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From:Archives of Disease in Childhood (Vol. 85, Issue 4) Peer-ReviewedAbstract Aims--To examine the clinical and biological features of acute lymphoblastic leukaemia in children with Down's syndrome (DS), to compare their survival with other children, and to determine if entry to...
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From:Science (Vol. 246, Issue 4937) Peer-ReviewedAcute lymphoblastic leukemia (ALL) of the non-T type is the most common leukemia in children. A living (in vivo) animal model for studying the growth and progression of ALL was devised using a special strain of mice....
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From:BMC Research Notes (Vol. 15, Issue 1) Peer-ReviewedObjective Acute lymphoblastic leukemia (ALL) is one of the most common cancers in children for which the exact pathogenesis is not yet known. Single-nucleotide variants (SNVs) in different DNA repair genes are reported...
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From:Expert Review of Anticancer Therapy (Vol. 3, Issue 3) Peer-ReviewedGiven the recent advances in the treatment of hematologic malignancies and the many other treatments on the horizon, physicians and payers will be faced with the critical decisions of when to use new treatments in the...
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From:African Journal of Medical and Health Sciences (Vol. 12, Issue 2) Peer-ReviewedByline: Kaumudee. Pattnaik, Asaranti. Kar, Sabita. Palai, Bibudhendu. Pati, Chandrasekhar. Mohapatra Chronic myeloid leukemia (CML) is a rare hematological malignancy in children. The more common acute lymphoblastic...
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From:Archives of Disease in Childhood (Vol. 89, Issue 4) Peer-ReviewedIntroduction: New trends for the treatment of childhood acute myeloblastic and lymphoblastic leukaemia (AML, ALL) include more aggressive schedules whose effects on the immunisation status remain unknown. Method: As...
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From:Science (Vol. 223) Peer-ReviewedChildhood Leukemia and Fallout from the Nevada Nuclear Tests In 1979 Lyon et al. (1) reported an association between increased risk of mortality from childhood leukemia and residence in the southern 17 counties of...
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From:Indian Journal of Medical and Paediatric Oncology (Vol. 41, Issue 1) Peer-ReviewedByline: Mahmood. Al-Mendalawi Sir, In October-December 2018 issue of the Indian Journal of Medical and Paediatric Oncology , Anoop et al .[1] described a case of concurrent hairy cell leukemia (HCL) and chronic...
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From:Archives of Disease in Childhood (Vol. 89, Issue 4) Peer-ReviewedAims: This paper will examine the development of clinical trials for childhood leukemias in order to compare treatment results and event free survival rates in the US and UK from 1950-1990. Methods: The investigator...
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From:Indian Journal of Medical and Paediatric Oncology (Vol. 32, Issue 4) Peer-ReviewedByline: Narendra. Chaudhary, Rubeena. Majeed, Anupama. Borker Parieto-occipital region is the most commonly involved site in posterior reversible encephalopathy syndrome (PRES). Cerebellar involvement has been...
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From:Science (Vol. 225) Peer-ReviewedChronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized in over 90 percent of cases by the presence of the Philadelphia chroosome (Ph1) (1). A number of recent findings suggest that the human...
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From:Reactions Weekly (Issue 1300)* [S] A man [age not clearly stated] developed Philadelphianegative acute lymphoblastic leukaemia (Ph-ALL) during treatment with dasatinib for chronic myeloid leukaemia (CML). The man was diagnosed with CML in...
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From:The Egyptian Journal of Haematology (Vol. 39, Issue 4) Peer-Reviewed
Prognostic impact of neuropilin-1 expression in children with B-lineage acute lymphoblastic leukemia
Byline: Nahla. Nosair, Adel. Hagag Background Neuropilins are transmembrane glycoproteins that act as receptors for vascular endothelial growth factors and are involved in the process of tumor angiogenesis. Objective... -
From:Aging Health (Vol. 8, Issue 3) Peer-ReviewedAuthor(s): Anne-Sophie Michallet [*] 1 2 , Pierre Feugier 2 , Alain Delmer 2 , Loic Ysebaert 2 , Bruno Cazin 2 , Caroline Dartigeas 2 , Luc Fornecker 2 , Eric Van de Neste 2 , Florence Cymbalista 2 , Vincent Lévy 2 ,...
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From:Postgraduate Medical Journal (Vol. 77, Issue 907) Peer-ReviewedQuestions A 4 year old boy was brought with history of low back pain of seven days' duration after a trivial fall. On examination the child had tenderness in the lower lumbar spine. There was no paraspinal swelling...
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From:Science (Vol. 224) Peer-ReviewedDifferentiation of the mammalian erythrocyte from its nucleated erythroblast precursor takes 4 to 6 days and involves extensive remodeling of the cell surface membrane (1). At least two cell surface glycoproteins, "band...
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From:Indian Journal of Pathology and Microbiology (Vol. 57, Issue 1) Peer-ReviewedByline: Anurag. Gupta, Manu. Goyal, Koteswara. Nidamanuri, Palanki. Dattatreya B-cell acute lymphoblastic leukemia (B-ALL) is characterized by CD19 expression, which is one of the most important prerequisites, along...
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From:Journal of Hematology & Oncology (Vol. 6, Issue 1) Peer-Reviewedp53 is a powerful tumor suppressor and is an attractive cancer therapeutic target. A breakthrough in cancer research came from the discovery of the drugs which are capable of reactivating p53 function. Most anti-cancer...
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From:Emerging Infectious Diseases (Vol. 17, Issue 2) Peer-ReviewedTo the Editor: Xenotropic murine leukemia virus-related virus (XMRV) is a recently described human retrovirus that has been associated with prostate cancer and chronic fatigue syndrome (CFS) (1,2). XMRV is similar to a...
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From:Pediatric Drugs (Vol. 23, Issue 5) Peer-ReviewedAsparaginase therapy is a vital agent in the treatment of acute lymphoblastic leukemia (ALL), with increasing evidence of its high importance in high-risk ALL populations. However, despite the clear clinical and...