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From:Science (Vol. 247, Issue 4944) Peer-ReviewedGenetic Analysis of Histone H4; Essential Role of Lysines Subject to Reversible Acetylation THE [NH.sub.2]-terminal domain of histone H4 has been highly conserved throughout evolution. The first 20 amino acids of...
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From:Science (Vol. 232) Peer-ReviewedShape Analysis of the Histone Octamer in Solution THE FUNDAMENTAL SIZE, SHAPE, and DNA superhelical parameters of core nucleosomes, deduced from x-ray crystallographic studies (1, 2), are the cornerstones of virtually...
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From:PLoS ONE (Vol. 9, Issue 2) Peer-ReviewedAuthor(s): Eva Polanská 1, Sárka Pospísilová 2, Michal Stros 1,2,* Introduction Chromatin-associated protein HMGB1 has been implicated in DNA replication, recombination, repair and transcription, as well as in...
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From:Epigenetics & Chromatin (Vol. 4) Peer-ReviewedBackground Protein exchange kinetics correlate with the level of chromatin condensation and, in many cases, with the level of transcription. We used fluorescence recovery after photobleaching (FRAP) to analyse the...
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From:Nature Medicine (Vol. 15, Issue 1) Peer-ReviewedAlenghat, T. et al. Nature published online, doi:10.1038/nature07541 (26 November). A protein complex is identified that mediates the epigenetic regulation of genes that govern circadian behaviors--including genes...
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From:PLoS ONE (Vol. 11, Issue 7) Peer-ReviewedThe bacterial RecA protein plays a role in the complex system of DNA damage repair. Here, we report the functional and structural characterization of the Herbaspirillum seropedicae RecA protein (HsRecA). HsRecA protein...
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From:PLoS ONE (Vol. 11, Issue 7) Peer-ReviewedSingle-stranded DNA binding (SSB) proteins coordinate DNA replication, repair, and recombination and are critical for maintaining genomic integrity. SSB binds to single-stranded DNA (ssDNA) rapidly and with very high...
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From:PLoS ONE (Vol. 13, Issue 11) Peer-ReviewedRabies is a fatal encephalitic disease in humans and animals caused by lyssaviruses, most commonly rabies virus (RABV). Human antemortem diagnosis of rabies is a complex process involving multiple sample types and tests...
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From:PLoS ONE (Vol. 13, Issue 5) Peer-ReviewedAmong various genome editing tools available for functional genomic studies, reagents based on clustered regularly interspersed palindromic repeats (CRISPR) have gained popularity due to ease and versatility. CRISPR...
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From:Japan Academy Proceedings Series A: Mathematical Sciences (Vol. 88A, Issue 8) Peer-ReviewedThe 1061st General Meeting of the Academy was held on Monday, September 12, 2012, at 1:00 p.m., Dr. Masaaki KUBO, President, taking the chair. Ninety-eight members were present, and the following communications were...
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From:Nature (Vol. 468, Issue 7321) Peer-ReviewedTo establish productive infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA (1,2). This process is operated by the intasome, a nucleoprotein complex composed of an integrase...
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From:PLoS ONE (Vol. 10, Issue 5) Peer-ReviewedNucleophosmin 1 (NPM1) mutations are frequently found in patients with acute myeloid leukemia (AML) and the newly generated sequences were suggested to induce immune response contributing to the relatively favorable...
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From:Science (Vol. 262, Issue 5137) Peer-Reviewed5-Iodouracil-substituted RNA and DNA were crosslinked regiospecifically to associated proteins in yields of 70 to 94% of bound nucleic acid. Irradiation of the iodouracil chromophore with monochromatic, long-wavelength...
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From:PLoS ONE (Vol. 4, Issue 7) Peer-ReviewedA number of nuclear events occur during apoptosis, including DNA laddering, nuclear lamina breakdown, phosphorylation of histones H2B and histone H2AX, and the tight binding to chromatin of HMGB1 and CAD, the nuclease...
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From:Emerging Infectious Diseases (Vol. 16, Issue 4) Peer-ReviewedTo the Editor: In 1998, a new lineage of triple reassortant influenza A (H3N2) virus (TR-H3N2) with genes from humans (hemmaglutinin [HA], neuraminidase [NA], and polymerase basic 1 [PB1]), swine (matrix [M],...
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From:PLoS ONE (Vol. 12, Issue 8) Peer-ReviewedHighly pathogenic avian influenza viruses (HPAIVs) of H5 subtype have persistently caused outbreaks in domestic poultry and wild birds worldwide and sporadically infected humans. Rapid and accurate diagnosis is one of...
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From:Science (Vol. 254, Issue 5029) Peer-ReviewedTO UNRAVEL THE MECHANISMS BY WHICH GENES ARE activated in eukaryotes, it is necessary to examine the factors that are involved in the pathway leading to initiation of transcription. Transcription of protein coding genes...
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From:Science (Vol. 230) Peer-ReviewedThe 3' Splice Site of Pre-Messenger RNA Is Recognized by a Small Nuclear Ribonucleoprotein Three regions in mammalian messenger RNA precursors (pre-mRNA's) are important for the specificity and efficiency of RNA...
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From:Science (Vol. 271, Issue 5247) Peer-ReviewedCBP2 is an RNA tertiary structure binding protein required for efficient splicing of a yeast mitochondrial group I intron. CBP2 must wait for folding of the two RNA domains that make up the catalytic core before it can...
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From:Science (Vol. 297, Issue 5582) Peer-ReviewedThe passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a...