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Academic Journals
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From:Biochemistry (Moscow) (Vol. 79, Issue 13) Peer-ReviewedMost of the mammalian genome consists of nucleotide sequences not coding for proteins. Exons of genes make up only 3% of the human genome, while the significance of most other sequences remains unknown. Recent genome...
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From:Epigenomics (Vol. 7, Issue 4) Peer-ReviewedAuthor(s): Sun-Min Lee aff1 , Won-Young Choi aff2 , Jungwoo Lee aff2 , Young-Joon Kim [*] aff1 aff2 Keywords: cancer; gene body methylation; splicing; transcriptional elongation DNA methylation has crucial...
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From:Epigenomics (Vol. 4, Issue 3) Peer-ReviewedAuthor(s): James B Kirkbride [*] 1 2 3 , Ezra Susser 2 3 , Marija Kundakovic 2 3 4 , Jacob K Kresovich 2 3 , George Davey Smith 5 , Caroline L Relton 6 KEYWORDS : Agouti; DNA methylation; epigenetic...
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From:Environmental Health Perspectives (Vol. 119, Issue 9) Peer-ReviewedIngested inorganic arsenic (InAs) is methylated to monomethylated (MMA) and dimethylated (DMA) metabolites. Methylation may play an important role in arsenic toxicity because the monomethylated trivalcnt metabolite...
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From:Expert Review of Proteomics (Vol. 6, Issue 2) Peer-ReviewedA study carried out through a collaboration between researchers at the Cardiovascular Proteomics Center at Boston University School of Medicine, the Whitaker Cardiovascular Institute at Boston University School of...
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From:Epigenomics (Vol. 2, Issue 2) Peer-ReviewedThis finding will have an impact on our understanding of the origins of individual phenotypic differences and will have implications for future genetic studies of complex disease. The February 2010 issue of the...
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From:Epigenomics (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Hideharu Hashimoto 1 , Paula M Vertino 2 3 , Xiaodong Cheng [[dagger]] 4 KEYWORDS : ADD; CpG-binding domain; CXXC; H3K4me0-binding domain; hemi-methyl-CpG-binding domain; MBD; methyl-CpG-binding...
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From:Epigenomics (Vol. 3, Issue 6) Peer-ReviewedAuthor(s): Mawussi Adjakly 1 2 3 , Rémy Bosviel 1 2 3 , Nadège Rabiau 1 2 3 , Jean-Paul Boiteux 2 3 4 , Yves-Jean Bignon [**] 5 , Laurent Guy 2 3 4 , Dominique Bernard-Gallon 1 2 3 KEYWORDS : DNA...
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From:Biomarkers in Medicine (Vol. 2, Issue 4) Peer-ReviewedAuthor(s): Guntram Schernthaner 1 , Katarzyna Krzyzanowska [[dagger]] 2 The endogenous competitive nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) is a naturally occurring amino acid [1] . It...
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From:Pharmacogenomics (Vol. 9, Issue 12) Peer-ReviewedAuthor(s): Adam JW Paige [[dagger]] 1 , Robert Brown 1 KEYWORDS: drug resistance; miRNA; polymorphisms; promoter methylation Ovarian cancer is the fourth most common tumor type in women in the UK, with...
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From:Environmental Health Perspectives (Vol. 117, Issue 8) Peer-ReviewedIn their article, Tarantini et al. (2009) focused on the basic question of mutual relationships between environmental and genetic factors. From a more general point of view, this also involves the question concerning...
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From:Regenerative Medicine (Vol. 2, Issue 2)Author(s): Lorraine E Young [[dagger]] 1 , Chris Denning 1 Keywords: differentiation; DNA methylation; gene repression and silencing; germ cell nuclear factor; methyl-binding domain proteins; Oct4; pluripotency...
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From:Expert Review of Molecular Diagnostics (Vol. 2, Issue 2) Peer-ReviewedAuthor(s): Alison Kraus, Marcus Schuermann 2 Keywords: early detection; methylation; molecular screening; oncogene; PCR; PNA-clamping; tumor markers Author Affiliation(s): 2 'Klinik für Hämatologie,...
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From:The Scientist (Vol. 17, Issue 12) Peer-ReviewedWhen good genes go bad and cancer arises, mutation normally gets the blame. But, newer evidence is challenging that one-dimensional view. Epigenetic modifications, such as DNA methylation, can also shut down tumor...
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From:Proceedings of the North Dakota Academy of Science (Vol. 67) Peer-ReviewedMethylation reactions are important for the establishment and maintenance of epigenetic methylation tags on DNA and histone molecules critical for the development and life-long function of an organism. Global DNA...
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From:Science (Vol. 252, Issue 5009) Peer-ReviewedTHE FRAGILE X SYNDROME MAY BE THE MOST FREQUENT cause of inherited mental retardation; the incidence is about 1 in 1500 males and 1 in 2500 females [1, 2]. The diagnosis is based on the presence in a variable proportion...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedAuthor(s): Katja Hebestreit 1 , Sören Gröttrup 1 , Daniel Emden 1 , Jannis Veerkamp 1 , Christian Ruckert 1 , Hans-Ulrich Klein 1 , Carsten Müller-Tidow 2 , Martin Dugas 1 , * Introduction Recent advances in...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedAuthor(s): Yu-Wen Zhang 1 , * , Ben Staal 1 , Karl J. Dykema 2 , Kyle A. Furge 2 , George F. Vande Woude 1 , * Introduction Mitogen inducible gene 6 (MIG-6 ) (also known as gene 33, ERRFI1 , or RALT ) is an...
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From:PLoS ONE (Vol. 7, Issue 1) Peer-ReviewedAuthor(s): Yong Jae Shin, Jeong-Ho Kim * Introduction Metastasis-the spread of cancer cells from a primary site to other parts of the body-is a common feature of malignant tumors. The process of cancer metastasis...
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From:PLoS ONE (Vol. 7, Issue 2) Peer-ReviewedAuthor(s): Martin Braunschweig 1 , * , Vidhya Jagannathan 1 , Andreas Gutzwiller 2 , Giuseppe Bee 2 Introduction There is a growing body of evidence that environmental effects including nutrition affect the...