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From:Expert Review of Clinical Immunology (Vol. 3, Issue 3) Peer-ReviewedAuthor(s): Sarah M Burke 1 , Jean S Marshall [[dagger]] 2 The Keystone meeting entitled 'Mast cells, Basophils and IgE' was held in the wonderful Copper Mountain resort, CO, USA, from January 20th to 24th, organized...
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From:Fibrogenesis & Tissue Repair (Vol. 3) Peer-ReviewedBackground Idiopathic arthrofibrosis occurs in 3-4% of patients who undergo total knee arthroplasty (TKA). However, little is known about the cellular or molecular changes involved in the onset or progression of this...
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From:Journal of Hematology & Oncology (Vol. 4) Peer-ReviewedMast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every organ system,...
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From:Review of Optometry (Vol. 138, Issue 4) Peer-ReviewedThe latest research studies on efficacy and patient comfort show why your first-line prescription preparation for ocular allergy should be a mast cell stabilizer/antihistamine combination. BY the time patients with...
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From:Journal of Clinical Investigation (Vol. 121, Issue 8) Peer-ReviewedAsthma is considered a Th2 cell-associated disorder. Despite this, both the Th1 cell-associated cytokine IFN-[gamma] and airway neutrophilia have been implicated in severe asthma. To investigate the relative...
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From:PLoS ONE (Vol. 15, Issue 10) Peer-ReviewedOccupational exposure to toxic chemicals increases the risk of developing localized provoked vulvodynia-a prevalent, yet poorly understood, chronic condition characterized by sensitivity to touch and pressure, and...
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From:PLoS ONE (Vol. 11, Issue 12) Peer-ReviewedHere we addressed the potential impact of chymase, a mast-cell restricted protease, on mouse bone phenotype. We show that female mice lacking the chymase Mcpt4 acquired a persistent expansion of diaphyseal bone in...
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From:Journal of Clinical Investigation (Vol. 125, Issue 7) Peer-ReviewedMast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and...
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From:Immunotherapy (Vol. 3, Issue 6) Peer-ReviewedResearchers from King'âs College London (UK) have published a detailed model of the structure of an IgE molecule bound to a mast cell, sparking excitement in the asthma community. It is hoped that this new level of...
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From:Indian Journal of Pharmacology (Vol. 39, Issue 2) Peer-ReviewedByline: A. Kumar, K. Elango, S. Markanday, C. Undhad, A. Kotadiya, B. Savaliya, D. Vyas, D. Datta Coleus aromaticus Benth ., (Lamiaceae), syn. Coleus amboinicus (Lour.) Spreng. or Plectranthus ambonicus Lour, is...
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From:Journal of Clinical Investigation (Vol. 126, Issue 11) Peer-ReviewedRush desensitization (DS) is a widely used and effective clinical strategy for the rapid inhibition of IgE-mediated anaphylactic responses. However, the cellular targets and underlying mechanisms behind this process...
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From:Journal of Clinical Investigation (Vol. 116, Issue 5) Peer-ReviewedWhen exposed to a pathogen, a naive [CD4.sup.+] T cell is forced to make a cell fate decision that leads to a polarized population of Th1 IFN-[gamma]- or Th2 IL-4--producing cells. Although IL-4 has traditionally been...
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From:Journal of Clinical Investigation (Vol. 116, Issue 4) Peer-ReviewedHaving identified renin in cardiac mast cells, we assessed whether its release leads to cardiac dysfunction. In Langendorff-perfused guinea pig hearts, mast cell degranulation with compound 48/80 released Ang I-forming...
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From:Biochemistry (Moscow) (Vol. 82, Issue 12) Peer-ReviewedThe therapeutic effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl)decyltriphenylphosphonium bromide (SkQ1) in experimental models of acute inflammation and wound repair has been shown earlier. It was...
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From:Allergy, Asthma & Clinical Immunology (Vol. 4) Peer-ReviewedAlthough there is much circumstantial evidence implicating eosinophils as major orchestrators in the pathophysiology of asthma, recent studies have cast doubt on their importance. Not only does anti-interleukin-5...
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From:PLoS ONE (Vol. 11, Issue 11) Peer-ReviewedBackground Mast cells (MC) are bone marrow derived haematopoetic cells playing a crucial role not only in immune response but also in the tumor microenvironment with protumorigenic and antitumorigenic functions. The...
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From:PLoS ONE (Vol. 12, Issue 3) Peer-ReviewedMast cells (MCs) participate in all stages of skin healing and one of their mediators is the Annexin A1 protein (AnxA1), linked to inflammation, proliferation, migration and apoptosis processes, but not studied in...
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From:PLoS ONE (Vol. 13, Issue 4) Peer-ReviewedMRL/MpJ mice have abundant ovarian mast cells (MCs) as compared with other strains at postnatal day 0 (P0); however, they sharply decrease after birth. These ovarian MCs, particularly beneath the ovarian surface...
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From:Neural Regeneration Research (Vol. 16, Issue 11) Peer-ReviewedByline: Piplu. Bhuiyan, Yi-Wei. Wang, Huan-Huan. Sha, Hong-Quan. Dong, Yan-Ning. Qian Corticotropin-releasing hormone is a critical component of the hypothalamic-pituitary-adrenal axis, which plays a major role in the...
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From:Thorax (Vol. 57, Issue 12) Peer-Reviewed[S55] EXPRESSION OF TRANSFORMING GROWTH FACTOR ISOFORMS IN HUMAN AIRWAY SMOOTH MUSCLE AND NORMAL LUNG TISSUE B. Islam, D. Bradbury, L. Corbett, I. Soomro, J. Ronan, A. Knox. (1) Division of Respiratory Medicine; (2)...