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    Academic Journals

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• Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

  Authors:Yihui Cui, Yan Yang, Zheyi Ni, Yiyan Dong, Guohong Cai, Alexandre Foncelle, et al.From:Nature (Vol. 554, Issue 7692) Peer-Reviewed

  Feb. 15, 20189,332 words Report 1470LAuthor(s): Yihui Cui [1, 2]; Yan Yang [1, 2]; Zheyi Ni [1]; Yiyan Dong [1]; Guohong Cai [3]; Alexandre Foncelle [4, 5]; Shuangshuang Ma [1]; Kangning Sang [1]; Siyang Tang [1]; Yuezhou Li [1]; Ying Shen [1]; Hugues...

• Ketamine does not increase intracranial pressure compared with opioids: meta-analysis of randomized controlled trials

  Authors:Xin Wang, Xibing Ding, Yao Tong, Jiaying Zong, Xiang Zhao, Hao Ren, et al.From:Journal of Anesthesia (Vol. 28, Issue 6) Peer-Reviewed

  Dec. 20143,720 words Report 1240LBackground Ketamine is traditionally avoided in sedation management of patients with risk of intracranial hypertension. However, results from many clinical trials contradict this concern. We critically analyzed the...

• Comparison of ketofol (ketamine and propofol) and etomidate in electro convulsive therapy: A double-blinded randomized controlled trial

  Authors:Chhaya Joshi, Thapisrija, Basavaraja Ayyanagouda, Narayan Mutalik, Shivanand Hulakund, and Harini JalapatiFrom:The Indian Anaesthetists’ Forum (Vol. 22, Issue 1) Peer-Reviewed

  January-June 20213,218 words Report 1560LByline: Chhaya. Joshi, Thapisrija, Basavaraja. Ayyanagouda, Narayan. Mutalik, Shivanand. Hulakund, Harini. Jalapati Background and Aims: Electroconvulsive therapy (ECT) is the most effective treatment modality for...

• Impact of repeated anesthesia with ketamine and xylazine on the well-being of C57BL/6JRj mice

  Authors:Katharina Hohlbaum, Bettina Bert, Silke Dietze, Rupert Palme, Heidrun Fink, and Christa Thone-ReinekeFrom:PLoS ONE (Vol. 13, Issue 9) Peer-Reviewed

  Sept. 19, 201811,821 words Report 1390LWithin the scope of the 3Rs of Russel and Burch, the number of laboratory animals can be reduced by repeated use of an animal. This strategy only becomes relevant, if the total amount of pain, distress or harm the...

• Subanesthetic ketamine rapidly alters medial prefrontal miRNAs involved in ubiquitin-mediated proteolysis.

  Authors:Yunjung Choi, Baeksun Kim, Suji Ham, Sooyoung Chung, Sungho Maeng, Hye-Sun Kim, et al.From:PLoS ONE (Vol. 16, Issue 8) Peer-Reviewed

  Aug. 26, 20216,239 words Report 1500LKetamine is a dissociative anesthetic and a non-competitive NMDAR antagonist. At subanesthetic dose, ketamine can relieve pain and work as a fast-acting antidepressant, but the underlying molecular mechanism remains...

• Practical application of the neuroregenerative properties of ketamine: real world treatment experience

  Author:Theodore HendersonFrom:Neural Regeneration Research (Vol. 11, Issue 2) Peer-Reviewed

  Feb. 20164,929 words Report 1260LByline: Theodore. Henderson While controversial, ketamine has emerged as an effective treatment for refractory depression. Serial infusions have been performed 3 times per week, but our practical experience has...

• Lifting the mood with ketamine

  Authors:James W. Murrough and Dennis S. CharneyFrom:Nature Medicine (Vol. 16, Issue 12) Peer-Reviewed

  Dec. 20101,205 words Report 1660LMajor depression is one of the most disabling and costly medical illnesses worldwide. Despite the large public health burden, the pace of therapeutic discovery for depression has markedly lagged behind other areas of...

• Ketamine steps out of the darkness.

  Author:Roberto MalinowFrom:Nature (Vol. 533, Issue 7604) Peer-Reviewed

  May 26, 20161,405 words Report 1340LThe way in which ketamine exerts its antidepressant effects has been perplexing. Evidence that a metabolite of the drug is responsible, and acts on a different target from ketamine, might be the key to an answer. See...

• Dexmedetomidine-propofol vs ketamine-propofol anaesthesia in paediatric and young adult patients undergoing device closure procedures in cardiac catheterisation laboratory: An open label randomised trial

  Authors:Kunal Tewari, Vishal Tewari, and Subroto DattaFrom:Indian Journal of Anaesthesia (Vol. 62, Issue 7) Peer-Reviewed

  July 20183,943 words Report 1580LByline: Kunal. Tewari, Vishal. Tewari, Subroto. Datta Background and Aims: Several drug combinations have been tried in patients with acyanotic congenital heart disease (ACHD) undergoing transcatheter device closure...

• The use of ketamine as rescue analgesia in the recovery room following morphine administration--a double-blind randomised controlled trial in postoperative patients

  Authors:A. Gillies, D. Lindholm, M. Angliss, and A. OrrFrom:Anaesthesia and Intensive Care (Vol. 35, Issue 2) Peer-Reviewed

  Apr. 20072,670 words Clinical report SUMMARY In some patients, control of postoperative pain can be difficult with morphine alone. This double-blind randomised controlled trial was designed to evaluate whether a small bolus dose of ketamine could...

• Oral ketamine for phantom limb pain: An option for challenging cases

  Authors:Sukanya Mitra and Sunita KazalFrom:Indian Journal of Anaesthesia (Vol. 59, Issue 7) Peer-Reviewed

  July 20151,245 words Report 1570LByline: Sukanya. Mitra, Sunita. Kazal Introduction Phantom limb pain (PLP) is a referred neuropathic pain perceived to arise from an amputated part of the body. It occurs in up to 80% of limb amputees and affects...

• Gargling with Ketamine Attenuates the Postoperative Sore Throat

  Authors:A. Rudra, Suchanda Ray, S. Chatterjee, A. Ahmed, and S. GhoshFrom:Indian Journal of Anaesthesia (Vol. 53, Issue 1) Peer-Reviewed

  January-February 20092,017 words Report Byline: A. Rudra, Suchanda. Ray, S. Chatterjee, A. Ahmed, S. Ghosh Postoperative sore throat (POST) is a common complication of anaesthesia with endotracheal tube that affects patient satisfaction after surgery....

• Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy

  Authors:G. Erdogan Kayhan, A. Yucel, Y.Z. Colak, U. Ozgul, S. Yologlu, R. Karlidag, et al.From:Anaesthesia and Intensive Care (Vol. 40, Issue 2) Peer-Reviewed

  Mar. 20123,886 words Report 1330LThe aim of this study was to evaluate the effect of a ketamine:propofol combination ('ketofol') for electroconvulsive therapy on seizure activity, haemodynamic response and recovery parameters, and to compare with these...

• Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression.

  Authors:Lily R. Aleksandrova, Yu Tian Wang, and Anthony G. PhillipsFrom:Molecular Brain (Vol. 13, Issue 1) Peer-Reviewed

  June 16, 202010,248 words Report 1740LAccumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of...

• Ketamine-Induced Oscillations in the Motor Circuit of the Rat Basal Ganglia

  Authors:Maria Jesus Nicolas, Jon Lopez-Azcarate, Miguel Valencia, Manuel Alegre, Marta Perez-Alcazar, Jorge Iriarte, et al.From:PLoS ONE (Vol. 6, Issue 7) Peer-Reviewed

  July 29, 20118,229 words Article 1490LOscillatory activity can be widely recorded in the cortex and basal ganglia. This activity may play a role not only in the physiology of movement, perception and cognition, but also in the pathophysiology of psychiatric...

• Ketamine infusion in emergency care rapidly reduces suicidal ideation.

  From:The Brown University Psychopharmacology Update (Vol. 31, Issue 3)

  Mar. 2020333 words Brief article 1480LWith no strong evidence base to suggest that brief hospitalization of individuals who present to the emergency department with suicidal ideation reduces the potential for suicide, there is a need for more effective...

• Ketamine for continuous sedation of mechanically ventilated patients

  Authors:Ben-Paul Umunna, Karis Tekwani, Dave Barounis, Nick Kettaneh, and Erik KulstadFrom:Journal of Emergencies, Trauma, and Shock (Vol. 8, Issue 1) Peer-Reviewed

  January-March 20152,870 words Report 1610LByline: Ben-Paul. Umunna, Karis. Tekwani, Dave. Barounis, Nick. Kettaneh, Erik. Kulstad Context: Long-term sedation with midazolam or propofol has been demonstrated to have serious adverse side effects, such as toxic...

• Ketamine and children

  Author:Rabina TindaleFrom:Emergency Nurse (Vol. 12, Issue 3) Peer-Reviewed

  June 2004190 words Brief article Ketamine is accepted as a standard method of paediatric procedural sedation in emergency departments in Australia and the US. In the UK however, using this extremely powerful and quick acting drug remains controversial....

• Imaging of striatal dopamine release elicited with NMDA antagonists: is there anything there to be seen?

  Author:Eugenii A. RabinerFrom:Journal of Psychopharmacology (Vol. 21, Issue 3) Peer-Reviewed

  May 20074,014 words Article 1450LAbstract Increased release of striatal dopamine, indexed with in vivo imaging of the [D.sub.2] receptor, has been reported following an acute challenge with N-methyl-D-aspartate (NMDA) antagonist ketamine in humans....

• Ketamine and Propofol Protect Neuron Cells from Oxygen-Glucose Deprivation-Induced Injury through SAPK/JNK Signalling Pathway.

  Authors:Aihua Qi, Yiyun Cao, and Aizhong WangFrom:BioMed Research International (Vol. 2020) Peer-Reviewed

  Dec. 16, 20203,604 words Report 1390LKetamine and propofol are commonly used anaesthetic reagents. Recent research revealed that ketamine and propofol have an important role in cell survival. However, it remains unknown whether they affect the outcome of...