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Academic Journals
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From:PLoS ONE (Vol. 14, Issue 11) Peer-ReviewedConcurrent chemotherapy and radiotherapy (cCRT) is considered the standard treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Unfortunately, management is still heterogeneous across different...
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From:PLoS ONE (Vol. 14, Issue 3) Peer-ReviewedImmunotherapy has fundamentally changed the landscape of cancer treatment. Despite the encouraging results with the checkpoint modulators, response rates vary widely across tumor types, with a majority of patients...
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From:PLoS ONE (Vol. 14, Issue 11) Peer-ReviewedSystemic lupus erythematosus (SLE) is an autoimmune disorder that is associated with lupus nephritis, initiated by the deposition of immune complexes in the kidney; subsequently, this induces the overexpression of...
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From:Nature Medicine (Vol. 19, Issue 3) Peer-ReviewedOncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an...
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From:Journal of Hematology & Oncology (Vol. 13, Issue 1) Peer-ReviewedVISTA (V-domain immunoglobulin suppressor of T cell activation) is a well-established immune regulatory receptor. However, pre-clinical investigations indicated more complicated influences of VISTA on cancer immunity...
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From:Gene Therapy (Vol. 25, Issue 1) Peer-ReviewedAuthor(s): R Eggers [1]; A Philippi [1]; M O Altmeyer [1]; F Breinig [2]; M J Schmitt [2] Introduction In cancer immunotherapy, part of the body's immune system is used to fight the cancer by enhancing the impact...
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From:PeerJ (Vol. 7) Peer-ReviewedThere has been an increase in the mortality rate and morbidity of kidney cancer (KC) with kidney renal clear cell carcinoma (KIRC) being the most common subtype of KC. GRAMD1C (GRAM Domain Containing 1C) has not been...
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From:Nature Medicine (Vol. 25, Issue 12) Peer-ReviewedAuthor(s): Jason A. Carter 1 2 , Philip Gilbo 2 3 , Gurinder S. Atwal 2 Author Affiliations: (1) Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA (2) Cold Spring Harbor...
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From:Nature Biotechnology (Vol. 27, Issue 5) Peer-ReviewedAntibodies can be programmed to bind cancer cells using covalently binding antigens and adapters. The concept of redirecting the immune system to attack new targets by administering a small-molecule 'switch' is...
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From:Primary Health Care (Vol. 19, Issue 3)Summary Hay fever is a debilitating disease associated with significant morbidity. It is treatable in most cases but success depends on recognition, appropriate treatment selection, patient education and regular...
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From:Saudi Journal of Kidney Diseases and Transplantation (Vol. 30, Issue 6) Peer-ReviewedByline: Nawaz. Zahir, Dujana. Mousa, Alawi. Al Taweel, Attia. Ashraf, Akhtar. Fahim, Khan. Taqi, Rafat. Zahid, Naveed. Aslam Steroids remain an essential part of immunosuppressive therapy for renal transplant patients...
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From:eLife (Vol. 9) Peer-ReviewedInvasive fungal infections cause 1.6 million deaths annually, primarily in immunocompromised individuals. Mortality rates are as high as 90% due to limited treatments. The azole class antifungal, fluconazole, is widely...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 39, Issue 1) Peer-ReviewedTumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive tumor...
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From:Stem Cells International (Vol. 2017) Peer-ReviewedImmune modulation at the fetomaternal interface is crucial to ensure that the fetal allograft is not rejected. In the present review, the focus is to describe basic functions of lymphocyte populations and how they may...
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From:Annals of the Rheumatic Diseases (Vol. 62, Issue 3) Peer-ReviewedBehcet's disease (BD) is a relapsing systemic vasculitis of b unknown definite cause, mainly characterised by recurrent oral and genital ulceration, uveitis, skin lesions, and arthritis. It is also one of the best...
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From:Journal of Clinical Investigation (Vol. 129, Issue 9) Peer-ReviewedNatural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and elimination of cancer. As we have learned more and more about the mechanisms NK cells employ to recognize and eliminate tumor...
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From:Journal of Clinical Investigation (Vol. 130, Issue 1) Peer-ReviewedPancreatic ductal adenocarcinomas (PDACs) are classically immunologically cold tumors that have failed to demonstrate a significant response to immunotherapeutic strategies. This feature is attributed to both the...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-ReviewedBackground Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer...
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From:Journal of Immunology Research (Vol. 2018) Peer-ReviewedHepatocellular carcinoma (HCC) most often develops in patients with underlying liver disease characterized by chronic nonresolving inflammation. Tumor-associated macrophages (TAMs) are one of the most abundant immune...
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From:BioMed Research InternationalPeer-ReviewedComparing with the traditional therapeutic methods, newly developed cancer therapy based on the nanoparticulates attracted extensively interest due to its unique advantages. However, there are still some drawbacks such...