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    Academic Journals

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• Select CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer

  1

  CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer

  Authors:Kristina Stenstedt, Sandra Travica, Jia Guo, Isabel Barragan, Klaus Pors, Laurence Patterson, et al.From:Pharmacogenomics (Vol. 14, Issue 13) Peer-Reviewed

  Oct. 20134,548 words Report 1480LAuthor(s): Kristina Stenstedt 1 2 , Sandra Travica 2 , Jia Guo 2 , Isabel Barragan 2 , Klaus Pors 3 , Laurence Patterson 3 , David Edler 1 , Souren Mkrtchian 2 , Inger Johansson 2 , Magnus Ingelman-Sundberg [*] 4...
• Select Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics

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  Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics

  Author:Ingolf CascorbiFrom:Pharmacogenomics (Vol. 14, Issue 15) Peer-Reviewed

  Nov. 20131,921 words Article 1600LAuthor(s): Ingolf Cascorbi 1 KEYWORDS : epigenetics; miRNA; pharmacogenetics; systems biology The influence of genetic variants on drug response is becoming increasingly better understood. In particular,...
• Select Evolution of olfactory receptors in mammals

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  Evolution of olfactory receptors in mammals

  From:Nature Reviews Genetics (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 2014127 words Brief article 1410LOlfactory receptors (ORs) detect odorants and are vital for the survival of most mammals. In this study, the researchers developed a new phylogeny-based method to analyse >10,000 OR genes from 13 placental mammals to...
• Select Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

  4

  Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

  Authors:James Curtis, Yang Luo, Helen L. Zenner, Delphine Cuchet-Lourenco, Changxin Wu, Kitty Lo, et al.From:Nature Genetics (Vol. 47, Issue 5) Peer-Reviewed

  May 20154,994 words Report 1430LHuman genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined analysis of these subjects and the...
• Select Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

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  Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

  Authors:Otito F Iwuchukwu, QiPing Feng, Wei-Qi Wei, Lan Jiang, Min Jiang, Hua Xu, et al.From:Pharmacogenomics (Vol. 15, Issue 14) Peer-Reviewed

  Nov. 20145,511 words Report 1620LAuthor(s): Otito F Iwuchukwu [*] aff1 , QiPing Feng aff1 , Wei-Qi Wei aff2 , Lan Jiang aff3 , Min Jiang aff4 , Hua Xu aff4 , Joshua C Denny aff2 , Russell A Wilke aff5 , Ronald M Krauss aff6 , Dan M Roden aff1 aff7 , C...
• Select Simultaneous discovery, estimation and prediction analysis of complex traits using a Bayesian mixture model

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  Simultaneous discovery, estimation and prediction analysis of complex traits using a Bayesian mixture model

  Authors:Gerhard Moser, Sang Hong Lee, Ben J. Hayes, Michael E. Goddard, Naomi R. Wray, and Peter M. VisscherFrom:PLoS Genetics (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 20159,987 words Report 1480LGene discovery, estimation of heritability captured by SNP arrays, inference on genetic architecture and prediction analyses of complex traits are usually performed using different statistical models and methods,...
• Select Evaluation of molecular genetic variation associated with deep venous thrombosis in lower limb fractures in traumatic patients

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  Evaluation of molecular genetic variation associated with deep venous thrombosis in lower limb fractures in traumatic patients

  Authors:Ali Tabrizi, Mohammad Bazavar, Asghar Elmi, Amir Vahedi, and Nilsa DourandishFrom:Indian Journal of Medical Sciences (Vol. 66, Issue 9) Peer-Reviewed

  Sept. 20122,917 words Report 1670LByline: Ali. Tabrizi, Mohammad. Bazavar, Asghar. Elmi, Amir. Vahedi, Nilsa. Dourandish Background: Genetic variation in multiple genes associated with hemostasis and thrombosis is well documented to impact the rates...
• Select Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response

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  Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response

  Authors:Gerald A Higgins, Ari Allyn-Feuer, and Brian D AtheyFrom:Pharmacogenomics (Vol. 16, Issue 14) Peer-Reviewed

  Sept. 201511,449 words Report 1970LAuthor(s): Gerald A Higgins aff1 aff2 , Ari Allyn-Feuer aff1 , Brian D Athey [*] aff1 aff3 Keywords: chromatin spatial interactions; pharmacodynamics; pharmacogenomics; pharmacokinetics The majority of SNPs...
• Select Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection

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  Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection

  Authors:Karolina Rembeck and Martin LaggingFrom:Pharmacogenomics (Vol. 16, Issue 10) Peer-Reviewed

  July 20157,042 words Report 2870LAuthor(s): Karolina Rembeck aff1 , Martin Lagging [*] aff1 Keywords: genetic variant; HCV; histology; IL28B; inosine triphosphate pyrophosphatase; interferon-λ; ITPA; ITPase; natural history; PNPLA3;...
• Select Genetic variations of [beta]-MYH7 in hypertrophic cardiomyopathy and dilated cardiomyopathy

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  Genetic variations of [beta]-MYH7 in hypertrophic cardiomyopathy and dilated cardiomyopathy

  Authors:Reena Tanjore, Advithi RangaRaju, Shivani Vadapalli, Sushant Remersu, Calambur Narsimhan, and Pratibha NallariFrom:Indian Journal of Human Genetics (Vol. 16, Issue 2) Peer-Reviewed

  May-August 20102,329 words Report Byline: Reena. Tanjore, Advithi. RangaRaju, Shivani. Vadapalli, Sushant. Remersu, Calambur. Narsimhan, Pratibha. Nallari Context: Hypertrophic cardiomyopathy (HCM) is known to be manifested by mutations in 12...
• Select CNV-seq, a new method to detect copy number variation using high-throughput sequencing

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  CNV-seq, a new method to detect copy number variation using high-throughput sequencing

  Authors:Chao Xie and Martti T. TammiFrom:BMC Bioinformatics (Vol. 10) Peer-Reviewed

  Mar. 6, 20095,046 words Report Authors: Chao Xie [1]; Martti T Tammi (corresponding author) [1,2,3] Background DNA copy number variation (CNV) has long been known as a source of genetic variation, but its importance has only been recognized...
• Select A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history

  12

  A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history

  Authors:Encarna B. Gomez Garcia, Jan C. Oosterwijk, Maarten Timmermans, Christi J. van Asperen, Frans BL. Hogervorst, Nicoline Hoogerbrugge, et al.From:Breast Cancer Research (Vol. 11) Peer-Reviewed

  Feb. 6, 20096,330 words Report Authors: Encarna B Gómez García (corresponding author) [1,2]; Jan C Oosterwijk [3]; Maarten Timmermans [2]; Christi J van Asperen [4]; Frans BL Hogervorst [5]; Nicoline Hoogerbrugge [6]; Rogier Oldenburg [7]; Senno...
• Select Lipid-altering gene variants and cardiovascular risk in the older population

  13

  Lipid-altering gene variants and cardiovascular risk in the older population

  Authors:Tisha R Joy and Robert A HegeleFrom:Clinical Lipidology (Vol. 4, Issue 6)

  Dec. 20092,606 words Report 1400LAuthor(s): Tisha R Joy [[dagger]â ] 1 , Robert A Hegele 1 KEYWORDS : cardiovascular disease; DNA diagnosis; lipid; pharmacogenetics; risk factor; single nucleotide polymorphism Summary of methods & results...
• Select Stroke association

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  Stroke association

  Author:Kyle VoganFrom:Nature Genetics (Vol. 41, Issue 6) Peer-Reviewed

  June 2009195 words Brief article, Repor... 1360LRisk of stroke is known to have a heritable component, but efforts to identify specific genetic susceptibility factors have had limited success. Arfan Ikram and colleagues (N. Engl. J. Med. 360, 1718-1728; 2009) now...
• Select Personal medicine for the rich

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  Personal medicine for the rich

  Author:Chris BatemanFrom:CME: Your SA Journal of CPD (Vol. 26, Issue 4) Peer-Reviewed

  Apr. 2008175 words Brief article 1400LMedicine that is tailor-made to suit individuals' specific genetic make-up is at the cutting edge of medical research in Europe and the USA. It offers hope to people with genetic variations that make them suffer...
• Select Structural variation

  16

  Structural variation

  From:Nature Medicine (Vol. 14, Issue 6) Peer-Reviewed

  June 200834 words Brief article May 1 The first sequence-based map of large-scale structural variation in the human genome was published, paving the way to better understanding of how such variation contributes to disease risk (Nature 453, 56-64;...
• Select RAPD analysis of three deer species in Malaysia

  17

  RAPD analysis of three deer species in Malaysia

  Authors:Habiba A.A. El-Jaafari, Jothi M. Panandam, Ismail Idris, and Siti Shapor SirajFrom:Asian - Australasian Journal of Animal Sciences (Vol. 21, Issue 9) Peer-Reviewed

  Sept. 20083,436 words Report 1400LABSTRACT : The genetic variability within and among three deer species in Malaysia, namely Cervus nippon (sika), Cervus timorensis (rusa) and Cervus unicolor (sambar), were evaluated using the RAPD technique. The DNA...
• Select Islands of linkage disequilibrium

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  Islands of linkage disequilibrium

  Author:David B. GoldsteinFrom:Nature Genetics (Vol. 29, Issue 2) Peer-Reviewed

  Oct. 20012,312 words Article 1590LAuthor(s): David B. Goldstein [1] The natural world is not famous for making life easy for human geneticists. Despite application of an increasingly powerful set of tools provided by the Human Genome Project, the...
• Select Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases

  19

  Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases

  Authors:L. Tiret, O. Poirier, V. Nicaud, S. Barbaux, S.M. Herrmann, C. Perret, et al.From:Pharmacogenomics (Vol. 3, Issue 3) Peer-Reviewed

  May 1, 2002101 words Brief article 1380LTiret L, Poirier O, Nicaud V, Barbaux S, Herrmann SM, Perret C, Raoux S, Francomme C, Lebard G, Tregouet D, Cambien F: Hum. Mol.Genet. 11(4), 419-429 (2002). Linkage disequilibrium (LD) is the central concept of...
• Select Sequence variation in the E2-binding domain of HPV16 and biological function evaluation in tunisian cervical cancers

  20

  Sequence variation in the E2-binding domain of HPV16 and biological function evaluation in tunisian cervical cancers

  Authors:Saloua Kahla, Lotfi Kochbati, Samia Hammami, Mohamed Badis Chanoufi, Mongi Maalej, and Ridha OueslatiFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20145,381 words Report 1530LHPV16 E2 variants have different effects on the transcriptional activity of the LCR. In this study, we examined the nucleotide and amino acid sequence variation within the HPV16 E2 gene and to correlate with disease...