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    Academic Journals

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• High-throughput determination of mode of inhibition in lead identification and optimization

  Authors:Min Wei, Richard Wynn, Gregory Hollis, Boshan Liao, Alexander Margulis, Brian G. Reid, et al.From:Journal of Biomolecular Screening (Vol. 12, Issue 2) Peer-Reviewed

  Mar. 20075,353 words Article 1440LAfter finishing the primary high-throughput screening, the screening team is often faced with thousands of hits to be evaluated further. Effective filtering of these hits is crucial in identifying leads. Mode of...

• GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans

  Authors:Koji Inui, Nobuyuki Takeuchi, Shunsuke Sugiyama, Eishi Motomura, and Makoto NishiharaFrom:PLoS ONE (Vol. 13, Issue 1) Peer-Reviewed

  Jan. 3, 20186,857 words Report 1430LAuthor(s): Koji Inui 1,2,*, Nobuyuki Takeuchi 3, Shunsuke Sugiyama 4, Eishi Motomura 5, Makoto Nishihara 6 Introduction The outputs of a neural circuit are influenced by the balance between excitation and...

• Biological data questions the support of the self inhibition required for pattern generation in the half center model

  Authors:Matthias Kohler, Philipp Stratmann, Florian Rohrbein, Alois Knoll, Alin Albu-Schaffer, and Henrik JorntellFrom:PLoS ONE (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 11, 20208,993 words Report 1490LLocomotion control in mammals has been hypothesized to be governed by a central pattern generator (CPG) located in the circuitry of the spinal cord. The most common model of the CPG is the half center model, where two...

• The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

  Authors:Brenda L. Bloodgood, Nikhil Sharma, Heidi Adlman Browne, Alissa Z. Trepman, and Michael E. GreenbergFrom:Nature (Vol. 503, Issue 7474) Peer-Reviewed

  Nov. 7, 20136,018 words Report 1500LA heterogeneous population of inhibitory neurons controls the flow of information through a neural circuit (1-3). Inhibitory synapses that form on pyramidal neuron dendrites modulate the summation of excitatory synaptic...

• Spatiotemporal interplay between multisensory excitation and recruited inhibition in the lamprey optic tectum

  Authors:Andreas A Kardamakis, Juan Perez-Fernandez, and Sten GrillnerFrom:eLife (Vol. 5) Peer-Reviewed

  Sept. 16, 201617,536 words Report 1460LAnimals integrate the different senses to facilitate event-detection for navigation in their environment. In vertebrates, the optic tectum (superior colliculus) commands gaze shifts by synaptic integration of different...

• Structural basis of kynurenine 3-monooxygenase inhibition

  Authors:Marta Amaral, Colin Levy, Derren J. Heyes, Pierre Lafite, Tiago F. Outeiro, Flaviano Giorgini, et al.From:Nature (Vol. 496, Issue 7445) Peer-Reviewed

  Apr. 18, 20135,132 words Report 1420LInhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (that is, kynurenine pathway), leads to amelioration of Huntington's-disease-relevant phenotypes in yeast,...

• Interhemispheric modulation induced by cortical stimulation and motor training

  Authors:Julie A. Williams, Alvaro Pascual-Leone, and Felipe FregniFrom:Physical Therapy (Vol. 90, Issue 3) Peer-Reviewed

  Mar. 20107,308 words Clinical report 1590LBackground. Interhemispheric inhibition might be a beneficial cortico-cortical interaction, but also might be maladaptive in people with neurological disorders. One recently revisited technique that has been shown to be...

• Structural brain correlates of response inhibition in Bipolar Disorder I

  Authors:Morgan Haldane, Giles Cunningham, Chris Androutsos, and Sophia FrangouFrom:Journal of Psychopharmacology (Vol. 22, Issue 2) Peer-Reviewed

  Mar. 20086,453 words Clinical report 1460LByline: Morgan Haldane (Section of Neurobiology of Psychosis (Box P066), Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK); Giles Cunningham (Section of Neurobiology of Psychosis (Box P066), Institute of...

• Meal-induced insulin sensitization and its parasympathetic regulation in humans

  Authors:Rita S. Patarrao, W. Wayne Lautt, Ricardo A. Afonso, Rogerio T. Ribeiro, Maria P. Guarino, Ana B. Fernandes, et al.From:Canadian Journal of Physiology and Pharmacology (Vol. 86, Issue 12) Peer-Reviewed

  Dec. 20086,976 words Report In animal studies, the whole-body glucose disposal effect of insulin is low in the fasted state or after atropine infusion, but doubles after a meal, consistent with the hepatic insulin-sensitizing substance (HISS)...

• Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

  Authors:Nami Tajima, Erkan Karakas, Timothy Grant, Noriko Simorowski, Ruben Diaz-Avalos, Nikolaus Grigorieff, et al.From:Nature (Vol. 534, Issue 7605) Peer-Reviewed

  June 2, 20165,291 words Report 1570LThe physiology of N-methyl-D-aspartate (NMDA) receptors is fundamental to brain development and function. NMDA receptors are ionotropic glutamate receptors that function as heterotetramers composed mainly of GluN1 and...

• Sculpting neuronal connectivity

  Authors:Emily Sylwestrak and Peter ScheiffeleFrom:Nature (Vol. 503, Issue 7474) Peer-Reviewed

  Nov. 7, 20131,225 words Critical essay 1430LIt emerges that a transcription program differentially regulates inhibitory inputs in distinct neuronal compartments-- an unexpected coordinated switch for achieving experience-dependent 'plasticity' in neural circuits....

• Multivariate association between brain function and eating disorders using sparse canonical correlation analysis

  Authors:Hyebin Lee, Bo-yong Park, Kyoungseob Byeon, Ji Hye Won, Mansu Kim, Se-Hong Kim, et al.From:PLoS ONE (Vol. 15, Issue 8) Peer-Reviewed

  Aug. 12, 20206,179 words Report 1440LAuthor(s): Hyebin Lee 1,2, Bo-yong Park 3, Kyoungseob Byeon 1,2, Ji Hye Won 1,2, Mansu Kim 4, Se-Hong Kim 5, Hyunjin Park 2,6,* Introduction Eating disorder is one of the important factors underlying obesity...

• Pluripotent stem cell derived inhibitory interneurons - principles and applications in health and disease

  Authors:Francesca Keefe and Meng LiFrom:Neural Regeneration Research (Vol. 15, Issue 2) Peer-Reviewed

  Feb. 20202,158 words Report 1490LByline: Francesca. Keefe, Meng. Li Inhibitory interneurons are gamma-aminobutyric acid-ergic (GABAergic) nerve cells that act to maintain the appropriate excitation-inhibition balance, and synchronise the output of...

• Roundabout receptor 2 maintains inhibitory control of the adult midbrain

  Authors:Bryan B Gore, Samara M Miller, Yong Sang Jo, Madison A Baird, Mrinalini Hoon, Christina A Sanford, et al.From:eLife (Vol. 6) Peer-Reviewed

  Apr. 10, 201716,143 words Report 1450LThe maintenance of excitatory and inhibitory balance in the brain is essential for its function. Here we find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical for the maintenance of...

• SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate.

  Authors:Hugo Ducuing, Thibault Gardette, Aurora Pignata, Karine Kindbeiter, Muriel Bozon, Olivier Thoumine, et al.From:eLife (Vol. 9) Peer-Reviewed

  Dec. 21, 202018,934 words Report 1400LSpinal commissural axon navigation across the midline in the floor plate requires repulsive forces from local Slit repellents. The long-held view is that Slits push growth cones forward and prevent them from turning back...

• Bringing back neuronal inhibition

  Author:Eva ChmielnickiFrom:Nature Medicine (Vol. 20, Issue 5) Peer-Reviewed

  May 2014216 words Brief article 1570LSome genetic versions of autism, such as Dravet syndrome, caused by mutations in the voltage-gated sodium channel gene Scnla, have been linked to reductions in inhibitory neurotransmission, but the extent to which this...

• Attenuated inhibition of medium spiny neurons participates in the pathogenesis of childhood depression

  Authors:Dandan Liu, Linghan Hu, Junqi Zhang, Ping Zhang, and Shengtian LiFrom:Neural Regeneration Research (Vol. 9, Issue 10) Peer-Reviewed

  May 15, 20145,936 words Report 1280LByline: Dandan. Liu, Linghan. Hu, Junqi. Zhang, Ping. Zhang, Shengtian. Li Accumulating evidence suggests that the nucleus accumbens, which is involved in mechanisms of reward and addiction, plays a role in the...

• Inhibition dominates sensory responses in the awake cortex

  Authors:Bilal Haider, Michael Hausser, and Matteo CarandiniFrom:Nature (Vol. 493, Issue 7430) Peer-Reviewed

  Jan. 3, 20134,812 words Report 1380LThe activity of the cerebral cortex is thought to depend on the precise relationship between synaptic excitation and inhibition (1-4). In the visual cortex, in particular, intracellular measurements have related...

• Suppression and facilitation of human neural responses

  Authors:Michael-Paul Schallmo, Alexander M Kale, Rachel Millin, Anastasia V Flevaris, Zoran Brkanac, Richard AE Edden, et al.From:eLife (Vol. 7) Peer-Reviewed

  Jan. 29, 201818,551 words Report 1400LEfficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and...

• The neural basis of inhibition in cognitive control

  Author:Adam R. AronFrom:The Neuroscientist (Vol. 13, Issue 3) Peer-Reviewed

  June 20078,620 words Article 1470LThe concept of "inhibition" is widely used in synaptic, circuit, and systems neuroscience, where it has a clear meaning because it is clearly observable. The concept is also ubiquitous in psychology. One common use is...