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    Academic Journals

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• Evaluation of cutaneous drug reactions in patients visiting out patient departments of Indira Gandhi Government Medical College and Hospital (IGGMC and H), Nagpur

  Authors:Sachin Hiware, Meena Shrivastava, Dharmendra Mishra, Jayesh Mukhi, and Gaurav PuppalwarFrom:Indian Journal of Dermatology (Vol. 58, Issue 1) Peer-Reviewed

  January-February 20131,920 words Report 1670LByline: Sachin. Hiware, Meena. Shrivastava, Dharmendra. Mishra, Jayesh. Mukhi, Gaurav. Puppalwar Objectives: To detect cutaneous drug reactions through spontaneous reporting system in IGGMCand H, Nagpur and analyze...

• Role of cytochrome P450 2C8*3 (CYP2C8*3) in paclitaxel metabolism and paclitaxel-induced neurotoxicity

  Authors:Mi-Young Lee, Maria Apellaniz-Ruiz, Inger Johansson, Svante Vikingsson, Troels K Bergmann, Kim Brosen, et al.From:Pharmacogenomics (Vol. 16, Issue 9) Peer-Reviewed

  June 20155,402 words Report 1540LAuthor(s): Mi-Young Lee aff1 , María Apellániz-Ruiz aff2 , Inger Johansson aff1 , Svante Vikingsson aff3 , Troels K Bergmann aff4 , Kim Brøsen aff4 , Henrik Green aff3 aff5 , Cristina Rodríguez-Antona aff2 aff6 , Magnus...

• Influence of hydrogen peroxide in drinking water on diazepam pharmacokinetics in chicks

  Authors:Yaareb J. Mousa and Fouad K. MohammadFrom:Veterinary World (Vol. 5, Issue 11)

  Nov. 20122,670 words Report 1320LAim: Stressful conditions affect drug pharmacokinetics and pharmacodynamics. This study examines the effect of hydrogen peroxide ([H.sub.2][O.sub.2]) in drinking water on the pharmacokinetics of diazepam in a chick...

• Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: Possible role of CYP3A4 inhibition by pravastatin

  Authors:Chong-Ki Lee, Jun-Shik Choi, and Dong-Hyun ChoiFrom:Indian Journal of Pharmacology (Vol. 44, Issue 5) Peer-Reviewed

  September-October 20123,162 words Report 1610LByline: Chong-Ki. Lee, Jun-Shik. Choi, Dong-Hyun. Choi Objective: The aim of this study was to investigate the effects of pravastatin on the pharmacokinetics of nimodipine in rats. Materials and Methods: The effect...

• Comparison of knowledge, attitude and practices of resident doctors and nurses on adverse drug reaction monitoring and reporting in a tertiary care hospital

  Authors:H. Rehan, Ravinder Sah, and Deepti ChopraFrom:Indian Journal of Pharmacology (Vol. 44, Issue 6) Peer-Reviewed

  November-December 20122,779 words Report 1460LByline: H. Rehan, Ravinder. Sah, Deepti. Chopra Background: Lack of knowledge of pharmacovigilance (PhV) and adverse event (AE) reporting culture among the healthcare providers have been identified as major factors...

• Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I

  From:Molecular Diagnosis & Therapy (Vol. 14, Issue 4) Peer-Reviewed

  July-August 2010461 words Report 1320LThe calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant drugs used for the prevention of organ rejection following transplantation. Both agents are metabolic substrates for cytochrome...

• Generics: need for clinical concern?

  Authors:F.R. Heller and A.G. DupontFrom:Acta Clinica Belgica (Vol. 64, Issue 5) Peer-Reviewed

  September-October 20095,509 words Report The market of generic drugs is in continuous development in all countries, including Belgium. Their low cost explains their success in western and developed countries. However, clinical concerns have been raised when...

• 27. Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis

  From:Pharmaceutical Medicine (Vol. 22, Issue 6) Peer-Reviewed

  November-December 2008318 words Brief article, Clini... 1400LBackground: Liver cirrhosis is a progressive disease characterized by loss of functional hepatocytes with concomitant connective tissue and nodule formation in the liver. The morphological and physiological changes...

• Chylous transport of amiodarone

  Authors:Charlie Strange, David P. Nicolau, and Scott R. DryzerFrom:Chest (Vol. 101, Issue 2) Peer-Reviewed

  Feb. 1992722 words Article A patient receiving amiodarone for longstanding ventricular dysrhythmias presented with idiopathic chylothorax. During drainage of chylothorax fox pleurodesis, serial plasma amiodarone concentrations declined while...

• Assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach

  Authors:Alex Zwiers, Michiel van den Heuvel, Jean Smeets, and Samantha RutherfordFrom:Clinical Drug Investigation (Vol. 31, Issue 2) Peer-Reviewed

  Feb. 20114,395 words Clinical report 1670LBackground: Sugammadex is a g-cyclodextrin that binds with high affinity to the neuromuscular blocking agents (NMBAs) rocuronium (bromide) and vecuronium (bromide) by encapsulation. Cyclodextrins are known to form...

• Preparation, Characterization, and In Vivo Pharmacoscintigraphy Evaluation of an Intestinal Release Delivery System of Prussian Blue for Decorporation of Cesium and Thallium

  Authors:Nidhi Sandal, Gaurav Mittal, Aseem Bhatnagar, Dharam Pal Pathak, and Ajay Kumar SinghFrom:Journal of Drug Delivery (Vol. 2017) Peer-Reviewed

  Annual 20175,310 words Report 1410LBackground. Prussian blue (PB, ferric hexacyanoferrate) is approved by US-FDA for internal decorporation of Cesium-137 ([sup.137]Cs) and Thallium-201 ([sup.201]Tl). Aim. Since PB is a costly drug, pH-dependent oral...

• Ketolides--the modern relatives of macrolides: the pharmacokinetic perspective

  Authors:Markus Zeitlinger, Claudia Christina Wagner, and Birgit HeinischFrom:Clinical Pharmacokinetics (Vol. 48, Issue 1) Peer-Reviewed

  Jan. 200911,352 words Article 2130LAs with other widely used antibacterials, the abundant use of macrolides for management of ambulant infections has promoted emergence of resistance against them. Ketolides are structurally related to macrolides and were...

• Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery

  Authors:An Van den Bergh, Vikash Sinha, Ron Gilissen, Roel Straetemans, Koen Wuyts, Denise Morrison, et al.From:Clinical Pharmacokinetics (Vol. 50, Issue 8) Peer-Reviewed

  Aug. 20115,941 words Report 1580LBackground and Objectives: Empirically based methods remain one of our tools in human pharmacokinetic predictions. The Dedrick approach and the steady-state plasma drug concentration ([C.sub.ss])-mean residence time...

• Tissue penetration of cefpodoxime and cefixime in healthy subjects

  Authors:Ping Liu, Markus Muller, Maria Grant, Bernd Obermann, and Hartmut DerendorfFrom:Journal of Clinical Pharmacology (Vol. 45, Issue 5) Peer-Reviewed

  May 20052,923 words Article Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, 2-way...

• Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice

  Authors:Attila S. Farkas and Stanley NattelFrom:Drugs (Vol. 70, Issue 5) Peer-Reviewed

  Mar. 15, 201017,864 words Report 2060LProarrhythmia, the development of new or worse arrhythmias in response to drug therapy, is a major limitation to the development and use of new drugs. There are different types of drug-induced proarrhythmia, including...

• In vitro intestinal permeability studies and pharmacokinetic evaluation of famotidine microemulsion for oral delivery

  Authors:Sajal Kumar Jha, Roopa Karki, Venkatesh Dinnekere Puttegowda, and D. HarinarayanaFrom:International Scholarly Research NoticesPeer-Reviewed

  Annual 20143,464 words Report 1400LThe absolute bioavailability of famotidine after oral administration is about 40-45% and absorbance only in the initial part of small intestine may be due to low intestinal permeability. Hence, an olive oil based...

• Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer

  Authors:Bunzo Nakata, Ryosuke Amano, Shigetomi Nakao, Tatsuro Tamura, Osamu Shinto, Toshiki Hirakawa, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 29) Peer-Reviewed

  Feb. 24, 20103,622 words Report Background The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer. Methods Six patients...

• Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

  Authors:Lars Ole Schwen, Arne Schenk, Clemens Kreutz, Jens Timmer, Maria Matilde Bartolome Rodriguez, Lars Kuepfer, et al.From:PLoS ONE (Vol. 10, Issue 7) Peer-Reviewed

  July 29, 201519,922 words Article 1500LThe mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body. The corresponding biochemical processes are typically subject to spatial variations at different length scales. Zonal...

• Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men

  Authors:Fabian Y. S. Kong, Thusitha W. Rupasinghe, Julie A. Simpson, Lenka A. Vodstrcil, Christopher K. Fairley, Malcolm J. McConville, et al.From:PLoS ONE (Vol. 12, Issue 3) Peer-Reviewed

  Mar. 28, 20175,705 words Report 1660LChlamydia is the most common bacterial sexually transmitted infection among men who have sex with men. Repeat infection following treatment with 1g azithromycin is common and treatment failure of up to 22% has been...

• Robust estimation of hemo-dynamic parameters in traditional DCE-MRI models

  Authors:Mikkel B. Hansen, Anna Tietze, Soren Haack, Jesper Kallehauge, Irene K. Mikkelsen, Leif Ostergaard, et al.From:PLoS ONE (Vol. 14, Issue 1) Peer-Reviewed

  Jan. 3, 20197,417 words Report 1580LPurpose In dynamic contrast enhanced (DCE) MRI, separation of signal contributions from perfusion and leakage requires robust estimation of parameters in a pharmacokinetic model. We present and quantify the...