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From:PLoS ONE (Vol. 7, Issue 2) Peer-ReviewedAuthor(s): Luisa Salvatori 1 , 2 , * , Francesca Caporuscio 2 , 3 , Alessandra Verdina 2 , Giuseppe Starace 2 , Stefania Crispi 4 , Maria Rita Nicotra 1 , Andrea Russo 5 , Raffaele Adolfo Calogero 6 , Emanuela Morgante...
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From:PLoS ONE (Vol. 7, Issue 11) Peer-ReviewedAuthor(s): Weiqun Yu 1 , 2 , * , Mark L. Zeidel 1 , 2 , Warren G. Hill 1 , 3 Introduction In the gastrointestinal tract, interstitial cells of Cajal (ICC) function as pacemakers, neurotransmitter transducers, and...
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From:PLoS ONE (Vol. 8, Issue 12) Peer-ReviewedAuthor(s): Dong Liu 1,2, Chaoxu Liu 1,2, Junqiang Li 3, Kazem Azadzoi 2, Yun Yang 2, Zhou Fei 1, Kefeng Dou 1, Neil W. Kowall 2, Han-Pil Choi 4, Fernando Vieira 5, Jing-Hua Yang 2,3,4,* Introduction Amyotrophic...
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From:PLoS ONE (Vol. 8, Issue 10) Peer-ReviewedAuthor(s): Louise Bennett 1,*, Cindy Kersaitis 2, Stuart Lance Macaulay 3, Gerald Münch 2,6,7, Garry Niedermayer 2, Julie Nigro 3, Matthew Payne 4, Paul Sheean 1, Pascal Vallotton 4, Dimitrios Zabaras 5, Michael Bird 2...
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From:PLoS ONE (Vol. 9, Issue 2) Peer-ReviewedAuthor(s): Zhenguang Chen 1,2,3,*, Jiancheng Wang 4, Lie Cai 5, Beilong Zhong 6, Honghe Luo 1,3, Yuantao Hao 7, Weihua Yu 4, Binchao Wang 8, Chunhua Su 1,3, Yiyan Lei 1,3, Amos Ela Bella 3,9, Andy Peng Xiang 4,10, Tao...
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From:PLoS ONE (Vol. 8, Issue 5) Peer-ReviewedAuthor(s): Tanya C. Burch 1,2, Megan T. Watson 1,2, Julius O. Nyalwidhe 1,2,* Introduction In Europe and the US, Prostate cancer (PCa) is the most prevalent cancer among men and the third most common cause of...
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From:Diabetes Care (Vol. 36, Issue 11) Peer-ReviewedOBJECTIVE--Relative contributions of reversible [beta]-cell dysfunction and true decrease in [beta]-cell mass in type 2 diabetes remain unclear. Definitive rodent lineage-tracing studies have identified [beta]-cell...
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From:Journal of Biomedical Science (Vol. 16) Peer-ReviewedAuthors: Chun-Kuei Su (corresponding author) [1]; Chiu-Ming Ho [2]; Hsiao-Hui Kuo [1,2]; Yu-Chuan Wen [1]; Chok-Yung Chai [1,3] Background Autonomous generation of tonic sympathetic activity is fundamental to...
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From:PLoS ONE (Vol. 6, Issue 9) Peer-ReviewedA homozygous mutation in STK38L in dogs impairs the late phase of photoreceptor development, and is followed by photoreceptor cell death (TUNEL) and proliferation (PCNA, PHH3) events that occur independently in...
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From:PLoS ONE (Vol. 4, Issue 4) Peer-ReviewedBackground An arg120gly (R120G) missense mutation in HSPB5 ([alpha]-[beta]-crystallin ), which belongs to the small heat shock protein (HSP) family, causes desmin-related cardiomyopathy (DRM), a muscle disease that...
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From:PLoS ONE (Vol. 5, Issue 2) Peer-ReviewedBackground Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately...
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From:PLoS ONE (Vol. 5, Issue 1) Peer-ReviewedBackground Neural stem cells (NSCs) represent an optimal tool for studies and therapy of neurodegenerative diseases. We recently established a v-myc immortalized human NSC (IhNSC) line, which retains stem properties...
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From:PLoS ONE (Vol. 2, Issue 6) Peer-ReviewedLamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function. Vertebrate A-type lamins are...
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From:PLoS ONE (Vol. 4, Issue 7) Peer-ReviewedBackground The lack of axonal regeneration in the central nervous system is attributed among other factors to the formation of a glial scar. This cellular structure is mainly composed of reactive astrocytes that...
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From:PLoS ONE (Vol. 10, Issue 2) Peer-ReviewedWe tested the hypothesis that phenotypically modulated smooth muscle cells (SMCs) and related inflammation are associated with the progression of experimental occlusive pulmonary vascular disease (PVD). Occlusive PVD...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedBackground The aim of the present study was to analyze the expression of Zinc finger E-box Binding homeobox 2 (ZEB2) in glioma and to explore the molecular mechanisms of ZEB2 that regulate cell proliferation,...
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From:PLoS ONE (Vol. 6, Issue 11) Peer-ReviewedStem cell therapy is a promising strategy to treat neurodegenerative diseases, traumatic brain injury, and stroke. For stem cells to progress towards clinical use, the risks associated with invasive intracranial surgery...
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From:PLoS ONE (Vol. 10, Issue 8) Peer-ReviewedBackground and Purpose Myocardial infarction leads to heart failure. Autophagy is excessively activated in myocardial ischemia/reperfusion (I/R) in rats. The aim of this study is to investigate whether the protection...
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From:PLoS ONE (Vol. 6, Issue 8) Peer-ReviewedFunctional and reactive neurogenesis and astrogenesis are observed in deafferented vestibular nuclei after unilateral vestibular nerve section in adult cats. The newborn cells survive up to one month and contribute...
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From:PLoS ONE (Vol. 8, Issue 6) Peer-ReviewedRecombinant adeno-associated virus (AAV) vectors are versatile tools for gene transfer to the central nervous system (CNS) and proof-of-concept studies in adult rodents have shown that the use of cell type-specific...