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Academic Journals
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From:Chest (Vol. 97, Issue 6) Peer-ReviewedIn order to determine if human LAK cells were cytotoxic against autologous AM[phi], we studied the ability of human peripheral blood MNCs, stimulated in vitro with recombinant human IL-2, to lyse AM[phi] in a four-hour...
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From:PLoS ONE (Vol. 8, Issue 4) Peer-ReviewedAuthor(s): Kai-Lin Yang 1, Yu-Shan Wang 1, Chao-Chun Chang 1, Su-Chen Huang 1, Yi-Chun Huang 1, Mau-Shin Chi 1, Kwan-Hwa Chi 1,2,* Introduction Radiation is a highly effective tumoricidal modality, but its...
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From:PLoS ONE (Vol. 7, Issue 9) Peer-ReviewedAuthor(s): Jui-Min Sung, Chien-Kuo Lee, Betty A. Wu-Hsieh * Introduction Dengue virus (DENV) infection causes dengue fever (DF) which may progress to become life-threatening dengue hemorrhagic fever (DHF) and/or...
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From:Journal of Clinical Investigation (Vol. 127, Issue 1) Peer-ReviewedHuman NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that...
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From:BMC Research Notes (Vol. 7, Issue 1) Peer-ReviewedAuthor(s): Nayeon Choi1 , Jae Keun Cho1 , Chung-Hwan Baek1 , Young-Hyeh Ko2 and Han-Sin Jeong1 Background Spontaneous regression of a malignant tumor is the phenomenon of disappearance of cancer cells without any...
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From:Lung (Vol. 192, Issue 1) Peer-ReviewedPurpose The clinical diagnosis of pulmonary sarcoidosis is based on the presence of noncaseating granulomas in an appropriate clinical setting with either bilateral hilar adenopathy and/or parenchymal infiltrates....
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From:Hepatitis Research and TreatmentPeer-ReviewedAim. We analyzed the pretreatment natural killer (NK) cell functions with the aim of predicting the sustained virological response (SVR) or the interleukin (IL) 28B polymorphism that is strongly associated with the...
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From:Journal of Immunology Research (Vol. 2018) Peer-ReviewedNatural killer (NK) cells are crucial in tumor recognition and eradication, but their activity is impaired in cancer patients, becoming poorly cytotoxic. A particular type of NK cells, from the decidua, has low...
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From:PLoS ONE (Vol. 5, Issue 10) Peer-ReviewedBackground RAE-1 is a ligand of the activating receptor NKG2D expressed by NK cells, NKT, [gamma][delta]T and some CD8.sup.+ T lymphocytes. RAE-1 is overexpressed in tumor cell lines and its expression is induced...
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From:PLoS ONE (Vol. 3, Issue 4) Peer-ReviewedNatural killer (NK) cells and dendritic cells (DC) are thought to play critical roles in the first phases of HIV infection. In this study, we examined changes in the NK cell repertoire and functions occurring in...
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From:PLoS ONE (Vol. 4, Issue 1) Peer-ReviewedCD8 T cells play an important role in controlling viral infections. We investigated the in situ localization of simian immunodeficiency virus (SIV)-specific T cells in lymph and genital tissues from SIV-infected...
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From:PLoS ONE (Vol. 6, Issue 12) Peer-ReviewedBackground Infection by the pandemic influenza A (H1N1/09) virus resulted in significant pathology among specific ethnic groups worldwide. Natural Killer (NK) cells are important in early innate immune responses to...
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From:PLoS ONE (Vol. 7, Issue 10) Peer-ReviewedMembrane nanotubes are thin membranous projections that physically connect two cells. While nanotubes have been studied in human natural killer (NK) cells and are implicated in aiding NK cell cytotoxic function,...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedHuman embryonic stem cells (hESCs) can be induced to differentiate into blood cells using either co-culture with stromal cells or following human embryoid bodies (hEBs) formation. It is now well established that the...
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From:Journal of Hematology & Oncology (Vol. 9, Issue 40) Peer-ReviewedAggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of l-asparaginase-based regimens for ANKL...
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From:Nature Biotechnology (Vol. 35, Issue 8) Peer-ReviewedPolymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the Beta-2 Microglobulin (B2M) gene...
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From:PLoS ONE (Vol. 9, Issue 11) Peer-ReviewedLeishmania mexicana causes localized (LCL) or diffuse cutaneous leishmaniasis (DCL). The cause of dissemination in DCL remains unknown, yet NK cells possibly play a role in activating leishmanicidal mechanisms during...
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From:PLoS ONE (Vol. 9, Issue 10) Peer-ReviewedType I interferons (IFN) are unique cytokines transcribed from intronless genes. They have been extensively studied because of their anti-viral functions. The anti-viral effects of type I IFN are mediated in part by...
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From:Journal of Biomedicine and BiotechnologyPeer-ReviewedNatural killer (NK) cells are powerful effector cells that can be directed to eliminate tumor cells through tumor- targeted monoclonal antibodies (mAbs). Some tumor-targeted mAbs have been successfully applied in the...
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From:Journal of Biomedicine and BiotechnologyPeer-ReviewedNatural killer (NK) cells provide an initial host immune response to infection by many viral pathogens. Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral...