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• 8B Multiple sclerosis

  From:MPR Pharmacists' Edition (Vol. 6, Issue 3)

  Fall 20121,267 words Drug overview 750LAMPYRA Acorda Rx Potassium channel blocker. Dalfampridine 10mg; ext-rel tabs. Indications: To improve walking in patients with multiple sclerosis (demonstrated by an increase in walking speed). Adults: Swallow...

• Interferon Plus Ribavirin

  From:Family Practice News (Vol. 31, Issue 6)

  Mar. 15, 2001111 words Brief article The combination of interferon and ribavirin modestly increased response rates in patients with hepatitis C virus infection who didn't respond to interferon alone, said Dr. Kristin J. Cummings of Johns Hopkins...

• Optimization of a high-throughput whole blood expression profiling methodology and its application to assess the pharmacodynamics of interferon (IFN) beta-1a or polyethylene glycol-conjugated IFN beta-1a in healthy clinical trial subjects

  Authors:Normand E Allaire, Steven E Bushnell, Jadwiga Bienkowska, Graham Brock, and John CarulliFrom:BMC Research Notes (Vol. 6, Issue 1) Peer-Reviewed

  Jan. 5, 20136,563 words Report 1630LBackground Clinical trials offer a unique opportunity to study human disease and response to therapy in a highly controlled setting. The application of high-throughput expression profiling to peripheral blood from...

• Antitumor efficacy of combination of interferon-gamma-inducible protein 10 gene with gemcitabine, a study in murine model

  Authors:Kai Mei, Lian Wang, Ling Tian, Jingrui Yu, Zhixuan Zhang, and Yuquan WeiFrom:Journal of Experimental & Clinical Cancer Research (Vol. 27) Peer-Reviewed

  Nov. 5, 20085,802 words Clinical report Background Interferon-[gamma]-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects....

• Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

  Authors:Michael David, Emanuel Petricoin, III, Christopher Benjamin, Richard Pine, Michael J. Weber, and Andrew C. LarnerFrom:Science (Vol. 269, Issue 5231) Peer-Reviewed

  Sept. 22, 19951,680 words Article Activation of early response genes by interferons (IFNS) requires tyrosine phosphorylation of STAT (signal transducers and activators of transcription) proteins. it was found that the serine-threonine kinase...

• Case study: uncontrolled type 2 diabetes in a 48-year-old woman on interferon [beta]-1b treatment for multiple sclerosis

  Author:Hema PadmanabhanFrom:Clinical Diabetes (Vol. 22, Issue 1) Peer-Reviewed

  Winter 20041,096 words Article Presentation M.W. is a 48-year-old woman with a 15-year history of type 2 diabetes that has been treated with insulin for 13 years. She has a history of multiple sclerosis for 8 years, and had been relatively stable...

• 8B Multiple sclerosis

  From:MPR Pharmacists' Edition (Vol. 6, Issue 4)

  Winter 20121,755 words Drug overview 830LAMPYRA Acorda Rx Potassium channel blocker. Dalfampridine 10mg; ext-rel tabs. Indications: To improve walking in patients with multiple sclerosis (demonstrated by an increase in walking speed). Adults: Swallow...

• Interferon-[beta]-1a/interferon-[beta]-1b: idiopathic thrombocytopenic purpura: case report

  From:Reactions Weekly (Issue 1317)

  Sept. 4, 2010157 words Brief article, Case ... 850L[S] A 21-year-old man with multiple sclerosis who received interferon-[beta]-1a [dosage and route not stated] for one year developed idiopathic thrombocytopenic purpura (ITP) [time to reaction onset not stated]. The...

• Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells

  Authors:Michael St Paul, Neda Barjesteh, Sarah Paolucci, Yanlong Pei, and Shayan SharifFrom:BMC Research Notes (Vol. 5, Issue 1) Peer-Reviewed

  Nov. 1, 20123,536 words Report 1590LBackground Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors that mediate host responses to pathogens. To date, at least 10 different TLRs have been identified in chickens...

• Randomized controlled trial of interferon gamma versus amantadine in combination with interferon alpha and ribavirin for hepatitis C genotype 3 non-responders and relapsers

  Authors:Zaigham Abbas, Sajjad Raza, Saeed Hamid, and Wasim JafriFrom:Journal of Pakistan Medical Association (Vol. 62, Issue 4)

  Apr. 30, 20124,106 words Report 1530LByline: Zaigham Abbas, Sajjad Raza, Saeed Hamid and Wasim Jafri Abstract Objectives: To evaluate the efficacy and safety of triple combination regimens comprising of interferon alpha-2b (IFN-alpha) and ribavirin...

• Elevated Serum IP-l0 Levels Observed in Type 1 Diabetes

  Authors:AKIRA SHIMADA, JIRO MORIMOTO, KEIICHI KODAMA, RYUJI SUZUKI, YOICHI OIKAWA, OSAMU FUNAE, et al.From:Diabetes Care (Vol. 24, Issue 3) Peer-Reviewed

  Mar. 20015,014 words Article AKIRA SHIMADA, MD [1] JIRO MORIMOTO, MD [1] KEIICHI KODAMA, MD [1] RYUJI SUZUKI, MD [1] YOICHI OIKAWA, MD [1] OSAMU FUNAE, MD [1] AKIRA KASUGA, MD [1] TAKAO SARUTA, MD [1] SHOSAKU NARUMI, MD [2]...

• Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. (Reports)

  Authors:Eileen Foy, Kui Li, Chunfu Wang, Rhea Sumpter, Jr., Masanori Ikeda, Stanley M. Lemon, et al.From:Science (Vol. 300, Issue 5622) Peer-Reviewed

  May 16, 20032,191 words Article Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease blocks the phosphorylation and effector action of interferon...

• Sieving treatment biomarkers from blood gene-expression profiles: a pharmacogenomic update on two types of multiple sclerosis therapy

  Authors:Robert H Goertsches, Uwe K Zettl, and Michael HeckerFrom:Pharmacogenomics (Vol. 12, Issue 3) Peer-Reviewed

  Mar. 20117,020 words Article 1440LAuthor(s): Robert H Goertsches [[dagger]] 2 , Uwe K Zettl 1 , Michael Hecker 1 KEYWORDS : mechanism of action; molecular biomarker; multiple sclerosis; therapy; transcriptomics During the last decade,...

• Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection

  Authors:Nadia Echebli, Nicolas Tchitchek, Stephanie Dupuy, Timothee Bruel, Caroline Peireira Bittencourt Passaes, Nathalie Bosquet, et al.From:PLoS ONE (Vol. 13, Issue 1) Peer-Reviewed

  Jan. 11, 201811,474 words Report 1680LAuthor(s): Nadia Echebli 1, Nicolas Tchitchek 1, Stéphanie Dupuy 1, Timothée Bruel 1, Caroline Peireira Bittencourt Passaes 1, Nathalie Bosquet 1, Roger Le Grand 1, Christine Bourgeois 1, Benoit Favier 1, Rémi Cheynier...

• Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

  Authors:Eisuke Miyaki, Nobuhiko Hiraga, Michio Imamura, Takuro Uchida, Hiromi Kan, Masataka Tsuge, et al.From:PLoS ONE (Vol. 12, Issue 3) Peer-Reviewed

  Mar. 2, 20175,564 words Article 1450LInterferon (IFN) inhibits hepatitis C virus (HCV) replication through up-regulation of intrahepatic IFN-stimulated gene expression but also through activation of host immune cells. In the present study, we analyzed the...

• The role of plasmacytoid dendritic cells and interferon-alpha in the immunopathogenesis of psoriasis

  Author:Rafael DenadaiFrom:Indian Journal of Dermatology (Vol. 58, Issue 3) Peer-Reviewed

  May-June 2013719 words Report 2860LByline: Rafael. Denadai Sir, I read with great interest the recent review by Coondoo, [sup][1] and specifically on the topic immunopathogenesis of psoriasis, I have the following comments to offer: In addition...

• Interferon-[beta]-1a: panniculitis: case report

  From:Reactions Weekly (Issue 1324)

  Oct. 23, 2010143 words Brief article, Case ... 890L[S] A 30-year-old woman with multiple sclerosis had received subcutaneous interferon-[beta]-1a [Rebif] injections 44[micro]g twice weekly at the same site on her abdomen since 2004. However, in April 2010 at the site...

• IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay

  Authors:Morten Ruhwald, Morten Bjerregaard-Andersen, Paulo Rabna, Jesper Eugen-Olsen, and Pernille RavnFrom:BMC Research Notes (Vol. 2) Peer-Reviewed

  Feb. 4, 20092,785 words Report Authors: Morten Ruhwald (corresponding author) [1,2]; Morten Bjerregaard-Andersen [3,4]; Paulo Rabna [4]; Jesper Eugen-Olsen [2]; Pernille Ravn [2,5] Background Until recently the tuberculin skin test has been the...

• Effect of Antiviral Therapy on Hepatitis C Virus Related Glomerulopathy

  Authors:Ghulam Abbas, Shahid Hussain, and Tahir ShafiFrom:Saudi Journal of Kidney Diseases and Transplantation (Vol. 19, Issue 5) Peer-Reviewed

  September-October 20082,646 words Article 1530LByline: Ghulam. Abbas, Shahid. Hussain, Tahir. Shafi To determine the efficacy of antiviral therapy in hepatitis C virus associated glome-rulopathy, we studied 30 patients with HCV-associated glomerulopathy at Sheikh...

• Evaluating the use of b-interferon in the UK: from whose perspective? (ABN Abstracts)

  Authors:Hobart J, Riazi A, Lamping D, Fitzpatrick R, and Thompson AJFrom:Journal of Neurology, Neurosurgery and Psychiatry (Vol. 73, Issue 2) Peer-Reviewed

  Aug. 2002236 words Brief article The Department of Health have announced they intend to fund a scheme making [beta]-interferon available far people with MS in the UK. Longitudinal data will be collected to evaluate change over time. We examined how the...