascorbi 1 KEYWORDS : epigenetics; miRNA; pharmacogenetics; systems biology The influence of genetic variants on drug response is becoming increasingly better understood. In particular,...

• Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β.sub.2-agonists: results of the pacman cohort

  Authors:Miranda JL Zuurhout, Susanne JH Vijverberg, Jan AM Raaijmakers, Leo Koenderman, Dirkje S Postma, Gerard H Koppelman, et al.From:Pharmacogenomics (Vol. 14, Issue 16) Peer-Reviewed

  Dec. 20134,648 words Report 1300LAuthor(s): Miranda JL Zuurhout 1 , Susanne JH Vijverberg 1 2 , Jan AM Raaijmakers 1 , Leo Koenderman 2 , Dirkje S Postma 3 , Gerard H Koppelman 4 , Anke Hilse Maitland-van der Zee [*] 5 KEYWORDS : ADRB2; Arg16;...

• Calcineurin inhibitors and hypertension: a role for pharmacogenetics?

  Authors:Arthur D Moes, Dennis A Hesselink, Robert Zietse, Ron HN van Schaik, Teun van Gelder, and Ewout J HoornFrom:Pharmacogenomics (Vol. 15, Issue 9) Peer-Reviewed

  June 20146,888 words Report 2210LAuthor(s): Arthur D Moes aff1 , Dennis A Hesselink aff1 , Robert Zietse aff1 , Ron HN van Schaik aff2 , Teun van Gelder aff1 aff3 , Ewout J Hoorn [*] aff1 Keywords: ABCB1; CYP3A5; sodium chloride cotransporter;...

• Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

  Authors:Otito F Iwuchukwu, QiPing Feng, Wei-Qi Wei, Lan Jiang, Min Jiang, Hua Xu, et al.From:Pharmacogenomics (Vol. 15, Issue 14) Peer-Reviewed

  Nov. 20145,511 words Report 1620LAuthor(s): Otito F Iwuchukwu [*] aff1 , QiPing Feng aff1 , Wei-Qi Wei aff2 , Lan Jiang aff3 , Min Jiang aff4 , Hua Xu aff4 , Joshua C Denny aff2 , Russell A Wilke aff5 , Ronald M Krauss aff6 , Dan M Roden aff1 aff7 , C...

• Genetic variation in Otos is associated with cisplatin-induced ototoxicity

  Authors:Timothy F Spracklen, Heather Whitehorn, Anna Alvera Vorster, Lebogang Ramma, Sameera Dalvie, and Rajkumar S RamesarFrom:Pharmacogenomics (Vol. 15, Issue 13) Peer-Reviewed

  Oct. 20146,242 words Report 1600LAuthor(s): Timothy F Spracklen aff1 , Heather Whitehorn aff1 , Anna Alvera Vorster aff1 , Lebogang Ramma aff2 , Sameera Dalvie aff3 , Rajkumar S Ramesar [*] aff1 Keywords: cisplatin; hearing loss; Otos ;...

• Pharmacogenomics in practice: a case report of personalized inpatient psychiatric care

  Authors:Alok Madan, Cory R Walker, Benjamin Weinstein, and J Christopher FowlerFrom:Pharmacogenomics (Vol. 16, Issue 5) Peer-Reviewed

  Apr. 20154,291 words Clinical report 1530LAuthor(s): Alok Madan [*] aff1 aff2 , Cory R Walker aff1 aff2 , Benjamin Weinstein aff1 aff2 , J Christopher Fowler aff1 aff2 Keywords: inpatient psychiatry; pharmacogenomics; psychosis; psychotropic medications...

• Role of obesity on the efficacy of exemestane plus ovarian suppression in hormone receptor-positive premenopausal breast cancer

  Authors:Sercan Aksoy, Muhammed Bulent Akinci, Nuriye Ozdemir, Kadri Altundag, Nurullah Zengin, and Bulent YalcinFrom:Future Oncology (Vol. 11, Issue 6) Peer-Reviewed

  Mar. 20152,208 words Report 2360LAuthor(s): Mehmet Ali Nahit Şendur [*] aff1 , Sercan Aksoy aff2 , Muhammed Bülent Akinci aff1 , Nuriye Ozdemir aff1 , Didem Şener Dede aff1 , Kadri Altundag aff2 , Nurullah Zengin aff1 , Bülent Yalçin aff1...

• Is there a role for pharmacogenetics in the treatment of panic disorder?

  Authors:Daniela Caldirola and Giampaolo PernaFrom:Pharmacogenomics (Vol. 16, Issue 8) Peer-Reviewed

  July 20152,642 words Report 1800LAuthor(s): Daniela Caldirola [*] aff1 , Giampaolo Perna aff1 aff2 aff3 Keywords: genetic; panic disorder; polymorphism; serotonin Pharmacogenetics & personalized psychiatry The ultimate goal of a...

• Pharmaceutical care: Need of the hour in India

  Authors:A. Tumkur, P. Muragundi, R. Shetty, and A. NaikFrom:Journal of Young Pharmacists (Vol. 4, Issue 4) Peer-Reviewed

  October-December 20123,086 words Report 1710LByline: A. Tumkur, P. Muragundi, R. Shetty, A. Naik Pharmaceutical care signifies a shift of practice in pharmacy from being drug product-oriented to the one that is patient-oriented to achieve definite outcomes that...

• Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry

  Authors:Yasufumi Fukano, Naohiro Tsuyama, Hajime Mizuno, Sachiko Date, Mikihisa Takano, and Tsutomu MasujimaFrom:Nanomedicine (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 20124,533 words Report 1390LAuthor(s): Yasufumi Fukano 1 2 , Naohiro Tsuyama 1 , Hajime Mizuno 1 , Sachiko Date 3 , Mikihisa Takano 1 , Tsutomu Masujima [*] 4 KEYWORDS : live single-cell analysis; mass spectrometry; metabolite profiling;...

• Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response

  Authors:Gerald A Higgins, Ari Allyn-Feuer, and Brian D AtheyFrom:Pharmacogenomics (Vol. 16, Issue 14) Peer-Reviewed

  Sept. 201511,449 words Report 1970LAuthor(s): Gerald A Higgins aff1 aff2 , Ari Allyn-Feuer aff1 , Brian D Athey [*] aff1 aff3 Keywords: chromatin spatial interactions; pharmacodynamics; pharmacogenomics; pharmacokinetics The majority of SNPs...

• Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection

  Authors:Karolina Rembeck and Martin LaggingFrom:Pharmacogenomics (Vol. 16, Issue 10) Peer-Reviewed

  July 20157,042 words Report 2870LAuthor(s): Karolina Rembeck aff1 , Martin Lagging [*] aff1 Keywords: genetic variant; HCV; histology; IL28B; inosine triphosphate pyrophosphatase; interferon-λ; ITPA; ITPase; natural history; PNPLA3;...

• Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations

  Authors:Alan HB Wu, Ping Wang, Andrew Smith, Christine Haller, Katherine Drake, Mark Linder, et al.From:Pharmacogenomics (Vol. 9, Issue 2) Peer-Reviewed

  Feb. 20086,344 words Report 1370LAuthor(s): Alan HB Wu [[dagger]] 1 , Ping Wang 1 , Andrew Smith 1 , Christine Haller 1 , Katherine Drake 1 , Mark Linder 2 , Roland Valdes 2 Keywords: cytochrome 2C9; pharmacogenomics; vitamin K epoxide reductase...

• The Pharmacokinetic-Pharmacodynamic Model of Azithromycin for Lipopolysaccharide-Induced Depressive-Like Behavior in Mice

  Authors:Kun Hao, Qu Qi, Haiping Hao, Guangji Wang, Yuancheng Chen, Yan Liang, et al.From:PLoS ONE (Vol. 8, Issue 1) Peer-Reviewed

  Jan. 24, 20136,208 words Report 1350LAuthor(s): Kun Hao 1 , Qu Qi 1 , Haiping Hao 1 , Guangji Wang 1 , * , Yuancheng Chen 2 , Yan Liang 1 , Lin Xie 1 Introduction Increased major depressive-like disorders occur in many diseases (e.g.,...

• 57 Varieties: the human cytochromes P450

  Author:David F.V. LewisFrom:Pharmacogenomics (Vol. 5, Issue 3) Peer-Reviewed

  Apr. 1, 20042,686 words Report 1590LThe human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that approximately one-half are associated with the...

• ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2

  Authors:Reinhold Kerb, Sven Hoffmeyer, and Ulrich BrinkmannFrom:Pharmacogenomics (Vol. 2, Issue 1) Peer-Reviewed

  Feb. 1, 20017,315 words Report 1360LTransport by ATP-dependent efflux pumps, such as P-glycoprotein (PGP) and multi-drug resistance related proteins (MRPs), influences bioavailability and disposition of drugs. These efflux pumps serve as defence...

• A new era of rationally designed antipsychotics

  Authors:David R. Sibley and Lei ShiFrom:Nature (Vol. 555, Issue 7695) Peer-Reviewed

  Mar. 8, 20181,026 words Article 1520LAuthor(s): David R. Sibley; Lei Shi Schizophrenia is a disorder that involves hallucinations, delusions and cognitive impairment, and that affects nearly 1% of the global population. The mainstays of therapy have...

• Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study

  Authors:Arani Chatterjee, Raghunadharao Digumarti, Kasiram Katneni, Vijay V. Upreti, Rao N.V.S. Mamidi, Ramesh Mullangi, et al.From:Journal of Clinical Pharmacology (Vol. 45, Issue 4) Peer-Reviewed

  Apr. 20053,627 words Article The purpose of this bridging phase I study was to characterize the toxicity, pharmacokinetics, and antitumor effects of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory solid tumor patients....

• Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a pilot study

  Authors:Paola Stiuso, Ilaria Scognamiglio, Marianna Murolo, Pasquale Ferranti, Carmela De Simone, Maria Rosaria Rizzo, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2014) Peer-Reviewed

  Annual 20144,363 words Report 1500LLiver steatosis can evolve to steatohepatitis (NASH) through a series of biochemical steps related to oxidative stress in hepatocytes. Antioxidants, such as silybin, have been proposed as a treatment of patients with...

• Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents

  Authors:Maria Filippova, Valery Filippov, Vonetta M. Williams, Kangling Zhang, Anatolii Kokoza, Svetlana Bashkirova, et al.From:BioMed Research InternationalPeer-Reviewed

  Annual 20147,081 words Report 1490LTreatment of advanced and relapsed cervical cancer is frequently ineffective, due in large part to chemoresistance. To examine the pathways responsible, we employed the cervical carcinoma-derived SiHa and CaSki cells as...