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Academic Journals
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From:Science (Vol. 247, Issue 4946) Peer-ReviewedThe discovery of viral oncogenes, genes that are responsible for the cancer-causing effects of some viruses, led to the identification of proto-oncogenes, which are similar genes found in all normal cells. Many...
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From:Science (Vol. 254, Issue 5035) Peer-ReviewedSignaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer. Oncogenes identified by a variety of approaches have been shown to function at critical steps in mitogeneic...
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From:Science (Vol. 247, Issue 4946) Peer-ReviewedThe identification of viral oncogenes, which are responsible for the cancer-causing effects of some viruses, led to the identification of proto-oncogenes, which are similar genes found in all normal cells. Although the...
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From:The Western Journal of Medicine (Vol. 155, Issue 5) Peer-ReviewedCancer is caused by specific DNA damage. Several common mechanisms that cause DNA damage result in specific malignant disorders: First, proto-oncogenes can be activted by translocations. For example, translocation of the...
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From:Future Oncology (Vol. 6, Issue 10) Peer-ReviewedDoctors use clues from genome sequencing of rare tongue tumor to personalize treatment regimen. Doctors at the BC Cancer Agency Genome Sciences Centre (British Columbia, Canada) used massively parallel sequencing to...
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From:Science (Vol. 249, Issue 4965) Peer-ReviewedIdentification of Small Clusters of Divergent Amino Acids That Mediate the Opposing Effects of ras and Krev-1 INTERPLAY BETWEEN POSITIVE AND negative regulators determines whether a cell will grow and divide, with...
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From:Science (Vol. 248, Issue 4959) Peer-ReviewedActivation of ras Oncogenes Preceding the Onset of Neoplasia ACTIVATED ras ONCOGENES HAVE been identified in some common forms of human cancer including carcinomas of the lung, colon, and pancreas [1]. In many...
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From:Science (Vol. 239, Issue 4842) Peer-ReviewedFirst Portrait of an Oncogene Product A research article in this issue of Science marks a new milestone in the quest to understand the action of the cancer-causing oncogenes. On page 888, Sung-Hou Kim of the...
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From:Science (Vol. 242, Issue 4883) Peer-ReviewedA c-myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro THE PROTO-ONCOGENE C-myb, THE normal cellular homolog of the avian myeloblastosis virus transforming gene v-myb, may play an...
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From:Science (Vol. 238, Issue 4832) Peer-ReviewedHuman Proto-Oncogene c-jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1 AGROWING NUMBER OF VIRAL AND CELLULAR GENES HAVE been identified as potential cancer...
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From:Science (Vol. 235) Peer-ReviewedI have recently had the opportunity to canvass the work and views of a group of scientists who attended a Nobel symposium on "Membrane proteins: Structure, function and assembly," held in Kalskoga, Sweden, in beautiful...
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From:Science (Vol. 236) Peer-ReviewedEfficient Packaging of Readthrough RNA in ALV: Implications for Oncogene Transduction INTEGRATED PROVIRAL DNA OF RETROVIRUSESis flanked by long terminal repeats (LTRs) that contain transcriptional regulatory signals...
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From:Science (Vol. 232) Peer-ReviewedIdentification and Characterization of the Protein Encoded by the Human N-myc Oncogene THE N-MYC GENE, WHILE NOT A classic proto-oncogene in that it does not have a homolog carried by an acutely transforming...
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From:Science (Vol. 289, Issue 5483) Peer-ReviewedChromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not in carcinomas, the most common human cancers. Here, we report that t(2;3)(q13;p25),...
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From:Oncology (Vol. 32, Issue 3) Peer-ReviewedRapidly advancing genomic sequencing technologies are changing all areas of cancer, from diagnosis to surveillance, and prognostication to treatment. The role of genomic testing in melanoma is expanding, and multiple...
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From:Science (Vol. 283, Issue 5400) Peer-ReviewedThe Fos and Jun oncoproteins form dimeric complexes that stimulate transcription of genes containing activator protein-1 regulatory elements. We found, by representational difference analysis, that expression of DNA...
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From:PLoS ONE (Vol. 13, Issue 4) Peer-ReviewedDisturbances in one-carbon metabolism, intracellular reactions involved in nucleotide synthesis and methylation, likely increase the risk of colorectal cancer (CRC). However, results have been inconsistent. To explore...
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From:Journal of Thyroid ResearchPeer-ReviewedPapillary thyroid carcinoma (PTC) accounts for over 80% of all thyroid malignancies. The molecular pathogenesis remains incompletely clarified although activation of the RET fusion oncogenes, and RAS and BRAF oncogenes,...
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From:Nature Medicine (Vol. 15, Issue 1) Peer-ReviewedWe report the development of a new method to induce glioblastoma multiforme in adult immunocompetent mice by injecting Cre-loxP-controlled lentiviral vectors expressing oncogenes. Cell type- or region-specific...
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From:Nature Biotechnology (Vol. 26, Issue 1) Peer-ReviewedIn a stunning experiment published in 2006, Shinya Yamanaka and his coworkers (1) first reported that fibroblast cells from mouse fetal tissue could be reprogrammed to the pluripotent state through the beguilingly...