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    Academic Journals

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• Plasma leptin and insulin relationships in obese and nonobese humans

  Authors:Samuel Dagogo-Jack, Carmine Fanelli, Deanna Paramore, Joy Brothers, and Michael LandtFrom:Diabetes (Vol. 45, Issue 5) Peer-Reviewed

  May 19962,672 words Article Hyperinsulinemia is associated with an overexpression of mRNA for the ob protein leptin in rodent models of genetic obesity, and insulin has been reported to directly stimulate leptin mRNA in rat adipocytes. Human...

• Insulin sensitivity accounts for glucose and lactate kinetics after intravenous glucose injection

  Authors:Richard M. Watanabe, Jennifer Lovejoy, Gary M. Steil, Mario DiGirolamo, and Richard N. BergmanFrom:Diabetes (Vol. 44, Issue 8) Peer-Reviewed

  Aug. 19956,199 words Article Mathematical modeling was used to explore the interaction between glucose, insulin, and lactate during the frequently sampled intravenous glucose tolerance test (FSIGTT). Insulin-modified FSIGTs were performed in 25 lean...

• Physiological insulinemia acutely modulates plasma leptin

  Authors:Mohammed F. Saad, Arshad Khan, Alok Sharma, Ragui Michael, Maggy G. Riad-Gabriel, Rima Boyadjian, et al.From:Diabetes (Vol. 47, Issue 4) Peer-Reviewed

  Apr. 19984,397 words Article Whether insulin acutely regulates plasma leptin in humans is controversial. We examined the dosage-response and time-course characteristics of the effect of insulin on leptin in 10 men (age 42 [+ or -] 2 years [mean [+...

• The Link between Insulin Resistance and Hyperinsulinemia: Inhibition of Phosphatidylinositol 3-Kinase(PI3K) by Wortmannin Augments Glucose(G)-Induced Insulin Secretion

  Authors:WALTER S. ZAWALICH and KATHLEEN C. ZAWALICHFrom:Diabetes (Vol. 49, Issue 5) Peer-Reviewed

  May 2000282 words Brief article To maintain euglycemia in the face of developing insulin resistance, a proportionate increase in insulin secretion from the [Beta]-cell is essential. In peripheral tissues such as liver, muscle and adipose cells insulin...

• miR-720 Regulates Insulin Secretion by Targeting Rab35.

  Authors:Chunting Lu, Dan Wang, Yunlu Feng, Lie Feng, and Zejian LiFrom:BioMed Research International (Vol. 2021) Peer-Reviewed

  Apr. 7, 20215,325 words Report 1380LmiRNAs pose a good prospect in the diagnosis and treatment of type 2 diabetes (T2D). This study is aimed at investigating whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular...

• Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice: imaging analysis of GLUT4 - enhanced green fluorescent protein vesicle dynamics

  Authors:Hans P.M.M. Lauritzen, Henrik Galbo, Josef Brandauer, Laurie J. Goodyear, and Thorkil PlougFrom:Diabetes (Vol. 57, Issue 2) Peer-Reviewed

  Feb. 20085,799 words Clinical report 1470LOBJECTIVE--Insulin stimulates glucose transport in skeletal muscle by GLUT4 translocation from intracellular compartments to sarcolemma and t-tubules. We studied in living animals the recruitment of GLUT4 vesicles in...

• Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways

  Authors:Cecilia C. Low Wang, Inga Gurevich, and Boris DrazninFrom:Diabetes (Vol. 52, Issue 10) Peer-Reviewed

  Oct. 20034,663 words Article Insulin maintains vascular smooth muscle cell (VSMC) quiescence yet can also promote VSMC migration. The mechanisms by which insulin exerts these contrasting effects were examined using [alpha]-smooth muscle actin...

• Insulin withdrawal induces apoptosis via a free radical-mediated mechanism (1)

  Authors:Craig Ricci, Viktor Pastukh, Mahmood Mozaffari, and Stephen W. SchafferFrom:Canadian Journal of Physiology and Pharmacology (Vol. 85, Issue 3-4) Peer-Reviewed

  March-April 20075,275 words Clinical report 1460LAbstract: Diabetes is characterized by chronic hyperglycemia as well as insulin deficiency or resistance. However, the majority of research has focused on the consequences of hyperglycemia in development of diabetic...

• Insulin Enhances the Bradykinin Response in L8 Rat Skeletal Myoblasts

  Authors:Akira Kudoh, Guenther J. Dietze, and Sara F. RabitoFrom:Diabetes (Vol. 49, Issue 2) Peer-Reviewed

  Feb. 20004,404 words Article Inhibitors of ACE/kininase II enhance insulin sensitivity, an action that is mediated in part by bradykinin (BK). We investigated whether insulin interacts with the BK receptor signaling to modulate the inositol...

• Impact of Adenosine Analogue, Adenosine-5[sup.?]-N-Ethyluronamide (NECA), on Insulin Signaling in Skeletal Muscle Cells.

  Author:Mansour HaddadFrom:BioMed Research International (Vol. 2021) Peer-Reviewed

  June 28, 20215,336 words Report 1450LBackground and Objectives. To investigate whether there are molecular interactions between adenosine analogue (NECA) and insulin signaling pathways at multiple nuclear receptors and at the metabolic and inflammatory...

• Physiological concentrations of insulin induce cellular desensitization to the mitogenic effects of insulin-like growth factor I

  Authors:Cheryl A. Conover, Jay T. Clarkson, and Laurie K. BaleFrom:Diabetes (Vol. 43, Issue 9) Peer-Reviewed

  Sept. 19944,687 words Article Insulin and insulin-like growth factor I (IGF-I) are structurally related peptides capable of stimulating a variety of metabolic and mitogenic processes. In this study, we investigated the interaction between these...

• Kinetics of insulin action in vivo: identification of rate-limiting steps

  Authors:Philip D.G. Miles, Matteo Levisetti, Donna Reichart, Mousa Khoursheed, A.R. Moossa, and Jerrold M. OlefskyFrom:Diabetes (Vol. 44, Issue 8) Peer-Reviewed

  Aug. 19956,365 words Article To examine the kinetic steps in insulin's in vivo action, we have assessed the temporal relationship between arterial insulin, interstitial insulin, glucose disposal rate (GDR), and insulin receptor kinase (IRK) activity...

• Insulin staining of ES cell progeny from insulin uptake. (Development)

  Authors:Jayaraj Rajagopal, William J. Anderson, Shoen Kume, Olga I. Martinez, and Douglas A. MeltonFrom:Science (Vol. 299, Issue 5605) Peer-Reviewed

  Jan. 17, 2003759 words Article Recent reports describe derivation of insulin-containing cells from embryonic stem (ES) cells (1-5) and putative adult stem cells (6-8). Of particular note is the report that mouse ES cells efficiently form islet-like...

• Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2

  Authors:Renaud Dentin, Yi Liu, Seung-Hoi Koo, Susan Hedrick, Thomas Vargas, Jose Heredia, et al.From:Nature (Vol. 449, Issue 7160) Peer-Reviewed

  Sept. 20, 20073,439 words Clinical report 1300LDuring feeding, increases in circulating pancreatic insulin inhibit hepatic glucose output through the activation of the Ser/Thr kinase AKT and subsequent phosphorylation of the forkhead transcription factor FOXO1 (refs...

• Regulation of Uncoupling Protein-2 and Uncoupling Protein-3 mRNA Expression During Lipid Infusion in Human Skeletal Muscle and Subcutaneous Adipose Tissue

  Authors:Yadh Khalfallah, Sophie Fages, Martine Laville, Dominique Langin, and Hubert VidalFrom:Diabetes (Vol. 49, Issue 1) Peer-Reviewed

  Jan. 20006,025 words Article To study the effect of nonesterified fatty acids (NEFAs) on uncoupling protein-2 (UCP-2) and uncoupling protein-3 (UCP-3) gene expression, a triglyceride emulsion was infused for 5 h in 14 healthy volunteers. A...

• Visfatin: a protein secreted by visceral fat that mimics the effects of insulin

  Authors:Atsunori Fukuhara, Morihiro Matsuda, Masako Nishizawa, Katsumori Segawa, Masaki Tanaka, Kae Kishimoto, et al.From:Science (Vol. 307, Issue 5708) Peer-Reviewed

  Jan. 21, 20052,534 words Article 1400LFat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans...

• Acute and chronic effect of insulin on leptin production in humans: studies in vivo and in vitro

  Authors:Jerzy W. Kolaczynski, Mark R. Nyce, Robert V. Considine, Guenther Boden, John J. Nolan, Robert Henry, et al.From:Diabetes (Vol. 45, Issue 5) Peer-Reviewed

  May 19962,079 words Article This study was undertaken to investigate the changes in obesity (OB) gene expression and production of leptin in response to insulin in vitro and in vivo under euglycemic and hyperglycemic conditions in humans. Three...