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Academic Journals
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From:Diabetes (Vol. 44, Issue 4) Peer-ReviewedPlasma endothelin-1 (ET-1) levels were studied in 15 obese hypertensive (mean age 48.5 [+ or - ] 3.9 years) and 15 obese normotensive men (mean age 49.5 [+ or -] 3.6 years) before and after weight loss due to an 800...
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From:PLoS ONE (Vol. 7, Issue 3) Peer-ReviewedAuthor(s): Nadine Binai 1 , Steven O'Reilly 1 , Bridget Griffiths 2 , Jacob M. van Laar 1 , Thomas Hügle 1 , 3 , * Introduction Systemic sclerosis (SSc) is an autoimmune multisystem connective disease where low...
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From:Canadian Journal of Physiology and Pharmacology (Vol. 93, Issue 9) Peer-ReviewedRecently, several vasoactive molecules have been found in pericardial fluid (PF). Thus, we hypothesized that in coronary artery disease due to ischemia or ischemia-reperfusion, the level of vasoconstrictors, mainly...
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From:Gut (Vol. 50, Issue 1) Peer-ReviewedBackground and aims: Renal failure occurs in approximately 55% of patients with acute liver failure. We have previously shown that plasma endothelin 1 concentrations are elevated in patients with acute liver failure and...
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From:Journal of Intensive Care Medicine (Vol. 22, Issue 4) Peer-ReviewedDysfunction of the vascular endothelium (ET) causes an increase in serum ET-1 concentration, as observed in septic patients. It was assumed that in this patient population the ET-1 level correlates with the degree of...
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From:Journal of Clinical Pharmacology (Vol. 47, Issue 11) Peer-ReviewedThis study investigated the influence of ethnic origin and, as a secondary objective, sex on the pharmacokinetics of the parenteral endothelin receptor antagonist clazosentan in healthy Caucasian and Japanese subjects....
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From:Canadian Journal of Physiology and Pharmacology (Vol. 98, Issue 9) Peer-ReviewedDiabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. It is also known that the activation of the endothelin (ET) system is associated with cognitive impairment and microglia...
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From:PLoS ONE (Vol. 6, Issue 5) Peer-ReviewedBackground NKX2-3 is associated with inflammatory bowel disease (IBD). NKX2-3 is expressed in microvascular endothelial cells and the muscularis mucosa of the gastrointestinal tract. Human intestinal microvascular...
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From:PLoS ONE (Vol. 10, Issue 6) Peer-ReviewedThe aging brain is often characterized by the presence of multiple comorbidities resulting in synergistic damaging effects in the brain as demonstrated through the interaction of Alzheimer's disease (AD) and stroke....
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From:Allergy, Asthma & Clinical Immunology (Vol. 15, Issue 1) Peer-ReviewedBackground There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial...
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From:PLoS ONE (Vol. 13, Issue 12) Peer-ReviewedBackground Endothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients,...
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From:PLoS ONE (Vol. 11, Issue 6) Peer-ReviewedCerebral vasculature is often the target of stroke studies. However, the vasculature supplying the eye might also be affected by ischemia. The aim of the present study was to investigate if the transient global cerebral...
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From:PLoS ONE (Vol. 9, Issue 6) Peer-ReviewedThe endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET.sub.A R and ET.sub.B R), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involvement of...
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From:Canadian Journal of Physiology and Pharmacology (Vol. 86, Issue 8) Peer-ReviewedAbstract: Since its identification as an endothelial cell-derived vasoconstrictor peptide in 1988, endothelin-1, the predominant member of the endothelin peptide family, has received considerable interest in basic...
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From:Canadian Journal of Physiology and Pharmacology (Vol. 88, Issue 5) Peer-ReviewedEndothelin-1 (ET-1) is a potent vasoactive peptide that exeits hypertrophic, migratory, and mitogenic effects in vascular smooth muscle cells. ET-1-induced activation of several signaling events has been shown to...
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From:Journal of Clinical Pharmacology (Vol. 48, Issue 5) Peer-ReviewedByline: Rebecca E. Wrishko, PhD (Lilly Research Laboratories, Indianapolis, Indiana, wrishkore@lilly.com); Jasper Dingemanse, PhD (Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil,...
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From:British Journal of Ophthalmology (Vol. 85, Issue 8) Peer-ReviewedAbstract Aim--To investigate the expression of Bcl-2 and heat shock proteins (HSPs), which are known to increase cell survival, in human corneal endothelial cells (HCECs) of corneas stored in organ culture....
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From:Chest (Vol. 124, Issue 1) Peer-ReviewedStudy objectives: We report on the long-term safety and efficacy of bosentan treatment in patients with pulmonary arterial hypertension (PAH). Background: In a preceding study, bosentan was well tolerated and...
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From:Journal of Biomedical Science (Vol. 27, Issue 1) Peer-ReviewedBackground Galectin-9 is a [beta]-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role...
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From:PLoS ONE (Vol. 11, Issue 3) Peer-ReviewedEndothelin-1 is a potent vasoconstrictor and mitogenic peptide involved in the regulation of vasomotor tone and maintenance of blood pressure. Oxidative stress activates the endothelin system, and is implicated in...