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From:Journal of Clinical Investigation (Vol. 118, Issue 3) Peer-ReviewedIL-7 is integral to the generation and maintenance of [CD8.sup.+] T cell memory, and insufficient IL-7 is believed to limit survival and the persistence of memory [CD8.sup.+] T cells. Here, we show that during the mouse...
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From:Journal of Clinical Investigation (Vol. 122, Issue 10) Peer-ReviewedDifficulty obtaining sufficient hematopoietic stem cells (HSCs) directly from the donor has limited the clinical use of HSC transplantation. Numerous attempts to stimulate the ex vivo growth of purified HSCs with...
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From:PLoS ONE (Vol. 12, Issue 12) Peer-ReviewedThe use of interleukin-7 (IL-7) as an immunorestorative therapeutic has proven effective in HIV infection, cancer and bone marrow transplantation. Mediating its activity through membrane-bound IL-7 receptor [alpha]...
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From:Indian Journal of Cancer (Vol. 51, Issue 3) Peer-ReviewedByline: Z. Mojtahedi, B. Khademi, N. Erfani, Y. Taregh, Z. Rafati, M. Malekzadeh, A. Ghaderi Background: The aim of this study was to investigate the association of head and neck squamous cell carcinoma (HNSCC) with...
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From:Nature Medicine (Vol. 16, Issue 2) Peer-ReviewedInterleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T helper type 17 ([T.sub.H]17) cells...
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From:BMC Research Notes (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Nouh S. Mohamed1,2,3 , Emmanuel E. Siddig 2,4,5 , Abdallah E. Ahmed2 , Musab M. A. Albsheer3 , Hanadi Abdelbagi6 , Eman T. Ali7 , Anadel A. Alsubki1 , Sabah A. Abdalaziz1 , Madinna Mustafa1 , Mohamed S....
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From:PLoS ONE (Vol. 11, Issue 9) Peer-ReviewedInterleukin-7 (IL-7) is a cytokine essential for T cell homeostasis, and is clinically important. However, the regulatory mechanism of IL-7 gene expression is not well known, and a systematic approach to screen...
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From:Diabetes (Vol. 61, Issue 12) Peer-ReviewedType 1 diabetes (T1D) is a complex disease whose pathogenesis involves islet-specific autoreactive T cells that destroy insulin producing (3-cells in the pancreas. Autoreactive T cells are usually under tight...
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From:Journal of Clinical Investigation (Vol. 124, Issue 4) Peer-ReviewedT cell depletion is commonly used in organ transplantation for immunosuppression; however, a restoration of T cell homeostasis following depletion leads to increased memory T cells, which may promote transplant...
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From:Immunotherapy (Vol. 3, Issue 1) Peer-ReviewedRecent findings from the University of Cambridge (UK) may shed new light on how the immune system is suppressed within the tumor microenvironment, and approaches to lift this suppression so that the antitumor immune...
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From:Therapy (Vol. 8, Issue 1) Peer-ReviewedThe US FDA has approved the first and only RANK ligand inhibitor, denosumab for the prevention of skeletal-related events (SREs) in cancer patients with bone metastasis. The approval was based on three Phase III trials...
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From:Gene Therapy (Vol. 13, Issue 15) Peer-ReviewedAllogeneic bone marrow transplantation (allo-BMT) is followed by a period of profound immune deficiency, which results in significant susceptibility to infections and limits the extensive application of this approach in...
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From:Nature Medicine (Vol. 16, Issue 2) Peer-ReviewedThe receptor for interleukin-7 is a susceptibility factor in multiple sclerosis, but its exact role in the disease has been unclear. New findings outline a function for interleukin-7 in the biology of T helper 17 cells,...
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From:PLoS ONE (Vol. 11, Issue 3) Peer-ReviewedGTPase of the immune associated nucleotide binding protein (GIMAP) family of proteins are expressed essentially in cells of the hematopoietic system. Mutation in the founding member of this gene family, Gimap5, results...
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From:Veterinary World (Vol. 9, Issue 2)Aim: Interleukin 7 (IL-7) is a [GAMMA]c family cytokine involved in the homeostatic proliferation and maintenance of immune cells. In the present study, we report the expression of bovine IL-7 (bIL-7) in Escherichia...
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From:Nature Medicine (Vol. 15, Issue 5) Peer-ReviewedIdentifying key factors that enhance immune responses is crucial for manipulating immunity to tumors. We show that after a vaccine-induced immune response, adjuvant interleukin-7 (IL-7) improves antitumor responses and...
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From:Journal of Clinical Investigation (Vol. 118, Issue 3) Peer-ReviewedAn inability to induce potent [CD8.sup.+] T cell responses has hampered the development of vaccines to protect against infection with a number of viruses, including HIV and HCV. Developing approaches to boost...
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From:Nature Medicine (Vol. 19, Issue 3) Peer-ReviewedThe cytokine interleukin-7 (IL-7) may facilitate transmission of HIV-1 to the female reproductive tract, according to new research published in PLoS Pathogens (9, e1003148). Most HIV-1 infections in women occur after...
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From:Journal of Clinical Investigation (Vol. 118, Issue 10) Peer-ReviewedMultiple sclerosis (MS) is a chronic inflammatory disease that results in demyelination in the central nervous system, and a defect in the regulatory function of [CD4.sup.+][CD25.sup.high] T cells has been implicated in...
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From:Diabetes (Vol. 62, Issue 7) Peer-ReviewedSoluble interleukin-7 (IL-7) receptor [alpha] (sCD127) is implicated in the pathogenesis of autoimmune diseases. We show that serum sCD127 concentrations are increased at the onset of type 1 diabetes (T1D; n = 390) as...