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    Academic Journals

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• Mannose-binding lectin and the balance between immune protection and complication

  Author:Kazue TakahashiFrom:Expert Review of Anti-infective Therapy (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 20119,593 words Article 1500LAuthor(s): Kazue Takahashi 1 Keywords : coagulation; complement; deficiency; infection; inflammation; mannose-binding lectin; MASP; pattern recognition molecules Innate immunity is the front-line of the host...

• Mannose-Binding Lectin Regulates Host Resistance and Pathology during Experimental Infection with Trypanosoma cruzi

  Authors:Antonio Gigliotti Rothfuchs, Ester Roffe, Amanda Gibson, Allen W. Cheever, R. Alan B. Ezekowitz, Kazue Takahashi, et al.From:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 6, 20126,143 words Article 1470LAuthor(s): Antonio Gigliotti Rothfuchs 1 , 5 , * , Ester Roffê 2 , Amanda Gibson 1 , Allen W. Cheever 1 , 3 , R. Alan B. Ezekowitz 4 , Kazue Takahashi 4 , Mario Steindel 6 , Alan Sher 1 , André Báfica 6 , *...

• Identification of Poly(ADP-Ribose) Polymerase-1 as a Cell Cycle Regulator through Modulating Sp1 Mediated Transcription in Human Hepatoma Cells

  Authors:Liu Yang, Kun Huang, Xiangrao Li, Meng Du, Xiang Kang, Xi Luo, et al.From:PLoS ONE (Vol. 8, Issue 12) Peer-Reviewed

  Dec. 19, 20136,330 words Article 1500LAuthor(s): Liu Yang 1, Kun Huang 1,2, Xiangrao Li 1, Meng Du 1, Xiang Kang 3, Xi Luo 1, Lu Gao 1, Cheng Wang 1, Yanqing Zhang 1, Chun Zhang 2, Qiangsong Tong 2, Kai Huang 1,2,*, Fengxiao Zhang 1,2,*, Dan Huang 1,2,*...

• Mannose-Binding Lectin Blunts Macrophage Polarization and Ameliorates Lupus Nephritis

  Authors:Yanxing Cai, Weijuan Zhang, and Sidong XiongFrom:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 23, 20137,819 words Article 1530LAuthor(s): Yanxing Cai 1, Weijuan Zhang 1, Sidong Xiong 1,2,* Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of various autoantibodes, complement...

• New conjugates of quinoxaline as potent antitubercular and antibacterial agents

  Authors:Ramalingam Peraman, Rajendran Kuppusamy, Sunil Kumar Killi, and Y. Padmanabha ReddyFrom:International Journal of Medicinal ChemistryPeer-Reviewed

  Annual 20164,012 words Report 1410LConsidering quinoxaline as a privileged structure for the design of potent intercalating agents, some new sugar conjugates of quinoxaline were synthesized and characterized by IR, [sup.1]HNMR, [sup.13]C NMR, and mass...

• The evolving landscape of predictive biomarkers of response to PARP inhibitors

  Authors:Anish Thomas, Junko Murai, and Yves PommierFrom:Journal of Clinical Investigation (Vol. 128, Issue 5) Peer-Reviewed

  May 20182,423 words Article 1400LPoly(ADP-ribose) polymerase inhibitors (PARPis) are DNA-damaging agents that trap PARP-DNA complexes and interfere with DNA replication. Three PARPis--olaparib, niraparib, and rucaparib--were recently approved by the...

• New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment.

  Authors:Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato, and Angela CelettiFrom:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-Reviewed

  Feb. 22, 20196,332 words Article 1680LBackground Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer...

• Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis.

  Authors:Noha M. Hammad, Nissreen E. El Badawy, Ashraf M. Nasr, Hamed A. Ghramh, and Laila M. Al KadyFrom:BioMed Research International (Vol. 2018) Peer-Reviewed

  Annual 20185,512 words Article 1470LRecurrent vulvovaginal candidiasis (RVVC) is a common illness influencing childbearing women worldwide. Most women suffering from RVVC develop infection without specified risk factors. Mannose-binding lectin (MBL) is an...

• Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells

  Authors:Chia-Woei Wang, Chien-Kai Wang, Yu-Jia Chang, Chen-Yen Choong, Chi-Shian Lin, Cheng-Jeng Tai, et al.From:Evidence - Based Complementary and Alternative Medicine (Vol. 2015) Peer-Reviewed

  Annual 20154,397 words Article 1600LFermented wheat germ extract (FWGE) is a nutrient supplement and a potential antitumor ingredient for developing an integrated chemotherapy with standard chemotherapeutic drugs for treating ovarian cancer patients. In...

• Potassium channel KCN11 is required for maintaining cellular osmolarity during nitrogen starvation to control proper cell physiology and TAG accumulation in Chlamydomonas reinhardtii.

  Authors:Feifei Xu and Junmin PanFrom:Biotechnology for Biofuels (Vol. 13, Issue 1) Peer-Reviewed

  July 20, 20205,658 words Article 1350LBackground Nitrogen (N) starvation in algae induces a variety of structural and metabolic changes including accumulation of triacylglycerol (TAG). Given the promising prospect of using algae as feedstock for biofuel...

• miR-223-3p Inhibits Antigen Endocytosis and Presentation and Promotes the Tolerogenic Potential of Dendritic Cells through Targeting Mannose Receptor Signaling and Rhob.

  Authors:Hao-Cheng Tang, Yin-Yan Lai, Jing Zheng, Hong-Yan Jiang, and Geng XuFrom:Journal of Immunology Research (Vol. 2020) Peer-Reviewed

  June 30, 20206,152 words Article 1410LBackground. The role of miR-223-3p in dendritic cells (DCs) is unknown. This study is aimed at investigating the effect of miR-223-3p on the antigen uptake and presentation capacities of DCs and the underlying molecular...

• Cell-based and cell-free biocatalysis for the production of d-glucaric acid

  Authors:Lu-Zhou Chen, Si-Ling Huang, Jin Hou, Xue-Ping Guo, Feng-Shan Wang, and Ju-Zheng ShengFrom:Biotechnology for Biofuels (Vol. 13, Issue 1) Peer-Reviewed

  Dec. 10, 20206,409 words Report 1470Ld-Glucaric acid (GA) is a value-added chemical produced from biomass, and has potential applications as a versatile platform chemical, food additive, metal sequestering agent, and therapeutic agent. Marketed GA is...

• Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis

  Authors:Anna P. Lucarelli, Silvia Buroni, Maria R. Pasca, Menico Rizzi, Andrea Cavagnino, Giovanna Valentini, et al.From:PLoS ONE (Vol. 5, Issue 11) Peer-Reviewed

  Nov. 15, 20108,108 words Article 1550LThe selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Currently, there is an urgent need for new...

• Acetylcholine Promotes Ca.sup.2+and NO-Oscillations in Adipocytes Implicating Ca.sup.2+[right arrow]NO[right arrow]cGMP[right arrow]cADP-ribose[right arrow]Ca.sup.2+ Positive Feedback Loop - Modulatory Effects of Norepinephrine and Atrial Natriuretic Peptide

  Authors:Egor A. Turovsky, Mariya V. Turovskaya, Ludmila P. Dolgacheva, Valery P. Zinchenko, and Vladimir V. DynnikFrom:PLoS ONE (Vol. 8, Issue 5) Peer-Reviewed

  May 16, 201314,715 words Article 1570LPurpose This study investigated possible mechanisms of autoregulation of Ca.sup.2+ signalling pathways in adipocytes responsible for Ca.sup.2+ and NO oscillations and switching phenomena promoted by acetylcholine...

• Effect of Differential N-linked and O-linked Mannosylation on Recognition of Fungal Antigens by Dendritic Cells

  Authors:Jennifer S. Lam, Haibin Huang, and Stuart M. LevitzFrom:PLoS ONE (Vol. 2, Issue 10) Peer-Reviewed

  Oct. 10, 20074,794 words Article 1430LBackground An experimental approach for improving vaccine efficacy involves targeting antigens to mannose receptors (MRs) on dendritic cells (DCs) and other professional antigen presenting cells. Previously, we...

• Diversity and Physiological Characterization of D-Xylose-Fermenting Yeasts Isolated from the Brazilian Amazonian Forest

  Authors:Raquel M. Cadete, Monaliza A. Melo, Kelly J. Dussan, Rita C. L. B. Rodrigues, Silvio S. Silva, Jerri E. Zilli, et al.From:PLoS ONE (Vol. 7, Issue 8) Peer-Reviewed

  Aug. 13, 20128,999 words Article 1620LBackground This study is the first to investigate the Brazilian Amazonian Forest to identify new D-xylose-fermenting yeasts that might potentially be used in the production of ethanol from sugarcane bagasse...

• Divergent Effects of Mycobacterial Cell Wall Glycolipids on Maturation and Function of Human Monocyte-Derived Dendritic Cells

  Authors:Jolanta Mazurek, Lech Ignatowicz, Gunilla Kallenius, Stefan B. Svenson, Andrzej Pawlowski, and Beston HamasurFrom:PLoS ONE (Vol. 7, Issue 8) Peer-Reviewed

  Aug. 3, 20129,766 words Article 1510LBackground Mycobacterium tuberculosis (Mtb) is able to evade the immune defenses and may persist for years, decades and even lifelong in the infected host. Mtb cell wall components may contribute to such persistence...

• Apoptotic and Autophagic Effects of Sesbania grandiflora Flowers in Human Leukemic Cells

  Authors:Rajneeta Roy, Deepak Kumar, Biswajit Chakraborty, Chinmay Chowdhury, and Padma DasFrom:PLoS ONE (Vol. 8, Issue 8) Peer-Reviewed

  Aug. 13, 201312,600 words Article 1380LBackground Identification of cytotoxic compounds that induce apoptosis has been the mainstay of anti-cancer therapeutics for several decades. In recent years, focus has shifted to inducing multiple modes of cell...

• Ethanol production from mixtures of wheat straw and wheat meal

  Authors:Borbala Erdei, Zsolt Barta, Balint Sipos, Kati Reczey, Mats Galbe, and Guido ZacchiFrom:Biotechnology for Biofuels (Vol. 3) Peer-Reviewed

  July 2, 20105,735 words Report Background Bioethanol can be produced from sugar-rich, starch-rich (first generation; 1G) or lignocellulosic (second generation; 2G) raw materials. Integration of 2G ethanol with 1G could facilitate the introduction...

• Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1

  Authors:Xiangduo Kong, Jared Stephens, Alexander R. Ball, Jason T. Heale, Daniel A. Newkirk, Michael W. Berns, et al.From:PLoS ONE (Vol. 6, Issue 8) Peer-Reviewed

  Aug. 12, 20114,377 words Article 1470LCondensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair....