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• Select Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes.

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  Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes.

  Authors:Lijuan Xu, Pengyuan Zhang, Zhimin Huang, Liangying Zhong, Hai Li, Liehua Liu, et al.From:Journal of Diabetes ResearchPeer-Reviewed

  Mar. 31, 20205,526 words Article 1480LBackground. Short-term intensive insulin therapy induces long-term glycemic remission in half of patients with newly diagnosed type 2 diabetes. The concomitant hypoglycemia needs further analysis. Methods. We collected...
• Select A Novel Type of Extreme Insulin Resistance: Nonhypoglycemic Insulin Autoimmune Syndrome.

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  A Novel Type of Extreme Insulin Resistance: Nonhypoglycemic Insulin Autoimmune Syndrome.

  Authors:He Liu, Siyu Liang, Yu Li, Junling Fu, Shi Chen, Ming Li, et al.From:Journal of Clinical Endocrinology & Metabolism (Vol. 106, Issue 4) Peer-Reviewed

  Apr. 20215,718 words Article 1350LContext: Extreme insulin resistance is caused by genetic defects intersecting with the insulin action pathway or by the insulin receptor antibodies. Insulin autoimmune syndrome (IAS) is not considered one of the causes...
• Select One-Year Course of Olanzapine-Induced Diabetic Ketoacidosis: A Case Report.

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  One-Year Course of Olanzapine-Induced Diabetic Ketoacidosis: A Case Report.

  Authors:Mohammed Zain Ulabedin Adhoni, Roomiyah Riyaz Assadi, and Saira AbbasFrom:Dubai Diabetes and Endocrinology Journal (Vol. 27, Issue 4) Peer-Reviewed

  Dec. 20211,926 words Report 1590LSecond-generation antipsychotics, despite being highly effective, are among the drugs known to cause insulin resistance and metabolic syndrome, eventually leading to diabetes mellitus and less commonly diabetic...
• Select Extremely high-dose insulin requirement in a diabetic patient with COVID-19: a case report.

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  Extremely high-dose insulin requirement in a diabetic patient with COVID-19: a case report.

  Authors:François R. Jornayvaz, Benjamin Assouline, Jérôme Pugin, and Karim GarianiFrom:BMC Endocrine Disorders (Vol. 20, Issue 1) Peer-Reviewed

  Oct. 16, 20201,536 words Report 1570LBackground Detailed description of hyperglycemia management in diabetic patients infected with SARS-CoV-2 remain limited, although patients with diabetes show higher complication and mortality rate than patients...
• Select Serious diabetic ketoacidosis induced by insulin allergy and anti‐insulin antibody in an individual with type 2 diabetes mellitus.

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  Serious diabetic ketoacidosis induced by insulin allergy and anti‐insulin antibody in an individual with type 2 diabetes mellitus.

  Authors:Kaio Takahashi, Takatoshi Anno, Haruka Takenouchi, Hideyuki Iwamoto, Megumi Horiya, Yukiko Kimura, et al.From:Journal of Cutaneous Immunology and Allergy (Vol. 13, Issue 10) Peer-Reviewed

  Oct. 20221,998 words Report 1290LABSTRACT: Diabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes mellitus, and is characterized by hyperglycemia, metabolic acidosis and increased total ketone body...
• Select IRS-2 Tyrosine Phosphorylation by the Insulin Receptor Kinase Is Modulated by Serine Phosphorylation In Vitro by Multiple Ser/Thr Kinases

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  IRS-2 Tyrosine Phosphorylation by the Insulin Receptor Kinase Is Modulated by Serine Phosphorylation In Vitro by Multiple Ser/Thr Kinases

  Authors:MICHAEL W. GREENE and ROBERT S. GAROFALOFrom:Diabetes (Vol. 49, Issue 5) Peer-Reviewed

  May 2000294 words Brief article Insulin and IGF-I receptor activation leads to tyrosine phosphorylation of IRS proteins, which contain docking sites for SH2 domain-containing signaling proteins. Tyrosine phosphorylation of IRS-1 is impaired in...
• Select Shots can provide same level of control as pumps. (The Diabetes Advisor)

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  Shots can provide same level of control as pumps. (The Diabetes Advisor)

  Author:Shauna S. RobertsFrom:Diabetes Forecast (Vol. 56, Issue 3)

  Mar. 2003517 words Article CHOOSING whether to stick with shots or to get an insulin pump involves weighing the many pluses and minuses of each. Shots are much cheaper and easier, take much less training, and involve little maintenance. Pumps,...
• Select SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins

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  SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins

  Authors:David L. Morris, Kae Won Cho, Yingjiang Zhou, and Liangyou RuiFrom:Diabetes (Vol. 58, Issue 9) Peer-Reviewed

  Sept. 20096,153 words Clinical report 1440LOBJECTIVE--SH2B1 is a SH2 domain-containing adaptor protein expressed in both the central nervous system and peripheral tissues. Neuronal SH2B1 controls body weight; however, the functions of peripheral SH2B1 remain...
• Select Late Systemic Lupus Erythematosus-Associated Insulin Resistance Syndrome: A Rare Cause of De Novo Diabetes Mellitus.

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  Late Systemic Lupus Erythematosus-Associated Insulin Resistance Syndrome: A Rare Cause of De Novo Diabetes Mellitus.

  Authors:José C. Alvarez-Payares, Daniel Ribero, Luis Rodríguez, Carlos E. Builes, Carolina Prieto, Clara Arango, et al.From:Case Reports in Medicine (Vol. 2022) Peer-Reviewed

  Oct. 14, 20224,853 words Article 1250LThe association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as systemic lupus erythematosus (SLE) is uncommon. This is partly due to the lack of established criteria for the diagnosis of...
• Select Isoproterenol Induced Insulin Resistance Leading to Diabetic Ketoacidosis in Type 1 Diabetes Mellitus

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  Isoproterenol Induced Insulin Resistance Leading to Diabetic Ketoacidosis in Type 1 Diabetes Mellitus

  Authors:Ryan Hoff and Chung-Kay KohFrom:Case Reports in Endocrinology (Vol. 2018) Peer-Reviewed

  Annual 20181,377 words Article 1280LIsoproterenol is known to cause insulin resistance and is often used to treat bradyarrhythmias from atrioventricular block. We report a case of isoproterenol induced diabetic ketoacidosis in a 77-year-old female patient...
• Select 3 Insulin (and other injected drugs): diabetes is a disease affecting the body's production of insulin (type 1) or both the body's use and its production of insulin (type 2). Injectable insulin is a lifesaver for people who can no longer produce it on their own

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  3 Insulin (and other injected drugs): diabetes is a disease affecting the body's production of insulin (type 1) or both the body's use and its production of insulin (type 2). Injectable insulin is a lifesaver for people who can no longer produce it on their own

  From:Diabetes Forecast (Vol. 62, Issue 1)

  Jan. 20091,817 words Article 1140LChoosing the insulin that's most appropriate for you is a collaboration between you and your health care provider. Still, it's important to understand the basics of how insulin works. Here, we've broken it down into key...
• Select Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients.

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  Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients.

  Authors:Anastasios Serbis, Vasileios Giapros, Konstantinos Tsamis, Foteini Balomenou, Assimina Galli-Tsinopoulou, and Ekaterini SiomouFrom:Nutrients (Vol. 15, Issue 9) Peer-Reviewed

  May 202319,010 words Article 1000LTraditionally a disease of adults, type 2 diabetes (T2D) has been increasingly diagnosed in youth, particularly among adolescents and young adults of minority ethnic groups. Especially, during the recent COVID-19...
• Select Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels

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  Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels

  Authors:Omar El Safoury, Olfat Shaker, and May FawzyFrom:Indian Journal of Dermatology (Vol. 57, Issue 2) Peer-Reviewed

  March-April 20123,023 words Report 1650LByline: Omar. El Safoury, Olfat. Shaker, May. Fawzy Background: Skin tags (ST) are papillomas commonly found in the neck, axillae of middle-aged and elderly people Aim: Insulin and insulin-like growth factor (IGF-1)...
• Select To pump or not to pump. (Editorial)

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  To pump or not to pump. (Editorial)

  From:Diabetes Care (Vol. 25, Issue 11) Peer-Reviewed

  Nov. 20022,057 words Editorial First fully described in 1983, intensive insulin therapy attempts to match the levels of insulin in the blood with the physiologic needs of the diabetic patient (1). The results of the Diabetes Control and Complications...
• Select Elucidation of the Mechanism of Severe Impairment of Insulin Signaling in a Patient with Type B Insulin Resistance

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  Elucidation of the Mechanism of Severe Impairment of Insulin Signaling in a Patient with Type B Insulin Resistance

  Authors:N. FUJITA, H. YAMASAKI, M. YAMAUCHI, H. MIYAZOE, K. YAMAKAWA, M. OZAKI, et al.From:Diabetes (Vol. 49, Issue 5) Peer-Reviewed

  May 2000332 words Brief article Aim: Anti-insulin receptor autoantibodies (IRAb) play an important pathophysiologic factor for the development of type B insulin resistance. Although insulin binding has been shown to be strongly inhibited by IRAb, the...
• Select Gender difference in the association of insulin and the insulin-like growth factor axis with colorectal neoplasia

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  Gender difference in the association of insulin and the insulin-like growth factor axis with colorectal neoplasia

  Authors:T. Yamaji, M. Iwasaki, S. Sasazuki, and S. TsuganeFrom:International Journal of Obesity (Vol. 36, Issue 3) Peer-Reviewed

  Mar. 20124,420 words Report 1820LObjective: Accumulating evidence has implicated insulin and the insulin-like growth factor (IGF) axis in colorectal carcinogenesis. Of interest, adiposity is likely to impose a greater risk on men than on women, which...
• Select Lothian service model for continuous subcutaneous insulin infusion

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  Lothian service model for continuous subcutaneous insulin infusion

  Authors:Heather Maxwell and Jacqueline GeddesFrom:Journal of Diabetes Nursing (Vol. 11, Issue 5) Peer-Reviewed

  May 20072,090 words Clinical report 1440LHypoglycaemia is a common side effect of insulin administration in the treatment of diabetes (Pramming et al, 1991). High levels of insulin decrease the levels of glucose in the blood stream, which starves the brain of...
• Select Metabolic phenotype in the brothers of women with polycystic ovary syndrome

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  Metabolic phenotype in the brothers of women with polycystic ovary syndrome

  Authors:Susan Sam, Andrea D. Coviello, Yeon-Ah Sung, Richard S. Legro, and Andrea DunaifFrom:Diabetes Care (Vol. 31, Issue 6) Peer-Reviewed

  June 20084,026 words Clinical report 1470LOBJECTIVE--Hyperandrogenemia, insulin resistance, and dyslipidemia demonstrate familial aggregation in the female first-degree relatives of women with polycystic ovary syndrome (PCOS), suggesting that these defects are...
• Select Osteogenesis of adipose-derived stem cells from patients with glucose metabolism disorders.

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  Osteogenesis of adipose-derived stem cells from patients with glucose metabolism disorders.

  Authors:Aleksandra Skubis-Sikora, Bartosz Sikora, Agnieszka Witkowska, Urszula Mazurek, and Joanna GolaFrom:Molecular Medicine (Vol. 26, Issue 1) Peer-Reviewed

  July 2, 20204,883 words Article 1330LBackground Adipose derived stem cells (ADSCs) are clinically widely used somatic stem cells obtained from white adipose tissue. They are characterized by ability to differentiate e.g. into osteoblasts and might...
• Select Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling.

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  Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling.

  Authors:Maryam Khoshnejat, Kaveh Kavousi, Ali Mohammad Banaei-Moghaddam, and Ali Akbar Moosavi-MovahediFrom:BMC Medical Genomics (Vol. 13, Issue 1) Peer-Reviewed

  Aug. 24, 20206,284 words Article 1380LBackground Type 2 diabetes mellitus (T2DM) is a complex multifactorial disease with a high prevalence worldwide. Insulin resistance and impaired insulin secretion are the two major abnormalities in the pathogenesis of...