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From:The Western Journal of Medicine (Vol. 162, Issue 3) Peer-ReviewedNeural tube defects, which include spina bifida and anencephaly, are among the most common, serious, and costly congenital malformations. About 4 anencephalic and 5 spina bifida births occur per 10,000 births in...
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From:PLoS ONE (Vol. 14, Issue 6) Peer-ReviewedFolate is a micronutrient required for the production of new cells, making it a key factor in early fetal development and ensuring normal growth and maintenance of health. The increase in consumption of folate due to...
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From:Archives of Pathology & Laboratory Medicine (Vol. 131, Issue 3) Peer-Reviewed* Context.--The mandated fortification of processed grains with folic acid in the United States and Canada in 1998 was intended to reduce the incidence of neural tube defects in pregnant women. The incidence of folate...
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From:Journal of the American Dietetic Association (Vol. 99, Issue 12) Peer-ReviewedMothers of children born with Down syndrome may have an imbalance in folate metabolism, according to a study at the FDA's National Center for Toxicological Research. A common genetic variation in an enzyme involved in...
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From:CMAJ: Canadian Medical Association Journal (Vol. 179, Issue 12) Peer-ReviewedIn this issue of CMAJ, Wen and colleagues report that the use of folic acid antagonists was associated with a higher risk of placenta-mediated adverse outcomes of pregnancy. (1) Had these medications appeared to be...
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From:European Journal of Clinical Nutrition (Vol. 86, Issue 10) Peer-ReviewedBACKGROUND/OBJECTIVES: Folic acid deficiency during pregnancy can lead to neural tube defects (NTD) in the fetus. Folate status was determined in a representative sample of Belgian pregnant women and determinants of...
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From:Alternative Medicine Review (Vol. 13, Issue 3) Peer-ReviewedAbstract Depression is common--one-fourth of the U.S. population will have a depressive episode sometime in life. Folate deficiency is also relatively common in depressed people, with approximately one-third of...
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From:Family Practice News (Vol. 31, Issue 13)SAN FRANCISCO -- People exposed to secondhand smoke have much lower folate levels than those who breathe mostly smoke-free air, Dr. David M. Mannino reported at the 97th International Conference of the American Thoracic...
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From:Gut (Vol. 51, Issue 2) Peer-ReviewedAims: Intracellular folate deficiency has been implicated in colonic carcinogenesis in epidemiological studies and animal and human cancer models. Our aim was to determine the effect of folate supplementation on...
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From:Townsend Letter for Doctors and Patients (Issue 216) Peer-ReviewedDoctor negligence The authors retrospectively reviewed all laboratory tests for serum or erythrocyte folate that were ordered in 1996 at 3 hospitals in Denver, Colorado; an urban public teaching hospital, a Veterans...
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From:Applied Physiology, Nutrition, and Metabolism (Vol. 39, Issue 3) Peer-ReviewedCanada fortifies certain products with folic acid and has periconceptional supplementation guidelines--policies designed to improve folate status and reduce the incidence of poor birth outcomes. Though optimal folate...
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From:European Journal of Clinical Nutrition (Vol. 69, Issue 10) Peer-ReviewedBACKGROUND/OBJECTIVES: Folic acid supplementation has been suggested to reduce the risk of preeclampsia. However, results from few epidemiologic studies have been inconclusive. We investigated the hypothesis that folic...
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From:European Journal of Clinical Nutrition (Vol. 64, Issue 8) Peer-ReviewedBackground/Objectives: B vitamins have been implicated in major chronic diseases but results have been inconsistent. This study evaluated the accuracy of dietary intakes of folate, vitamin B12, riboflavin and vitamin B6...
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From:Nanomedicine (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Youqing Shen [[dagger]] 5 , Zhuxian Zhou 2 , Meihua Sui 1 , Jianbin Tang 1 , Peisheng Xu 2 3 , Edward A Van Kirk 4 , William J Murdoch 4 , Maohong Fan 2 , Maciej Radosz 2 Keywords : acid-labile...
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From:Nursing Older People (Vol. 20, Issue 1) Peer-ReviewedCognitive function declines with age. Modifiable risk factors have been identified and poor folate status is suspected of being one such risk factor. This trial compared three years of folic acid supplementation with...
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From:Environmental Health Perspectives (Vol. 114, Issue 10) Peer-ReviewedDietary folic acid supplementation in women of childbearing age has been a major public health success story, reducing the incidence of neural tube defects (NTDs) by an estimated 50-70%. The CDC currently recommends...
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From:Alternative Medicine Review (Vol. 9, Issue 2) Peer-ReviewedPentieva K, McNulty H, Reichert R, et al. J Nutr 2004;134:580-585. The natural folate derivative, 5-methyltetrahydrofolate ([6S]-5-MTHF), could be an option for supplementation and fortification but its...
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From:Diabetes Care (Vol. 26, Issue 1) Peer-ReviewedSchnyder G, Roffi M, Flammer Y, Pin R, Hess OM: Effect of homocysteine-lowering therapy with folic acid, vitamin B(12), and vitamin B(6) on clinical outcome after percutaneous coronary intervention: the Swiss Heart...
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From:The Western Journal of Medicine (Vol. 155, Issue 6) Peer-ReviewedDietary folate, a vitamin required for DNA synthesis and cell regeneration, occurs as pteroylpolyglutamates that are hydrolyzed to pteroylglutamate during the process of intestinal absorption. Studies from our laboratory...
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From:Journal of Environmental and Public HealthPeer-ReviewedBackground. In Ethiopia, higher proportions of pregnant women are anemic. Despite the efforts to reduce iron deficiency anemia during pregnancy, only few women took an iron supplement as recommended. Thus, this study...