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• Select The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans

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  The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans

  Authors:Mark Samson, Margaret M. Jow, Catherine C.L. Wong, Colin Fitzpatrick, Aaron Aslanian, Israel Saucedo, et al.From:PLoS Genetics (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 201413,658 words Report 1440LIn addition to the DNA contributed by sperm and oocytes, embryos receive parent-specific epigenetic information that can include histone variants, histone post-translational modifications (PTMs), and DNA methylation....
• Select On fertilization in Chaetopleura apiculata and selected Chitonida

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  On fertilization in Chaetopleura apiculata and selected Chitonida

  Authors:John Buckland-Nicks and Elizabeth BrothersFrom:The Biological Bulletin (Vol. 214, Issue 2) Peer-Reviewed

  Apr. 20084,744 words Report 1390LEarly events of fertilization are described in Chaetopleura apiculata and other selected Chitonida. C. apiculata egg hulls are elaborated into multi-branched spines with interlocking polygonal bases. Around the...
• Select GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions

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  GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions

  Authors:Agata Rybarska, Martin Harterink, Britta Jedamzik, Adam P. Kupinski, Mark Schmid, and Christian R. EckmannFrom:PLoS Genetics (Vol. 5, Issue 5) Peer-Reviewed

  May 20098,035 words Report Post-transcriptional regulatory mechanisms are widely used to influence cell fate decisions in germ cells, early embryos, and neurons. Many conserved cytoplasmic RNA regulatory proteins associate with each other and...
• Select Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells.

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  Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells.

  Authors:Sung-Min Kim, Toshifumi Yokoyama, Dylan Ng, Ferhat Ulu, and Yukiko YamazakiFrom:PLoS ONEPeer-Reviewed

  Nov. 4, 201910,802 words Report 1460LIn murine fetal germ cells, retinoic acid (RA) is an extrinsic cue for meiotic initiation that stimulates transcriptional activation of the Stimulated by retinoic acid gene 8 (Stra8), which is required for entry of germ...
• Select Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos

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  Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos

  Authors:Lianchun Fan, Jesung Moon, Ten-Tsao Wong, Jennifer Crodian, and Paul CollodiFrom:Stem Cells and Development (Vol. 17, Issue 3) Peer-Reviewed

  June 20086,942 words Article 1520LABSTRACT Although embryonic germ (EG) cell-mediated gene transfer has been successful in the mouse for more than a decade, this approach is limited in other species due to the difficulty of isolating the small...
• Select Developmental origins of epigenetic transgenerational inheritance

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  Developmental origins of epigenetic transgenerational inheritance

  Authors:Mark A. Hanson and Michael K. SkinnerFrom:Environmental EpigeneticsPeer-Reviewed

  Mar. 6, 20166,201 words Essay 1580LEnvironmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic transgenerational inheritance...
• Select Genetic structure of a germplasm for hybrid breeding in rye (Secale cereale L.)

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  Genetic structure of a germplasm for hybrid breeding in rye (Secale cereale L.)

  Authors:Nikolaj M. Vendelbo, Pernille Sarup, Jihad Orabi, Peter S. Kristensen, and Ahmed JahoorFrom:PLoS ONE (Vol. 15, Issue 10) Peer-Reviewed

  Oct. 9, 20209,945 words Report 1700LRye (Secale cereale L.) responds strongly to changes in heterozygosity with hybrids portraying strong heterosis effect on all developmental and yielding characteristics. In order to achieve the highest potential...
• Select Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture

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  Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture

  Authors:Victor A. Naumenko, Yurii A. Tyulenev, Sergei A. Yakovenko, Lubov' F. Kurilo, Ludmila V. Shileyko, Aleksander S. Segal, et al.From:Herpesviridae (Vol. 2) Peer-Reviewed

  June 28, 20115,212 words Report 1370LBackground The presence of human cytomegalovirus (HCMV) in male genital tract suggests its vertical transmission with spermatozoa and the development of a potentially dangerous fetal infection. The objective of the...
• Select Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L

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  Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L

  Authors:Sophie La Salle, Christopher C. Oakes, Oana R. Neaga, Deborah Bourc'his, Timothy H. Bestor, and Jacquetta M. TraslerFrom:BMC Developmental Biology (Vol. 7) Peer-Reviewed

  Sept. 18, 200710,786 words Article 1510LBackground Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA...
• Select Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse

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  Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse

  Authors:Jessica E. M. Dunleavy, Hidenobu Okuda, Anne E. O'Connor, D. Jo Merriner, Liza O'Donnell, Duangporn Jamsai, et al.From:PLoS Genetics (Vol. 13, Issue 11) Peer-Reviewed

  Nov. 14, 201713,098 words Report 1530LThe katanin microtubule-severing proteins are essential regulators of microtubule dynamics in a diverse range of species. Here we have defined critical roles for the poorly characterised katanin protein KATNAL2 in...
• Select Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations

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  Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations

  Authors:Jessy Cartier, Thomas Smith, John P. Thomson, Catherine M. Rose, Batbayar Khulan, Andreas Heger, et al.From:Genome Biology (Vol. 19, Issue 1) Peer-Reviewed

  Apr. 10, 20189,719 words Report 1560LBackground Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female...
• Select Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis

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  Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis

  Authors:Stephan A. Raiders, Michael D. Eastwood, Meghan Bacher, and James R. PriessFrom:PLoS Genetics (Vol. 14, Issue 7) Peer-Reviewed

  July 19, 201824,945 words Report 1360LCell death plays a major role during C. elegans oogenesis, where over half of the oogenic germ cells die in a process termed physiological apoptosis. How germ cells are selected for physiological apoptosis, or instead...
• Select The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

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  The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

  Authors:Frank Sleutels, Widia Soochit, Marek Bartkuhn, Helen Heath, Sven Dienstbach, Philipp Bergmaier, et al.From:Epigenetics & Chromatin (Vol. 5, Issue 1) Peer-Reviewed

  June 18, 201213,744 words Report 1370LBackground CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and...
• Select The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.

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  The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.

  Authors:Yin Ho Vong, Lavanya Sivashanmugam, Rebecca Leech, Andreas Zaucker, Alex Jones, and Karuna SampathFrom:PLoS Genetics (Vol. 17, Issue 7) Peer-Reviewed

  July 2, 202111,742 words Report 1470LThe ability to reproduce is essential in all branches of life. In metazoans, this process is initiated by formation of the germline, a group of cells that are destined to form the future gonads, the tissue that will...
• Select Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules

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  Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules

  Authors:John G. Carman, Michelle Jamison, Estella Elliott, Krishna K. Dwivedi, and Tamara N. NaumovaFrom:BMC Plant Biology (Vol. 11) Peer-Reviewed

  Jan. 11, 20118,661 words Report 1480LBackground Genetically unreduced (2n) embryo sacs (ES) form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n ES form precociously during ovule...
• Select Spermatocytes lacking PUF-8 protein revert to mitotic germ cells

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  Spermatocytes lacking PUF-8 protein revert to mitotic germ cells

  From:Stem Cell Week

  Mar. 31, 2003298 words Brief article 2003 MAR 31 - (NewsRx.com & NewsRx.net) -- In the absence of the pumilio-like protein PUF-8, spermatocytes revert to mitotic germline stem cells. "PUF proteins are a conserved family of RNA binding proteins that...
• Select GAGE Cancer-Germline Antigens Are Recruited to the Nuclear Envelope by Germ Cell-Less (GCL)

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  GAGE Cancer-Germline Antigens Are Recruited to the Nuclear Envelope by Germ Cell-Less (GCL)

  Authors:Morten F. Gjerstorff, Heike I. Rosner, Christina B. Pedersen, Katrine B. V. Greve, Steffen Schmidt, Katherine L. Wilson, et al.From:PLoS ONE (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 20, 20127,087 words Report 1530LAuthor(s): Morten F. Gjerstorff 1 , * , Heike I. Rösner 2 , Christina B. Pedersen 1 , Katrine B. V. Greve 1 , Steffen Schmidt 1 , Katherine L. Wilson 3 , Jan Mollenhauer 1 , 4 , Hüseyin Besir 5 , Flemming M. Poulsen 2 ,...
• Select Identification and role of carbohydrates on the surface of gametes in the zebra mussel, Dreissena polymorpha

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  Identification and role of carbohydrates on the surface of gametes in the zebra mussel, Dreissena polymorpha

  Authors:Lindsey C. Fallis, Kathryn K. Stein, John W. Lynn, and Michael J. MisamoreFrom:The Biological Bulletin (Vol. 218, Issue 1) Peer-Reviewed

  Feb. 20108,114 words Report The objective of this study is to identify surface carbohydrates on zebra mussel, Dreissena polymorpha, eggs and sperm and to analyze their potential role in fertilization. The lectins WGA, Con A, LcH, LTA, SBA, PNA,...
• Select Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures

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  Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures

  Authors:Weston R. Bodily, Brian H. Shirts, Tom Walsh, Suleyman Gulsuner, Mary-Claire King, Alyssa Parker, et al.From:PLoS ONE (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 30, 202012,273 words Report 1310LMutations in BRCA1 and BRCA2 cause deficiencies in homologous recombination repair (HR), resulting in repair of DNA double-strand breaks by the alternative non-homologous end-joining pathway, which is more error prone....
• Select Follicle-stimulating hormone responsiveness in antral follicles from aryl hydrocarbon receptor knockout mice

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  Follicle-stimulating hormone responsiveness in antral follicles from aryl hydrocarbon receptor knockout mice

  Authors:Isabel Hernandez-Ochoa, Liying Gao, Jackye Peretz, Mallikarjuna S Basavarajappa, Stacey L Bunting, Bethany N Karman, et al.From:Reproductive Biology and Endocrinology (Vol. 11, Issue 1) Peer-Reviewed

  Apr. 1, 20135,967 words Report 1640LBackground Previous studies have demonstrated that pre-pubertal aryl hydrocarbon receptor knockout (AHRKO) mice have slow antral follicle growth and reduced capacity to produce estradiol compared to wild-type (WT)...