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    Academic Journals

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• Identification and validation of HELLS (Helicase, Lymphoid-Specific) and ICAM1 (Intercellular adhesion molecule 1) as potential diagnostic biomarkers of lung cancer

  Authors:Wei Zhu, Lin Lin Li, Yiyan Songyang, Zhan Shi, and Dejia LiFrom:PeerJ (Vol. 8) Peer-Reviewed

  Mar. 9, 20206,278 words Article 1440LAlthough lung cancer is one of the greatest threats to human health, its signaling pathway and related genes are still unknown. This study integrates data from three groups of people to study potential key candidate...

• TermGenie - a web-application for pattern-based ontology class generation

  Authors:Heiko Dietze, Tanya Z Berardini, Rebecca E Foulger, David P Hill, Jane Lomax, David Osumi-Sutherland, et al.From:Journal of Biomedical Semantics (Vol. 5, Issue 1) Peer-Reviewed

  Dec. 11, 20146,750 words Article 1310LBackground Biological ontologies are continually growing and improving from requests for new classes (terms) by biocurators. These ontology requests can frequently create bottlenecks in the biocuration process, as...

• Human genetic analyses of organelles highlight the nucleus in age-related trait heritability.

  Authors:Rahul Gupta, Konrad J Karczewski, Daniel Howrigan, Benjamin M Neale, and Vamsi K MoothaFrom:eLife (Vol. 10) Peer-Reviewed

  Sept. 1, 202125,045 words Article 1530LMost age-related human diseases are accompanied by a decline in cellular organelle integrity, including impaired lysosomal proteostasis and defective mitochondrial oxidative phosphorylation. An open question, however, is...

• Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation.

  Authors:W. Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, et al.From:Journal of Clinical Investigation (Vol. 129, Issue 11) Peer-Reviewed

  Nov. 201911,457 words Article 1540LCancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and therapeutic consequences of this missplicing...

• The regulatory genome constrains protein sequence evolution: implications for the search for disease-associated genes.

  Authors:Patrick Evans, Nancy J. Cox, and Eric R. GamazonFrom:PeerJ (Vol. 8) Peer-Reviewed

  July 21, 202014,254 words Article 1590LThe development of explanatory models of protein sequence evolution has broad implications for our understanding of cellular biology, population history, and disease etiology. Here we analyze the GTEx transcriptome...

• In silico-driven analysis of the Glossina morsitans morsitans antennae transcriptome in response to repellent or attractant compounds.

  Authors:Consolata Gakii, Billiah Kemunto Bwana, Grace Gathoni Mugambi, Esther Mukoya, Paul O. Mireji, and Richard RimiruFrom:PeerJ (Vol. 9) Peer-Reviewed

  July 1, 20217,735 words Article 1460LBackground High-throughput sequencing generates large volumes of biological data that must be interpreted to make meaningful inference on the biological function. Problems arise due to the large number of...

• How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis: Natural Language Processing of the PubMed Database.

  Authors:J. Bouaziz, R. Mashiach, S. Cohen, A. Kedem, A. Baron, M. Zajicek, et al.From:BioMed Research International (Vol. 2018) Peer-Reviewed

  Annual 20184,577 words Report 1440LEndometriosis is a disease characterized by the development of endometrial tissue outside the uterus, but its cause remains largely unknown. Numerous genes have been studied and proposed to help explain its pathogenesis....

• The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

  Authors:Christina FS Mages, Axel Wintsche, Stephan H Bernhart, and Gerd A MullerFrom:eLife (Vol. 6) Peer-Reviewed

  Sept. 18, 201714,486 words Article 1480LThe retinoblastoma Rb protein is an important factor controlling the cell cycle. Yet, mammalian cells carrying Rb deletions are still able to arrest under growth-limiting conditions. The Rb-related proteins p107 and...

• Identification of a novel autophagy signature for predicting survival in patients with lung adenocarcinoma.

  Authors:Jin Duan, Youming Lei, Guoli Lv, Yinqiang Liu, Wei Zhao, Qingmei Yang, et al.From:PeerJ (Vol. 9) Peer-Reviewed

  Apr. 21, 20216,807 words Article 1380LBackground Lung adenocarcinoma (LUAD) is the most commonhistological lung cancer subtype, with an overall five-year survivalrate of only 17%. In this study, we aimed to identify autophagy-related genes (ARGs) and...

• A Novel Four-Gene Signature as a Potential Prognostic Biomarker for Hepatocellular Carcinoma.

  Authors:Guangfeng Wang, Hao Zou, Yujie Feng, Wei Zhao, Kun Li, Kui Liu, et al.From:Journal of Oncology (Vol. 2021) Peer-Reviewed

  Dec. 14, 20216,465 words Article 1330LHepatocellular carcinoma (HCC) is a common malignant tumor with high incidence and mortality rates. However, a reliable prognostic signature has not yet been confirmed. Thus, the purpose of the present study was to...

• Mapping life's reaction

  Author:Mitch LeslieFrom:Science (Vol. 304, Issue 5677) Peer-Reviewed

  June 11, 2004198 words Brief article 1390LA cell works hard to stay alive, performing tasks as varied as slicing apart glucose, mending frayed DNA, and responding to hormones. To unravel such biochemical reactions or trace the connections between pathways,...

• Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

  Authors:David R Hill, Sha Huang, Melinda S Nagy, Veda K Yadagiri, Courtney Fields, Dishari Mukherjee, et al.From:eLife (Vol. 6) Peer-Reviewed

  Nov. 7, 201727,587 words Article 1490LThe human gastrointestinal tract is immature at birth, yet must adapt to dramatic changes such as oral nutrition and microbial colonization. The confluence of these factors can lead to severe inflammatory disease in...

• Immune Response to Rotavirus and Gluten Sensitivity

  Authors:Antonio Puccetti, Daniele Saverino, Roberta Opri, Oretta Gabrielli, Giovanna Zanoni, Andrea Pelosi, et al.From:Journal of Immunology Research (Vol. 2018) Peer-Reviewed

  Annual 20186,613 words Article 1640LRotavirus is a double-stranded RNA virus belonging to the family of Reoviridae. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of...

• Expression and prognosis of CDC45 in cervical cancer based on the GEO database.

  Authors:Zikang He, Xiaojin Wang, Zhiming Yang, Ying Jiang, Luhui Li, Xingyun Wang, et al.From:PeerJ (Vol. 9) Peer-Reviewed

  Sept. 3, 20217,085 words Article 1370LCervical cancer is one of the most common malignant tumors in women, and its morbidity and mortality are increasing year by year worldwide. Therefore, an urgent and challenging task is to identify potential biomarkers...

• Associations between Maternal Tobacco Smoke Exposure and the Cord Blood [CD4.sup.+] DNA Methylome

  Authors:Caitlin G. Howe, Meng Zhou, Xuting Wang, Gary S. Pittman, Isabel J. Thompson, Michelle R. Campbell, et al.From:Environmental Health Perspectives (Vol. 127, Issue 4) Peer-Reviewed

  Apr. 20199,994 words Article 1550LBackground: Maternal tobacco smoke exposure has been associated with altered DNA methylation. However, previous studies largely used methylation arrays, which cover a small fraction of CpGs, and focused on whole cord...

• Transcriptional responses of ecologically diverse Drosophila species to larval diets differing in relative sugar and protein ratios

  Authors:Nestor O. Nazario-Yepiz, Mariana Ramirez Loustalot-Laclette, Javier Carpinteyro-Ponce, Cei Abreu-Goodger, and Therese Ann MarkowFrom:PLoS ONE (Vol. 12, Issue 8) Peer-Reviewed

  Aug. 23, 20176,682 words Report 1500LWe utilized three ecologically diverse Drosophila species to explore the influence of ecological adaptation on transcriptomic responses to isocaloric diets differing in their relative proportions of protein to sugar....

• Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development.

  Authors:Jason T Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J Mirando, Tuyet Nguyen, et al.From:eLife (Vol. 11) Peer-Reviewed

  Feb. 18, 202222,313 words Article 1520LHypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that...

• The Ontology for Biomedical Investigations

  Authors:Anita Bandrowski, Ryan Brinkman, Mathias Brochhausen, Matthew H. Brush, Bill Bug, Marcus C. Chibucos, et al.From:PLoS ONE (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 29, 201610,428 words Report 1320LThe Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI...

• THAP11.sub.F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation.

  Authors:Harmonie Dehaene, Viviane Praz, Philippe Lhôte, Maykel Lopes, and Winship HerrFrom:PLoS ONE (Vol. 15, Issue 1) Peer-Reviewed

  Jan. 6, 202010,674 words Article 1460LTwelve human THAP proteins share the THAP domain, an evolutionary conserved zinc-finger DNA-binding domain. Studies of different THAP proteins have indicated roles in gene transcription, cell proliferation and...

• BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.

  Authors:Cynthia J. Sieben, Karthik B. Jeganathan, Grace G. Nelson, Ines Sturmlechner, Cheng Zhang, Willemijn H. van Deursen, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 1) Peer-Reviewed

  Jan. 202012,171 words Article 1510LMosaic-variegated aneuploidy (MVA) syndrome is a rare childhood disorder characterized by biallelic BUBR1, CEP57, or TRIP13 aberrations; increased chromosome missegregation; and a broad spectrum of clinical features,...