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• Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy

  Authors:Takashi Kasai, Takahiko Tokuda, Takuma Ohmichi, Ryotaro Ishii, Harutsugu Tatebe, Masanori Nakagawa, et al.From:PLoS ONE (Vol. 11, Issue 1) Peer-Reviewed

  Jan. 26, 20162,925 words Report 1450LThe COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this gene have recently been identified in families with multiple system atrophy (MSA). Moreover, specific...

• The Economic Costs of Progressive Supranuclear Palsy and Multiple System Atrophy in France, Germany and the United Kingdom

  Authors:Paul McCrone, Christine Anne Mary Payan, Martin Knapp, Albert Ludolph, Yves Agid, P. Nigel Leigh, et al.From:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 8, 20116,532 words Article 1290LProgressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are progressive disabling neurological conditions usually fatal within 10 years of onset. Little is known about the economic costs of these...

• Striatofrontal Deafferentiation in MSA-P: Evaluation with [.sup.18F]FDG Brain PET

  Authors:Hae Won Kim, Minyoung Oh, Jungsu S. Oh, Seung Jun Oh, Sang Ju Lee, Sun Ju Chung, et al.From:PLoS ONE (Vol. 12, Issue 1) Peer-Reviewed

  Jan. 13, 20175,113 words Report 1620LBackground Although cognitive impairment is not a consistent feature of multiple system atrophy (MSA), increasing evidence suggests that cognitive impairment is common in MSA with predominant parkinsonism (MSA-P). It...

• The hot cross bun sign

  Authors:A. Gulati, V. Virmani, P. Singh, and N. KhandelwalFrom:Neurology India (Vol. 57, Issue 1) Peer-Reviewed

  January-February 2009402 words Report Byline: A. Gulati, V. Virmani, P. Singh, N. Khandelwal Hot cross bun sign refers to the cruciform-shaped hyperintensity on T2W axial magnetic resonance images (MRI) in multisystem atrophy due to the selective loss of...

• Clinical utility of skin biopsy in differentiating between Parkinson's disease and multiple system atrophy

  Authors:Rie Haga, Kazuhiro Sugimoto, Haruo Nishijima, Yasuo Miki, Chieko Suzuki, Koichi Wakabayashi, et al.From:Parkinson's DiseasePeer-Reviewed

  Annual 20154,332 words Report 1390LBackground. It is often difficult to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), especially in their early stages. Objectives. To examine the clinical utility of histopathological analysis...

• Plasma homocysteine, vitamin B12 and folate levels in multiple system atrophy: A case-control study

  Authors:Shuyu Zhang, Changhe Shi, Chengyuan Mao, Bo Song, Haiman Hou, Jun Wu, et al.From:PLoS ONE (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 20, 20153,236 words Report 1360LBackground Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of [alpha]-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated...

• Acoustic Characteristics of Stridor in Multiple System Atrophy

  Authors:Dae Lim Koo, Jee Young Lee, Eun Yeon Joo, Seung Bong Hong, and Hyunwoo NamFrom:PLoS ONE (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 19, 20164,069 words Report 1270LNocturnal stridor is a breathing disorder prevalent in patients with multiple system atrophy (MSA). An improved understanding of this breathing disorder is essential since nocturnal stridor carries a poor prognosis (an...

• Genomic copy number variation analysis in multiple system atrophy

  Authors:Yuka Hama, Masataka Katsu, Ichigaku Takigawa, Ichiro Yabe, Masaaki Matsushima, Ikuko Takahashi, et al.From:Molecular Brain (Vol. 10, Issue 1) Peer-Reviewed

  Nov. 29, 20175,597 words Article 1360LGenomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements...

• FAS-Dependent Cell Death in [alpha]-Synuclein Transgenic Oligodendrocyte Models of Multiple System Atrophy

  Authors:Christine L. Kragh, Gwenaelle Fillon, Amanda Gysbers, Hanne D. Hansen, Manuela Neumann, Christiane Richter-Landsberg, et al.From:PLoS ONE (Vol. 8, Issue 1) Peer-Reviewed

  Jan. 25, 20136,702 words Report 1510LAuthor(s): Christine L. Kragh 1 , Gwenaëlle Fillon 2 , Amanda Gysbers 3 , Hanne D. Hansen 4 , Manuela Neumann 5 , Christiane Richter-Landsberg 6 , Christian Haass 2 , Bernard Zalc 7 , Catherine Lubetzki 7 , Wei-Ping Gai...

• Parkinson-plus patients--an unknown group with severe symptoms

  Authors:Anne-Christine Sjostrom, Bjorn Holmberg, and Peter StrangFrom:Journal of Neuroscience Nursing (Vol. 34, Issue 6) Peer-Reviewed

  Dec. 20024,190 words Article Abstract: The Parkinson-plus syndromes, which include multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), are still not well-known. Research concerning diagnosis and...

• Multiple System Atrophy: A Common Form of Atypical Parkinsonism: Multiple system atrophy is a rare, progressive neurodegenerative condition for which there is currently no cure

  Authors:Sudhisha Jala and Lisa DaitchFrom:Clinical Advisor (Vol. 21, Issue 11)

  Nov. 20181,532 words Cover story 1850LMultiple system atrophy (MSA) is a progressive neurodegenerative disorder with an unknown cause. Previously known as Shy-Drager syndrome, MSA is a form of atypical parkinsonism that primarily affects the autonomic...

• Abnormal Pulmonary Function and Respiratory Muscle Strength Findings in Chinese Patients with Parkinson's Disease and Multiple System Atrophy-Comparison with Normal Elderly

  Authors:Yao Wang, Wei-bo Shao, Li Gao, Jie Lu, Hao Gu, Li-hua Sun, et al.From:PLoS ONE (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 29, 20144,311 words Article 1530LBackground There have been limited comparative data regarding the investigations on pulmonary and respiratory muscle function in the patients with different parkinsonism disorders such as Parkinson's disease (PD) and...

• Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy

  Authors:Amanda Worker, Camilla Blain, Jozef Jarosz, K. Ray Chaudhuri, Gareth J. Barker, Steven C. R. Williams, et al.From:PLoS ONE (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 2, 20145,448 words Article 1740LObjective Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current...

• Meta-analysis of cerebrospinal fluid neuron-specific enolase levels in Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

  Authors:Takayuki Katayama, Jun Sawada, Kae Takahashi, Osamu Yahara, and Naoyuki HasebeFrom:Alzheimer's Research & Therapy (Vol. 13, Issue 1) Peer-Reviewed

  Oct. 5, 20213,733 words Report 1450LBackground This study examined the usefulness of cerebrospinal fluid (CSF) neuron-specific enolase (NSE) levels as a candidate biomarker of neurodegeneration in Alzheimer's disease (AD), Parkinson's disease (PD), PD...

• Multiple system atrophy: pathophysiology, treatment and nursing care

  Author:Joanne HardyFrom:Nursing Standard (Vol. 22, Issue 22) Peer-Reviewed

  Feb. 6, 20084,818 words Article 1460LSummary This article gives a brief overview of the symptoms and management of multiple system atrophy, a degenerative neurological condition causing parkinsonism, ataxia and autonomic dysfunction. It focuses on the...

• Diffusion-weighted MRI distinguishes Parkinson disease from the parkinsonian variant of multiple system atrophy: A systematic review and meta-analysis

  Authors:Sweta Bajaj, Florian Krismer, Jose-Alberto Palma, Gregor K. Wenning, Horacio Kaufmann, Werner Poewe, et al.From:PLoS ONE (Vol. 12, Issue 12) Peer-Reviewed

  Dec. 29, 20173,190 words Report 1670LBackground Putaminal diffusivity in brain magnetic resonance diffusion-weighted imaging (DWI) is increased in patients with the parkinsonian variant of multiple system atrophy (MSA-P) compared to Parkinson disease...

• Copy number loss of (src homology 2 domain containing)-transforming protein 2 ( SHC2 ) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy

  Authors:Hidenao Sasaki, Mitsuru Emi, Hiroshi Iijima, Noriko Ito, Hidenori Sato, Ichiro Yabe, et al.From:Molecular Brain (Vol. 4) Peer-Reviewed

  June 10, 20115,827 words Report 1410LBackground Multiple system atrophy (MSA) is a sporadic disease. Its pathogenesis may involve multiple genetic and nongenetic factors, but its etiology remains largely unknown. We hypothesized that the genome of a...

• Proinflammatory Cytokines Are Elevated in Serum of Patients with Multiple System Atrophy

  Authors:Eli Kaufman, Sara Hall, Yulia Surova, Hakan Widner, Oskar Hansson, and Daniel LindqvistFrom:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 23, 20133,271 words Article 1420LAuthor(s): Eli Kaufman 1, Sara Hall 2,3, Yulia Surova 2,3, Håkan Widner 2,3, Oskar Hansson 3,4, Daniel Lindqvist 1,5,* Introduction Multiple System Atrophy (MSA) is an adult-onset, neurodegenerative disease with...

• Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection

  Authors:Sylvia Stemberger, Angelika Jamnig, Nadia Stefanova, Gunter Lepperdinger, Markus Reindl, and Gregor K. WenningFrom:PLoS ONE (Vol. 6, Issue 5) Peer-Reviewed

  May 18, 20118,225 words Article 1560LBackground Mesenchymal stem cells (MSC) are currently strong candidates for cell-based therapies. They are well known for their differentiation potential and immunoregulatory properties and have been proven to be...

• Safety and preliminary efficacy of intranasal insulin for cognitive impairment in Parkinson disease and multiple system atrophy: A double-blinded placebo-controlled pilot study

  Authors:Peter Novak, Daniela Arantxa Pimentel Maldonado, and Vera NovakFrom:PLoS ONE (Vol. 14, Issue 4) Peer-Reviewed

  Apr. 25, 20194,926 words Report 1400LParkinson disease (PD) is associated with cognitive impairment. We aimed to determine the effects of intranasal insulin (INI) on cognition and motor performance in PD. This was a proof of concept, randomized,...