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    Academic Journals

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• Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle

  Authors:Satyanarayana Rachagani, Ye Cheng, and James M. ReecyFrom:BMC Research Notes (Vol. 3) Peer-Reviewed

  Nov. 11, 20103,007 words Clinical report 1420LBackground Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that...

• Effect of ZFN-edited myostatin loss-of-function mutation on gut microbiota in Meishan pigs

  Authors:Wen-Tao Cui, Gao-Jun Xiao, Sheng-Wang Jiang, Li-Li Qian, Chun-Bo Cai, Biao Li, et al.From:PLoS ONE (Vol. 14, Issue 1) Peer-Reviewed

  Jan. 15, 20194,920 words Report 1410LIntestine contains the body's second largest genetic information, so a relatively stable microbiota ecosystems and interactions between intestinal micro-organisms play a pivotal role in the normal growth and development...

• Functional assessment of skeletal muscle in intact mice lacking myostatin by concurrent NMR imaging and spectroscopy

  Authors:C. Baligand, H. Gilson, J.C. Menard, O. Schakman, C. Wary, J.-P. Thissen, et al.From:Gene Therapy (Vol. 17, Issue 3) Peer-Reviewed

  Mar. 20107,213 words Report Inhibiting myostatin (mstn) causes spectacular increase in muscle mass, spurring research for therapeutic approaches against neuromuscular disorders. Yet, possible functional deterioration and compromised force...

• Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study

  Authors:Shozo Yano, Atsushi Nagai, Minoru Isomura, Masayuki Yamasaki, Tsunetaka Kijima, Miwako Takeda, et al.From:PLoS ONE (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 26, 20153,876 words Report 1450LObjectives Myostatin (MSTN), a member of TGF-[beta] superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic...

• Growth differentiation factor-15 levels and the risk of contrast induced nephropathy in patients with acute myocardial infarction undergoing percutaneous coronary intervention: A retrospective observation study

  Authors:Ling Sun, Xuejun Zhou, Jianguang Jiang, Xuan Zang, Xin Chen, Haiyan Li, et al.From:PLoS ONE (Vol. 13, Issue 5) Peer-Reviewed

  May 23, 20185,223 words Report 1270LAims To investigate the association between growth differentiation factor-15 (GDF-15) and contrast-induced nephropathy (CIN) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary...

• Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice

  Authors:Powen Tu, Shalender Bhasin, Paul W. Hruz, Karen L. Herbst, Lawrence W. Castellani, Ning Hua, et al.From:Diabetes (Vol. 58, Issue 8) Peer-Reviewed

  Aug. 20095,760 words Report 1470LOBJECTIVE--Insulin-resistant states, such as obesity and type 2 diabetes, contribute substantially to accelerated atherogenesis. Null mutations of myostatin (Mstn) are associated with increased muscle mass and decreased...

• Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass

  Authors:N. Kinouchi, Y. Ohsawa, N. Ishimaru, H. Ohuchi, Y. Sunada, Y. Hayashi, et al.From:Gene Therapy (Vol. 15, Issue 15) Peer-Reviewed

  Aug. 20082,689 words Report 1870LRNA interference (RNAi) offers a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. Since it relies on small interfering RNAs (siRNAs), a major issue is the delivery of...

• A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5

  Authors:Madhushika Ratnayake, Maria Tselepi, Robert Bloxham, Frank Ploger, Louise N. Reynard, and John LoughlinFrom:PLoS ONE (Vol. 12, Issue 5) Peer-Reviewed

  May 8, 20177,628 words Report 1530LOsteoarthritis (OA) is a common joint disease characterised by the focal loss of the protective cartilage layer at the ends of the bones. It is painful, disabling, multifactorial and polygenic. The growth...

• The "speed gene" effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion

  Authors:Mary F. Rooney, Emmeline W. Hill, Vincent P. Kelly, and Richard K. PorterFrom:PLoS ONE (Vol. 13, Issue 10) Peer-Reviewed

  Oct. 31, 20189,817 words Report 1450LThoroughbred horses are finely-tuned athletes with a high aerobic capacity relative to skeletal muscle mass, attributable to centuries of genetic selection for speed and stamina. Polymorphisms in the myostatin gene...

• Discovery of a Mammalian Splice Variant of Myostatin That Stimulates Myogenesis

  Authors:Ferenc Jeanplong, Shelley J. Falconer, Jenny M. Oldham, Mark Thomas, Tarra S. Gray, Alex Hennebry, et al.From:PLoS ONE (Vol. 8, Issue 12) Peer-Reviewed

  Dec. 2, 20138,364 words Report 1530LAuthor(s): Ferenc Jeanplong 1,*, Shelley J. Falconer 1, Jenny M. Oldham 1, Mark Thomas 1, Tarra S. Gray 1, Alex Hennebry 1, Kenneth G. Matthews 1, Frederick C. Kemp 2, Ketan Patel 2, Carole Berry 1, Gina Nicholas 1,...

• Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals.

  Authors:Jeong Hwan Kim, Jeong Han Kim, Lisa Andriani Sutikno, Sang Beum Lee, Deuk-Hee Jin, Yong-Ki Hong, et al.From:PLoS ONE (Vol. 14, Issue 4) Peer-Reviewed

  Apr. 18, 20198,772 words Report 1570LMyostatin (MSTN) negatively regulates skeletal muscle growth, and its activity is inhibited by the binding of MSTN propeptide (MSTNpro), the N-terminal domain of proMSTN that is proteolytically cleaved from the proMSTN....

• Irisin regulates cardiac physiology in zebrafish

  Authors:Lakshminarasimhan Sundarrajan, Chanel Yeung, Logan Hahn, Lynn P. Weber, and Suraj UnniappanFrom:PLoS ONE (Vol. 12, Issue 8) Peer-Reviewed

  Aug. 3, 20177,072 words Report 1480LIrisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome...

• Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents

  Authors:L.H. Manfredi, S. Paula-Gomes, N.M. Zanon, and I.C. KettelhutFrom:Brazilian Journal of Medical and Biological Research (Vol. 50, Issue 12) Peer-Reviewed

  Dec. 20175,851 words Report 1470LMyostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin...

• Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-[kappa]B pathways

  Authors:Min Liu, Jian Qin, Yarong Hao, Jun Luo, Tao Luo, and Lei WeiFrom:Oxidative Medicine and Cellular Longevity (Vol. 2014) Peer-Reviewed

  Annual 20144,911 words Report 1400LObjective. The antidiabetes drug astragalus polysaccharide (APS) is capable of increasing insulin sensitivity in skeletal muscle and improving whole-body glucose homeostasis. Recent studies suggest that skeletal muscle...

• Molecular characterization of exon 3 of caprine myostatin gene in Marwari goat

  Authors:Jai Prakash Khichar, Gyan Chand Gahlot, Vijay Kumar Agrawal, Kiran, Ajay Singh Dewna, Prakash, et al.From:Veterinary World (Vol. 9, Issue 6)

  June 20162,839 words Report 1510LAim: To estimate genetic variability in exon 3 of caprine myostatin gene in Marwari goats. Materials and Methods: A total of 120 blood samples from unrelated Marwari goats were randomly collected from different...

• Effects of myostatin on the mechanical properties of muscles during repeated active lengthening in the mouse

  Authors:Danguole Satkunskiene, Aivaras Ratkevicius, Sigitas Kamandulis, and Tomas VenckunasFrom:Applied Physiology, Nutrition, and Metabolism (Vol. 44, Issue 4) Peer-Reviewed

  Apr. 20196,973 words Report 1460LThe aim of the present study was to investigate how myostatin dysfunction affects fast and slow muscle stiffness and viscosity during severe repeated loading. Isolated extensor digitorum longus (EDL) and soleus muscles...

• Evaluation of Electrical Impedance as a Biomarker of Myostatin Inhibition in Wild Type and Muscular Dystrophy Mice

  Authors:Benjamin Sanchez, Jia Li, Sung Yim, Adam Pacheck, Jeffrey J. Widrick, and Seward B. RutkoveFrom:PLoS ONE (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 20, 20156,150 words Report 1510LObjectives Non-invasive and effort independent biomarkers are needed to better assess the effects of drug therapy on healthy muscle and that affected by muscular dystrophy (mdx). Here we evaluated the use of...

• His daughter's DNA: despite a training in clinical genetics, Hugh Rienhoff didn't know what was wrong with his daughter. So, as he tells Brendan Maher, he set about finding out

  Author:Brendan MaherFrom:Nature (Vol. 449, Issue 7164) Peer-Reviewed

  Oct. 18, 20073,969 words Article 1210LNearly four years ago, Hugh Rienhoff watched as his baby girl was pulled from a small incision in his wife's belly. It was their third child--the two boys had also been delivered by caesarean--and Rienhoff was there for...

• Loss-of-function mutation in myostatin reduces tumor necrosis factor [alpha] production and protects liver against obesity-induced insulin resistance

  Authors:Jason J. Wilkes, David J. Lloyd, and Nick GekakisFrom:Diabetes (Vol. 58, Issue 5) Peer-Reviewed

  May 20096,048 words Report 1480LOBJECTIVE--Insulin resistance develops in tandem with obesity. Ablating myostatin (Mstn) prevents obesity, so we investigated if Mstn deficiency could improve insulin sensitivity. A loss-of-function mutation...

• Myostatin activates the ubiquitin-proteasome and autophagy-lysosome systems contributing to muscle wasting in chronic kidney disease

  Authors:Dong-Tao Wang, Ya-Jun Yang, Ren-Hua Huang, Zhi-Hua Zhang, and Xin LinFrom:Oxidative Medicine and Cellular Longevity (Vol. 2015) Peer-Reviewed

  Annual 20157,167 words Report 1410LOur evidence demonstrated that CKD upregulated the expression of myostatin, TNF-[alpha], and p-IkBa and downregulated the phosphorylation of PI3K, Akt, and FoxO3a, which were also associated with protein degradation and...