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From:PLoS ONE (Vol. 8, Issue 5) Peer-ReviewedB. burgdorferi sensu stricto, B. afzelii, B. garinii and B. bavariensis are the principal species which account for Lyme borreliosis (LB) globally. We have developed an internally controlled duplex quantitative real...
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From:Science (Vol. 256, Issue 5064) Peer-ReviewedAs the summer heat rolls across the country, enticing people into the fields and forests, it brings with it the seasonal concern about Lyme disease. And although there isn't yet any surefire way to prevent the disease,...
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From:Expert Review of Vaccines (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): P Noel Barrett 1 * , Daniel Portsmouth 2 Keywords : Borrelia; borreliosis; lyme; Osp; OspA; tick; vaccine Lyme borreliosis (LB) is a multisystem inflammatory disease caused by infection with...
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From:The Western Journal of Medicine (Vol. 169, Issue 6) Peer-ReviewedA new vaccine against rotavirus (RotaShield, Wyeth-Lederle) has recently been licensed by the FDA. Licensure is expected for a new vaccine against Lyme disease in early 1999. Both vaccines will pose challenges to...
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From:Pediatrics (Vol. 105, Issue 6) Peer-ReviewedABBREVIATIONS. LD, Lyme disease; Osp A, outer surface protein A; ELISA, enzyme-linked immunosorbent assay. In 1977, Steere and colleagues[1] described a mysterious disease (in 39 children and 12 adults) characterized...
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From:Emerging Infectious Diseases (Vol. 5, Issue 3) Peer-ReviewedTo determine the cost effectiveness of vaccinating against Lyme disease, we used a decision tree to examine the impact on society of six key components. The main measure of outcome was the cost per case averted....
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From:Family Practice News (Vol. 29, Issue 12)NEW YORK -- Fears that the Lyme disease vaccine might trigger autoimmune arthritis loomed large at a meeting on the disease sponsored by the Lyme Disease Foundation. "I am concerned about the possible adverse effects...
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From:Consultant (Vol. 38, Issue 11) Peer-ReviewedTwo large scale clinical trials were conducted to determine the efficacy of a vaccine based on the outer-surface protein A of Borrelia burgdorferi, the causative organism. The investigators were A.C. Steere and coworkers...
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From:Expert Review of Vaccines (Vol. 2, Issue 5) Peer-ReviewedLess than 20 years elapsed between the 1982 report of the identification and isolation of Borrelia burgdorferi and the licensure and marketing in the USA of a prophylactic vaccine against this pathogen. However, the...
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From:Future Microbiology (Vol. 4, Issue 4)Author(s): Dean T Nardelli 1 , Erik L Munson 2 , Steven M Callister 3 , Ronald F Schell [[dagger]] 4 Keywords: Keywords Borrelia burgdorferi; Lyme disease; Lyme vaccine; OspA; OspC Lyme disease is a...
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From:Canadian Journal of Public Health (Vol. 108, Issue 1) Peer-ReviewedBACKGROUND: Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America. Currently, no vaccine is available to prevent LB in humans, although monovalent and multivalent vaccines have...
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From:The Science Teacher (Vol. 77, Issue 1) Peer-ReviewedA protein found in tick saliva helps protect mice from developing Lyme disease, Yale University researchers have discovered. The findings, published in Cell Host & Microbe, may spur development of a new vaccine for Lyme...
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From:PLoS ONE (Vol. 9, Issue 2) Peer-ReviewedAuthor(s): Christina M. Small, Dharani K. Ajithdoss **, Aline Rodrigues Hoffmann, Waithaka Mwangi, Maria D. Esteve-Gassent * Introduction Lyme disease (LD) is the most prevalent arthropod-borne infection in the...
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From:Clinical Advisor (Vol. 14, Issue 2)Why is there a canine Lyme disease immunization but nothing for humans?--JUANITA A. CARNES, FNP-BC, Westfield, Mass. A Lyme disease vaccine (LYMErix) was developed in the early 1990s and received FDA approval in...
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From:Expert Review of Vaccines (Vol. 1, Issue 1) Peer-ReviewedWhen a deer tick bites a human or other mammalian host, it takes more than 24 h before the Lyme disease bacterium travels from the tick's gut to the tick's salivary glands and then into the host. During that time,...
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From:Pediatrics (Vol. 108, Issue 1) Peer-ReviewedObjective. A recombinant lipoprotein outer surface protein A (OspA) Lyme disease (LD) vaccine (LYMErix) has been shown to be safe and effective in preventing LD in adults and in adolescents 15 years of age and older....
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From:PLoS ONE (Vol. 5, Issue 6) Peer-ReviewedBackground Over the past decade there has been increasing interest in the use of lactic acid bacteria as mucosal delivery vehicles for vaccine antigens, microbicides and therapeutics. We investigated the mechanism by...
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From:Expert Review of Vaccines (Vol. 12, Issue 9) Peer-ReviewedAuthor(s): P Noel Barrett 1 , Daniel Portsmouth 2 Keywords : Borrelia; Lyme borreliosis; OspA; tick; vaccine Lyme borreliosis (LB) is a multisystem inflammatory disease involving the skin, joints, heart and...
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From:The Journal of Musculoskeletal Medicine (Vol. 17, Issue 2) Peer-ReviewedSuggestions from the Advisory Committee on Immunization Practices The recent availability of the Lyme disease vaccine leaves many physicians--and patients--wondering just who should be immunized and when. According...
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From:Contemporary Pediatrics (Vol. 19, Issue 4) Peer-ReviewedJust in time for what is generally the beginning of deer tick season in early April--a season extended somewhat in the Northeast because of a mild winter--the only licensed Lyme disease vaccine has been pulled off the...