Search Results

• • 774 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders

  Authors:Julie Mollet, Irina Giurgea, Dimitri Schlemmer, Gustav Dallner, Dominique Chretien, Agnes Delahodde, et al.From:Journal of Clinical Investigation (Vol. 117, Issue 3) Peer-Reviewed

  Mar. 20074,330 words Article 1370LCoenzyme [Q.sub.10] (Co[Q.sub.10]) plays a pivotal role in oxidative phosphorylation (OXPHOS), as it distributes electrons among the various dehydrogenases and the cytochrome segments of the respiratory chain. We have...

• Monitoring protein phosphorylation: phosphospecific antibodies and new techniques free signaling researchers from the perils of radioactivity handling. (Lab Consumer)

  Authors:Christine Yanicek and Jeffrey M. PerkelFrom:The Scientist (Vol. 17, Issue 13) Peer-Reviewed

  June 30, 2003846 words Article Signal transduction pathways comprise the cell's communications system; they transmit cues--from hormones, growth factors, or cytokines, for instance--that tell the ceil to proliferate, differentiate, activate (or...

• Insulin receptor phosphorylation may not be a prerequisite for acute insulin action

  Authors:Ian A. Simpson and Jose A. HedoFrom:Science (Vol. 223) Peer-Reviewed

  Mar. 23, 19841,696 words Article Since the initial observations by Kasuga et al. (1) that insulin can induce the phosphorylation of the [beta] subunit (molecular weight, [is approx. =] 95,000) of its own receptor in both IM-9 lymphocytes and H-35...

• Phosphorylation of the transcription factor PHO4 by a cyclin-cdk complex, PHO8O-PHO85

  Authors:Arie Kaffman, Ira Herskowitz, Robert Tjian, and Erin K. O'SheaFrom:Science (Vol. 263, Issue 5150) Peer-Reviewed

  Feb. 25, 19944,013 words Article Induction of the yeast gene PHO5 is mediated by the transcription factors PHO2 and PHO4. PHO5 transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and PHO85 inactivate PHO2...

• Modulation of the dimerization of a transcriptional antiterminator protein by phosphorylation

  Authors:Orna Amster-Choder and Andrew WrightFrom:Science (Vol. 257, Issue 5075) Peer-Reviewed

  Sept. 4, 19922,141 words Article The transcriptional antiterminator protein BglG inhibits transcription termination of the bgl operon in Escherichia coli when it is in the nonphosphorylated state. The BglG protein is now shown to exist in two...

• Calmodulin trapping by calcium-calmodulin-dependent protein kinase

  Authors:Tobias Meyer, Phyllis I. Hanson, Lubert Stryer, and Howard SchulmanFrom:Science (Vol. 256, Issue 5060) Peer-Reviewed

  May 22, 19922,866 words Article Multifunctional calcium-calmodulin-dependent protein kinase (CaM kinase) transduces transient elevations in intracellular calcium into changes in the phosphorylation state and activity of target proteins. By fluorescence...

• Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

  Authors:Jagan M.R. Pongubala, Charles Van Beveren, Sujatha Nagulapalli, Michael J. Klemsz, Scott R. McKercher, Richard A. Maki, et al.From:Science (Vol. 259, Issue 5101) Peer-Reviewed

  Mar. 12, 19932,953 words Article PU.1 recruits the binding of a second B cell--restricted nuclear factor, NF-EM5, to a DNA site in the immunoglobulin [Kappa] 3' enhancer. DNA binding by NF-EM5 requires a protein-protein interaction with PU.1 and...

• Activation of smooth muscle contraction: relation between myosin phosphorylation and stiffness

  Authors:Kristine E. Kamm and James T. StullFrom:Science (Vol. 232) Peer-Reviewed

  Apr. 4, 19861,760 words Article Activation of Smooth Muscle Contraction: Relation Between Myosin Phosphorylation and Stiffness SMOOTH MUSCLE MYOSIN FILAMENTS are composed of myosin monomers that consist of two heavy chains [each with a molecular weight...

• Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination

  Authors:Tiago Ferreira da Silva, Jessica Eira, Andre T. Lopes, Ana R. Malheiro, Vera Sousa, Adrienne Luoma, et al.From:Journal of Clinical Investigation (Vol. 124, Issue 6) Peer-Reviewed

  June 20146,899 words Report 1430LRhizomelic chondrodysplasia punctata (RCDP) is a developmental disorder characterized by hypotonia, cataracts, abnormal ossification, impaired motor development, and intellectual disability. The underlying etiology of...

• The high-affinity Hsp90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

  Authors:Chad A. Dickey, Adeela Kamal, Karen Lundgren, Natalia Klosak, Rachel M. Bailey, Judith Dunmore, et al.From:Journal of Clinical Investigation (Vol. 117, Issue 3) Peer-Reviewed

  Mar. 20077,133 words Article 1380LA primary pathologic component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). Expediting the removal of these p-tau species may be a relevant...

• Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats

  Authors:Xiao-Bo Huang, Yu-Jing Chen, Wen-Qiang Chen, Ning-Qun Wang, Xi-Ling Wu, and Yan LiuFrom:Brain Circulation (Vol. 4, Issue 1) Peer-Reviewed

  January-March 20184,804 words Report 1540LByline: Xiao-Bo. Huang, Yu-Jing. Chen, Wen-Qiang. Chen, Ning-Qun. Wang, Xi-Ling. Wu, Yan. Liu BACKGROUND: Tenuigenin (TEN), a major active component of the Chinese herb Polygala tenuifolia root, has been used to...

• A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

  Authors:Janet H. C. Yeo, Jarrod P. J. Skinner, Matthew J. Bird, Luke E. Formosa, Jian-Guo Zhang, Ruth M. Kluck, et al.From:PLoS ONE (Vol. 10, Issue 7) Peer-Reviewed

  July 29, 20156,640 words Article 1300LWe identified Mrpl44 in a search for mammalian proteins that contain RNase III domains. This protein was previously found in association with the mitochondrial ribosome of bovine liver extracts. However, the precise...

• PKD2 and RSK1 regulate integrin [beta]4 phosphorylation at threonine 1736

  Authors:Lisa te Molder and Arnoud SonnenbergFrom:PLoS ONE (Vol. 10, Issue 11) Peer-Reviewed

  Nov. 18, 20159,123 words Report 1440LThe integrin [alpha]6[beta]4, a major component of hemidesmosomes (HDs), stabilizes keratinocyte cell adhesion to the epidermal basement membrane through binding to the cytoskeletal linker protein plectin and...

• Protein kinase C coordinates histone H3 phosphorylation and acetylation

  Authors:Zoulfia Darieva, Aaron Webber, Stacey Warwood, and Andrew D SharrocksFrom:eLife (Vol. 4) Peer-Reviewed

  Oct. 15, 201510,780 words Report 1530LThe re-assembly of chromatin following DNA replication is a critical event in the maintenance of genome integrity. Histone H3 acetylation at K56 and phosphorylation at T45 are two important chromatin modifications that...

• Expression of genes belonging to the interacting TLR cascades, NADPH-oxidase and mitochondrial oxidative phosphorylation in septic patients

  Authors:Laura A. Nucci, Sidneia S. Santos, Milena K. C. Brunialti, Narendra Kumar Sharma, Flavia R. Machado, Murillo Assuncao, et al.From:PLoS ONE (Vol. 12, Issue 2) Peer-Reviewed

  Feb. 9, 20175,260 words Report 1450LBackground and objectives Sepsis is a complex disease that is characterized by activation and inhibition of different cell signaling pathways according to the disease stage. Here, we evaluated genes involved in the...

• Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function

  Authors:Victor H. Navas, Celine Cuche, Andres Alcover, and Vincenzo Di BartoloFrom:PLoS ONE (Vol. 12, Issue 1) Peer-Reviewed

  Jan. 20, 20177,222 words Report 1450LThe adapter protein SLP76 is a key orchestrator of T cell receptor (TCR) signal transduction. We previously identified a negative feedback loop that modulates T cell activation, involving phosphorylation of Ser376 of...

• Structure of protein O-mannose kinase reveals a unique active site architecture

  Authors:Qinyu Zhu, David Venzke, Ameya S Walimbe, Mary E Anderson, Qiuyu Fu, Lisa N Kinch, et al.From:eLife (Vol. 5) Peer-Reviewed

  Nov. 23, 201611,247 words Report 1380LThe 'pseudokinase' SgK196 is a protein O-mannose kinase (POMK) that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan on [alpha]-dystroglycan. However, the catalytic mechanism...

• Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex

  Authors:Daniel Horvath, Istvan Tamas, Adrienn Sipos, Zsuzsanna Darula, Balint Becsi, Denes Nagy, et al.From:PLoS ONE (Vol. 12, Issue 5) Peer-Reviewed

  May 9, 201710,385 words Report 1410LReversible phosphorylation of neuronal proteins plays an important role in the regulation of neurotransmitter release. Myosin phosphatase holoenzyme (MP) consists of a protein phosphatase-1 (PP1) catalytic subunit...

• Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A

  Authors:Esti Wahyu Widowati, Simone Bamberg-Lemper, and Walter BeckerFrom:BMC Research Notes (Vol. 11, Issue 1) Peer-Reviewed

  May 15, 20182,579 words Report 1420LObjective Dual specificity tyrosine phosphorylation-regulated kinases (DYRK) contain a characteristic sequence motif (DYRK homology box, DH box) that is located N-terminal of the catalytic domain and supports the...

• Acidic pH triggers the phosphorylation of the response regulator NtrX in alphaproteobacteria

  Authors:Ignacio Fernandez, Gabriela Sycz, Fernando Alberto Goldbaum, and Mariela del Carmen CarricaFrom:PLoS ONE (Vol. 13, Issue 4) Peer-Reviewed

  Apr. 10, 20188,856 words Report 1580LMany signaling pathways that control cellular development, cell-cycle progression and nutritional versatility have been studied in Caulobacter crescentus. For example, it was suggested that the response regulator NtrX...