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    Academic Journals

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• Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

  Authors:Elena Kudryashova, Irina Kramerova, and Melissa J. SpencerFrom:Journal of Clinical Investigation (Vol. 122, Issue 5) Peer-Reviewed

  May 2012 Report 1380L

• A U-Box E3 Ubiquitin Ligase, PUB20, Interacts with the Arabidopsis G-Protein [beta] Subunit, AGB1

  Authors:Shio Kobayashi, Daisuke Tsugama, Shenkui Liu, and Tetsuo TakanoFrom:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 15, 20124,098 words Article 1420LAuthor(s): Shio Kobayashi 1 , Daisuke Tsugama 1 , Shenkui Liu 2 , Tetsuo Takano 1 , * Introduction Heterotrimeric G-proteins (G-proteins) are evolutionarily conserved plasma membrane-bound proteins that are...

• Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments

  Authors:BethAnn McLaughlin, Matthew A. Buendia, Tommy P. Saborido, Amy M. Palubinsky, Jeannette N. Stankowski, and Gregg D. StanwoodFrom:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 11, 20125,655 words Article 1550LAuthor(s): BethAnn McLaughlin 1 , 2 , 3 , * , Matthew A. Buendia 2 , Tommy P. Saborido 2 , Amy M. Palubinsky 3 , 4 , Jeannette N. Stankowski 4 , Gregg D. Stanwood 2 , 3 Introduction Heat shock proteins (HSPs) are...

• Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation

  Authors:Lynn Burchell, Viduth K. Chaugule, and Helen WaldenFrom:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 4, 20123,368 words Article 1440LAuthor(s): Lynn Burchell, Viduth K. Chaugule ** , Helen Walden * Introduction Parkin is a RING E3 ubiquitin ligase [1], [2], [3] which, in conjunction with a ubiquitin-activating enzyme (E1) and a...

• Regulation of p53 Level by UBE4B in Breast Cancer

  Authors:Ying Zhang, Yanrong Lv, Yongyang Zhang, and Haidong GaoFrom:PLoS ONE (Vol. 9, Issue 2) Peer-Reviewed

  Feb. 26, 20143,294 words Article 1460LAuthor(s): Ying Zhang 1, Yanrong Lv 1, Yongyang Zhang 2, Haidong Gao 1,* Introduction Ubiquitin (Ub) is a highly conserved 8 kDa protein that covalently attaches to the lysine (Lys) residues of target proteins....

• CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes

  Authors:Domingo Jimenez-Lopez, Laura Aguilar-Henonin, Juan Manuel Gonzalez-Prieto, Victor Aguilar-Hernandez, and Plinio GuzmanFrom:PLoS ONE (Vol. 13, Issue 1) Peer-Reviewed

  Jan. 11, 20189,162 words Report 1460LAuthor(s): Domingo Jiménez-López 1,2, Laura Aguilar-Henonin 1, Juan Manuel González-Prieto 2, Victor Aguilar-Hernández 3, Plinio Guzmán 1,* Introduction Plant proteins frequently undergo modifications that...

• Mechanisms of c-Myc Degradation by Nickel Compounds and Hypoxia

  Authors:Qin Li, Thomas Kluz, Hong Sun, and Max CostaFrom:PLoS ONE (Vol. 4, Issue 12) Peer-Reviewed

  Dec. 31, 20097,335 words Article 1430LAuthor(s): Qin Li, Thomas Kluz, Hong Sun, Max Costa * Introduction Nickel (Ni) compounds have been found to cause cancer in humans and animal models and to transform cells in culture [1], [2], [3], [4]. Recent...

• The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

  Authors:Claudio A. P. Joazeiro, Simon S. Wing, Han-kuei Huang, Joel D. Leverson, Tony Hunter, and Yun-Cai LiuFrom:Science (Vol. 286, Issue 5438) Peer-Reviewed

  Oct. 8, 19993,100 words Article Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation, c-Cbl, an adapter protein for RPTKs, positively regulates RPTK ubiquitination in a manner...

• Bidirectional histone-gene promoters in Aspergillus: characterization and application for multi-gene expression.

  Authors:Jakob K. H. Rendsvig, Christopher T. Workman, and Jakob B. HoofFrom:Fungal Biology and Biotechnology (Vol. 6, Issue 1) Peer-Reviewed

  Dec. 9, 20199,632 words Article 1480LBackground Filamentous fungi are important producers of enzymes and bioactive secondary metabolites and are exploited for industrial purposes. Expression and characterization of biosynthetic pathways requires stable...

• Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1[alpha]/[beta]-mediated adaptive stress response pathway in skeletal muscle cells.

  Authors:Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba Nadeef, and Valerio OrlandoFrom:Epigenetics & Chromatin (Vol. 12, Issue 1) Peer-Reviewed

  Dec. 19, 20197,085 words Article 1430LBackground While the role of Polycomb group protein-mediated "cell memory" is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells....

• The deubiquitylase Ubp15 couples transcription to mRNA export.

  Authors:Fanny Eyboulet, Célia Jeronimo, Jacques Côté, and François RobertFrom:eLife (Vol. 9) Peer-Reviewed

  Nov. 23, 202013,955 words Article 1450LNuclear export of messenger RNAs (mRNAs) is intimately coupled to their synthesis. pre-mRNAs assemble into dynamic ribonucleoparticles as they are being transcribed, processed, and exported. The role of ubiquitylation in...

• Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

  Authors:Thomas L. Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick Yim, et al.From:PLoS ONE (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 30, 20156,821 words Article 1390LThe two cytosolic/nuclear isoforms of the molecular chaperone HSP90, stress-inducible HSP90[alpha] and constitutively expressed HSP90[beta], fold, assemble and maintain the three-dimensional structure of numerous client...

• RNA Sequencing Revealed Numerous Polyketide Synthase Genes in the Harmful Dinoflagellate Karenia mikimotoi

  Authors:Kei Kimura, Shujiro Okuda, Kei Nakayama, Tomoyuki Shikata, Fumio Takahashi, Haruo Yamaguchi, et al.From:PLoS ONE (Vol. 10, Issue 11) Peer-Reviewed

  Nov. 11, 20157,279 words Report 1380LThe dinoflagellate Karenia mikimotoi forms blooms in the coastal waters of temperate regions and occasionally causes massive fish and invertebrate mortality. This study aimed to elucidate the toxic effect of K....

• Concerted Action of the Ubiquitin-Fusion Degradation Protein 1 (Ufd1) and Sumo-Targeted Ubiquitin Ligases (STUbLs) in the DNA-Damage Response

  From:PLoS ONE (Vol. 8, Issue 11) Peer-Reviewed

  Nov. 12, 201310,358 words Article 1470LIn eukaryotes many players in the DNA-damage response (DDR) catalyze protein sumoylation or ubiquitylation. Emphasis has been placed on how these modifications orchestrate the sequential recruitment of repair factors to...

• Association of Histamine N-Methyltransferase Thr105Ile Polymorphism with Parkinson's Disease and Schizophrenia in Han Chinese: A Case-Control Study

  Authors:Xinglong Yang, Chuanxin Liu, Jinxiang Zhang, Hongying Han, Xiuyan Wang, Zhoulin Liu, et al.From:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 13, 20154,478 words Article 1420LParkinson's disease (PD) and schizophrenia (SCZ) are frequent central nervous disorders that have unclear etiologies but that show similarities in their pathogenesis. Since elevated histamine levels in the brain have...

• Glutamine Synthetase Sensitivity to Oxidative Modification during Nutrient Starvation in Prochlorococcus marinus PCC 9511

  Authors:Guadalupe Gomez-Baena, Maria Agustina Dominguez-Martin, Robert P. Donaldson, Jose Manuel Garcia-Fernandez, and Jesus DiezFrom:PLoS ONE (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 13, 20156,786 words Article 1450LGlutamine synthetase plays a key role in nitrogen metabolism, thus the fine regulation of this enzyme in Prochlorococcus, which is especially important in the oligotrophic oceans where this marine cyanobacterium...

• Autophagy-Associated Atrophy and Metabolic Remodeling of the Mouse Diaphragm after Short-Term Intermittent Hypoxia

  Authors:Christian Giordano, Christian Lemaire, Tong Li, R. John Kimoff, and Basil J. PetrofFrom:PLoS ONE (Vol. 10, Issue 6) Peer-Reviewed

  June 24, 20157,516 words Article 1550LBackground Short-term intermittent hypoxia (IH) is common in patients with acute respiratory disorders. Although prolonged exposure to hypoxia induces atrophy and increased fatigability of skeletal muscle, the...

• Mitotic UV Irradiation Induces a DNA Replication-Licensing Defect that Potentiates G1 Arrest Response

  Authors:Masayuki Morino, Kohei Nukina, Hiroki Sakaguchi, Takeshi Maeda, Michiyo Takahara, Yasushi Shiomi, et al.From:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 23, 20157,964 words Article 1460LCdt1 begins to accumulate in M phase and has a key role in establishing replication licensing at the end of mitosis or in early G1 phase. Treatments that damage the DNA of cells, such as UV irradiation, induce Cdt1...

• Inactivation of MARCH5 Prevents Mitochondrial Fragmentation and Interferes with Cell Death in a Neuronal Cell Model

  Authors:Lei Fang, Charles Hemion, David Goldblum, Peter Meyer, Selim Orgul, Stephan Frank, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 19, 20124,851 words Article 1550LPurpose To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress...

• Adaptation of Mouse Skeletal Muscle to Long-Term Microgravity in the MDS Mission

  Authors:Dorianna Sandona, Jean-Francois Desaphy, Giulia M. Camerino, Elisa Bianchini, Stefano Ciciliot, Daniela Danieli-Betto, et al.From:PLoS ONE (Vol. 7, Issue 3) Peer-Reviewed

  Mar. 28, 20129,424 words Article 1570LThe effect of microgravity on skeletal muscles has so far been examined in rat and mice only after short-term (5-20 day) spaceflights. The mice drawer system (MDS) program, sponsored by Italian Space Agency, for the...