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From:Journal of Clinical Investigation (Vol. 126, Issue 4) Peer-ReviewedTumor-derived exosomes (TEX) are harbingers of tumor-induced immune suppression: they carry immunosuppressive molecules and factors known to interfere with immune cell functions. By delivering suppressive cargos...
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From:Canadian Journal of Microbiology (Vol. 64, Issue 9) Peer-ReviewedAll Gram-negative bacteria release membrane vesicles. These vesicles contain a cargo of proteins and enzymes that include one or more autolysins. Autolysins are a group of enzymes with specificity for the different...
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From:PLoS ONE (Vol. 10, Issue 12) Peer-ReviewedBackground Exosomes are emerging targets for biomedical research. However, suitable methods for the isolation of blood plasma-derived exosomes without impurities have not yet been described. Aim Therefore, we...
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From:Nature (Vol. 460, Issue 7253) Peer-ReviewedTo view the innards of a cell is to view architecture reminiscent of Antoni Gaudi: the gentle arc of the cell membrane, the contortions of internal tubing, the tight bubbles of vesicles. But for biologists, this...
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From:Science (Vol. 293, Issue 5533) Peer-ReviewedThe transport of organelles within eukaryotic cells depends on motor proteins that bind to the organelles (cargo) and move them along tracks composed of microtubules or actin filaments. Although the human genome encodes...
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From:Nature (Vol. 520, Issue 7548) Peer-ReviewedThe essential autophagy mediator ATG14 promotes vesicle fusion by forming homo-oligomers, which bind to a component of the SNARE membrane fusion complex and stabilize this complex on autophagosomes. Autophagy-specific...
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From:Neural Regeneration Research (Vol. 15, Issue 12) Peer-ReviewedByline: Alexandra. Iavorovschi, Aijun. Wang Treatment for central nervous system (CNS) disorders is known to be limited by the low regenerative potential of neurons, and thus neurodegenerative insults became known as...
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From:PLoS ONE (Vol. 15, Issue 9) Peer-ReviewedUpon internalization, receptors are trafficked to sorting endosomes (SE) where they undergo sorting and are then packaged into budding vesicles that undergo fission and transport within the cell. Eps15 Homology Domain...
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From:Nature Biotechnology (Vol. 37, Issue 12) Peer-ReviewedCells compartmentalize their intracellular environment to orchestrate countless simultaneous biochemical processes. Many intracellular tasks rely on membrane-less organelles, multicomponent condensates that assemble by...
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From:Neurology India (Vol. 70, Issue 1) Peer-ReviewedByline: Sreekanth. Patnam, Rasmita. Samal, Rajeswari. Koyyada, Partha. Joshi, Anula. Singh, Balakrishna. Nagalla, Madan. Soma, Rajesh. Sannareddy, Kaushal. Ippili, Subodh. Raju, Ratnam. Boola, Rahul. Lath, Alok. Ranjan,...
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From:PLoS ONE (Vol. 15, Issue 9) Peer-ReviewedExosomes are vesicles involved in intercellular communication. Their membrane structure and core content is largely dependent on the cell of origin. Exosomes have been investigated both for their biological roles and...
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From:Transactions of the Illinois State Academy of Science (Vol. 114) Peer-ReviewedUltrasonography is commonly used by producers to determine pregnancy in their flocks (Scott 2012; Jones et al., 2016). Transabdominal ultrasonography is a simple, non-invasive method; however, it is not frequently used...
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From:Annual Review of Microbiology (Vol. 48) Peer-ReviewedTrypanosomes are parasitic protozoa which exhibit compartmentalization of glycolytic enzymes through organelles known as glycosomes. The protein targeting mechanism displayed by glycosomal proteins are similar to that in...
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From:Journal of Clinical Investigation (Vol. 126, Issue 4) Peer-ReviewedIntercellular signaling via extracellular vesicles (EVs) is an underappreciated modality of cell-cell crosstalk that enables cells to convey packages of complex instructions to specific recipient cells. EVs transmit...
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From:PLoS ONE (Vol. 15, Issue 9) Peer-ReviewedExtracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis,...
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From:eLife (Vol. 4) Peer-ReviewedRecent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1[beta] (IL-1[beta]). Here, we reconstituted an autophagy-regulated secretion of mature...
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From:eLife (Vol. 5) Peer-ReviewedThe thylakoid proton motive force (pmf) generated during photosynthesis is the essential driving force for ATP production; it is also a central regulator of light capture and electron transfer. We investigated the...
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From:PLoS ONE (Vol. 13, Issue 6) Peer-ReviewedCancer cells secrete many exosomes, which facilitate metastasis and the later growth of cancer. For early cancer diagnosis, the detection of exosomes is a crucial step. Exosomes exist in biological fluid, such as blood,...
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From:Pediatric Nephrology (Vol. 34, Issue 1) Peer-ReviewedExtracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in size, including exosomes, microvesicles, and apoptotic bodies. They are released under physiological conditions, but also upon...
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From:Nature (Vol. 463, Issue 7280) Peer-ReviewedA living cell can be thought of as a building of extremely peculiar architecture, in which the walls are formed by films just a few nanometres thick--the cell membranes. The numerous rooms, halls and corridors of the...