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    Academic Journals

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• Potential role of NK cells in the pathogenesis of inflammatory bowel disease

  Authors:Praveen K. Yadav, Chi Chen, and Zhanju LiuFrom:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20115,267 words Report 1560LNK cells are a major component of the innate immune system and play an important role in the tissue inflammation associated with autoimmune diseases such as inflammatory bowel disease (IBD). NK cells are unique in...

• NK cells: immune cross-talk and therapeutic implications

  Authors:Anshu Malhotra and Anil ShankerFrom:Immunotherapy (Vol. 3, Issue 10) Peer-Reviewed

  Oct. 201117,753 words Report 1490LAuthor(s): Anshu Malhotra 1 , Anil Shanker [[dagger]] 2 KEYWORDS : adoptive therapy; autoimmunity; cancer; immunoregulation; immunotherapy; inflammation; NK cell activation; receptor signaling; viral infection...

• Lysis of human alveolar macrophages by lymphokine-activated killer cells

  Authors:Muneharu Maruyama, Akira Kawasaki, Hidehiko Suzuki, Naohiro Yamashita, and Saburo YanoFrom:Chest (Vol. 97, Issue 6) Peer-Reviewed

  June 19903,034 words Article In order to determine if human LAK cells were cytotoxic against autologous AM[phi], we studied the ability of human peripheral blood MNCs, stimulated in vitro with recombinant human IL-2, to lyse AM[phi] in a four-hour...

• Inhibition of natural killer cell activity by oral administration of theophylline

  Authors:Akihito Yokoyama, Naohiro Yamashita, Yutaka Mizushima, and Saburo YanoFrom:Chest (Vol. 98, Issue 4) Peer-Reviewed

  Oct. 19902,220 words Article Asthmatic patients have a low incidence of malignancies, and this is possibly due to higher NK cell activity in this population. Because theophylline is used widely in this population, we evaluated the influence of...

• Chelerythrine delayed tumor growth and increased survival duration of Dalton's lymphoma bearing BALB/c H [sup]2d mice by activation of NK cells in vivo

  Authors:Sanjay Kumar, Munendra Tomar, and Arbind AcharyaFrom:Journal of Cancer Research and Therapeutics (Vol. 11, Issue 4) Peer-Reviewed

  October-December 20154,821 words Report 1880LByline: Sanjay. Kumar, Munendra. Tomar, Arbind. Acharya Aim: The aims of the present investigation were to evaluate the antitumor effect of chelerythrine (CHE) on in vivo growth and survival duration of BALB/c (H...

• [beta]-defensin 2 as an Adjuvant Promotes Anti-Melanoma Immune Responses and Inhibits the Growth of Implanted Murine Melanoma In Vivo

  Authors:Han-fang Mei, Xiao-bao Jin, Jia-yong Zhu, Ai-hua Zeng, Qiang Wu, Xue-mei Lu, et al.From:PLoS ONE (Vol. 7, Issue 2) Peer-Reviewed

  Feb. 13, 20127,038 words Article 1540LAuthor(s): Han-fang Mei 1 , 2 , 3 , 4 , Xiao-bao Jin 1 , 2 , Jia-yong Zhu 1 , * , Ai-hua Zeng 1 , Qiang Wu 1 , 2 , 4 , Xue-mei Lu 1 , 4 , Xiao-bo Li 1 , 2 , 4 , Juan Shen 1 , 4 Introduction Malignant melanoma is...

• Reciprocal Complementation of the Tumoricidal Effects of Radiation and Natural Killer Cells

  Authors:Kai-Lin Yang, Yu-Shan Wang, Chao-Chun Chang, Su-Chen Huang, Yi-Chun Huang, Mau-Shin Chi, et al.From:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 25, 20136,626 words Article 1450LAuthor(s): Kai-Lin Yang 1, Yu-Shan Wang 1, Chao-Chun Chang 1, Su-Chen Huang 1, Yi-Chun Huang 1, Mau-Shin Chi 1, Kwan-Hwa Chi 1,2,* Introduction Radiation is a highly effective tumoricidal modality, but its...

• The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines

  Authors:Jan M. Klein, Alexander Henke, Maike Sauer, Martina Bessler, Katrin S. Reiners, Andreas Engert, et al.From:PLoS ONE (Vol. 8, Issue 11) Peer-Reviewed

  Nov. 21, 20134,122 words Article 1300LAuthor(s): Jan M. Klein, Alexander Henke, Maike Sauer, Martina Bessler, Katrin S. Reiners, Andreas Engert, Hinrich P. Hansen, Elke Pogge von Strandmann * Introduction In Hodgkin lymphoma (HL), the affected lymph...

• Phenotypic and Functional Characteristics of Blood Natural Killer Cells from Melanoma Patients at Different Clinical Stages

  Authors:Giulia Fregni, Meriem Messaoudene, Emmanuelle Fourmentraux-Neves, Sarra Mazouz-Dorval, Johan Chanal, Eve Maubec, et al.From:PLoS ONE (Vol. 8, Issue 10) Peer-Reviewed

  Oct. 18, 20136,077 words Article 1410LAuthor(s): Giulia Fregni 1, Meriem Messaoudene 1, Emmanuelle Fourmentraux-Neves 1, Sarra Mazouz-Dorval 1, Johan Chanal 1,2, Eve Maubec 3, Eduardo Marinho 3, Isabelle Scheer-Senyarich 3, Isabelle Cremer 4,...

• Intrahepatic Infiltrating NK and CD8 T Cells Cause Liver Cell Death in Different Phases of Dengue Virus Infection

  Authors:Jui-Min Sung, Chien-Kuo Lee, and Betty A. Wu-HsiehFrom:PLoS ONE (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 26, 20126,382 words Article 1480LAuthor(s): Jui-Min Sung, Chien-Kuo Lee, Betty A. Wu-Hsieh * Introduction Dengue virus (DENV) infection causes dengue fever (DF) which may progress to become life-threatening dengue hemorrhagic fever (DHF) and/or...

• Biallelic mutations in IRF8 impair human NK cell maturation and function

  Authors:Emily M. Mace, Venetia Bigley, Justin T. Gunesch, Ivan K. Chinn, Laura S. Angelo, Matthew A. Care, et al.From:Journal of Clinical Investigation (Vol. 127, Issue 1) Peer-Reviewed

  Jan. 201710,398 words Report 1510LHuman NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that...

• Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells

  Authors:Lu Han, Yi-Man Shang, Yong-Ping Song, and Quan-Li GaoFrom:Journal of Immunology Research (Vol. 2016) Peer-Reviewed

  Annual 20165,465 words Article 1360LAdoptive cell therapy (ACT) using autologous cytokine-induced killer (CIK) cells is a promising treatment for metastatic carcinomas. In this study, we investigated the impact of RetroNectin on the proliferation,...

• Spontaneous regression of metastatic cancer cells in the lymph node: a case report

  Authors:Nayeon Choi, Jae Keun Cho, Chung-Hwan Baek, Young-Hyeh Ko, and Han-Sin JeongFrom:BMC Research Notes (Vol. 7, Issue 1) Peer-Reviewed

  May 13, 20142,621 words Article 1450LAuthor(s): Nayeon Choi1 , Jae Keun Cho1 , Chung-Hwan Baek1 , Young-Hyeh Ko2 and Han-Sin Jeong1 Background Spontaneous regression of a malignant tumor is the phenomenon of disappearance of cancer cells without any...

• Activated [CD8.sup.+] T cells and NKT cells in BAL fluid improve diagnostic accuracy in sarcoidosis

  Authors:A. Tondell, A.D. Ro, A. Asberg, M. Borset, T. Moen, and M. Sue-ChuFrom:Lung (Vol. 192, Issue 1) Peer-Reviewed

  Feb. 20144,050 words Report 1490LPurpose The clinical diagnosis of pulmonary sarcoidosis is based on the presence of noncaseating granulomas in an appropriate clinical setting with either bilateral hilar adenopathy and/or parenchymal infiltrates....

• Interferon-[alpha]-induced changes to natural killer cells are associated with the treatment outcomes in patients with HCV infections

  Authors:Shinji Shimoda, Kosuke Sumida, Sho Iwasaka, Satomi Hisamoto, Hironori Tanimoto, Hideyuki Nomura, et al.From:Hepatitis Research and TreatmentPeer-Reviewed

  Annual 20133,501 words Report 1420LAim. We analyzed the pretreatment natural killer (NK) cell functions with the aim of predicting the sustained virological response (SVR) or the interleukin (IL) 28B polymorphism that is strongly associated with the...

• Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization

  Authors:Annalisa Bosi, Silvia Zanellato, Barbara Bassani, Adriana Albini, Alessandra Musco, Maria Cattoni, et al.From:Journal of Immunology Research (Vol. 2018) Peer-Reviewed

  Annual 20188,410 words Article 1590LNatural killer (NK) cells are crucial in tumor recognition and eradication, but their activity is impaired in cancer patients, becoming poorly cytotoxic. A particular type of NK cells, from the decidua, has low...

• Killers 2.0: NK cell therapies at the forefront of cancer control.

  Authors:Jonathan J. Hodgins, Sarwat T. Khan, Maria M. Park, Rebecca C. Auer, and Michele ArdolinoFrom:Journal of Clinical Investigation (Vol. 129, Issue 9) Peer-Reviewed

  Sept. 201910,612 words Article 1360LNatural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and elimination of cancer. As we have learned more and more about the mechanisms NK cells employ to recognize and eliminate tumor...

• How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance

  Authors:Maria Jamela Revilleza, Rui Wang, Janet Mans, Manqing Hong, Kannan Natarajan, and David H. MarguliesFrom:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20118,282 words Report 1620LNatural killer (NK) cells provide an initial host immune response to infection by many viral pathogens. Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral...

• Clinical cancer therapy by NK cells via antibody-dependent cell-mediated cytotoxicity

  Authors:Kory L. Alderson and Paul M. SondelFrom:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20115,452 words Report 1490LNatural killer (NK) cells are powerful effector cells that can be directed to eliminate tumor cells through tumor- targeted monoclonal antibodies (mAbs). Some tumor-targeted mAbs have been successfully applied in the...

• The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review.

  Authors:Xiuhua Yang, Yahui Yang, Yiru Yuan, Lin Liu, and Tao MengFrom:BioMed Research InternationalPeer-Reviewed

  Apr. 30, 20207,800 words Article 1470LPreeclampsia (PE) is termed as a systemic disease that involves multiple organs; however, the exact etiology is still quite unclear. It is believed that the poor remodeling of uterine spiral arteries triggers PE, thereby...