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Academic Journals
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From:The Scientist (Vol. 19, Issue 8) Peer-ReviewedK.S. Kobayashi et al., "Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract," Science, 307:731-4, Feb. 4, 2005. This study provides strong confirmation evidence supporting one of the...
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From:Pediatrics (Vol. 96, Issue 2) Peer-ReviewedObjective. Preterm formulas are nutritionally better for preterm infants; however, it has been observed that these formulas cause more feeding intolerance than do regular formulas. Because intestinal motor activity is...
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From:Nature (Vol. 531, Issue 7592) Peer-ReviewedAuthor(s): Robert O. Heuckeroth (corresponding author) [1] The enteric nervous system (ENS) is a network of neurons and supporting glial cells in the bowel wall that is essential for digestion [1]. When ENS precursor...
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From:Nature (Vol. 528, Issue 7581) Peer-ReviewedSomatic stem cells maintain tissue homeostasis by dynamically adjusting proliferation and differentiation in response to stress and metabolic cues. Here we identify [Ca.sup.2+] signalling as a central regulator of...
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From:Mayo Clinic Proceedings (Vol. 93, Issue 9) Peer-ReviewedA 39-year-old woman presented to the clinic with an 8-month history of worsening constipation, abdominal pain, and intermittent episodes of hematochezia. On average, she reported having one bowel movement per week. Each...
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From:Gut (Vol. 49, Issue 6) Peer-ReviewedThe irritable bowel syndrome (IBS) may be defined as a painful chronic abdominal symptom complex which is usually associated with altered bowel habit, and for which there is no discernible underlying structural...
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From:BioMed Research InternationalPeer-ReviewedBioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies....
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From:Nature (Vol. 569, Issue 7754) Peer-ReviewedIntestinal organoids are complex three-dimensional structures that mimic the cell-type composition and tissue organization of the intestine by recapitulating the self-organizing ability of cell populations derived from...
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From:PLoS ONE (Vol. 13, Issue 9) Peer-ReviewedThe intestinal mucosal development of piglets (Sus scrofa) during the weaning stage is important to their disease susceptibility and later growth. Quantitative real-time PCR (RT-qPCR) is commonly used to screen for...
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From:Journal of the American Dietetic Association (Vol. 100, Issue 6) Peer-ReviewedABSTRACT Advances in intestinal transplantation provide a promising alternative to patients with intestinal failure and chronic dependence on total parenteral nutrition. However, many physiologic complications...
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From:Science (Vol. 286, Issue 5437) Peer-ReviewedPrecursors of [Alpha]-defensin peptides require activation for bactericidal activity. In mouse small intestine, matrilysin colocalized with [Alpha]-defensins (cryptdins) in Paneth cell granules, and in vitro it cleaved...
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From:Nature (Vol. 483, Issue 7390) Peer-ReviewedA coin-sized device created by a team at Harvard University mimics the structure and physiology of the human intestine by supporting gut microbes and imitating the organ's rhythmic motion. Donald Ingber and his...
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From:Gut (Vol. 52, Issue 2) Peer-ReviewedBackground and aims: Locally and systemically acting corticosteroids alter the morphology and transport function of the intestine. This study was undertaken to assess the effect of budesonide, prednisone, and...
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From:Nature (Vol. 551, Issue 7681) Peer-ReviewedAuthor(s): Doris Vandeputte [1, 2, 3]; Gunter Kathagen [1, 2]; Kevin Dhoe [1, 2, 3]; Sara Vieira-Silva [1, 2]; Mireia Valles-Colomer [1, 2]; Joo Sabino [4]; Jun Wang [1, 2]; Raul Y. Tito [1, 2, 3]; Lindsey De Commer...
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From:Journal of Biomedicine and BiotechnologyPeer-ReviewedThe intestinal microbiota plays an important role in modulation of mucosal immune responses. To seek interactions between intestinal epithelial cells (IEC) and commensal bacteria, we screened 49 commensal strains for...
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From:Journal of Family Practice (Vol. 31, Issue 1) Peer-ReviewedInflammatory bowel diseases such as Crohn's disease and ulcerative colitis may occur in young men. A case study of an 18-year-old man with chronic diarrhea and 30 lb. weight loss is presented. Abdominal X-ray revealed a...
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From:Advances in Natural and Applied Sciences (Vol. 7, Issue 5) Peer-ReviewedTight junctions (TJs) are cell-cell adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and lateral membrane. Occludin and ZO-1 are the most important for TJs structures and...
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From:PLoS ONE (Vol. 12, Issue 12) Peer-ReviewedThe kidney was recognized as a dominant organ for uric acid excretion. The main aim of the study demonstrated intestinal tract was an even more important organ for serum uric acid (SUA) lowering. Sprague-Dawley rats...
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From:Nature (Vol. 557, Issue 7706) Peer-ReviewedTissues that undergo rapid cellular turnover, such as the mammalian haematopoietic system or the intestinal epithelium, are dependent on stem and progenitor cells that proliferate to provide differentiated cells to...
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From:Nature (Vol. 558, Issue 7708) Peer-ReviewedThe cellular microenvironment required to sustain adult intestinal stem cells has long been controversial. Cells that release proteins needed for intestinal-tissue renewal have now been defined. The cellular...