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    Academic Journals

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• Signal transduction from the endoplasmic reticulum to the cell nucleus

  Author:Heike L. PahlFrom:Physiological Reviews (Vol. 79, Issue 3) Peer-Reviewed

  July 199914,540 words Article Recent developments in understanding signal transduction from the endoplasmic reticulum (ER) to the cell nucleus has been studied. Emphasis is given on the three types of stress experienced by the ER. These are the...

• Endoplasmic reticulum proteins in cardiac development and dysfunction

  Authors:Daniel Prins and Marek MichalakFrom:Canadian Journal of Physiology and Pharmacology (Vol. 87, Issue 6) Peer-Reviewed

  June 20095,365 words Report An understanding of cardiac pathologies and the molecular mechanisms thereof is essential for the development of therapies for cardiovascular disease, a common cause of death in Western societies. Investigations into...

• Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibition, annexin 1 and endoplasmic reticulum protein 28

  Authors:Pooi-Fong Wong, Wei-Fun Cheong, Meng-Hooi Shub, Chin-Hoe Teh, Kit-Lam Chan, and Sazaly AbuBakarbFrom:Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Vol. 19, Issue 2) Peer-Reviewed

  Feb. 15, 20125,422 words Report 1470LABSTRACT Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines. Here we examined the effects of purified...

• Endoplasmic reticulum stress-related inflammation and cardiovascular diseases

  Authors:Tomomi Gotoh, Motoyoshi Endo, and Yuichi OikeFrom:International Journal of InflammationPeer-Reviewed

  Annual 20116,617 words Report 1500LThe endoplasmic reticulum (ER) is the site of synthesis and maturation of proteins designed for secretion or for localization on the cell membrane. Various types of stress from both inside and outside cells disturb ER...

• Endoplasmic reticulum stress inhibits collagen synthesis independent of collagen-modifying enzymes in different chondrocyte populations and dermal fibroblasts

  Authors:Lucienne A. Vonk, Behrouz Zandieh Doulabi, Chun-Ling Huang, Marco N. Helder, Vincent Everts, and Ruud A. BankFrom:Biochemistry and Cell Biology (Vol. 88, Issue 3) Peer-Reviewed

  June 20106,828 words Report 1400LChondrocytes respond 10 glucose deprivation with a decreased collagen synthesis due lo disruption of a proper functioning of the endoplasmic reticulum (ER): ER stress. Since the mechanisms involved in the decreased...

• Effect of FKBP65, a putative elastin chaperone, on the coacervation of tropoelastin in vitro

  Authors:Kevin L.Y. Cheung, Matthew Bates, and Vettai S. AnanthanarayananFrom:Biochemistry and Cell Biology (Vol. 88, Issue 6) Peer-Reviewed

  Dec. 20106,283 words Report 1460LFKBP65 is a protein of the endoplasmic reticulum that is relatively abundant in elastin-producing cells and is associated with tropoelastin in the secretory pathway. To test an earlier suggestion by Davis and co-workers...

• Klotho and neurons: mutual crosstalk between autophagy, endoplasmic reticulum, and inflammatory response.

  Author:Jennifer MytychFrom:Neural Regeneration Research (Vol. 16, Issue 8) Peer-Reviewed

  Aug. 20212,310 words Viewpoint essay 1520LByline: Jennifer. Mytych Klotho is one of a number of well-known longevity-associated genes. Its depletion in aging or disease may promote several neuropathologies associated with the central nervous system, including...

• Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells

  Authors:Chung-Weng Phang, Saiful Anuar Karsani, Gautam Sethi, and Sri Nurestri Abd MalekFrom:PLoS ONE (Vol. 11, Issue 2) Peer-Reviewed

  Feb. 9, 201611,658 words Report 1440LFlavokawain C (FKC) is a naturally occurring chalcone which can be found in Kava (Piper methysticum Forst) root. The present study evaluated the effect of FKC on the growth of various human cancer cell lines and the...

• T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys.sup.319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation

  Authors:Richard P. Laura, David Dong, Wanda F. Reynolds, and Richard A. MakiFrom:PLoS ONE (Vol. 11, Issue 2) Peer-Reviewed

  Feb. 18, 201619,838 words Report 1630LAmong the human heme-peroxidase family, myeloperoxidase (MPO) has a unique disulfide-linked oligomeric structure resulting from multi-step processing of the pro-protein monomer (proMPO) after it exits the endoplasmic...

• c-FLIP and the NOXA/Mcl-1 axis participate in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells

  Authors:Xiaofei Zhao, Feng Kong, Lei Wang, and Han ZhangFrom:PLoS ONE (Vol. 12, Issue 9) Peer-Reviewed

  Sept. 1, 20176,072 words Article 1370LChoroidal melanoma is the most common primary malignant intraocular tumor, and very few effective therapies are available to treat it. Our study aimed to understand whether pemetrexed plus cisplatin exerts a beneficial...

• Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

  Authors:Rodney Elwood Infante and Arun RadhakrishnanFrom:eLife (Vol. 6) Peer-Reviewed

  Apr. 17, 201716,803 words Report 1670LCells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis. To date, all...

• Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

  Authors:Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni, and Gabriella D'OraziFrom:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-Reviewed

  June 14, 20194,133 words Report 1780LAutophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an...

• Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

  Authors:Gian-Luca McLelland, Thomas Goiran, Wei Yi, Genevieve Dorval, Carol X Chen, Nadine D Lauinger, et al.From:eLife (Vol. 7) Peer-Reviewed

  Apr. 20, 201822,086 words Report 1510LDespite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER...

• Loss of the ER membrane protein complex subunit Emc3 leads to retinal bipolar cell degeneration in aged mice

  Authors:Xiong Zhu, Xin Qi, Yeming Yang, Wanli Tian, Wenjing Liu, Zhilin Jiang, et al.From:PLoS ONE (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 4, 20207,363 words Report 1250LThe endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved protein complex involved in inserting the transmembrane domain of membrane proteins into membranes in the ER. EMC3 is an essential component...

• Jasmonic Acid Induces Endoplasmic Reticulum Stress with Different Outcome in Cultured Normal and Tumor Epidermal Cells

  Authors:M.S. Vildanovaa, A.A. Saidova, A.I. Fokin, D.M. Potashnikova, G.E. Onishchenko, and E.A. SmirnovaFrom:Biochemistry (Moscow) (Vol. 84, Issue 9) Peer-Reviewed

  Sept. 20195,437 words Clinical report 1460LPlant hormones produce cytotoxic effect on human cells and can trigger the processes unrelated to cell death, e.g., biosynthetic system stress. The goal of this study was to investigate activation of the endoplasmic...

• The neuroprotective potential of endoplasmic reticulum chaperones

  Authors:Todd McLaughlin and Sarah ZhangFrom:Neural Regeneration Research (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 20152,169 words Report 1660LByline: Todd. McLaughlin, Sarah. Zhang Diseases of the nervous system are characterized by axon dysfunction, axon degeneration, and neuronal cell death. The roster of neurodegenerative diseases is striking in the...

• Attenuation of endoplasmic reticulum stress as a treatment strategy against ischemia/reperfusion injury

  Author:Chih-Li LinFrom:Neural Regeneration Research (Vol. 10, Issue 12) Peer-Reviewed

  Dec. 20151,659 words Report 1410LByline: Chih-Li. Lin Brain ischemic stroke is the leading cause of long-lasting injury, disability, and death in adults. Although the brain represents only about 2% of the total body mass, it consumes almost 20% of...

• Smoke particulates stress lung cells

  Authors:Tracy L. Adair-Kirk, Jeffrey J. Atkinson, and Robert M. SeniorFrom:Nature Medicine (Vol. 14, Issue 10) Peer-Reviewed

  Oct. 2008938 words Report 1480LInflammation is central to the development of chronic obstructive pulmonary disease (COPD), a disease often triggered by cigarette smoke and smoke from biomass fuels (1)--yet the mechanisms responsible for inflammation...

• Errant ER morphogenesis causes hereditary spastic paraplegias

  From:Journal of Clinical Investigation (Vol. 122, Issue 2) Peer-Reviewed

  Feb. 2012187 words Brief article, Repor... 1500LHereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative disorders characterized by progressive weakness and spasticity of the legs. Mutations in more than 20 genes and over 40 chromosomal loci...

• Role of ER Export Signals in Controlling Surface Potassium Channel Numbers

  Authors:Dzwokai Ma, Noa Zerangue, Yu-Fung Lin, Anthony Collins, Mei Yu, Yuh Nung Jan, et al.From:Science (Vol. 291, Issue 5502) Peer-Reviewed

  Jan. 12, 20012,206 words Article Little is known about the identity of endoplasmic reticulum (ER) export signals and how they are used to regulate the number of proteins on the cell surface. Here, we describe two ER export signals that profoundly...