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    Academic Journals

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• CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer

  Authors:Kristina Stenstedt, Sandra Travica, Jia Guo, Isabel Barragan, Klaus Pors, Laurence Patterson, et al.From:Pharmacogenomics (Vol. 14, Issue 13) Peer-Reviewed

  Oct. 20134,548 words Report 1480LAuthor(s): Kristina Stenstedt 1 2 , Sandra Travica 2 , Jia Guo 2 , Isabel Barragan 2 , Klaus Pors 3 , Laurence Patterson 3 , David Edler 1 , Souren Mkrtchian 2 , Inger Johansson 2 , Magnus Ingelman-Sundberg [*] 4...

• Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics

  Author:Ingolf CascorbiFrom:Pharmacogenomics (Vol. 14, Issue 15) Peer-Reviewed

  Nov. 20131,921 words Article 1600LAuthor(s): Ingolf Cascorbi 1 KEYWORDS : epigenetics; miRNA; pharmacogenetics; systems biology The influence of genetic variants on drug response is becoming increasingly better understood. In particular,...

• Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

  Authors:Otito F Iwuchukwu, QiPing Feng, Wei-Qi Wei, Lan Jiang, Min Jiang, Hua Xu, et al.From:Pharmacogenomics (Vol. 15, Issue 14) Peer-Reviewed

  Nov. 20145,511 words Report 1620LAuthor(s): Otito F Iwuchukwu [*] aff1 , QiPing Feng aff1 , Wei-Qi Wei aff2 , Lan Jiang aff3 , Min Jiang aff4 , Hua Xu aff4 , Joshua C Denny aff2 , Russell A Wilke aff5 , Ronald M Krauss aff6 , Dan M Roden aff1 aff7 , C...

• Evaluation of molecular genetic variation associated with deep venous thrombosis in lower limb fractures in traumatic patients

  Authors:Ali Tabrizi, Mohammad Bazavar, Asghar Elmi, Amir Vahedi, and Nilsa DourandishFrom:Indian Journal of Medical Sciences (Vol. 66, Issue 9) Peer-Reviewed

  Sept. 20122,917 words Report 1670LByline: Ali. Tabrizi, Mohammad. Bazavar, Asghar. Elmi, Amir. Vahedi, Nilsa. Dourandish Background: Genetic variation in multiple genes associated with hemostasis and thrombosis is well documented to impact the rates...

• Genetic variation in nucleotide excision repair pathway genes influence prostate and bladder cancer susceptibility in North Indian population

  Authors:Rama Mittal and Raju MandalFrom:Indian Journal of Human Genetics (Vol. 18, Issue 1) Peer-Reviewed

  January-April 20123,831 words Report 1590LByline: Rama. Mittal, Raju. Mandal Background : Inherited polymorphisms of XPD and XPC genes may contribute to subtle variations in NER DNA repair capacity and genetic susceptibility to development of urological...

• Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response

  Authors:Gerald A Higgins, Ari Allyn-Feuer, and Brian D AtheyFrom:Pharmacogenomics (Vol. 16, Issue 14) Peer-Reviewed

  Sept. 201511,449 words Report 1970LAuthor(s): Gerald A Higgins aff1 aff2 , Ari Allyn-Feuer aff1 , Brian D Athey [*] aff1 aff3 Keywords: chromatin spatial interactions; pharmacodynamics; pharmacogenomics; pharmacokinetics The majority of SNPs...

• Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection

  Authors:Karolina Rembeck and Martin LaggingFrom:Pharmacogenomics (Vol. 16, Issue 10) Peer-Reviewed

  July 20157,042 words Report 2870LAuthor(s): Karolina Rembeck aff1 , Martin Lagging [*] aff1 Keywords: genetic variant; HCV; histology; IL28B; inosine triphosphate pyrophosphatase; interferon-λ; ITPA; ITPase; natural history; PNPLA3;...

• Genetic variations of [beta]-MYH7 in hypertrophic cardiomyopathy and dilated cardiomyopathy

  Authors:Reena Tanjore, Advithi RangaRaju, Shivani Vadapalli, Sushant Remersu, Calambur Narsimhan, and Pratibha NallariFrom:Indian Journal of Human Genetics (Vol. 16, Issue 2) Peer-Reviewed

  May-August 20102,329 words Report Byline: Reena. Tanjore, Advithi. RangaRaju, Shivani. Vadapalli, Sushant. Remersu, Calambur. Narsimhan, Pratibha. Nallari Context: Hypertrophic cardiomyopathy (HCM) is known to be manifested by mutations in 12...

• Lipid-altering gene variants and cardiovascular risk in the older population

  Authors:Tisha R Joy and Robert A HegeleFrom:Clinical Lipidology (Vol. 4, Issue 6)

  Dec. 20092,606 words Report 1400LAuthor(s): Tisha R Joy [[dagger]â ] 1 , Robert A Hegele 1 KEYWORDS : cardiovascular disease; DNA diagnosis; lipid; pharmacogenetics; risk factor; single nucleotide polymorphism Summary of methods & results...

• Structural variation

  From:Nature Medicine (Vol. 14, Issue 6) Peer-Reviewed

  June 200834 words Brief article May 1 The first sequence-based map of large-scale structural variation in the human genome was published, paving the way to better understanding of how such variation contributes to disease risk (Nature 453, 56-64;...

• Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases

  Authors:L. Tiret, O. Poirier, V. Nicaud, S. Barbaux, S.M. Herrmann, C. Perret, et al.From:Pharmacogenomics (Vol. 3, Issue 3) Peer-Reviewed

  May 1, 2002101 words Brief article 1380LTiret L, Poirier O, Nicaud V, Barbaux S, Herrmann SM, Perret C, Raoux S, Francomme C, Lebard G, Tregouet D, Cambien F: Hum. Mol.Genet. 11(4), 419-429 (2002). Linkage disequilibrium (LD) is the central concept of...

• Sequence variation in the E2-binding domain of HPV16 and biological function evaluation in tunisian cervical cancers

  Authors:Saloua Kahla, Lotfi Kochbati, Samia Hammami, Mohamed Badis Chanoufi, Mongi Maalej, and Ridha OueslatiFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20145,381 words Report 1530LHPV16 E2 variants have different effects on the transcriptional activity of the LCR. In this study, we examined the nucleotide and amino acid sequence variation within the HPV16 E2 gene and to correlate with disease...

• Genetic Variants and Increased Expression of Parascaris equorum P-glycoprotein-11 in Populations with Decreased Ivermectin Susceptibility

  Authors:I. Jana I. Janssen, Jurgen Krucken, Janina Demeler, Marta Basiaga, Slawomir Kornas, and Georg von Samson-HimmelstjernaFrom:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 24, 20139,245 words Report 1480LAuthor(s): I. Jana I. Janssen 1, Jürgen Krücken 1, Janina Demeler 1, Marta Basiaga 2, Slawomir Kornas 2, Georg von Samson-Himmelstjerna 1,* Introduction For decades macrocyclic lactones (MLs) have been used for...

• Two-faced cancer gene

  From:Nature (Vol. 502, Issue 7471) Peer-Reviewed

  Oct. 17, 2013125 words Brief article 1350LA genetic variant that greatly boosts the risk of testicular cancer may protect light-skinned individuals from skin cancer by helping them to tan. A team led by Douglas Bell at the US National Institutes of Health in...

• TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury

  Authors:Peixiang Lan, Yihui Fan, Yue Zhao, Xiaohua Lou, Howard P. Monsour, Xiaolong Zhang, et al.From:Journal of Clinical Investigation (Vol. 127, Issue 6) Peer-Reviewed

  June 20179,542 words Report 1450LTissue-resident immune cells play a key role in local and systemic immune responses. The liver, in particular, hosts a large number of invariant natural killer T (iNKT) cells, which are involved in diverse immune...

• Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

  Authors:Wen Lin, David R. Vann, Paschalis-Thomas Doulias, Tao Wang, Gavin Landesberg, Xueli Li, et al.From:Journal of Clinical Investigation (Vol. 127, Issue 6) Peer-Reviewed

  June 20178,601 words Report 1440LGenetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are associated with the regulation of wholeblood manganese (Mn) and multiple physiological traits. SLC39A8 encodes ZIP8, a divalent metal...

• The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster

  Authors:Shanshan Zhou, Tatiana V. Morozova, Yasmeen N. Hussain, Sarah E. Luoma, Lenovia McCoy, Akihiko Yamamoto, et al.From:Environmental Health Perspectives (Vol. 124, Issue 7) Peer-Reviewed

  July 20167,385 words Report 1540LBACKGROUND: Lead toxicity presents a worldwide health problem, especially due to its adverse effects on cognitive development in children. However, identifying genes that give rise to individual variation in...

• Genetic variation in a compound short tandem repeat/Alu haplotype system at the SB19.3 locus: properties and interpretation

  Authors:Paulo Gaspar, Susana Seixas, and Jorge RochaFrom:Human Biology (Vol. 76, Issue 2) Peer-Reviewed

  Apr. 20043,953 words Article The genetic variation at a compound nonrecombining haplotype system, consisting of the previously reported SB19.3 Alu insertion polymorphism and a newly identified adjacent short tandem repeat (STR), was studied in...

• Association of genetic variation within UBL5 with phenotypes of metabolic syndrome

  Authors:Kiymet Bozaoglu, Joanne E. Curran, Kate S. Elliott, Ken R. Walder, Thomas D. Dyer, David L. Rainwater, et al.From:Human Biology (Vol. 78, Issue 2) Peer-Reviewed

  Apr. 20064,555 words Clinical report 1540LThe BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity....

• Interactome-Wide Prediction of Protein-Protein Binding Sites Reveals Effects of Protein Sequence Variation in Arabidopsis thaliana

  Authors:Felipe Leal Valentim, Frank Neven, Peter Boyen, and Aalt D. J. van DijkFrom:PLoS ONE (Vol. 7, Issue 10) Peer-Reviewed

  Oct. 15, 201210,324 words Report 1470LAuthor(s): Felipe Leal Valentim 1 , Frank Neven 2 , Peter Boyen 2 , Aalt D. J. van Dijk 1 , * Introduction Genotype-to-phenotype relationships are mediated via molecular networks, including protein-protein...