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    Academic Journals

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• STING is a direct innate immune sensor of cyclic di-GMP

  Authors:Dara L. Burdette, Kathryn M. Monroe, Katia Sotelo-Troha, Jeff S. Iwig, Barbara Eckert, Mamoru Hyodo, et al.From:Nature (Vol. 478, Issue 7370) Peer-Reviewed

  Oct. 27, 20114,349 words Report 1420LThe innate immune system detects infection by using germline-encoded receptors that are specific for conserved microbial molecules. The recognition of microbial ligands leads to the production of cytokines, such as type...

• Ubiquitylation of Terminal Deoxynucleotidyltransferase Inhibits Its Activity

  Authors:So Maezawa, Rie Fukushima, Toyofumi Matsushita, Tomoyoshi Kato, Yoshiki Takagaki, Yoshihiro Nishiyama, et al.From:PLoS ONE (Vol. 7, Issue 7) Peer-Reviewed

  July 11, 20129,030 words Article 1390LAuthor(s): So Maezawa * , Rie Fukushima, Toyofumi Matsushita, Tomoyoshi Kato, Yoshiki Takagaki, Yoshihiro Nishiyama, Sachiko Ando, Takuro Matsumoto, Kousuke Kouda, Takahide Hayano, Masahiro Suzuki, Kotaro Koiwai, Osamu...

• Structure-Function Relationship of Substituted Bromomethylcoumarins in Nucleoside Specificity of RNA Alkylation

  From:PLoS ONE (Vol. 8, Issue 7) Peer-Reviewed

  July 3, 20136,992 words Article 1500LIntroduction RNA labeling Scientific investigations of the principle biopolymers face a need for effective and selective labeling agents. This applies in particular to ribonucleic acids (RNA), which have such...

• Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

  Authors:Holger Rehmann, Ernesto Arias-Palomo, Michael A. Hadders, Frank Schwede, Oscar Llorca, and Johannes L. BosFrom:Nature (Vol. 455, Issue 7209) Peer-Reviewed

  Sept. 4, 20084,457 words Report 1410LEpac proteins are activated by binding of the second messenger cAMP and then act as guanine nucleotide exchange factors for Rap proteins (1,2). The Epac proteins are involved in the regulation of cell adhesion 3 and...

• Interaction between cannabinoid and nucleotide systems as a new mechanism of signaling in retinal cell death

  Authors:Ricardo Reis and Ana VenturaFrom:Neural Regeneration Research (Vol. 14, Issue 12) Peer-Reviewed

  Dec. 20191,870 words Report 1690LByline: Hercules. Freitas, Ricardo. Reis, Ana. Ventura, Guilherme. Franca Nervous system emerges from complex signaling interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic...

• Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process.

  Authors:Derrick J. Reynolds and Klemens J. HertelFrom:PLoS ONE (Vol. 14, Issue 10) Peer-Reviewed

  Oct. 3, 20198,371 words Report 1660LAlternative splicing diversifies mRNA transcripts in human cells. While the spliceosome pairs exons with a high degree of accuracy, the rates of rare aberrant and non-canonical pre-mRNA splicing have not been evaluated...

• Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter

  Authors:Emma E. Smith, Gwenaelle Conseil, and Susan P. C. ColeFrom:PLoS ONE (Vol. 16, Issue 2) Peer-Reviewed

  Feb. 11, 202110,560 words Report 1610LMultidrug resistance protein 1 (MRP1) (gene symbol ABCC1) is an ATP-binding cassette (ABC) transporter which effluxes xeno- and endobiotic organic anions including estradiol glucuronide and the pro-inflammatory...

• Raloxifene and Desmethylarzoxifene Block Estrogen-Induced Malignant Transformation of Human Breast Epithelial Cells

  Authors:Irida Kastrati, Praneeth D. Edirisinghe, L-P-Madhubani P. Hemachandra, Esala R. Chandrasena, Jaewoo Choi, Yue-Ting Wang, et al.From:PLoS ONE (Vol. 6, Issue 11) Peer-Reviewed

  Nov. 29, 20118,509 words Article 1510LThere is association between exposure to estrogens and the development and progression of hormone-dependent gynecological cancers. Chemical carcinogenesis by catechol estrogens derived from oxidative metabolism is...

• Identification and Characterization of a Novel Non-Coding RNA Involved in Sperm Maturation

  Authors:Min-Jie Ni, Zhi-Hong Hu, Qiang Liu, Mo-Fang Liu, Min-hua Lu, Jin-Song Zhang, et al.From:PLoS ONE (Vol. 6, Issue 10) Peer-Reviewed

  Oct. 12, 201111,471 words Article 1450LA long and ever-expanding roster of small (~20-30 nucleotides) RNAs has emerged during the last decade, and most can be subsumed under the three main headings of microRNAs(miRNAs), Piwi-interacting RNAs(piRNAs), and...

• The First Insight into the Tissue Specific Taxus Transcriptome via Illumina Second Generation Sequencing

  Authors:Da Cheng Hao, GuangBo Ge, PeiGen Xiao, YanYan Zhang, and Ling YangFrom:PLoS ONE (Vol. 6, Issue 6) Peer-Reviewed

  June 22, 201111,206 words Article 1460LBackground Illumina second generation sequencing is now an efficient route for generating enormous sequence collections that represent expressed genes and quantitate expression level. Taxus is a world-wide endangered...

• Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis

  Authors:Anna P. Lucarelli, Silvia Buroni, Maria R. Pasca, Menico Rizzi, Andrea Cavagnino, Giovanna Valentini, et al.From:PLoS ONE (Vol. 5, Issue 11) Peer-Reviewed

  Nov. 15, 20108,108 words Article 1550LThe selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Currently, there is an urgent need for new...

• Application of Equilibrium Models of Solution Hybridization to Microarray Design and Analysis

  Authors:Raad Z. Gharaibeh, Joshua M. Newton, Jennifer W. Weller, and Cynthia J. GibasFrom:PLoS ONE (Vol. 5, Issue 6) Peer-Reviewed

  June 10, 20108,759 words Article 1470LBackground The probe percent bound value, calculated using multi-state equilibrium models of solution hybridization, is shown to be useful in understanding the hybridization behavior of microarray probes having 50...

• Template-directed synthesis of a genetic polymer in a model protocell

  Authors:Sheref S. Mansy, Jason P. Schrum, Mathangi Krishnamurthy, Sylvia Tobe, Douglas A. Treco, and Jack W. SzostakFrom:Nature (Vol. 454, Issue 7200) Peer-Reviewed

  July 3, 20084,993 words Article 1510LOrigins of life: The first cell membranes The phospholipids that form the membranes of modern cells present a formidable barrier to polar and charged molecules, necessitating complex channels and pumps to permit the...

• Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments

  Authors:Yuan Qi, Xiuping Liu, Chang-gong Liu, Bailing Wang, Kenneth R. Hess, W. Fraser Symmans, et al.From:PLoS ONE (Vol. 10, Issue 7) Peer-Reviewed

  July 2, 20156,890 words Article 1570LNucleotide alterations detected by next generation sequencing are not always true biological changes but could represent sequencing errors. Even highly accurate methods can yield substantial error rates when applied to...

• Structural Constraints Identified with Covariation Analysis in Ribosomal RNA

  Authors:Lei Shang, Weijia Xu, Stuart Ozer, and Robin R. GutellFrom:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 19, 201211,444 words Article 1520LCovariation analysis is used to identify those positions with similar patterns of sequence variation in an alignment of RNA sequences. These constraints on the evolution of two positions are usually associated with a...

• Crumple: A Method for Complete Enumeration of All Possible Pseudoknot-Free RNA Secondary Structures

  Authors:Samuel Bleckley, Jonathan W. Stone, and Susan J. SchroederFrom:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 27, 20127,560 words Article 1420LThe diverse landscape of RNA conformational space includes many canyons and crevices that are distant from the lowest minimum free energy valley and remain unexplored by traditional RNA structure prediction methods. A...

• Ligand Binding Study of Human PEBP1/RKIP: Interaction with Nucleotides and Raf-1 Peptides Evidenced by NMR and Mass Spectrometry

  Authors:Laurette Tavel, Lucie Jaquillard, Andreas I. Karsisiotis, Fabienne Saab, Laurence Jouvensal, Alain Brans, et al.From:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 27, 20127,922 words Article 1480LBackground Human Phosphatidylethanolamine binding protein 1 (hPEBP1) also known as Raf kinase inhibitory protein (RKIP), affects various cellular processes, and is implicated in metastasis formation and Alzheimer's...

• In Vitro HIV-1 LTR Integration into T-Cell Activation Gene CD27 Segment and the Decoy Effect of Modified-Sequence DNA

  Authors:Rei Ohmori and Tatsuaki TsuruyamaFrom:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 28, 20124,145 words Article 1360LIntegration into the host genome is an essential step in the HIV-1 life cycle. However, the host genome sequence that is favored by HIV-1 during integration has never been documented. Here, we report that CD27, a T cell...

• The Biosynthesis of UDP-d-QuiNAc in Bacillus cereus ATCC 14579

  Authors:Soyoun Hwang, Avi Aronov, and Maor Bar-PeledFrom:PLoS ONE (Vol. 10, Issue 7) Peer-Reviewed

  July 24, 20157,820 words Article 1490LN-acetylquinovosamine (2-acetamido-2,6-di-deoxy-d-glucose, QuiNAc) is a relatively rare amino sugar residue found in glycans of few pathogenic gram-negative bacteria where it can play a role in infection. However,...

• Inferring interactions in complex microbial communities from nucleotide sequence data and environmental parameters

  Authors:Yu Shang, Johannes Sikorski, Michael Bonkowski, Anna-Maria Fiore-Donno, Ellen Kandeler, Sven Marhan, et al.From:PLoS ONE (Vol. 12, Issue 3) Peer-Reviewed

  Mar. 13, 201711,423 words Report 1540LInteractions occur between two or more organisms affecting each other. Interactions are decisive for the ecology of the organisms. Without direct experimental evidence the analysis of interactions is difficult....