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From:International Journal of RheumatologyPeer-ReviewedWe evaluated changes in gene expression of mTOR, p21, caspase-3, ULK1, TNF[alpha], matrixmetalloproteinase (MMP)-9, and cathepsin K in the whole blood of rheumatoid arthritic (RA) patients treated with methotrexate...
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From:Pharmacogenomics (Vol. 13, Issue 14) Peer-ReviewedAuthor(s): Petra Bohanec Grabar 1 , Luis J Leandro-García 2 , Lucía Inglada-Pérez 2 3 , Dušan Logar 4 , Cristina Rodríguez-Antona 2 3 , Vita Dolzan [*] 5 KEYWORDS : methotrexate; polymorphism; reduced...
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From:Reactions Weekly (Issue 1289)[S] A 54-year-old man with cutaneous and arthritic psoriasis developed skin ulcers and eventration during treatment with methotrexate. In July 2004, the man experienced a psoriasis exacerbation and started...
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From:Reactions Weekly (Issue 1293)[S] A 55-year-old woman developed Kaposi's sarcoma (KS) during ciclosporin, methylprednisolone and methotrexate therapy for arthritis. The woman, who was diagnosed with undifferentiated arthritis in April 2001,...
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From:Reactions Weekly (Issue 1315)[S] Multiple congenital anomalies, including holoprosencephaly and hydronephrosis, occurred in a male neonate following in utero exposure to methotrexate, which his mother had received for suspected systemic lupus...
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From:Reactions Weekly (Issue 1323)A 49-year-old woman with plaque psoriasis self-administered methotrexate 5 mg/day for 4 days [route not stated]. Two days later, she developed three painful plaques in her antecubital fossae and right axilla associated...
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From:Reactions Weekly (Issue 1331)Paudyal B, et al. A case of low-dose oral methotrexate-induced reversible neurotoxicity. American Journal of Neuroradiology 31: E77, No. 9, Oct 2010. Available from: URL: http://dx.doi.org/10.3174/ajnr.a2191--USA...
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From:Biomedical Research (Vol. 20, Issue 1) Peer-ReviewedByline: Ajit. Saxena, Divya. Singh, Gajendra. Singh Drug like methotrexate were used in the present study because of dual impor-tance, both for clinicians as well as an interest of basic scientists. Methotrexate, an...
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From:Expert Review of Clinical Immunology (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Graeme Jones 1 Keywords : IL-6; rheumatoid; tocilizumab; trial Rheumatoid arthritis (RA) is the most common type of inflammatory arthritis. There have been a number of nonbiologic disease...
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From:Reactions Weekly (Issue 1249)[*][S] A 21-year-old man with a arthritis developed thymic hyperplasia, mediastinal lymphadenopathy and pleurisy during treatment with etanercept. The man, who had a 15-year history of juvenile idiopathic...
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From:Reactions Weekly (Issue 1262)The results of a systematic literature review* do not suggest serious toxicity problems with long-term use of methotrexate monotherapy at relatively low dosages in patients with rheumatoid arthritis. The researchers...
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From:Reactions Weekly (Issue 1280)[X][S] A 14-year-old boy with mediastinal T lymphoblastic lymphoma developed kidney disorders whilst receiving methotrexate and glutamine concomitantly. The boy received his third cycle of methotrexate (5...
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From:Expert Review of Dermatology (Vol. 3, Issue 3) Peer-ReviewedAuthor(s): Stamatis Gregoriou [[dagger]] 1 , Dimitris Kalogeromitros 2 , Nikolaos Kosionis 3 , Aikaterini Gkouvi 4 , Dimitris Rigopoulos 5 Keywords: 5-fluorouracil; acitretin; alefacept; anthralin; calcipotriol;...
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From:MPR Hematology and Oncology Edition (Vol. 2, Issue 4)PRESCRIBING NOTES Ethyol is dephosphorylated to the active free thiol metabolite form which is able to bind and detoxify reactive metabolites of cisplatin and scavenge reactive oxygen species generated by exposure to...
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From:Expert Review of Clinical Immunology (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Gary Kunkel [[dagger]] 1 , Grant W Cannon 1 Keywords: clinical trials; juvenile rheumatoid arthritis; leflunomide; rheumatoid arthritis Rheumatoid arthritis (RA) is a chronic, disabling disease that...
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From:British Medical Journal (Vol. 326, Issue 7383) Peer-ReviewedMethotrexate is an antimetabolite that, apart from its use in malignant disorders, is taken orally in low doses for the control of conditions such as rheumatoid arthritis and psoriasis. When used in chemotherapy it...
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From:Indian Journal of Pharmacology (Vol. 48, Issue 3) Peer-ReviewedByline: Sadaf. Karbelkar, Anuradha. Majumdar Objective: Intestinal mucositis is a significant problem haunting clinicians for decades. One of the major reasons for its occurrence is high-dose chemotherapy. The study...
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From:PLoS ONE (Vol. 9, Issue 3) Peer-ReviewedAuthor(s): The PLOS ONE staff There are multiple errors in the Funding statement. The Funding statement should read: "This work was supported by Natural Science Foundation of China (NSFC) (grant #81202598), Shanghai...
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From:PLoS ONE (Vol. 9, Issue 2) Peer-ReviewedAuthor(s): Ahmed F. Hawwa 1,2, AbdelQader AlBawab 1, Madeleine Rooney 3, Lucy R. Wedderburn 4,5, Michael W. Beresford 6, James C. McElnay 1,* Introduction Juvenile idiopathic arthritis (JIA) and Juvenile...
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From:Indian Journal of Pharmacology (Vol. 49, Issue 1) Peer-Reviewed
A study of the use of drugs in patients suffering from psoriasis and their impact on quality of life
Byline: V. Karamata, A. Gandhi, P. Patel, A. Sutaria, M. Desai Objective: To study the use of drugs in patients suffering from psoriasis and their effect on quality of life (QOL). Materials and Methods: This was a...