Search Results

• • 13 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage.

  Authors:Liting Liu, Kaixin Zhai, Yue Chen, Xiaowen Chen, Guofu Wang, and Lixian WuFrom:BioMed Research International (Vol. 2021) Peer-Reviewed

  Jan. 5, 20214,031 words Report 1150LThe study is aimed at investigating the role and mechanism of LpqH of Mycobacterium tuberculosis in the activation of NLRP3 inflammasome in mouse Ana-1 macrophages. ExPASy-ProtParam, PHYRE2, ABCpred, and SYFPEITHI were...

• Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves Spinal Cord Injury via MK2/TTP Signalling Pathway.

  Authors:Li Na, Shuai Wang, Tongtong Liu, and Lixin ZhangFrom:BioMed Research International (Vol. 2020) Peer-Reviewed

  Dec. 7, 20206,700 words Report 1400LObjective. To investigate the curative effects of HUC-MSCs combined with USW on spinal cord injury (SCI) and the effects on inflammatory microenvironment and to explore the regulatory mechanisms of MK2/TTP signalling...

• NLRP3 Susceptible Gene Polymorphisms in Patients with Primary Gouty Arthritis and Hyperuricemia.

  Authors:Bei Zhang, Kahaer Mayina, Xiao-bo Zhang, Mei-ting Liang, Wu-jin Chen, Ting-ting Tian, et al.From:BioMed Research International (Vol. 2022) Peer-Reviewed

  Aug. 23, 20225,250 words Report 1280LPolymorphisms have been identified to predispose to primary gouty arthritis (GA) and hyperuricemia (HUA). Here, we accessed the five polymorphisms of rs10754558, rs35829419, rs3738448, rs3806268, and rs7525979 in NLRP3...

• Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1.

  Authors:Mariam J. Shaheen, Amira M. Bekdash, Hana A. Itani, and Jamilah M. BorjacFrom:PLoS ONE (Vol. 16, Issue 9) Peer-Reviewed

  Sept. 10, 20219,395 words Report 1470LTraumatic brain injury (TBI) remains a major cause of morbidity and disability worldwide and a healthcare burden. TBI is an important risk factor for neurodegenerative diseases hallmarked by exacerbated...

• A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1? Axis.

  Authors:Wenxiang Chen, Pan Tang, Shunwu Fan, and Xuesheng JiangFrom:BioMed Research International (Vol. 2022) Peer-Reviewed

  July 13, 20225,619 words Report 1300LPurpose. A balance between osteoblasts and osteoclasts is essential to maintain skeletal integrity, regulating bone metabolism and bone remodeling. The nucleotide binding oligomerization domain, leucine-rich repeat and...

• Human Umbilical Cord Mesenchymal Stem Cells Improve Premature Ovarian Failure through Cell Apoptosis of miR-100-5p/NOX4/NLRP3.

  Authors:Jing Niu, Fan Yu, Xiping Luo, and Shiling ChenFrom:BioMed Research International (Vol. 2022) Peer-Reviewed

  July 7, 20224,783 words Report 1320LPremature ovarian failure refers to a series of symptoms of perimenopausal hot flashes, night sweats, decreased libido, vaginal dryness, insomnia, reduced menstruation, sparse hair, even amenorrhea, and even infertility...

• The key role of NLRP3 and STING in APOL1-associated podocytopathy.

  Authors:Junnan Wu, Archana Raman, Nathan J. Coffey, Xin Sheng, Joseph Wahba, Matthew J. Seasock, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 20) Peer-Reviewed

  Oct. 15, 202110,832 words Report 1310LCoding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess kidney disease risk in African Americans; however, the molecular pathways of APOL1-induced kidney dysfunction remain poorly...

• NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

  Authors:Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, et al.From:Nature (Vol. 464, Issue 7293) Peer-Reviewed

  Apr. 29, 20105,700 words Report 1560LCholesterol crystals cleared A study in atherosclerosis-prone (apolipoprotein E-deficient) mice on a high cholesterol diet shows that small cholesterol crystals appear in the earliest stages of atherogenesis, and...

• IL-17A Promotes the Migration, Invasion and the EMT Process of Lung Cancer Accompanied by NLRP3 Activation.

  Authors:Wenping Liu, Miaomiao Xin, Qing Li, Linqian Sun, Xiao Han, and Jibo WangFrom:BioMed Research International (Vol. 2022) Peer-Reviewed

  Oct. 30, 20226,556 words Report 1300LBackground. Lung cancer is a deadly cancer worldwide, and its pathogenesis and treatment methods require continuous research and exploration. As a representative factor of adaptive immunity, the role of interleukin-17A...

• Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway.

  Authors:Guocheng Ren, Qiujie Zhou, Meili Lu, and Hongxin WangFrom:Canadian Journal of Physiology and Pharmacology (Vol. 99, Issue 9) Peer-Reviewed

  Sept. 20216,429 words Report 1420LRosuvastatin has been found to possess antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate whether rosuvastatin was effective in attenuating cardiac injury in lipopolysaccharide...

• Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

  Authors:Lieselotte Vande Walle Nina Van Opdenbosch, Peggy Jacques, Amelie Fossoul, Eveline Verheugen, Peter Vogel, Rudi Beyaert, et al.From:Nature (Vol. 512, Issue 7512) Peer-Reviewed

  Aug. 7, 20144,369 words Report 1500LRheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation. Interleukin-1 is an important mediator of cartilage...

• Melatonin Ameliorates the Progression of Alzheimer's Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity.

  Authors:Li Fan, Xie Zhaohong, Wang Xiangxue, Xu Yingying, Zhang Xiao, Zhou Xiaoyan, et al.From:BioMed Research International (Vol. 2022) Peer-Reviewed

  Aug. 9, 20225,838 words Report 1240LBackground. The NLRP3 inflammasome is overactivated in the brains of APP/PS1 transgenic mice and AD patients, and mitophagy has an obvious negative regulatory role on NLRP3 inflammasome activation. The protective effect...

• Associations Between Blood Levels of NLRP3 Inflammasome Components and Obsessive Compulsive Disorder.

  Authors:Melike Tetik, Nese Direk, Betul Onder Uzgan, Cansu Aykac, Burcu Ekinci, Tutku Yaras, et al.From:Archives of Neuropsychiatry (Vol. 60, Issue 1) Peer-Reviewed

  Mar. 20234,320 words Report 1370LIntroduction: Even though the effect of inflammation on pathogenesis of obsessive compulsive disorder (OCD) is known, information regard ing the underlying mechan isms are yet to be revealed. The NLRP3 inflammasome...