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    Academic Journals

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• Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity.

  Authors:Gregory Noel, Mireille Langouo Fontsa, Soizic Garaud, Pushpamali De Silva, Alexandre de Wind, Gert G. Van den Eynden, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 19) Peer-Reviewed

  Oct. 1, 202111,802 words Report 1490LWe previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13-producing T follicular helper (Tfh) cells....

• Neurological complications in late-stage hospitalized patients with HIV disease

  Authors:Rakendra Singh, Manjot Kaur, and Deepak AroraFrom:Annals of Indian Academy of Neurology (Vol. 14, Issue 3) Peer-Reviewed

  July-September 20113,954 words Clinical report 1700LByline: Rakendra. Singh, Manjot. Kaur, Deepak. Arora Background and Objective: The nervous system is the most frequent and serious targets of human immunodeficiency virus (HIV) infection. In spite of a wide...

• Tumor infiltrating cytotoxic CD8 T-Cells predict clinical outcome of neuroblastoma in children

  Authors:Mahtab Rahbar, Mitra Mehrazma, and Mersedeh KarimianFrom:Indian Journal of Medical and Paediatric Oncology (Vol. 39, Issue 2) Peer-Reviewed

  April-June 20183,662 words Report 1820LByline: Mahtab. Rahbar, Mitra. Mehrazma, Mersedeh. Karimian Context: Neuroblastoma is often infiltrated by inflammatory cells, particularly macrophages and T lymphocytes, but the significance of these cells remains...

• Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

  Authors:McLane J. Watson, Paolo D. A. Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, et al.From:Nature (Vol. 591, Issue 7851) Peer-Reviewed

  Mar. 25, 202112,296 words Report 1580LRegulatory T (T.sub.reg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity...

• Prognostic significance of tumor-infiltrating lymphocytes in oropharyngeal cancer

  Authors:Samer Rajjoub, Suzanne R. Basha, Eugene Einhorn, Marc C. Cohen, Doug M. Marvel, and Duane A. SewellFrom:Ear, Nose and Throat Journal (Vol. 86, Issue 8) Peer-Reviewed

  Aug. 20073,382 words Clinical report 1290LAbstract The presence of tumor-infiltrating lymphocytes has been shown to significantly improve clinical outcomes in many types of cancer. However, their effects on outcomes in patients with oropharyngeal cancer...

• Peripheral T cell expansion predicts tumour infiltration and clinical response.

  Authors:Thomas D. Wu, Shravan Madireddi, Patricia E. de Almeida, Romain Banchereau, Ying-Jiun J. Chen, Avantika S. Chitre, et al.From:Nature (Vol. 579, Issue 7798) Peer-Reviewed

  Mar. 202016,734 words Clinical report 1600LDespite the resounding clinical success in cancer treatment of antibodies that block the interaction of PD1 with its ligand PDL1.sup.1, the mechanisms involved remain unknown. A major limitation to understanding the...

• A novel cancer immunotherapy using tumor-infiltrating B cells in the APC.sup.min/+ mouse model

  Authors:Xinying Wang, Shohei Asami, and Daisuke KitamuraFrom:PLoS ONE (Vol. 16, Issue 1) Peer-Reviewed

  Jan. 19, 20217,169 words Report 1520LAccumulating evidence has suggested a correlation of tumor infiltrating B cells (TiBcs) and a good prognosis of cancer diseases. In some cases, TiBcs appear to have experienced antigen stimulation since they have...

• Requirement for the SLP-76 Adaptor GADS in T Cell Development

  Authors:Jeff Yoder, Christine Pham, Yoshie-Matsubayashi Iizuka, Osami Kanagawa, Stanley K. Liu, Jane McGlade, et al.From:Science (Vol. 291, Issue 5510) Peer-Reviewed

  Mar. 9, 20012,200 words Article GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation...

• Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype

  Authors:Kenichi Harano, Ying Wang, Bora Lim, Robert S. Seitz, Stephan W. Morris, Daniel B. Bailey, et al.From:PLoS ONE (Vol. 13, Issue 10) Peer-Reviewed

  Oct. 12, 20183,857 words Report 1440LIn patients with triple-negative breast cancer (TNBC), tumor-infiltrating lymphocytes (TILs) are associated with improved survival. Lehmann et al. identified 4 molecular subtypes of TNBC [basal-like (BL) 1, BL2,...

• Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set

  Authors:Kuo-Hao Ho, Chih-Ju Chang, Tzu-Wen Huang, Chwen-Ming Shih, Ann-Jeng Liu, Peng-Hsu Chen, et al.From:PLoS ONE (Vol. 13, Issue 12) Peer-Reviewed

  Dec. 6, 20186,180 words Report 1520LTumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune...

• Tumor infiltrating lymphocytes in head and neck squamous cell carcinoma - Evaluation and clinical impact.

  Authors:Senjuti Dasgupta, Sudipta Chakrabarti, and Asit DebFrom:Journal of Cancer Research and Therapeutics (Vol. 18, Issue 1) Peer-Reviewed

  Jan-March 20223,077 words Report 1700LByline: Senjuti. Dasgupta, Sudipta. Chakrabarti, Asit. Deb Background: Head-and-neck squamous cell carcinomas (HNSCCs) are one of the most common malignancies worldwide. Emerging evidence reveals that...

• Cancer's other conduit: evidence suggests that some tumors sprout lymph vessels for metastasis

  Author:Steve BunkFrom:The Scientist (Vol. 17, Issue 17) Peer-Reviewed

  Sept. 8, 20031,567 words Article For years, scientists largely ignored the lymphatic system, instead focusing on blood vessels and their growth process, called angiogenesis. Only since the mid-1990s has knowledge started to accumulate about the...

• Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies

  Authors:Zuoan Yi, Ramiro Diz, Aaron J. Martin, Yves Maurice Morillon, Douglas E. Kline, Li Li, et al.From:Diabetes (Vol. 61, Issue 11) Peer-Reviewed

  Nov. 20125,699 words Report 1420LResidual [beta]-cells found at the time of clinical onset of type 1 diabetes are sufficient to control hyperglycemia if rescued from ongoing autoimmune destruction. The challenge, however, is to develop an immunotherapy...

• ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.

  Authors:John Alec Moral, Joanne Leung, Luis A. Rojas, Jennifer Ruan, Julia Zhao, Zachary Sethna, et al.From:Nature (Vol. 579, Issue 7797) Peer-Reviewed

  Mar. 202013,525 words Report 1650LGroup 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues.sup.1,2. Although ILC2s are found in cancers of these tissues.sup.3, their roles in cancer immunity and immunotherapy are...

• Targeting HIF-1[alpha] abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.

  Authors:Christopher M. Bailey, Yan Liu, Mingyue Liu, Xuexiang Du, Martin Devenport, Pan Zheng, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 9) Peer-Reviewed

  May 1, 20228,752 words Report 1350LA combination of anti-CTLA-4 plus anti-PD-1/PD-L1 is the most effective cancer immunotherapy but causes high incidence of immune-related adverse events (irAEs). Here we report that targeting of HIF-1[alpha] suppressed...

• Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma.

  Authors:Haiting Zhou, Yi He, Lingling Li, Cheng Wu, and Guoqing HuFrom:BioMed Research International (Vol. 2020) Peer-Reviewed

  Nov. 24, 20207,592 words Report 1390LLung adenocarcinoma (LUAD) is a major pathological type of lung cancer. Understanding the mechanism of LUAD at the molecular level is important for a clinical decision. In this study, we use bioinformatic analysis to...

• Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8.sup.+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

  Authors:Jessica Ann Chacon, Richard C. Wu, Pariya Sukhumalchandra, Jeffrey J. Molldrem, Amod Sarnaik, Shari Pilon-Thomas, et al.From:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 1, 201310,745 words Report 1610LAuthor(s): Jessica Ann Chacon 1 , 2 , Richard C. Wu 1 , 2 , Pariya Sukhumalchandra 3 , Jeffrey J. Molldrem 2 , 3 , Amod Sarnaik 4 , Shari Pilon-Thomas 4 , Jeffrey Weber 4 , Patrick Hwu 1 , 2 , Laszlo Radvanyi 1 , 2 , *...

• PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes

  Authors:Bin Liu, Yoshiki Arakawa, Ryuta Yokogawa, Shinya Tokunaga, Yukinori Terada, Daiki Murata, et al.From:PLoS ONE (Vol. 13, Issue 4) Peer-Reviewed

  Apr. 4, 20186,070 words Report 1330LOne histopathological characteristic of intracranial germinoma is abundant tumor-infiltrating lymphocytes (TILs) showing a two-cell pattern with large undifferentiated tumor cells. The programmed cell death 1...

• Actively personalized vaccination trial for newly diagnosed glioblastoma

  Authors:Norbert Hilf, Sabrina Kuttruff-Coqui, Katrin Frenzel, Valesca Bukur, Stefan Stevanovic, Cecile Gouttefangeas, et al.From:Nature (Vol. 565, Issue 7738) Peer-Reviewed

  Jan. 201915,301 words Clinical report 1510LPatients with glioblastoma currently do not sufficiently benefit from recent breakthroughs in cancer treatment that use checkpoint inhibitors.sup.1,2. For treatments using checkpoint inhibitors to be successful, a high...

• Role of CD4/CD8 ratio on the incidence of tuberculosis in HIV-infected patients on antiretroviral therapy followed up for more than a decade

  Authors:Dawit Wolday, Yazezew Kebede, Dorsisa Legesse, Dawd S. Siraj, Joseph A. McBride, Mitchell J. Kirsch, et al.From:PLoS ONE (Vol. 15, Issue 5) Peer-Reviewed

  May 22, 20205,301 words Report 1450LAuthor(s): Dawit Wolday 1,*, Yazezew Kebede 1, Dorsisa Legesse 2, Dawd S. Siraj 3, Joseph A. McBride 3, Mitchell J. Kirsch 3, Robert Striker 3 Introduction Cumulative findings have demonstrated that antiretroviral...